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sox11  (Atlas Antibodies)


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    Structured Review

    Atlas Antibodies sox11
    The molecular structure of <t>SOX11.</t> The SOX11 protein is composed of 441 amino acids. SOX11 contains two functional domains, the N-terminal HMG domain and the conserved TAD. SOX11, sex-determining region Y-related high-mobility-group box transcription factor 11; HMG, high mobility group; TAD, C-terminal transactivation domain.
    Sox11, supplied by Atlas Antibodies, used in various techniques. Bioz Stars score: 93/100, based on 31 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/tissue+microarray+based+immunohistochemistry+analysis/Anti-SOX11/pmc06547177-27-12-8
    Average 93 stars, based on 31 article reviews
    sox11 - by Bioz Stars, 2026-11
    93/100 stars

    Images

    1) Product Images from "SOX11: friend or foe in tumor prevention and carcinogenesis?"

    Article Title: SOX11: friend or foe in tumor prevention and carcinogenesis?

    Journal: Therapeutic Advances in Medical Oncology

    doi: 10.1177/1758835919853449

    The molecular structure of SOX11. The SOX11 protein is composed of 441 amino acids. SOX11 contains two functional domains, the N-terminal HMG domain and the conserved TAD. SOX11, sex-determining region Y-related high-mobility-group box transcription factor 11; HMG, high mobility group; TAD, C-terminal transactivation domain.
    Figure Legend Snippet: The molecular structure of SOX11. The SOX11 protein is composed of 441 amino acids. SOX11 contains two functional domains, the N-terminal HMG domain and the conserved TAD. SOX11, sex-determining region Y-related high-mobility-group box transcription factor 11; HMG, high mobility group; TAD, C-terminal transactivation domain.

    Techniques Used: Functional Assay

    Overview of SOX11 function reported in diverse types of cancer.
    Figure Legend Snippet: Overview of SOX11 function reported in diverse types of cancer.

    Techniques Used: Expressing, Over Expression, Biomarker Discovery, Migration, Methylation, DNA Methylation Assay

    Overall carcinogenic actions of SOX11 on the hallmarks of tumor biology. SOX11 exerts tumor-stimulative effects through increasing cell proliferation, repressing cell differentiation, inducing angiogenesis, and promoting metastasis. BCL6, B-cell lymphoma 6; BNIP3, B-cell lymphoma 2 (BCL2)/adenovirus E1B 19 kDa protein-interacting protein 3; CIC, cancer-initiating cell; PAX5, Paired box protein 5; PDGFA, platelet-derived growth factor A; SETMAR, SET domain and mariner transposase fusion gene; SOX11, Sex-determining region Y-related high-mobility-group box transcription factor 11; TANK, TRAF family member-associated NF-κB activator.
    Figure Legend Snippet: Overall carcinogenic actions of SOX11 on the hallmarks of tumor biology. SOX11 exerts tumor-stimulative effects through increasing cell proliferation, repressing cell differentiation, inducing angiogenesis, and promoting metastasis. BCL6, B-cell lymphoma 6; BNIP3, B-cell lymphoma 2 (BCL2)/adenovirus E1B 19 kDa protein-interacting protein 3; CIC, cancer-initiating cell; PAX5, Paired box protein 5; PDGFA, platelet-derived growth factor A; SETMAR, SET domain and mariner transposase fusion gene; SOX11, Sex-determining region Y-related high-mobility-group box transcription factor 11; TANK, TRAF family member-associated NF-κB activator.

    Techniques Used: Cell Differentiation, Derivative Assay

    Different prognostic significance of SOX11 in tumor cases.
    Figure Legend Snippet: Different prognostic significance of SOX11 in tumor cases.

    Techniques Used: Expressing, Microarray, Over Expression

    Related Articles

    Formalin-fixed Paraffin-Embedded:

    Article Title: CD5-negative Mantle Cell Lymphoma: Clinicopathologic features of an indolent variant that confers a survival advantage
    Article Snippet: .. Formalin-fixed paraffin-embedded tissue sections were stained for SOX11 (1:100; Atlas Antibodies, Stockholm, Sweden). ..

    Staining:

    Article Title: CD5-negative Mantle Cell Lymphoma: Clinicopathologic features of an indolent variant that confers a survival advantage
    Article Snippet: .. Formalin-fixed paraffin-embedded tissue sections were stained for SOX11 (1:100; Atlas Antibodies, Stockholm, Sweden). ..

    Sequencing:

    Article Title: SOX11 regulates SWI/SNF complex components as member of the adrenergic neuroblastoma core regulatory circuitry
    Article Snippet: .. Sequencing depth IMR-32 SOX11 ChIP: Total mapped reads:75269021, Uniqually mapped reads: 58444500, Read length: 75 bp, single-end IMR-32 INPUT ChIP: Total mapped reads: 46283806, Uniqually mapped reads: 38101144, Read length: 75 bp, single-end IMR-32 SOX11 CUT&RUN: Total mapped reads: 9055406, Uniqually mapped reads: 6399393, Read length: 75 bp, pair-end IMR-32 IgG CUT&RUN: Total mapped reads: 8941165, Uniqually mapped reads: 5925768 Read length: 75 bp, pair-end CLB-GA SOX11 CUT&RUN: Total mapped reads: 9071586, Uniqually mapped reads: 6736893 Read length: 75 bp, pair-end CLB-GA IgG CUT&RUN: Total mapped reads: 8633535, Uniqually mapped reads: 594113, Read length: 75 bp, pair-end NGP SOX11 CUT&RUN: Total mapped reads: 9121804, Uniqually mapped reads: 6603935, Read length: 75 bp, pair-end NGP IgG CUT&RUN: Total mapped reads: 9118638, Uniqually mapped reads: 5897926, Read length: 75 bp, pair-end SH-EP SOX11 OE SOX11 CUT&RUN: Total mapped reads: 8509115, Uniqually mapped reads: 5373607, Read length: 75 bp, pair-end SH-EP SOX11 OE IgG CUT&RUN: Total mapped reads: 8247565, Uniqually mapped reads: 5869023, Read length: 75 bp, pair-end Antibodies CUT&RUN: anti-SOX11 antibody (HPA000536, Atlas Antibodies) and anti-IgG goat antibody (sc-2028, Santa Cruz Biotechnology) was used. .. ChIP: The rabbit polyclonal antibody, SOX11-PAb, was custom made (Absea biotechnology, China) against the immunogenic peptide p-SOX11C-term DDDDDDDDDELQLQIKQEPDEEDEEPPHQQLLQPPGQQPSQLLRRYNVAKVPASPTLSSSAESPEGASLYDEVRAGATSGAGGGSRLYYSFKNITKQHPP PLAQPALSPASSRSVSTSSS Peak calling parameters Read mapping was done with bowtie2 and index hg19.

    Chromatin Immunoprecipitation:

    Article Title: SOX11 regulates SWI/SNF complex components as member of the adrenergic neuroblastoma core regulatory circuitry
    Article Snippet: .. Sequencing depth IMR-32 SOX11 ChIP: Total mapped reads:75269021, Uniqually mapped reads: 58444500, Read length: 75 bp, single-end IMR-32 INPUT ChIP: Total mapped reads: 46283806, Uniqually mapped reads: 38101144, Read length: 75 bp, single-end IMR-32 SOX11 CUT&RUN: Total mapped reads: 9055406, Uniqually mapped reads: 6399393, Read length: 75 bp, pair-end IMR-32 IgG CUT&RUN: Total mapped reads: 8941165, Uniqually mapped reads: 5925768 Read length: 75 bp, pair-end CLB-GA SOX11 CUT&RUN: Total mapped reads: 9071586, Uniqually mapped reads: 6736893 Read length: 75 bp, pair-end CLB-GA IgG CUT&RUN: Total mapped reads: 8633535, Uniqually mapped reads: 594113, Read length: 75 bp, pair-end NGP SOX11 CUT&RUN: Total mapped reads: 9121804, Uniqually mapped reads: 6603935, Read length: 75 bp, pair-end NGP IgG CUT&RUN: Total mapped reads: 9118638, Uniqually mapped reads: 5897926, Read length: 75 bp, pair-end SH-EP SOX11 OE SOX11 CUT&RUN: Total mapped reads: 8509115, Uniqually mapped reads: 5373607, Read length: 75 bp, pair-end SH-EP SOX11 OE IgG CUT&RUN: Total mapped reads: 8247565, Uniqually mapped reads: 5869023, Read length: 75 bp, pair-end Antibodies CUT&RUN: anti-SOX11 antibody (HPA000536, Atlas Antibodies) and anti-IgG goat antibody (sc-2028, Santa Cruz Biotechnology) was used. .. ChIP: The rabbit polyclonal antibody, SOX11-PAb, was custom made (Absea biotechnology, China) against the immunogenic peptide p-SOX11C-term DDDDDDDDDELQLQIKQEPDEEDEEPPHQQLLQPPGQQPSQLLRRYNVAKVPASPTLSSSAESPEGASLYDEVRAGATSGAGGGSRLYYSFKNITKQHPP PLAQPALSPASSRSVSTSSS Peak calling parameters Read mapping was done with bowtie2 and index hg19.

    Incubation:

    Article Title: A large-scale functional analysis of genes expressed differentially in insulin secreting MIN6 sublines with high versus mildly reduced glucose-responsiveness.
    Article Snippet: .. Membranes were probed with rabbit anti-Sox11 antibody (1:500) (HPA000536; Atlas Antibodies) or with mouse anti-β-actin antibody (1:5000) (#60008-1-Ig, Proteintech) overnight at 4 °C, and then incubated for 1 h with donkey anti-rabbit IgG (1:10,000) or with sheep anti-mouse IgG (1:10,000) conjugated with horseradish peroxidase (GE Healthcare, Piscataway, NL, USA). ..

    Article Title: A large-scale functional analysis of genes expressed differentially in insulin secreting MIN6 sublines with high versus mildly reduced glucose-responsiveness
    Article Snippet: .. Membranes were probed with rabbit anti-Sox11 antibody (1:500) (HPA000536; Atlas Antibodies) or with mouse anti-β-actin antibody (1:5000) (#60008-1-Ig, Proteintech) overnight at 4 °C, and then incubated for 1 h with donkey anti-rabbit IgG (1:10,000) or with sheep anti-mouse IgG (1:10,000) conjugated with horseradish peroxidase (GE Healthcare, Piscataway, NL, USA). ..

    Tissue:

    Article Title: CD5-negative Mantle Cell Lymphoma: Clinicopathologic features of an indolent variant that confers a survival advantage
    Article Snippet: .. Formalin-fixed paraffin-embedded tissue sections were stained for SOX11 (1:100; Atlas Antibodies, Stockholm, Sweden). ..



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    Image Search Results


    Cell type specific genes demonstrated at mRNA level. (A) Heat map of genes with cell type specific expression. (B) Heat map of selected genes with endothelial or epithelial cell type specific expression. (C) Immunohistochemistry staining of protein C1orf116 across human tissues showing its epithelial cell type specific expression. The panel shows a magnified view (20×) from tissue microarrays.

    Journal: Nucleic Acids Research

    Article Title: A transcriptomic and proteomic map of primary human cell types

    doi: 10.1093/nar/gkaf1498

    Figure Lengend Snippet: Cell type specific genes demonstrated at mRNA level. (A) Heat map of genes with cell type specific expression. (B) Heat map of selected genes with endothelial or epithelial cell type specific expression. (C) Immunohistochemistry staining of protein C1orf116 across human tissues showing its epithelial cell type specific expression. The panel shows a magnified view (20×) from tissue microarrays.

    Article Snippet: The Human Protein Atlas (HPA) project provided a tissue-based map of the human proteome through transcriptomics and tissue microarray-based immunohistochemistry analysis [ , ].

    Techniques: Expressing, Immunohistochemistry, Staining