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thalidomide  (LKT Laboratories)


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    Structured Review

    LKT Laboratories thalidomide
    Thalidomide, supplied by LKT Laboratories, used in various techniques. Bioz Stars score: 93/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/thalidomide/Thalidomide/pmc09166406-38-86-89
    Average 93 stars, based on 4 article reviews
    thalidomide - by Bioz Stars, 2026-11
    93/100 stars

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    Related Articles

    Activation Assay:

    Article Title: Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production.
    Article Snippet: Thalidomide (Sigma, T144) lenalidomide (LKT Laboratories, L1852) were reconstituted to a stock concentration of 50 mg/mL pomalidomide (Sigma, P0018) and salirasib (Cayman Chemical Company, 10010501) were reconstituted to a concentration of 10 mg/mL and 20 mg/mL, respectively.

    Article Title: Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production
    Article Snippet: Thalidomide (Sigma, T144) lenalidomide (LKT Laboratories, L1852) were reconstituted to a stock concentration of 50 mg/mL pomalidomide (Sigma, P0018) and salirasib (Cayman Chemical Company, 10010501) were reconstituted to a concentration of 10 mg/mL and 20 mg/mL, respectively.

    Article Title: Sorafenib targets and inhibits the oncogenic properties of endometrial cancer stem cells via the RAF/ERK pathway
    Article Snippet: We assessed the following 14 putative CSC-targeting drugs as possible candidate endometrial CSC-targeting drugs: celecoxib [ ] (Sigma-Aldrich, St. Louis, MO), genistein [ ] (WAKO, Osaka, Japan), imatinib [ ] (WAKO), itraconazole [ ] (WAKO), lithium carbonate [ ] (Nacalai Tesque, Kyoto, Japan), niclosamide [ , ] (Santa Cruz Biotechnology, Dallas, Tx), retinyl acetate [ ] (Sigma-Aldrich,), bevacizumab [ ] (Roche, Basel, Switzerland), everolimus [ ] (WAKO), ramucirumab [ ] (Eli Lilly, Indianapolis, Indiana), sorafenib [ ] (LC Laboratories, Woburn, MA), temsirolimus [ , ] (WAKO), thalidomide [ ] (LKT Laboratories, Inc., MN), and tranilast [ ] (Tokyo Chemical Industry co., Ltd., Japan).

    Article Title: Application of stem cell derived neuronal cells to evaluate neurotoxic chemotherapy
    Article Snippet: Cisplatin and carboplatin (Sigma-Aldrich) were dissolved in DMSO and water, respectively, at a stock solution of 20 mM.

    Clinical Proteomics:

    Article Title: Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production.
    Article Snippet: Thalidomide (Sigma, T144) lenalidomide (LKT Laboratories, L1852) were reconstituted to a stock concentration of 50 mg/mL pomalidomide (Sigma, P0018) and salirasib (Cayman Chemical Company, 10010501) were reconstituted to a concentration of 10 mg/mL and 20 mg/mL, respectively.

    Article Title: Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production
    Article Snippet: Thalidomide (Sigma, T144) lenalidomide (LKT Laboratories, L1852) were reconstituted to a stock concentration of 50 mg/mL pomalidomide (Sigma, P0018) and salirasib (Cayman Chemical Company, 10010501) were reconstituted to a concentration of 10 mg/mL and 20 mg/mL, respectively.

    Article Title: Sorafenib targets and inhibits the oncogenic properties of endometrial cancer stem cells via the RAF/ERK pathway
    Article Snippet: We assessed the following 14 putative CSC-targeting drugs as possible candidate endometrial CSC-targeting drugs: celecoxib [ ] (Sigma-Aldrich, St. Louis, MO), genistein [ ] (WAKO, Osaka, Japan), imatinib [ ] (WAKO), itraconazole [ ] (WAKO), lithium carbonate [ ] (Nacalai Tesque, Kyoto, Japan), niclosamide [ , ] (Santa Cruz Biotechnology, Dallas, Tx), retinyl acetate [ ] (Sigma-Aldrich,), bevacizumab [ ] (Roche, Basel, Switzerland), everolimus [ ] (WAKO), ramucirumab [ ] (Eli Lilly, Indianapolis, Indiana), sorafenib [ ] (LC Laboratories, Woburn, MA), temsirolimus [ , ] (WAKO), thalidomide [ ] (LKT Laboratories, Inc., MN), and tranilast [ ] (Tokyo Chemical Industry co., Ltd., Japan).

    Article Title: Application of stem cell derived neuronal cells to evaluate neurotoxic chemotherapy
    Article Snippet: Cisplatin and carboplatin (Sigma-Aldrich) were dissolved in DMSO and water, respectively, at a stock solution of 20 mM.

    Staining:

    Article Title: Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production.
    Article Snippet: Thalidomide (Sigma, T144) lenalidomide (LKT Laboratories, L1852) were reconstituted to a stock concentration of 50 mg/mL pomalidomide (Sigma, P0018) and salirasib (Cayman Chemical Company, 10010501) were reconstituted to a concentration of 10 mg/mL and 20 mg/mL, respectively.

    Article Title: Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production
    Article Snippet: Thalidomide (Sigma, T144) lenalidomide (LKT Laboratories, L1852) were reconstituted to a stock concentration of 50 mg/mL pomalidomide (Sigma, P0018) and salirasib (Cayman Chemical Company, 10010501) were reconstituted to a concentration of 10 mg/mL and 20 mg/mL, respectively.

    Article Title: Sorafenib targets and inhibits the oncogenic properties of endometrial cancer stem cells via the RAF/ERK pathway
    Article Snippet: We assessed the following 14 putative CSC-targeting drugs as possible candidate endometrial CSC-targeting drugs: celecoxib [ ] (Sigma-Aldrich, St. Louis, MO), genistein [ ] (WAKO, Osaka, Japan), imatinib [ ] (WAKO), itraconazole [ ] (WAKO), lithium carbonate [ ] (Nacalai Tesque, Kyoto, Japan), niclosamide [ , ] (Santa Cruz Biotechnology, Dallas, Tx), retinyl acetate [ ] (Sigma-Aldrich,), bevacizumab [ ] (Roche, Basel, Switzerland), everolimus [ ] (WAKO), ramucirumab [ ] (Eli Lilly, Indianapolis, Indiana), sorafenib [ ] (LC Laboratories, Woburn, MA), temsirolimus [ , ] (WAKO), thalidomide [ ] (LKT Laboratories, Inc., MN), and tranilast [ ] (Tokyo Chemical Industry co., Ltd., Japan).

    Article Title: Application of stem cell derived neuronal cells to evaluate neurotoxic chemotherapy
    Article Snippet: Cisplatin and carboplatin (Sigma-Aldrich) were dissolved in DMSO and water, respectively, at a stock solution of 20 mM.

    Derivative Assay:

    Article Title: Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production.
    Article Snippet: Thalidomide (Sigma, T144) lenalidomide (LKT Laboratories, L1852) were reconstituted to a stock concentration of 50 mg/mL pomalidomide (Sigma, P0018) and salirasib (Cayman Chemical Company, 10010501) were reconstituted to a concentration of 10 mg/mL and 20 mg/mL, respectively.

    Article Title: Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production
    Article Snippet: Thalidomide (Sigma, T144) lenalidomide (LKT Laboratories, L1852) were reconstituted to a stock concentration of 50 mg/mL pomalidomide (Sigma, P0018) and salirasib (Cayman Chemical Company, 10010501) were reconstituted to a concentration of 10 mg/mL and 20 mg/mL, respectively.

    Article Title: Sorafenib targets and inhibits the oncogenic properties of endometrial cancer stem cells via the RAF/ERK pathway
    Article Snippet: We assessed the following 14 putative CSC-targeting drugs as possible candidate endometrial CSC-targeting drugs: celecoxib [ ] (Sigma-Aldrich, St. Louis, MO), genistein [ ] (WAKO, Osaka, Japan), imatinib [ ] (WAKO), itraconazole [ ] (WAKO), lithium carbonate [ ] (Nacalai Tesque, Kyoto, Japan), niclosamide [ , ] (Santa Cruz Biotechnology, Dallas, Tx), retinyl acetate [ ] (Sigma-Aldrich,), bevacizumab [ ] (Roche, Basel, Switzerland), everolimus [ ] (WAKO), ramucirumab [ ] (Eli Lilly, Indianapolis, Indiana), sorafenib [ ] (LC Laboratories, Woburn, MA), temsirolimus [ , ] (WAKO), thalidomide [ ] (LKT Laboratories, Inc., MN), and tranilast [ ] (Tokyo Chemical Industry co., Ltd., Japan).

    Article Title: Application of stem cell derived neuronal cells to evaluate neurotoxic chemotherapy
    Article Snippet: Cisplatin and carboplatin (Sigma-Aldrich) were dissolved in DMSO and water, respectively, at a stock solution of 20 mM.

    Inhibition:

    Article Title: Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production.
    Article Snippet: Thalidomide (Sigma, T144) lenalidomide (LKT Laboratories, L1852) were reconstituted to a stock concentration of 50 mg/mL pomalidomide (Sigma, P0018) and salirasib (Cayman Chemical Company, 10010501) were reconstituted to a concentration of 10 mg/mL and 20 mg/mL, respectively.

    Article Title: Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production
    Article Snippet: Thalidomide (Sigma, T144) lenalidomide (LKT Laboratories, L1852) were reconstituted to a stock concentration of 50 mg/mL pomalidomide (Sigma, P0018) and salirasib (Cayman Chemical Company, 10010501) were reconstituted to a concentration of 10 mg/mL and 20 mg/mL, respectively.

    Article Title: Sorafenib targets and inhibits the oncogenic properties of endometrial cancer stem cells via the RAF/ERK pathway
    Article Snippet: We assessed the following 14 putative CSC-targeting drugs as possible candidate endometrial CSC-targeting drugs: celecoxib [ ] (Sigma-Aldrich, St. Louis, MO), genistein [ ] (WAKO, Osaka, Japan), imatinib [ ] (WAKO), itraconazole [ ] (WAKO), lithium carbonate [ ] (Nacalai Tesque, Kyoto, Japan), niclosamide [ , ] (Santa Cruz Biotechnology, Dallas, Tx), retinyl acetate [ ] (Sigma-Aldrich,), bevacizumab [ ] (Roche, Basel, Switzerland), everolimus [ ] (WAKO), ramucirumab [ ] (Eli Lilly, Indianapolis, Indiana), sorafenib [ ] (LC Laboratories, Woburn, MA), temsirolimus [ , ] (WAKO), thalidomide [ ] (LKT Laboratories, Inc., MN), and tranilast [ ] (Tokyo Chemical Industry co., Ltd., Japan).

    Article Title: Application of stem cell derived neuronal cells to evaluate neurotoxic chemotherapy
    Article Snippet: Cisplatin and carboplatin (Sigma-Aldrich) were dissolved in DMSO and water, respectively, at a stock solution of 20 mM.

    Concentration Assay:

    Article Title: Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production.
    Article Snippet: Thalidomide (Sigma, T144) lenalidomide (LKT Laboratories, L1852) were reconstituted to a stock concentration of 50 mg/mL pomalidomide (Sigma, P0018) and salirasib (Cayman Chemical Company, 10010501) were reconstituted to a concentration of 10 mg/mL and 20 mg/mL, respectively.

    Article Title: Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production
    Article Snippet: Thalidomide (Sigma, T144) lenalidomide (LKT Laboratories, L1852) were reconstituted to a stock concentration of 50 mg/mL pomalidomide (Sigma, P0018) and salirasib (Cayman Chemical Company, 10010501) were reconstituted to a concentration of 10 mg/mL and 20 mg/mL, respectively.

    Article Title: Sorafenib targets and inhibits the oncogenic properties of endometrial cancer stem cells via the RAF/ERK pathway
    Article Snippet: We assessed the following 14 putative CSC-targeting drugs as possible candidate endometrial CSC-targeting drugs: celecoxib [ ] (Sigma-Aldrich, St. Louis, MO), genistein [ ] (WAKO, Osaka, Japan), imatinib [ ] (WAKO), itraconazole [ ] (WAKO), lithium carbonate [ ] (Nacalai Tesque, Kyoto, Japan), niclosamide [ , ] (Santa Cruz Biotechnology, Dallas, Tx), retinyl acetate [ ] (Sigma-Aldrich,), bevacizumab [ ] (Roche, Basel, Switzerland), everolimus [ ] (WAKO), ramucirumab [ ] (Eli Lilly, Indianapolis, Indiana), sorafenib [ ] (LC Laboratories, Woburn, MA), temsirolimus [ , ] (WAKO), thalidomide [ ] (LKT Laboratories, Inc., MN), and tranilast [ ] (Tokyo Chemical Industry co., Ltd., Japan).

    Article Title: Application of stem cell derived neuronal cells to evaluate neurotoxic chemotherapy
    Article Snippet: Cisplatin and carboplatin (Sigma-Aldrich) were dissolved in DMSO and water, respectively, at a stock solution of 20 mM.

    Binding Assay:

    Article Title: Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production.
    Article Snippet: Thalidomide (Sigma, T144) lenalidomide (LKT Laboratories, L1852) were reconstituted to a stock concentration of 50 mg/mL pomalidomide (Sigma, P0018) and salirasib (Cayman Chemical Company, 10010501) were reconstituted to a concentration of 10 mg/mL and 20 mg/mL, respectively.

    Article Title: Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production
    Article Snippet: Thalidomide (Sigma, T144) lenalidomide (LKT Laboratories, L1852) were reconstituted to a stock concentration of 50 mg/mL pomalidomide (Sigma, P0018) and salirasib (Cayman Chemical Company, 10010501) were reconstituted to a concentration of 10 mg/mL and 20 mg/mL, respectively.

    Article Title: Sorafenib targets and inhibits the oncogenic properties of endometrial cancer stem cells via the RAF/ERK pathway
    Article Snippet: We assessed the following 14 putative CSC-targeting drugs as possible candidate endometrial CSC-targeting drugs: celecoxib [ ] (Sigma-Aldrich, St. Louis, MO), genistein [ ] (WAKO, Osaka, Japan), imatinib [ ] (WAKO), itraconazole [ ] (WAKO), lithium carbonate [ ] (Nacalai Tesque, Kyoto, Japan), niclosamide [ , ] (Santa Cruz Biotechnology, Dallas, Tx), retinyl acetate [ ] (Sigma-Aldrich,), bevacizumab [ ] (Roche, Basel, Switzerland), everolimus [ ] (WAKO), ramucirumab [ ] (Eli Lilly, Indianapolis, Indiana), sorafenib [ ] (LC Laboratories, Woburn, MA), temsirolimus [ , ] (WAKO), thalidomide [ ] (LKT Laboratories, Inc., MN), and tranilast [ ] (Tokyo Chemical Industry co., Ltd., Japan).

    Article Title: Application of stem cell derived neuronal cells to evaluate neurotoxic chemotherapy
    Article Snippet: Cisplatin and carboplatin (Sigma-Aldrich) were dissolved in DMSO and water, respectively, at a stock solution of 20 mM.

    Recombinant:

    Article Title: Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production.
    Article Snippet: Thalidomide (Sigma, T144) lenalidomide (LKT Laboratories, L1852) were reconstituted to a stock concentration of 50 mg/mL pomalidomide (Sigma, P0018) and salirasib (Cayman Chemical Company, 10010501) were reconstituted to a concentration of 10 mg/mL and 20 mg/mL, respectively.

    Article Title: Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production
    Article Snippet: Thalidomide (Sigma, T144) lenalidomide (LKT Laboratories, L1852) were reconstituted to a stock concentration of 50 mg/mL pomalidomide (Sigma, P0018) and salirasib (Cayman Chemical Company, 10010501) were reconstituted to a concentration of 10 mg/mL and 20 mg/mL, respectively.

    Article Title: Sorafenib targets and inhibits the oncogenic properties of endometrial cancer stem cells via the RAF/ERK pathway
    Article Snippet: We assessed the following 14 putative CSC-targeting drugs as possible candidate endometrial CSC-targeting drugs: celecoxib [ ] (Sigma-Aldrich, St. Louis, MO), genistein [ ] (WAKO, Osaka, Japan), imatinib [ ] (WAKO), itraconazole [ ] (WAKO), lithium carbonate [ ] (Nacalai Tesque, Kyoto, Japan), niclosamide [ , ] (Santa Cruz Biotechnology, Dallas, Tx), retinyl acetate [ ] (Sigma-Aldrich,), bevacizumab [ ] (Roche, Basel, Switzerland), everolimus [ ] (WAKO), ramucirumab [ ] (Eli Lilly, Indianapolis, Indiana), sorafenib [ ] (LC Laboratories, Woburn, MA), temsirolimus [ , ] (WAKO), thalidomide [ ] (LKT Laboratories, Inc., MN), and tranilast [ ] (Tokyo Chemical Industry co., Ltd., Japan).

    Article Title: Application of stem cell derived neuronal cells to evaluate neurotoxic chemotherapy
    Article Snippet: Cisplatin and carboplatin (Sigma-Aldrich) were dissolved in DMSO and water, respectively, at a stock solution of 20 mM.

    Transfection:

    Article Title: Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production.
    Article Snippet: Thalidomide (Sigma, T144) lenalidomide (LKT Laboratories, L1852) were reconstituted to a stock concentration of 50 mg/mL pomalidomide (Sigma, P0018) and salirasib (Cayman Chemical Company, 10010501) were reconstituted to a concentration of 10 mg/mL and 20 mg/mL, respectively.

    Article Title: Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production
    Article Snippet: Thalidomide (Sigma, T144) lenalidomide (LKT Laboratories, L1852) were reconstituted to a stock concentration of 50 mg/mL pomalidomide (Sigma, P0018) and salirasib (Cayman Chemical Company, 10010501) were reconstituted to a concentration of 10 mg/mL and 20 mg/mL, respectively.

    Article Title: Sorafenib targets and inhibits the oncogenic properties of endometrial cancer stem cells via the RAF/ERK pathway
    Article Snippet: We assessed the following 14 putative CSC-targeting drugs as possible candidate endometrial CSC-targeting drugs: celecoxib [ ] (Sigma-Aldrich, St. Louis, MO), genistein [ ] (WAKO, Osaka, Japan), imatinib [ ] (WAKO), itraconazole [ ] (WAKO), lithium carbonate [ ] (Nacalai Tesque, Kyoto, Japan), niclosamide [ , ] (Santa Cruz Biotechnology, Dallas, Tx), retinyl acetate [ ] (Sigma-Aldrich,), bevacizumab [ ] (Roche, Basel, Switzerland), everolimus [ ] (WAKO), ramucirumab [ ] (Eli Lilly, Indianapolis, Indiana), sorafenib [ ] (LC Laboratories, Woburn, MA), temsirolimus [ , ] (WAKO), thalidomide [ ] (LKT Laboratories, Inc., MN), and tranilast [ ] (Tokyo Chemical Industry co., Ltd., Japan).

    Article Title: Application of stem cell derived neuronal cells to evaluate neurotoxic chemotherapy
    Article Snippet: Cisplatin and carboplatin (Sigma-Aldrich) were dissolved in DMSO and water, respectively, at a stock solution of 20 mM.

    Western Blot:

    Article Title: Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production.
    Article Snippet: Thalidomide (Sigma, T144) lenalidomide (LKT Laboratories, L1852) were reconstituted to a stock concentration of 50 mg/mL pomalidomide (Sigma, P0018) and salirasib (Cayman Chemical Company, 10010501) were reconstituted to a concentration of 10 mg/mL and 20 mg/mL, respectively.

    Article Title: Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production
    Article Snippet: Thalidomide (Sigma, T144) lenalidomide (LKT Laboratories, L1852) were reconstituted to a stock concentration of 50 mg/mL pomalidomide (Sigma, P0018) and salirasib (Cayman Chemical Company, 10010501) were reconstituted to a concentration of 10 mg/mL and 20 mg/mL, respectively.

    Article Title: Sorafenib targets and inhibits the oncogenic properties of endometrial cancer stem cells via the RAF/ERK pathway
    Article Snippet: We assessed the following 14 putative CSC-targeting drugs as possible candidate endometrial CSC-targeting drugs: celecoxib [ ] (Sigma-Aldrich, St. Louis, MO), genistein [ ] (WAKO, Osaka, Japan), imatinib [ ] (WAKO), itraconazole [ ] (WAKO), lithium carbonate [ ] (Nacalai Tesque, Kyoto, Japan), niclosamide [ , ] (Santa Cruz Biotechnology, Dallas, Tx), retinyl acetate [ ] (Sigma-Aldrich,), bevacizumab [ ] (Roche, Basel, Switzerland), everolimus [ ] (WAKO), ramucirumab [ ] (Eli Lilly, Indianapolis, Indiana), sorafenib [ ] (LC Laboratories, Woburn, MA), temsirolimus [ , ] (WAKO), thalidomide [ ] (LKT Laboratories, Inc., MN), and tranilast [ ] (Tokyo Chemical Industry co., Ltd., Japan).

    Article Title: Application of stem cell derived neuronal cells to evaluate neurotoxic chemotherapy
    Article Snippet: Cisplatin and carboplatin (Sigma-Aldrich) were dissolved in DMSO and water, respectively, at a stock solution of 20 mM.

    Co-Immunoprecipitation Assay:

    Article Title: Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production.
    Article Snippet: Thalidomide (Sigma, T144) lenalidomide (LKT Laboratories, L1852) were reconstituted to a stock concentration of 50 mg/mL pomalidomide (Sigma, P0018) and salirasib (Cayman Chemical Company, 10010501) were reconstituted to a concentration of 10 mg/mL and 20 mg/mL, respectively.

    Article Title: Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production
    Article Snippet: Thalidomide (Sigma, T144) lenalidomide (LKT Laboratories, L1852) were reconstituted to a stock concentration of 50 mg/mL pomalidomide (Sigma, P0018) and salirasib (Cayman Chemical Company, 10010501) were reconstituted to a concentration of 10 mg/mL and 20 mg/mL, respectively.

    Article Title: Sorafenib targets and inhibits the oncogenic properties of endometrial cancer stem cells via the RAF/ERK pathway
    Article Snippet: We assessed the following 14 putative CSC-targeting drugs as possible candidate endometrial CSC-targeting drugs: celecoxib [ ] (Sigma-Aldrich, St. Louis, MO), genistein [ ] (WAKO, Osaka, Japan), imatinib [ ] (WAKO), itraconazole [ ] (WAKO), lithium carbonate [ ] (Nacalai Tesque, Kyoto, Japan), niclosamide [ , ] (Santa Cruz Biotechnology, Dallas, Tx), retinyl acetate [ ] (Sigma-Aldrich,), bevacizumab [ ] (Roche, Basel, Switzerland), everolimus [ ] (WAKO), ramucirumab [ ] (Eli Lilly, Indianapolis, Indiana), sorafenib [ ] (LC Laboratories, Woburn, MA), temsirolimus [ , ] (WAKO), thalidomide [ ] (LKT Laboratories, Inc., MN), and tranilast [ ] (Tokyo Chemical Industry co., Ltd., Japan).

    Article Title: Application of stem cell derived neuronal cells to evaluate neurotoxic chemotherapy
    Article Snippet: Cisplatin and carboplatin (Sigma-Aldrich) were dissolved in DMSO and water, respectively, at a stock solution of 20 mM.



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    Excitability shifts in hippocampal circuitry point to pre-synaptic dysfunction after injury which is restored by application of <t>thalidomide.</t> (A-F) Fiber volley and fEPSP slope, at simulation ranging from 50 to 500 μA with error ellipses indicating 95% confidence. – demonstrate presynaptic dysfunctions, as the relationship between the fiber volley and the fEPSP does not significantly change after injury in all three subregions of the hippocampus. In – these disruptions are restored to sham levels post-thalidomide application in both area CA1 and omDG. However, in imDG , the correlation between fiber volley and fEPSP in injured vs. sham animals is different as shown by the lack of change in fiber volley slope and decreased overlap of the ellipses. This suggests that network excitability may be restored through a combination of presynaptic and postsynaptic means (see for details on analysis).
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    Image Search Results


    Excitability shifts in hippocampal circuitry point to pre-synaptic dysfunction after injury which is restored by application of thalidomide. (A-F) Fiber volley and fEPSP slope, at simulation ranging from 50 to 500 μA with error ellipses indicating 95% confidence. – demonstrate presynaptic dysfunctions, as the relationship between the fiber volley and the fEPSP does not significantly change after injury in all three subregions of the hippocampus. In – these disruptions are restored to sham levels post-thalidomide application in both area CA1 and omDG. However, in imDG , the correlation between fiber volley and fEPSP in injured vs. sham animals is different as shown by the lack of change in fiber volley slope and decreased overlap of the ellipses. This suggests that network excitability may be restored through a combination of presynaptic and postsynaptic means (see for details on analysis).

    Journal: Brain, behavior, and immunity

    Article Title: Microglia depletion improves hippocampal circuit function after mild traumatic brain injury in male mice

    doi: 10.1016/j.bbi.2025.106178

    Figure Lengend Snippet: Excitability shifts in hippocampal circuitry point to pre-synaptic dysfunction after injury which is restored by application of thalidomide. (A-F) Fiber volley and fEPSP slope, at simulation ranging from 50 to 500 μA with error ellipses indicating 95% confidence. – demonstrate presynaptic dysfunctions, as the relationship between the fiber volley and the fEPSP does not significantly change after injury in all three subregions of the hippocampus. In – these disruptions are restored to sham levels post-thalidomide application in both area CA1 and omDG. However, in imDG , the correlation between fiber volley and fEPSP in injured vs. sham animals is different as shown by the lack of change in fiber volley slope and decreased overlap of the ellipses. This suggests that network excitability may be restored through a combination of presynaptic and postsynaptic means (see for details on analysis).

    Article Snippet: Thalidomide (5 μM, Tocris Bioscience), an immunosuppressant ( ; ; ) was bath-applied in some slices from sham and injured animals to determine the effects of TNF-α on neural circuits.

    Techniques:

    Thalidomide restores excitability in hippocampal circuits at 7 dpi. (A) I/O curves of fEPSP slopes in area CA1 show no interaction effects; however, the significant increase in excitability in both injured and sham slices post 15-minute bath application of thalidomide suggest main effects of treatment; two-way ANOVA: F(1, 13) = 9.107, p < 0.0099. (B) Outer molecular layer Dentate Gyrus (omDG) show decreased excitability in injured slices after thalidomide application with no changes in sham slices; two-way ANOVA F(1, 117) = 18.23, p < 0.0001. (C) Inner molecular layer Dentate Gyrus (imDG) also revealed no changes in sham slices but an increase in excitability in injured animals post-thalidomide application; two-way ANOVA: F(1, 117) = 5.777, p = 0.0319. Data shown as mean ± SEM; Injured: N = 8; Sham: N = 7. Asterisks for multiple comparisons indicate ****p < 0.0001.

    Journal: Brain, behavior, and immunity

    Article Title: Microglia depletion improves hippocampal circuit function after mild traumatic brain injury in male mice

    doi: 10.1016/j.bbi.2025.106178

    Figure Lengend Snippet: Thalidomide restores excitability in hippocampal circuits at 7 dpi. (A) I/O curves of fEPSP slopes in area CA1 show no interaction effects; however, the significant increase in excitability in both injured and sham slices post 15-minute bath application of thalidomide suggest main effects of treatment; two-way ANOVA: F(1, 13) = 9.107, p < 0.0099. (B) Outer molecular layer Dentate Gyrus (omDG) show decreased excitability in injured slices after thalidomide application with no changes in sham slices; two-way ANOVA F(1, 117) = 18.23, p < 0.0001. (C) Inner molecular layer Dentate Gyrus (imDG) also revealed no changes in sham slices but an increase in excitability in injured animals post-thalidomide application; two-way ANOVA: F(1, 117) = 5.777, p = 0.0319. Data shown as mean ± SEM; Injured: N = 8; Sham: N = 7. Asterisks for multiple comparisons indicate ****p < 0.0001.

    Article Snippet: Thalidomide (5 μM, Tocris Bioscience), an immunosuppressant ( ; ; ) was bath-applied in some slices from sham and injured animals to determine the effects of TNF-α on neural circuits.

    Techniques: