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10X Genomics spatial transcriptomic data
Global Moran’s index revealing three spatial autocorrelation patterns. Clustered, z > 1.65 and P < 0.1; random, –1.65 < z < 1.65 and P > 0.1; dispersed, z < –1.65 and P < 0.1. ST, spatial <t>transcriptomic;</t> CI, confidence interval.
Spatial Transcriptomic Data, supplied by 10X Genomics, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Article Title: Detection of differentially expressed genes in spatial transcriptomics data by spatial analysis of spatial transcriptomics: A novel method based on spatial statistics

Journal: Frontiers in Neuroscience

doi: 10.3389/fnins.2022.1086168

Global Moran’s index revealing three spatial autocorrelation patterns. Clustered, z > 1.65 and P < 0.1; random, –1.65 < z < 1.65 and P > 0.1; dispersed, z < –1.65 and P < 0.1. ST, spatial transcriptomic; CI, confidence interval.
Figure Legend Snippet: Global Moran’s index revealing three spatial autocorrelation patterns. Clustered, z > 1.65 and P < 0.1; random, –1.65 < z < 1.65 and P > 0.1; dispersed, z < –1.65 and P < 0.1. ST, spatial transcriptomic; CI, confidence interval.

Techniques Used:

Differentially expressed genes (DEGs) in the different brain regions. (A) Brain region. ROI indicates sensorimotor cortex. (B) Yellow area indicates sensorimotor cortex in HE images. (C) Arpp19 of ST map. (D) Hotspot of Arpp19 . (E) DEGs in the sensorimotor cortex. Ratio = The number of H-H spots in sensorimotor cortex/The total number of spots in the section. (F) Septicity of DEGs in the sensorimotor cortex. Ratio = The number of H-H spots in each region/The total number of H-H spots. (G) Marker genes of each brain region. ST, spatial transcriptomic.
Figure Legend Snippet: Differentially expressed genes (DEGs) in the different brain regions. (A) Brain region. ROI indicates sensorimotor cortex. (B) Yellow area indicates sensorimotor cortex in HE images. (C) Arpp19 of ST map. (D) Hotspot of Arpp19 . (E) DEGs in the sensorimotor cortex. Ratio = The number of H-H spots in sensorimotor cortex/The total number of spots in the section. (F) Septicity of DEGs in the sensorimotor cortex. Ratio = The number of H-H spots in each region/The total number of H-H spots. (G) Marker genes of each brain region. ST, spatial transcriptomic.

Techniques Used: Marker

Downregulated DEGs revealed by saSpatial. (A) Bubble plots of top20 DEGs. P -values are indicated by circle size; scale adjacent to the plot. The rate difference are indicated by color. NC, normal control. P, penumbra. Typical DEGs of (B) ischemic core and (C) penumbra. N = 3. ST, spatial transcriptomic; CI, confidence interval.
Figure Legend Snippet: Downregulated DEGs revealed by saSpatial. (A) Bubble plots of top20 DEGs. P -values are indicated by circle size; scale adjacent to the plot. The rate difference are indicated by color. NC, normal control. P, penumbra. Typical DEGs of (B) ischemic core and (C) penumbra. N = 3. ST, spatial transcriptomic; CI, confidence interval.

Techniques Used: Control

Differentially expressed genes (DEGs) in the cortex layers. (A) Top 3 DEGs in the layers. (B) Typical DEGs. ST, spatial transcriptomic.
Figure Legend Snippet: Differentially expressed genes (DEGs) in the cortex layers. (A) Top 3 DEGs in the layers. (B) Typical DEGs. ST, spatial transcriptomic.

Techniques Used:

Heterogenicity of DEGs within the ischemic cortex. (A) Six layers of cortex in the ischemic cortex. (B) Typical DEGs. (C) ST map and Hotspot of typical DEGs. ST, spatial transcriptomic.
Figure Legend Snippet: Heterogenicity of DEGs within the ischemic cortex. (A) Six layers of cortex in the ischemic cortex. (B) Typical DEGs. (C) ST map and Hotspot of typical DEGs. ST, spatial transcriptomic.

Techniques Used:



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