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high-throughput screen of 4896 unique small molecules  (Johns Hopkins HealthCare)

 
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    Johns Hopkins HealthCare high-throughput screen of 4896 unique small molecules
    High Throughput Screen Of 4896 Unique Small Molecules, supplied by Johns Hopkins HealthCare, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/small+molecule+screening/high+throughput+screen+of+4896+unique+small+molecules/pmc03423201-366-4-8
    Average 90 stars, based on 1 article reviews
    high-throughput screen of 4896 unique small molecules - by Bioz Stars, 2026-10
    90/100 stars

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    High Throughput Screening Assay:

    Article Title: High-Throughput Screen Identifies Novel Inhibitors of Cancer Biomarker ?-Methylacyl Coenzyme A Racemase (AMACR/P504S)
    Article Snippet: .. High-Throughput Screen of 4896 Unique Small Molecules The Johns Hopkins Drug Library (JHDL) contains 3280 distinct molecules the majority of which are drugs currently approved by the U.S. Food and Drug Administration, or its foreign counterparts, in addition to numerous other bioactive compounds ( 32 ). ..

    Drug discovery:

    Article Title: High-Throughput Screen Identifies Novel Inhibitors of Cancer Biomarker ?-Methylacyl Coenzyme A Racemase (AMACR/P504S)
    Article Snippet: .. High-Throughput Screen of 4896 Unique Small Molecules The Johns Hopkins Drug Library (JHDL) contains 3280 distinct molecules the majority of which are drugs currently approved by the U.S. Food and Drug Administration, or its foreign counterparts, in addition to numerous other bioactive compounds ( 32 ). ..

    Food & Beverages:

    Article Title: High-Throughput Screen Identifies Novel Inhibitors of Cancer Biomarker ?-Methylacyl Coenzyme A Racemase (AMACR/P504S)
    Article Snippet: .. High-Throughput Screen of 4896 Unique Small Molecules The Johns Hopkins Drug Library (JHDL) contains 3280 distinct molecules the majority of which are drugs currently approved by the U.S. Food and Drug Administration, or its foreign counterparts, in addition to numerous other bioactive compounds ( 32 ). ..



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    Screening <t>of</t> <t>small-molecule</t> compounds targeting ANKRD22. A Schematic diagram of the virtual screening process for ANKRD22 small-molecule compounds. B LS-174 T cells were treated with small-molecule compounds at concentrations ranging from 0.1–10 μM for 24 h. WB analysis was performed to measure the levels of ANKRD22 in cells treated with 12 candidate small-molecule compounds. C Determination of the IC 50 values of four candidate small-molecule compounds. The horizontal axis is on a logarithmic scale (μM). D Effects of candidate small-molecule compounds on the expression of ANKRD22 in macrophages derived from THP-1 cells. E FCM analysis of the impact of Compound 3 on the expression of CD86 in macrophages derived from THP-1 cells. Macrophages derived from THP-1 cells were cotreated with 5 μM of Compound 3 and 1 ng/mL of IFN-γ for 24 h
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    Screening of small-molecule compounds targeting ANKRD22. A Schematic diagram of the virtual screening process for ANKRD22 small-molecule compounds. B LS-174 T cells were treated with small-molecule compounds at concentrations ranging from 0.1–10 μM for 24 h. WB analysis was performed to measure the levels of ANKRD22 in cells treated with 12 candidate small-molecule compounds. C Determination of the IC 50 values of four candidate small-molecule compounds. The horizontal axis is on a logarithmic scale (μM). D Effects of candidate small-molecule compounds on the expression of ANKRD22 in macrophages derived from THP-1 cells. E FCM analysis of the impact of Compound 3 on the expression of CD86 in macrophages derived from THP-1 cells. Macrophages derived from THP-1 cells were cotreated with 5 μM of Compound 3 and 1 ng/mL of IFN-γ for 24 h

    Journal: Cancer Immunology, Immunotherapy : CII

    Article Title: ANKRD22 participates in the proinflammatory activities of macrophages in the colon cancer tumor microenvironment

    doi: 10.1007/s00262-024-03930-z

    Figure Lengend Snippet: Screening of small-molecule compounds targeting ANKRD22. A Schematic diagram of the virtual screening process for ANKRD22 small-molecule compounds. B LS-174 T cells were treated with small-molecule compounds at concentrations ranging from 0.1–10 μM for 24 h. WB analysis was performed to measure the levels of ANKRD22 in cells treated with 12 candidate small-molecule compounds. C Determination of the IC 50 values of four candidate small-molecule compounds. The horizontal axis is on a logarithmic scale (μM). D Effects of candidate small-molecule compounds on the expression of ANKRD22 in macrophages derived from THP-1 cells. E FCM analysis of the impact of Compound 3 on the expression of CD86 in macrophages derived from THP-1 cells. Macrophages derived from THP-1 cells were cotreated with 5 μM of Compound 3 and 1 ng/mL of IFN-γ for 24 h

    Article Snippet: The small-molecule compound library used was the Topscience Database, which comprises 7,272,880 compounds.

    Techniques: Expressing, Derivative Assay