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Advanced Instruments Inc osmo1 single-sample micro-osmometer
At baseline, R607H KI/KI and L919X KI/KI mice exhibit alkaline urine and decreased urinary ammonium secretion. (A-F) Urinary pH (A), ammonium/creatine ratio (B), <t>osmolality</t> (C), sodium/creatinine ratio (D), chloride/creatinine ratio (E) and potassium/creatinine ratio (F) comparison between WT and L919X KI/KI mice. (G-L) Urinary pH (G), ammonium/creatine ratio (H), osmolality (I), sodium/creatinine ratio (J), chloride/creatinine ratio (K) and potassium/creatinine ratio (L) comparison between WT and R607H KI/KI mice. Error bars correspond to means±s.e.m. ** P <0.01, **** P <0.0001 using unpaired two-tailed Student's t -test or Mann–Whitney test. Note that the large sample size is due to the analysis of baseline urine samples from all experiments, resulting in 34-37 samples for WT and 35-39 samples for KI mice.
Osmo1 Single Sample Micro Osmometer, supplied by Advanced Instruments Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/single-sample+osmometer/osmo1+single+sample+micro+osmometer/pmc12128221-165-0-6
Average 90 stars, based on 1 article reviews
osmo1 single-sample micro-osmometer - by Bioz Stars, 2026-10
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1) Product Images from "Urinary sodium wasting and disrupted collecting duct function in mice with distal renal tubular acidosis mutations"

Article Title: Urinary sodium wasting and disrupted collecting duct function in mice with distal renal tubular acidosis mutations

Journal: Disease Models & Mechanisms

doi: 10.1242/dmm.052138

At baseline, R607H KI/KI and L919X KI/KI mice exhibit alkaline urine and decreased urinary ammonium secretion. (A-F) Urinary pH (A), ammonium/creatine ratio (B), osmolality (C), sodium/creatinine ratio (D), chloride/creatinine ratio (E) and potassium/creatinine ratio (F) comparison between WT and L919X KI/KI mice. (G-L) Urinary pH (G), ammonium/creatine ratio (H), osmolality (I), sodium/creatinine ratio (J), chloride/creatinine ratio (K) and potassium/creatinine ratio (L) comparison between WT and R607H KI/KI mice. Error bars correspond to means±s.e.m. ** P <0.01, **** P <0.0001 using unpaired two-tailed Student's t -test or Mann–Whitney test. Note that the large sample size is due to the analysis of baseline urine samples from all experiments, resulting in 34-37 samples for WT and 35-39 samples for KI mice.
Figure Legend Snippet: At baseline, R607H KI/KI and L919X KI/KI mice exhibit alkaline urine and decreased urinary ammonium secretion. (A-F) Urinary pH (A), ammonium/creatine ratio (B), osmolality (C), sodium/creatinine ratio (D), chloride/creatinine ratio (E) and potassium/creatinine ratio (F) comparison between WT and L919X KI/KI mice. (G-L) Urinary pH (G), ammonium/creatine ratio (H), osmolality (I), sodium/creatinine ratio (J), chloride/creatinine ratio (K) and potassium/creatinine ratio (L) comparison between WT and R607H KI/KI mice. Error bars correspond to means±s.e.m. ** P <0.01, **** P <0.0001 using unpaired two-tailed Student's t -test or Mann–Whitney test. Note that the large sample size is due to the analysis of baseline urine samples from all experiments, resulting in 34-37 samples for WT and 35-39 samples for KI mice.

Techniques Used: Comparison, Two Tailed Test, MANN-WHITNEY

After a salt-depleted acid diet, R607H KI/KI mice and L919X KI/KI mice are hypernatremic and hyperchloremic. (A,B) Plasma sodium (A) and chloride (B) concentrations from L919X KI/KI mice or WT littermates. (C) Renin gene expression in L919X KI/KI mice or WT littermates. (D,E) Urine osmolality (D) and water consumed (E) by L919X KI/KI mice or WT littermates over the 14-day time course of the diet. BW, body weight. (F,G) Plasma sodium (F) and chloride (G) concentrations from R607H KI/KI mice or WT littermates. (H) Renin gene expression in R607H KI/KI mice or WT littermates. (I,J) Urine osmolality (I) and water consumed (J) by R607H KI/KI mice or WT littermates over the 14-day time course of the diet. Error bars correspond to means±s.e.m. * P <0.05, ** P <0.01, *** P <0.001, **** P <0.0001 using unpaired two-tailed Student's t -test or two-way ANOVA with Tukey's multiple comparison test.
Figure Legend Snippet: After a salt-depleted acid diet, R607H KI/KI mice and L919X KI/KI mice are hypernatremic and hyperchloremic. (A,B) Plasma sodium (A) and chloride (B) concentrations from L919X KI/KI mice or WT littermates. (C) Renin gene expression in L919X KI/KI mice or WT littermates. (D,E) Urine osmolality (D) and water consumed (E) by L919X KI/KI mice or WT littermates over the 14-day time course of the diet. BW, body weight. (F,G) Plasma sodium (F) and chloride (G) concentrations from R607H KI/KI mice or WT littermates. (H) Renin gene expression in R607H KI/KI mice or WT littermates. (I,J) Urine osmolality (I) and water consumed (J) by R607H KI/KI mice or WT littermates over the 14-day time course of the diet. Error bars correspond to means±s.e.m. * P <0.05, ** P <0.01, *** P <0.001, **** P <0.0001 using unpaired two-tailed Student's t -test or two-way ANOVA with Tukey's multiple comparison test.

Techniques Used: Clinical Proteomics, Gene Expression, Two Tailed Test, Comparison

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Comparison:

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MANN-WHITNEY:

Article Title: Osmotic conditions shape fitness gains and resistance mechanisms during E. coli and T4 phage co-evolution
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Article Title: Overcoming barriers in formulating practically insoluble loteprednol etabonate in ophthalmic nanoemulsion.
Article Snippet: The osmolality of the NEs was determined using an OsmoTECH® Osmometer (Advanced Instruments, Norwood, USA).

Article Title: Standarization and characterization of intravenous drug dilutions in critically ill pediatric patients.
Article Snippet: La osmolalidad se midió utilizando el microsmómetro Osmo1® (Advanced Instruments Inc.) y los resultados, expresados como la media ± desviación estándar (DS) de 3 medidas diferentes, fueron utilizados para calcular la osmolaridad según la ecuación proporcionada.

Article Title: Drinking water instead of apple juice or no drink results in greater odds of 4 to 7 co-occurring protective oral health factors within the hour
Article Snippet: Fresh saliva samples, which were stored refrigerated or iced for less than 12 h, were next used to measure saliva osmolality in triplicate by freezing point depression osmometer (Osmo1, Advanced Instruments, MA).

Article Title: Urinary sodium wasting and disrupted collecting duct function in mice with distal renal tubular acidosis mutations
Article Snippet: Urine osmolality was measured with the Advanced Instruments Osmo1 Single-Sample Micro-Osmometer (Thermo Fisher Scientific), diluting samples at 1:10 or 1:100 with filtered ddH 2 O. Urine electrolytes were measured by ion chromatography (Dionex Aquion Ion Chromatography System, Thermo Fisher Scientific) with an autosampler.

Article Title: Others.
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Article Title: High-dose vitamin D 3 to improve outcomes in the convalescent phase of complicated severe acute malnutrition in Pakistan: a double-blind randomised controlled trial (ViDiSAM).
Article Snippet: Urine concentrations of calcium and creatinine and urine osmolarity were measured at Chughtai Laboratory (Lahore, Pakistan) by photometric methods & Freezing Point Depression on the Abbott Alinity ci & OSMO-1 platforms (Abbott Diagnostics, UK and Advanced Instruments, US, respectively) according to the manufacturer’s instructions.

Article Title: Expanding the Bacteroides synthetic biology toolkit to develop an in vivo intestinal malabsorption biosensor
Article Snippet: Overnight cultures were then subcultured 1:50 into base TYG medium or TYG supplemented with either NaCl (Fisher S271), PEG (Bayer® MiraLAX®), lactulose (MilliporeSigma 42758450GM), or sorbitol (ACROS Organics AC132730010) to achieve osmolalities of approximately 700 and 900 mOsm/kg, which were confirmed using an Advanced Instruments Osmo1 Single-sample Micro-osmometer.

Clinical Proteomics:

Article Title: Osmotic conditions shape fitness gains and resistance mechanisms during E. coli and T4 phage co-evolution
Article Snippet: Experiments were conducted under three different osmotic conditions using M9 minimal media ( ) supplemented with sodium chloride (NaCl) to achieve osmolalities of 240 mOsm/kg H 2 O, 450 mOsm/kg H 2 O, and 920 mOsm/kg H 2 O. Osmolality was measured using an Advanced Instruments Osmo1 Single-Sample Micro-Osmometer.

Article Title: Overcoming barriers in formulating practically insoluble loteprednol etabonate in ophthalmic nanoemulsion.
Article Snippet: The osmolality of the NEs was determined using an OsmoTECH® Osmometer (Advanced Instruments, Norwood, USA).

Article Title: Standarization and characterization of intravenous drug dilutions in critically ill pediatric patients.
Article Snippet: La osmolalidad se midió utilizando el microsmómetro Osmo1® (Advanced Instruments Inc.) y los resultados, expresados como la media ± desviación estándar (DS) de 3 medidas diferentes, fueron utilizados para calcular la osmolaridad según la ecuación proporcionada.

Article Title: Drinking water instead of apple juice or no drink results in greater odds of 4 to 7 co-occurring protective oral health factors within the hour
Article Snippet: Fresh saliva samples, which were stored refrigerated or iced for less than 12 h, were next used to measure saliva osmolality in triplicate by freezing point depression osmometer (Osmo1, Advanced Instruments, MA).

Article Title: Urinary sodium wasting and disrupted collecting duct function in mice with distal renal tubular acidosis mutations
Article Snippet: Urine osmolality was measured with the Advanced Instruments Osmo1 Single-Sample Micro-Osmometer (Thermo Fisher Scientific), diluting samples at 1:10 or 1:100 with filtered ddH 2 O. Urine electrolytes were measured by ion chromatography (Dionex Aquion Ion Chromatography System, Thermo Fisher Scientific) with an autosampler.

Article Title: Others.
Article Snippet: BACKGROUND : The diagnosis of skin tumors can cause difficulties due to their wide variety of overlapping differentiation and complicated nomenclature.. Histopathological study is the most valuable means of diagnosis.. Keeping in view these facts, an attempt is made to study the different varieties of tumours of skin AIMS : (1) To study the histomorphology of different skin tumors with ancillary technique necessary and to correlate with the clinical features(2)To find out the proportion of various skin tumors. (3)To classify and identify various skin tumors and study its variation according to age, sex, site, etc., which will bear impact on patient management and prognosis.

Article Title: High-dose vitamin D 3 to improve outcomes in the convalescent phase of complicated severe acute malnutrition in Pakistan: a double-blind randomised controlled trial (ViDiSAM).
Article Snippet: Urine concentrations of calcium and creatinine and urine osmolarity were measured at Chughtai Laboratory (Lahore, Pakistan) by photometric methods & Freezing Point Depression on the Abbott Alinity ci & OSMO-1 platforms (Abbott Diagnostics, UK and Advanced Instruments, US, respectively) according to the manufacturer’s instructions.

Article Title: Expanding the Bacteroides synthetic biology toolkit to develop an in vivo intestinal malabsorption biosensor
Article Snippet: Overnight cultures were then subcultured 1:50 into base TYG medium or TYG supplemented with either NaCl (Fisher S271), PEG (Bayer® MiraLAX®), lactulose (MilliporeSigma 42758450GM), or sorbitol (ACROS Organics AC132730010) to achieve osmolalities of approximately 700 and 900 mOsm/kg, which were confirmed using an Advanced Instruments Osmo1 Single-sample Micro-osmometer.

Gene Expression:

Article Title: Osmotic conditions shape fitness gains and resistance mechanisms during E. coli and T4 phage co-evolution
Article Snippet: Experiments were conducted under three different osmotic conditions using M9 minimal media ( ) supplemented with sodium chloride (NaCl) to achieve osmolalities of 240 mOsm/kg H 2 O, 450 mOsm/kg H 2 O, and 920 mOsm/kg H 2 O. Osmolality was measured using an Advanced Instruments Osmo1 Single-Sample Micro-Osmometer.

Article Title: Overcoming barriers in formulating practically insoluble loteprednol etabonate in ophthalmic nanoemulsion.
Article Snippet: The osmolality of the NEs was determined using an OsmoTECH® Osmometer (Advanced Instruments, Norwood, USA).

Article Title: Standarization and characterization of intravenous drug dilutions in critically ill pediatric patients.
Article Snippet: La osmolalidad se midió utilizando el microsmómetro Osmo1® (Advanced Instruments Inc.) y los resultados, expresados como la media ± desviación estándar (DS) de 3 medidas diferentes, fueron utilizados para calcular la osmolaridad según la ecuación proporcionada.

Article Title: Drinking water instead of apple juice or no drink results in greater odds of 4 to 7 co-occurring protective oral health factors within the hour
Article Snippet: Fresh saliva samples, which were stored refrigerated or iced for less than 12 h, were next used to measure saliva osmolality in triplicate by freezing point depression osmometer (Osmo1, Advanced Instruments, MA).

Article Title: Urinary sodium wasting and disrupted collecting duct function in mice with distal renal tubular acidosis mutations
Article Snippet: Urine osmolality was measured with the Advanced Instruments Osmo1 Single-Sample Micro-Osmometer (Thermo Fisher Scientific), diluting samples at 1:10 or 1:100 with filtered ddH 2 O. Urine electrolytes were measured by ion chromatography (Dionex Aquion Ion Chromatography System, Thermo Fisher Scientific) with an autosampler.

Article Title: Others.
Article Snippet: BACKGROUND : The diagnosis of skin tumors can cause difficulties due to their wide variety of overlapping differentiation and complicated nomenclature.. Histopathological study is the most valuable means of diagnosis.. Keeping in view these facts, an attempt is made to study the different varieties of tumours of skin AIMS : (1) To study the histomorphology of different skin tumors with ancillary technique necessary and to correlate with the clinical features(2)To find out the proportion of various skin tumors. (3)To classify and identify various skin tumors and study its variation according to age, sex, site, etc., which will bear impact on patient management and prognosis.

Article Title: High-dose vitamin D 3 to improve outcomes in the convalescent phase of complicated severe acute malnutrition in Pakistan: a double-blind randomised controlled trial (ViDiSAM).
Article Snippet: Urine concentrations of calcium and creatinine and urine osmolarity were measured at Chughtai Laboratory (Lahore, Pakistan) by photometric methods & Freezing Point Depression on the Abbott Alinity ci & OSMO-1 platforms (Abbott Diagnostics, UK and Advanced Instruments, US, respectively) according to the manufacturer’s instructions.

Article Title: Expanding the Bacteroides synthetic biology toolkit to develop an in vivo intestinal malabsorption biosensor
Article Snippet: Overnight cultures were then subcultured 1:50 into base TYG medium or TYG supplemented with either NaCl (Fisher S271), PEG (Bayer® MiraLAX®), lactulose (MilliporeSigma 42758450GM), or sorbitol (ACROS Organics AC132730010) to achieve osmolalities of approximately 700 and 900 mOsm/kg, which were confirmed using an Advanced Instruments Osmo1 Single-sample Micro-osmometer.



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At baseline, R607H KI/KI and L919X KI/KI mice exhibit alkaline urine and decreased urinary ammonium secretion. (A-F) Urinary pH (A), ammonium/creatine ratio (B), <t>osmolality</t> (C), sodium/creatinine ratio (D), chloride/creatinine ratio (E) and potassium/creatinine ratio (F) comparison between WT and L919X KI/KI mice. (G-L) Urinary pH (G), ammonium/creatine ratio (H), osmolality (I), sodium/creatinine ratio (J), chloride/creatinine ratio (K) and potassium/creatinine ratio (L) comparison between WT and R607H KI/KI mice. Error bars correspond to means±s.e.m. ** P <0.01, **** P <0.0001 using unpaired two-tailed Student's t -test or Mann–Whitney test. Note that the large sample size is due to the analysis of baseline urine samples from all experiments, resulting in 34-37 samples for WT and 35-39 samples for KI mice.
3250 Single Sample Osmometer, supplied by Advanced Instruments Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/single-sample+osmometer/3250+single+sample+osmometer/pm40197832-94-8-11
Average 90 stars, based on 1 article reviews
3250 single-sample osmometer - by Bioz Stars, 2026-10
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90
Advanced Instruments Inc 3205 single-sample osmometer
At baseline, R607H KI/KI and L919X KI/KI mice exhibit alkaline urine and decreased urinary ammonium secretion. (A-F) Urinary pH (A), ammonium/creatine ratio (B), <t>osmolality</t> (C), sodium/creatinine ratio (D), chloride/creatinine ratio (E) and potassium/creatinine ratio (F) comparison between WT and L919X KI/KI mice. (G-L) Urinary pH (G), ammonium/creatine ratio (H), osmolality (I), sodium/creatinine ratio (J), chloride/creatinine ratio (K) and potassium/creatinine ratio (L) comparison between WT and R607H KI/KI mice. Error bars correspond to means±s.e.m. ** P <0.01, **** P <0.0001 using unpaired two-tailed Student's t -test or Mann–Whitney test. Note that the large sample size is due to the analysis of baseline urine samples from all experiments, resulting in 34-37 samples for WT and 35-39 samples for KI mice.
3205 Single Sample Osmometer, supplied by Advanced Instruments Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/single-sample+osmometer/3250+single+sample+osmometer/pmc11691697-141-18-21
Average 90 stars, based on 1 article reviews
3205 single-sample osmometer - by Bioz Stars, 2026-10
90/100 stars
  Buy from Supplier

90
Fisher Scientific advanced instruments osmo1 single-sample micro-osmometer
At baseline, R607H KI/KI and L919X KI/KI mice exhibit alkaline urine and decreased urinary ammonium secretion. (A-F) Urinary pH (A), ammonium/creatine ratio (B), <t>osmolality</t> (C), sodium/creatinine ratio (D), chloride/creatinine ratio (E) and potassium/creatinine ratio (F) comparison between WT and L919X KI/KI mice. (G-L) Urinary pH (G), ammonium/creatine ratio (H), osmolality (I), sodium/creatinine ratio (J), chloride/creatinine ratio (K) and potassium/creatinine ratio (L) comparison between WT and R607H KI/KI mice. Error bars correspond to means±s.e.m. ** P <0.01, **** P <0.0001 using unpaired two-tailed Student's t -test or Mann–Whitney test. Note that the large sample size is due to the analysis of baseline urine samples from all experiments, resulting in 34-37 samples for WT and 35-39 samples for KI mice.
Advanced Instruments Osmo1 Single Sample Micro Osmometer, supplied by Fisher Scientific, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/single-sample+osmometer/advanced+instruments+osmo1+single+sample+micro+osmometer/bio_rxiv__2024__11__26__625504-246-13-16
Average 90 stars, based on 1 article reviews
advanced instruments osmo1 single-sample micro-osmometer - by Bioz Stars, 2026-10
90/100 stars
  Buy from Supplier

90
Advanced Instruments Inc single sample osmometer advanced instruments model 3250
At baseline, R607H KI/KI and L919X KI/KI mice exhibit alkaline urine and decreased urinary ammonium secretion. (A-F) Urinary pH (A), ammonium/creatine ratio (B), <t>osmolality</t> (C), sodium/creatinine ratio (D), chloride/creatinine ratio (E) and potassium/creatinine ratio (F) comparison between WT and L919X KI/KI mice. (G-L) Urinary pH (G), ammonium/creatine ratio (H), osmolality (I), sodium/creatinine ratio (J), chloride/creatinine ratio (K) and potassium/creatinine ratio (L) comparison between WT and R607H KI/KI mice. Error bars correspond to means±s.e.m. ** P <0.01, **** P <0.0001 using unpaired two-tailed Student's t -test or Mann–Whitney test. Note that the large sample size is due to the analysis of baseline urine samples from all experiments, resulting in 34-37 samples for WT and 35-39 samples for KI mice.
Single Sample Osmometer Advanced Instruments Model 3250, supplied by Advanced Instruments Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/single-sample+osmometer/freezing+point+osmometer/pm39420215-74-12-13
Average 90 stars, based on 1 article reviews
single sample osmometer advanced instruments model 3250 - by Bioz Stars, 2026-10
90/100 stars
  Buy from Supplier

Image Search Results


At baseline, R607H KI/KI and L919X KI/KI mice exhibit alkaline urine and decreased urinary ammonium secretion. (A-F) Urinary pH (A), ammonium/creatine ratio (B), osmolality (C), sodium/creatinine ratio (D), chloride/creatinine ratio (E) and potassium/creatinine ratio (F) comparison between WT and L919X KI/KI mice. (G-L) Urinary pH (G), ammonium/creatine ratio (H), osmolality (I), sodium/creatinine ratio (J), chloride/creatinine ratio (K) and potassium/creatinine ratio (L) comparison between WT and R607H KI/KI mice. Error bars correspond to means±s.e.m. ** P <0.01, **** P <0.0001 using unpaired two-tailed Student's t -test or Mann–Whitney test. Note that the large sample size is due to the analysis of baseline urine samples from all experiments, resulting in 34-37 samples for WT and 35-39 samples for KI mice.

Journal: Disease Models & Mechanisms

Article Title: Urinary sodium wasting and disrupted collecting duct function in mice with distal renal tubular acidosis mutations

doi: 10.1242/dmm.052138

Figure Lengend Snippet: At baseline, R607H KI/KI and L919X KI/KI mice exhibit alkaline urine and decreased urinary ammonium secretion. (A-F) Urinary pH (A), ammonium/creatine ratio (B), osmolality (C), sodium/creatinine ratio (D), chloride/creatinine ratio (E) and potassium/creatinine ratio (F) comparison between WT and L919X KI/KI mice. (G-L) Urinary pH (G), ammonium/creatine ratio (H), osmolality (I), sodium/creatinine ratio (J), chloride/creatinine ratio (K) and potassium/creatinine ratio (L) comparison between WT and R607H KI/KI mice. Error bars correspond to means±s.e.m. ** P <0.01, **** P <0.0001 using unpaired two-tailed Student's t -test or Mann–Whitney test. Note that the large sample size is due to the analysis of baseline urine samples from all experiments, resulting in 34-37 samples for WT and 35-39 samples for KI mice.

Article Snippet: Urine osmolality was measured with the Advanced Instruments Osmo1 Single-Sample Micro-Osmometer (Thermo Fisher Scientific), diluting samples at 1:10 or 1:100 with filtered ddH 2 O. Urine electrolytes were measured by ion chromatography (Dionex Aquion Ion Chromatography System, Thermo Fisher Scientific) with an autosampler.

Techniques: Comparison, Two Tailed Test, MANN-WHITNEY

After a salt-depleted acid diet, R607H KI/KI mice and L919X KI/KI mice are hypernatremic and hyperchloremic. (A,B) Plasma sodium (A) and chloride (B) concentrations from L919X KI/KI mice or WT littermates. (C) Renin gene expression in L919X KI/KI mice or WT littermates. (D,E) Urine osmolality (D) and water consumed (E) by L919X KI/KI mice or WT littermates over the 14-day time course of the diet. BW, body weight. (F,G) Plasma sodium (F) and chloride (G) concentrations from R607H KI/KI mice or WT littermates. (H) Renin gene expression in R607H KI/KI mice or WT littermates. (I,J) Urine osmolality (I) and water consumed (J) by R607H KI/KI mice or WT littermates over the 14-day time course of the diet. Error bars correspond to means±s.e.m. * P <0.05, ** P <0.01, *** P <0.001, **** P <0.0001 using unpaired two-tailed Student's t -test or two-way ANOVA with Tukey's multiple comparison test.

Journal: Disease Models & Mechanisms

Article Title: Urinary sodium wasting and disrupted collecting duct function in mice with distal renal tubular acidosis mutations

doi: 10.1242/dmm.052138

Figure Lengend Snippet: After a salt-depleted acid diet, R607H KI/KI mice and L919X KI/KI mice are hypernatremic and hyperchloremic. (A,B) Plasma sodium (A) and chloride (B) concentrations from L919X KI/KI mice or WT littermates. (C) Renin gene expression in L919X KI/KI mice or WT littermates. (D,E) Urine osmolality (D) and water consumed (E) by L919X KI/KI mice or WT littermates over the 14-day time course of the diet. BW, body weight. (F,G) Plasma sodium (F) and chloride (G) concentrations from R607H KI/KI mice or WT littermates. (H) Renin gene expression in R607H KI/KI mice or WT littermates. (I,J) Urine osmolality (I) and water consumed (J) by R607H KI/KI mice or WT littermates over the 14-day time course of the diet. Error bars correspond to means±s.e.m. * P <0.05, ** P <0.01, *** P <0.001, **** P <0.0001 using unpaired two-tailed Student's t -test or two-way ANOVA with Tukey's multiple comparison test.

Article Snippet: Urine osmolality was measured with the Advanced Instruments Osmo1 Single-Sample Micro-Osmometer (Thermo Fisher Scientific), diluting samples at 1:10 or 1:100 with filtered ddH 2 O. Urine electrolytes were measured by ion chromatography (Dionex Aquion Ion Chromatography System, Thermo Fisher Scientific) with an autosampler.

Techniques: Clinical Proteomics, Gene Expression, Two Tailed Test, Comparison