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ct26 cells  (Genecopoeia)


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    Genecopoeia ct26 cells
    Bystander effect of MSC-Tet-TK and MSC-TK cells. ( A ) Rluc activity in co-cultures (1:1) of naive MSCs and <t>CT26/Rluc</t> cells treated with the indicated concentrations of GCV for 48 h. ( B ) BLI images of the Rluc activity and quantitation data of <t>CT26/Rluc</t> in co-cultures (1:1) of MSC-TK or MSC-Tet-TK cells in the absence or presence of doxycycline (DOX(−) and DOX 2 μg/mL respectively). Three individual experiment values are expressed as the mean ± standard deviation (SD), * p < 0.05, ** p < 0.01, *** p < 0.001 (by Student’s t test). p/s, photons/second.
    Ct26 Cells, supplied by Genecopoeia, used in various techniques. Bioz Stars score: 94/100, based on 12 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/single+cell+expression+data/Mouse+cell+line+CT26+stably+expressing+Cas9%2C+randomly+inserted%2C+single+clone/pmc05979455-161-0-19
    Average 94 stars, based on 12 article reviews
    ct26 cells - by Bioz Stars, 2026-09
    94/100 stars

    Images

    1) Product Images from "Regulated Mesenchymal Stem Cells Mediated Colon Cancer Therapy Assessed by Reporter Gene Based Optical Imaging"

    Article Title: Regulated Mesenchymal Stem Cells Mediated Colon Cancer Therapy Assessed by Reporter Gene Based Optical Imaging

    Journal: International Journal of Molecular Sciences

    doi: 10.3390/ijms19041002

    Bystander effect of MSC-Tet-TK and MSC-TK cells. ( A ) Rluc activity in co-cultures (1:1) of naive MSCs and CT26/Rluc cells treated with the indicated concentrations of GCV for 48 h. ( B ) BLI images of the Rluc activity and quantitation data of CT26/Rluc in co-cultures (1:1) of MSC-TK or MSC-Tet-TK cells in the absence or presence of doxycycline (DOX(−) and DOX 2 μg/mL respectively). Three individual experiment values are expressed as the mean ± standard deviation (SD), * p < 0.05, ** p < 0.01, *** p < 0.001 (by Student’s t test). p/s, photons/second.
    Figure Legend Snippet: Bystander effect of MSC-Tet-TK and MSC-TK cells. ( A ) Rluc activity in co-cultures (1:1) of naive MSCs and CT26/Rluc cells treated with the indicated concentrations of GCV for 48 h. ( B ) BLI images of the Rluc activity and quantitation data of CT26/Rluc in co-cultures (1:1) of MSC-TK or MSC-Tet-TK cells in the absence or presence of doxycycline (DOX(−) and DOX 2 μg/mL respectively). Three individual experiment values are expressed as the mean ± standard deviation (SD), * p < 0.05, ** p < 0.01, *** p < 0.001 (by Student’s t test). p/s, photons/second.

    Techniques Used: Activity Assay, Quantitation Assay, Standard Deviation

    In vivo therapeutic effect of MSC-Tet-TK and MSC-TK cells on inhibiting colon tumor growth. ( A ) Renilla luciferase (Rluc) imaging of colon cancer cells (CT26/Rluc) in mice treated with either MSC-TK or MSC-Tet-TK cells with or without concurrent GCV treatment. BLI images were taken on days 0, 6, and 13 in five individual mice; ( B ) Quantitative analysis of the data shown in ( A ). ( C ) Tumor weights assessed at study end. Bioluminescence activity is shown in photons/second (p/s). * p < 0.05 compared separately to MSC-Tet-TK (GCV−) and MSC-TK (GCV−).
    Figure Legend Snippet: In vivo therapeutic effect of MSC-Tet-TK and MSC-TK cells on inhibiting colon tumor growth. ( A ) Renilla luciferase (Rluc) imaging of colon cancer cells (CT26/Rluc) in mice treated with either MSC-TK or MSC-Tet-TK cells with or without concurrent GCV treatment. BLI images were taken on days 0, 6, and 13 in five individual mice; ( B ) Quantitative analysis of the data shown in ( A ). ( C ) Tumor weights assessed at study end. Bioluminescence activity is shown in photons/second (p/s). * p < 0.05 compared separately to MSC-Tet-TK (GCV−) and MSC-TK (GCV−).

    Techniques Used: In Vivo, Luciferase, Imaging, Activity Assay

    Related Articles

    Infection:

    Article Title: Enhanced Apc Min/+ adenoma formation after epithelial CUL4B deletion by recruitment of myeloid-derived suppressor cells.
    Article Snippet: The antibodies used for ChIP included CUL4B (Sigma-Aldrich Cat# C9995, RRID: AB_1840781), EZH2 (Cell Signaling Technology, Cat# 5246S), H2AK119ub1 (Cell Signaling Technology, Cat# 8240S) and H3K27me3 (Cell Signaling Technology, Cat# 9733S). .. Cell lines culture and viral infection HCT116 and CT26 cell lines were procured from the cell bank of the Chinese Academy of Sciences and GeneCopoeia (Rockville, USA), respectively. .. HCT116 cells were cultured in McCoy’s 5A medium (Sigma-Aldrich, M4892) supplemented with 20 % fetal bovine serum (AusGeneX, FBSSA500-S), penicillin (100 mg/mL, BBI, A600135) and streptomycin (100 mg/mL, BBI, A100382).

    Article Title: Cancer-targeted photoimmunotherapy induces antitumor immunity and can be augmented by anti-PD-1 therapy for durable anticancer responses in an immunologically active murine tumor model
    Article Snippet: .. To create CT26-EphA2 cells, murine Ephrin A2 lentiviral particles containing the puromycin resistance gene (Genecopoeia, Cat. No. LPP-CS-Mm02340-Lv225-03–300) were added to wild-type CT26 cell (ATCC Cat. No. CRL-2638) cultures at a multiplicity of infection of 20:1 and incubated overnight. .. Culture media containing the lentiviral particles was then removed and cells were cultured for an additional 4 days at which time puromycin (InvivoGen, Cat. No. ant-pr-5) was added to create antibiotic selection.

    Article Title: Cancer-targeted photoimmunotherapy induces antitumor immunity and can be augmented by anti-PD-1 therapy for durable anticancer responses in an immunologically active murine tumor model.
    Article Snippet: .. To create CT26-EphA2 cells, murine Ephrin A2 lentiviral particles containing the puromycin resistance gene (Genecopoeia, Cat. No. LPP-CS-Mm02340-Lv225-03–300) were added to wild-type CT26 cell (ATCC Cat. No. CRL-2638) cultures at a multiplicity of infection of 20:1 and incubated overnight. .. Culture media containing the lentiviral particles was then removed and cells were cultured for an additional 4 days at which time puromycin (InvivoGen, Cat. No. antpr-5) was added to create antibiotic selection.

    Expressing:

    Article Title: E-selectin-targeted polymer-doxorubicin conjugate induces regression of established colorectal liver metastases and improves mice survival
    Article Snippet: Liver metastases arising from colorectal cancer (CRC) are a major challenge for cancer treatment, as they often emerge as unresectable and resistant to therapy.. Novel treatments targeting the specific metastatic tumor microenvironment (TME) may improve the therapeutic outcome.. One relevant receptor at the TME in the liver is the endothelial-expressed cell adhesion molecule E-selectin.

    Luciferase:

    Article Title: E-selectin-targeted polymer-doxorubicin conjugate induces regression of established colorectal liver metastases and improves mice survival
    Article Snippet: Liver metastases arising from colorectal cancer (CRC) are a major challenge for cancer treatment, as they often emerge as unresectable and resistant to therapy.. Novel treatments targeting the specific metastatic tumor microenvironment (TME) may improve the therapeutic outcome.. One relevant receptor at the TME in the liver is the endothelial-expressed cell adhesion molecule E-selectin.

    Incubation:

    Article Title: Cancer-targeted photoimmunotherapy induces antitumor immunity and can be augmented by anti-PD-1 therapy for durable anticancer responses in an immunologically active murine tumor model
    Article Snippet: .. To create CT26-EphA2 cells, murine Ephrin A2 lentiviral particles containing the puromycin resistance gene (Genecopoeia, Cat. No. LPP-CS-Mm02340-Lv225-03–300) were added to wild-type CT26 cell (ATCC Cat. No. CRL-2638) cultures at a multiplicity of infection of 20:1 and incubated overnight. .. Culture media containing the lentiviral particles was then removed and cells were cultured for an additional 4 days at which time puromycin (InvivoGen, Cat. No. ant-pr-5) was added to create antibiotic selection.

    Article Title: Cancer-targeted photoimmunotherapy induces antitumor immunity and can be augmented by anti-PD-1 therapy for durable anticancer responses in an immunologically active murine tumor model.
    Article Snippet: .. To create CT26-EphA2 cells, murine Ephrin A2 lentiviral particles containing the puromycin resistance gene (Genecopoeia, Cat. No. LPP-CS-Mm02340-Lv225-03–300) were added to wild-type CT26 cell (ATCC Cat. No. CRL-2638) cultures at a multiplicity of infection of 20:1 and incubated overnight. .. Culture media containing the lentiviral particles was then removed and cells were cultured for an additional 4 days at which time puromycin (InvivoGen, Cat. No. antpr-5) was added to create antibiotic selection.

    Injection:

    Article Title: Inducible CCR2 + nonclassical monocytes mediate the regression of cancer metastasis
    Article Snippet: The TLR7/8 agonist R848 (vac-r848, Invitrogen), Notch signaling inhibitors DAPT (208255-80-5, Cayman Chemical) and gliotoxin (G9893, MilliporeSigma), and LPS (L2630, MilliporeSigma) were administered to mice by i.v. injection at doses of 50 μg/mouse, 25 mg/kg and 10 mg/kg, and 1 μg/mouse, respectively. .. 3 × 10 5 (or the indicated number of cells) B16F10-LUC2 (catalog CRL-6475-LUC2, ATCC), B16F10-EGFP (CL053-STAN, Imanis Life Science), 4T1-LUC2-GFP or CT26-LUC2-GFP (SL020 and SL021, GeneCopoeia), or LL/2-LUC2 (ATCC) cells were injected into the mice by retro-orbital or i.v. tail vein injection. .. Total RNA was isolated using the miRNeasy Mini Kit (QIAGEN). cDNA synthesis and qPCR were conducted as described previously ( ).

    Article Title: Inducible CCR2+ nonclassical monocytes mediate the regression of cancer metastasis
    Article Snippet: The TLR7/8 agonist R848 (vac-r848, Invitrogen), Notch signaling inhibitors DAPT (208255-80-5, Cayman Chemical) and gliotoxin (G9893, MilliporeSigma), and LPS (L2630, MilliporeSigma) were administered to mice by i.v. injection at doses of 50 μg/mouse, 25 mg/kg and 10 mg/kg, and 1 μg/mouse, respectively. .. 3 × 105 (or the indicated number of cells) B16F10-LUC2 (catalog CRL-6475-LUC2, ATCC), B16F10-EGFP (CL053-STAN, Imanis Life Science), 4T1-LUC2-GFP or CT26-LUC2-GFP (SL020 and SL021, GeneCopoeia), or LL/2-LUC2 (ATCC) cells were injected into the mice by retro-orbital or i.v. tail vein injection. mRNA isolation and qPCR Total RNA was isolated using the miRNeasy Mini Kit (QIAGEN). cDNA synthesis and qPCR were conducted as described previously In conclusion, we described the presence of 2 distinct lineages of LY6Clo NCMs. ..

    Isolation:

    Article Title: Inducible CCR2+ nonclassical monocytes mediate the regression of cancer metastasis
    Article Snippet: The TLR7/8 agonist R848 (vac-r848, Invitrogen), Notch signaling inhibitors DAPT (208255-80-5, Cayman Chemical) and gliotoxin (G9893, MilliporeSigma), and LPS (L2630, MilliporeSigma) were administered to mice by i.v. injection at doses of 50 μg/mouse, 25 mg/kg and 10 mg/kg, and 1 μg/mouse, respectively. .. 3 × 105 (or the indicated number of cells) B16F10-LUC2 (catalog CRL-6475-LUC2, ATCC), B16F10-EGFP (CL053-STAN, Imanis Life Science), 4T1-LUC2-GFP or CT26-LUC2-GFP (SL020 and SL021, GeneCopoeia), or LL/2-LUC2 (ATCC) cells were injected into the mice by retro-orbital or i.v. tail vein injection. mRNA isolation and qPCR Total RNA was isolated using the miRNeasy Mini Kit (QIAGEN). cDNA synthesis and qPCR were conducted as described previously In conclusion, we described the presence of 2 distinct lineages of LY6Clo NCMs. ..

    Real-time Polymerase Chain Reaction:

    Article Title: Inducible CCR2+ nonclassical monocytes mediate the regression of cancer metastasis
    Article Snippet: The TLR7/8 agonist R848 (vac-r848, Invitrogen), Notch signaling inhibitors DAPT (208255-80-5, Cayman Chemical) and gliotoxin (G9893, MilliporeSigma), and LPS (L2630, MilliporeSigma) were administered to mice by i.v. injection at doses of 50 μg/mouse, 25 mg/kg and 10 mg/kg, and 1 μg/mouse, respectively. .. 3 × 105 (or the indicated number of cells) B16F10-LUC2 (catalog CRL-6475-LUC2, ATCC), B16F10-EGFP (CL053-STAN, Imanis Life Science), 4T1-LUC2-GFP or CT26-LUC2-GFP (SL020 and SL021, GeneCopoeia), or LL/2-LUC2 (ATCC) cells were injected into the mice by retro-orbital or i.v. tail vein injection. mRNA isolation and qPCR Total RNA was isolated using the miRNeasy Mini Kit (QIAGEN). cDNA synthesis and qPCR were conducted as described previously In conclusion, we described the presence of 2 distinct lineages of LY6Clo NCMs. ..

    cDNA Synthesis:

    Article Title: Inducible CCR2+ nonclassical monocytes mediate the regression of cancer metastasis
    Article Snippet: The TLR7/8 agonist R848 (vac-r848, Invitrogen), Notch signaling inhibitors DAPT (208255-80-5, Cayman Chemical) and gliotoxin (G9893, MilliporeSigma), and LPS (L2630, MilliporeSigma) were administered to mice by i.v. injection at doses of 50 μg/mouse, 25 mg/kg and 10 mg/kg, and 1 μg/mouse, respectively. .. 3 × 105 (or the indicated number of cells) B16F10-LUC2 (catalog CRL-6475-LUC2, ATCC), B16F10-EGFP (CL053-STAN, Imanis Life Science), 4T1-LUC2-GFP or CT26-LUC2-GFP (SL020 and SL021, GeneCopoeia), or LL/2-LUC2 (ATCC) cells were injected into the mice by retro-orbital or i.v. tail vein injection. mRNA isolation and qPCR Total RNA was isolated using the miRNeasy Mini Kit (QIAGEN). cDNA synthesis and qPCR were conducted as described previously In conclusion, we described the presence of 2 distinct lineages of LY6Clo NCMs. ..



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    Image Search Results


    Flowchart Overview of this MR-based study. LD linkage disequilibrium, ρ-HESS Heritability Estimation from Summary Statistics, GNOVA Genetic covariance analyser, MTAG Multi-Trait Analysis of GWAS, CPASSOC Cross Phenotype Association, GWAS Genome-wide Association Study, MR Mendelian Randomization, GSMR Generalized summary-data-based Mendelian randomization, LDSC-SEG linkage disequilibrium score regression applied to specifically expressed genes, MAGMA Multi-marker Analysis of GenoMic Annotation, SMR Summary-databased Mendelian randomization, Phe-MR phenotypes, MR BMI body mass index, LUSC squamous cell lung cancer; scRNA-seq single-cell RNA sequencing

    Journal: Discover Oncology

    Article Title: Genetic evidence supporting obesity as a risk factor for lung squamous cell carcinoma and the identification of MFAP1 as a shared genetic target

    doi: 10.1007/s12672-026-04793-9

    Figure Lengend Snippet: Flowchart Overview of this MR-based study. LD linkage disequilibrium, ρ-HESS Heritability Estimation from Summary Statistics, GNOVA Genetic covariance analyser, MTAG Multi-Trait Analysis of GWAS, CPASSOC Cross Phenotype Association, GWAS Genome-wide Association Study, MR Mendelian Randomization, GSMR Generalized summary-data-based Mendelian randomization, LDSC-SEG linkage disequilibrium score regression applied to specifically expressed genes, MAGMA Multi-marker Analysis of GenoMic Annotation, SMR Summary-databased Mendelian randomization, Phe-MR phenotypes, MR BMI body mass index, LUSC squamous cell lung cancer; scRNA-seq single-cell RNA sequencing

    Article Snippet: The Single-cell RNA sequencing gene expression data were available from https://www.ncbi.nlm.nih.gov/geo/ and [https://singlecell.broadinstitute.org/single_cell](https:/www.singlecell.broadinstitute.org/single_cell) .

    Techniques: GWAS, Marker, Single Cell, RNA Sequencing

    Tissue- and cell type–specific enrichment of SNP heritability for BMI and LUSC. A Tissue-level SNP heritability enrichment for BMI across 53 GTEx tissues estimated using LDSC-SEG. The x-axis shows tissues grouped by organ system, and the y-axis shows the estimated enrichment coefficient (log-scaled or standardized). Tissues surpassing the significance threshold (FDR-adjusted P < 0.05) are highlighted. B Tissue-level SNP heritability enrichment for LUSC using the same LDSC-SEG framework. The x-axis indicates GTEx tissues and the y-axis indicates enrichment coefficients, as in panel ( A ). Tissues with significant enrichment (FDR-adjusted P < 0.05) are labelled, illustrating the overlap and differences in tissue-specific genetic architecture between BMI and LUSC. C – G Cell type–specific SNP heritability enrichment for BMI and LUSC across single-cell RNA sequencing datasets from brain, ileum, heart, and colon, estimated using MAGMA-based cell typing. For each tissue, the left panel shows enrichment for BMI and the right panel shows enrichment for LUSC. The y-axis lists cell types (for example, neurons, epithelial cells, eosinophils, CD8⁺ T cells), and the x-axis shows –log₁₀(P) values for the association between cell type–specific expression and SNP heritability. Cell types with P < 0.05 are indicated in red, highlighting those most strongly enriched for the genetic signal of BMI and/or LUSC. BMI body mass index, LUSC lung squamous cell carcinoma, SNP single nucleotide polymorphism, LDSC-SEG linkage disequilibrium score regression applied to specifically expressed genes, MAGMA Multi-marker Analysis of GenoMic Annotation, scRNA-seq single-cell RNA sequencing, GTEx Genotype-Tissue Expression

    Journal: Discover Oncology

    Article Title: Genetic evidence supporting obesity as a risk factor for lung squamous cell carcinoma and the identification of MFAP1 as a shared genetic target

    doi: 10.1007/s12672-026-04793-9

    Figure Lengend Snippet: Tissue- and cell type–specific enrichment of SNP heritability for BMI and LUSC. A Tissue-level SNP heritability enrichment for BMI across 53 GTEx tissues estimated using LDSC-SEG. The x-axis shows tissues grouped by organ system, and the y-axis shows the estimated enrichment coefficient (log-scaled or standardized). Tissues surpassing the significance threshold (FDR-adjusted P < 0.05) are highlighted. B Tissue-level SNP heritability enrichment for LUSC using the same LDSC-SEG framework. The x-axis indicates GTEx tissues and the y-axis indicates enrichment coefficients, as in panel ( A ). Tissues with significant enrichment (FDR-adjusted P < 0.05) are labelled, illustrating the overlap and differences in tissue-specific genetic architecture between BMI and LUSC. C – G Cell type–specific SNP heritability enrichment for BMI and LUSC across single-cell RNA sequencing datasets from brain, ileum, heart, and colon, estimated using MAGMA-based cell typing. For each tissue, the left panel shows enrichment for BMI and the right panel shows enrichment for LUSC. The y-axis lists cell types (for example, neurons, epithelial cells, eosinophils, CD8⁺ T cells), and the x-axis shows –log₁₀(P) values for the association between cell type–specific expression and SNP heritability. Cell types with P < 0.05 are indicated in red, highlighting those most strongly enriched for the genetic signal of BMI and/or LUSC. BMI body mass index, LUSC lung squamous cell carcinoma, SNP single nucleotide polymorphism, LDSC-SEG linkage disequilibrium score regression applied to specifically expressed genes, MAGMA Multi-marker Analysis of GenoMic Annotation, scRNA-seq single-cell RNA sequencing, GTEx Genotype-Tissue Expression

    Article Snippet: The Single-cell RNA sequencing gene expression data were available from https://www.ncbi.nlm.nih.gov/geo/ and [https://singlecell.broadinstitute.org/single_cell](https:/www.singlecell.broadinstitute.org/single_cell) .

    Techniques: Single Cell, RNA Sequencing, Expressing, Marker

    a Gene expression levels (Transcripts Per Million, TPM) of major autoantibody targets identified in paraneoplastic pemphigus, showing a marked enrichment in the skin and other squamous epithelia (data from the GTEx database, v6p.v1.1.8). Each bar comprises stacked boxes, with the width of each box representing the interquartile range of gene expression in the corresponding tissue. b – d Heatmaps showing normalized single-cell transcript expression levels (nTPM), summarized per gene and cell type cluster for selected tissues, highlighting SERPINB3 expression in bronchiolar cells. Single-cell expression data were obtained from the Human Protein Atlas.

    Journal: Communications Medicine

    Article Title: Autoantibody repertoire analysis in paraneoplastic pemphigus reveals novel targets linked to mucocutaneous blistering and bronchiolitis obliterans

    doi: 10.1038/s43856-025-01335-2

    Figure Lengend Snippet: a Gene expression levels (Transcripts Per Million, TPM) of major autoantibody targets identified in paraneoplastic pemphigus, showing a marked enrichment in the skin and other squamous epithelia (data from the GTEx database, v6p.v1.1.8). Each bar comprises stacked boxes, with the width of each box representing the interquartile range of gene expression in the corresponding tissue. b – d Heatmaps showing normalized single-cell transcript expression levels (nTPM), summarized per gene and cell type cluster for selected tissues, highlighting SERPINB3 expression in bronchiolar cells. Single-cell expression data were obtained from the Human Protein Atlas.

    Article Snippet: Single-cell expression data were obtained from the Human Protein Atlas.

    Techniques: Gene Expression, Expressing