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hela cells  (Genecopoeia)


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    Genecopoeia hela cells
    Hela Cells, supplied by Genecopoeia, used in various techniques. Bioz Stars score: 94/100, based on 68 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/single+cell+expression+data/Human+cell+line+Hela+stably+expressing+CRISPR+Cas9%2C+AAVS1+inserted%2C+single+clone/pm36674737-305-0-16
    Average 94 stars, based on 68 article reviews
    hela cells - by Bioz Stars, 2026-11
    94/100 stars

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    Related Articles

    Infection:

    Article Title: Surfaceome analysis of extracellular vesicles from senescent cells uncovers uptake repressor DPP4
    Article Snippet: .. DPP4 was overexpressed in HeLa cells by infection with a lentivirus that expressed DPP4Myc (EX-F0106-Lv125, GeneCopoeia); control viral particles expressed the Myc tag alone. ..

    Control:

    Article Title: Surfaceome analysis of extracellular vesicles from senescent cells uncovers uptake repressor DPP4
    Article Snippet: .. DPP4 was overexpressed in HeLa cells by infection with a lentivirus that expressed DPP4Myc (EX-F0106-Lv125, GeneCopoeia); control viral particles expressed the Myc tag alone. ..

    Transfection:

    Article Title: H3.3-G34W in giant cell tumor of bone functionally aligns with the exon choice repressor hnRNPA1L2.
    Article Snippet: .. HeLa cell transfection was carried out using EndoFectin Max (#EF013, GeneCopoeia, USA). ..

    Article Title: The matrix protein of respiratory syncytial virus suppresses interferon signaling via RACK1 association.
    Article Snippet: .. In the poly(I:C) treatment experiment, HeLa cells were transfected with a plasmid expressing FLAG-M or myc-RACK1 for 24 h, followed by mock or poly(I:C) treatment for another 8 h. The luciferase activity was measured by Dual-Luciferase Reporter Assay System (GeneCopoeia, GCP-LF001) according to the manufacturer’s protocol. ..

    Article Title: Magnesium-dependent-protein phosphatase 1B regulates the protein arginine methyltransferase 5 through the modulation of myosin phosphatase
    Article Snippet: .. Mg 2+/ Mn 2+ dependent protein phosphatase 1B (PPM1B) was overexpressed in HeLa cells using 1.7 ng/μl human pRec-M11-FT-PPM1B plasmid (GeneCopoeia) and Gene Juice transfection reagent (5.32 μg dissolved in 1500 μl serum free DMEM) according to the manufacturer’s protocol (labeled as FT-PPM1B group). ..

    Article Title: Magnesium-dependent-Protein Phosphatase 1B Regulates the Protein Arginine Methyltransferase 5 Through the Modulation of Myosin Phosphatase.
    Article Snippet: .. Mg2+/Mn2+ dependent Protein Phosphatase 1B (PPM1B) was overexpressed in HeLa cells using 1,7 ng/μl human pRec-M11-FT-PPM1B plasmid (GeneCopoeia Rockville, USA) and Gene Juice transfection reagent (5.32 μg dissolved in 1500μl serum free DMEM) according to the manufacturer’s protocol (labelled as FT-PPM1B group). ..

    Polymerase Chain Reaction:

    Article Title: Regulation of cellular cholesterol distribution via non-vesicular lipid transport at ER-Golgi contact sites.
    Article Snippet: ForRNAi-mediated knockdown experiments, cells were transfected with either control siRNAs (siNC-1 from IDT), a pool of siRNAs against ORP10 and ORP11 (hs.Ri.OSBPL10.13.1 and hs.Ri.OSBPL11.13.1 from IDT), or a pool of siRNAs against OSBP (hs.Ri.OSBP.13.1, hs.Ri.OSBP.13.2, and hs.Ri.OSBP.13.3 from IDT), using Lipofectamine RNAiMAX (Thermo Fisher Scientific) for 4 days (~96 h) in the case of ORP10/ORP11 double knockdown (DKD) or 3 days (~72 h) in the case of OSBP knockdown before the imaging. .. Wild-type as well as genome-edited HeLa cell lines were routinely verified as free of mycoplasma contamination at least every two months, using MycoGuard Mycoplasma PCR Detection Kit (Genecopoeia). ..

    CRISPR:

    Article Title: Nup358 restricts ER-mitochondria connectivity by modulating mTORC2/Akt/GSK3β signalling
    Article Snippet: .. HeLa cells were co-transfected with Nup358 CRISPR-Cas9 (pCRISPR-CG01, GeneCopoeia) and pTSiN-puro-Cre constructs. ..

    Construct:

    Article Title: Nup358 restricts ER-mitochondria connectivity by modulating mTORC2/Akt/GSK3β signalling
    Article Snippet: .. HeLa cells were co-transfected with Nup358 CRISPR-Cas9 (pCRISPR-CG01, GeneCopoeia) and pTSiN-puro-Cre constructs. ..

    Plasmid Preparation:

    Article Title: The matrix protein of respiratory syncytial virus suppresses interferon signaling via RACK1 association.
    Article Snippet: .. In the poly(I:C) treatment experiment, HeLa cells were transfected with a plasmid expressing FLAG-M or myc-RACK1 for 24 h, followed by mock or poly(I:C) treatment for another 8 h. The luciferase activity was measured by Dual-Luciferase Reporter Assay System (GeneCopoeia, GCP-LF001) according to the manufacturer’s protocol. ..

    Article Title: Magnesium-dependent-protein phosphatase 1B regulates the protein arginine methyltransferase 5 through the modulation of myosin phosphatase
    Article Snippet: .. Mg 2+/ Mn 2+ dependent protein phosphatase 1B (PPM1B) was overexpressed in HeLa cells using 1.7 ng/μl human pRec-M11-FT-PPM1B plasmid (GeneCopoeia) and Gene Juice transfection reagent (5.32 μg dissolved in 1500 μl serum free DMEM) according to the manufacturer’s protocol (labeled as FT-PPM1B group). ..

    Article Title: Magnesium-dependent-Protein Phosphatase 1B Regulates the Protein Arginine Methyltransferase 5 Through the Modulation of Myosin Phosphatase.
    Article Snippet: .. Mg2+/Mn2+ dependent Protein Phosphatase 1B (PPM1B) was overexpressed in HeLa cells using 1,7 ng/μl human pRec-M11-FT-PPM1B plasmid (GeneCopoeia Rockville, USA) and Gene Juice transfection reagent (5.32 μg dissolved in 1500μl serum free DMEM) according to the manufacturer’s protocol (labelled as FT-PPM1B group). ..

    Expressing:

    Article Title: The matrix protein of respiratory syncytial virus suppresses interferon signaling via RACK1 association.
    Article Snippet: .. In the poly(I:C) treatment experiment, HeLa cells were transfected with a plasmid expressing FLAG-M or myc-RACK1 for 24 h, followed by mock or poly(I:C) treatment for another 8 h. The luciferase activity was measured by Dual-Luciferase Reporter Assay System (GeneCopoeia, GCP-LF001) according to the manufacturer’s protocol. ..

    Luciferase:

    Article Title: The matrix protein of respiratory syncytial virus suppresses interferon signaling via RACK1 association.
    Article Snippet: .. In the poly(I:C) treatment experiment, HeLa cells were transfected with a plasmid expressing FLAG-M or myc-RACK1 for 24 h, followed by mock or poly(I:C) treatment for another 8 h. The luciferase activity was measured by Dual-Luciferase Reporter Assay System (GeneCopoeia, GCP-LF001) according to the manufacturer’s protocol. ..

    Activity Assay:

    Article Title: The matrix protein of respiratory syncytial virus suppresses interferon signaling via RACK1 association.
    Article Snippet: .. In the poly(I:C) treatment experiment, HeLa cells were transfected with a plasmid expressing FLAG-M or myc-RACK1 for 24 h, followed by mock or poly(I:C) treatment for another 8 h. The luciferase activity was measured by Dual-Luciferase Reporter Assay System (GeneCopoeia, GCP-LF001) according to the manufacturer’s protocol. ..

    Labeling:

    Article Title: Magnesium-dependent-protein phosphatase 1B regulates the protein arginine methyltransferase 5 through the modulation of myosin phosphatase
    Article Snippet: .. Mg 2+/ Mn 2+ dependent protein phosphatase 1B (PPM1B) was overexpressed in HeLa cells using 1.7 ng/μl human pRec-M11-FT-PPM1B plasmid (GeneCopoeia) and Gene Juice transfection reagent (5.32 μg dissolved in 1500 μl serum free DMEM) according to the manufacturer’s protocol (labeled as FT-PPM1B group). ..



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    Image Search Results


    Flowchart Overview of this MR-based study. LD linkage disequilibrium, ρ-HESS Heritability Estimation from Summary Statistics, GNOVA Genetic covariance analyser, MTAG Multi-Trait Analysis of GWAS, CPASSOC Cross Phenotype Association, GWAS Genome-wide Association Study, MR Mendelian Randomization, GSMR Generalized summary-data-based Mendelian randomization, LDSC-SEG linkage disequilibrium score regression applied to specifically expressed genes, MAGMA Multi-marker Analysis of GenoMic Annotation, SMR Summary-databased Mendelian randomization, Phe-MR phenotypes, MR BMI body mass index, LUSC squamous cell lung cancer; scRNA-seq single-cell RNA sequencing

    Journal: Discover Oncology

    Article Title: Genetic evidence supporting obesity as a risk factor for lung squamous cell carcinoma and the identification of MFAP1 as a shared genetic target

    doi: 10.1007/s12672-026-04793-9

    Figure Lengend Snippet: Flowchart Overview of this MR-based study. LD linkage disequilibrium, ρ-HESS Heritability Estimation from Summary Statistics, GNOVA Genetic covariance analyser, MTAG Multi-Trait Analysis of GWAS, CPASSOC Cross Phenotype Association, GWAS Genome-wide Association Study, MR Mendelian Randomization, GSMR Generalized summary-data-based Mendelian randomization, LDSC-SEG linkage disequilibrium score regression applied to specifically expressed genes, MAGMA Multi-marker Analysis of GenoMic Annotation, SMR Summary-databased Mendelian randomization, Phe-MR phenotypes, MR BMI body mass index, LUSC squamous cell lung cancer; scRNA-seq single-cell RNA sequencing

    Article Snippet: The Single-cell RNA sequencing gene expression data were available from https://www.ncbi.nlm.nih.gov/geo/ and [https://singlecell.broadinstitute.org/single_cell](https:/www.singlecell.broadinstitute.org/single_cell) .

    Techniques: GWAS, Marker, Single Cell, RNA Sequencing

    Tissue- and cell type–specific enrichment of SNP heritability for BMI and LUSC. A Tissue-level SNP heritability enrichment for BMI across 53 GTEx tissues estimated using LDSC-SEG. The x-axis shows tissues grouped by organ system, and the y-axis shows the estimated enrichment coefficient (log-scaled or standardized). Tissues surpassing the significance threshold (FDR-adjusted P < 0.05) are highlighted. B Tissue-level SNP heritability enrichment for LUSC using the same LDSC-SEG framework. The x-axis indicates GTEx tissues and the y-axis indicates enrichment coefficients, as in panel ( A ). Tissues with significant enrichment (FDR-adjusted P < 0.05) are labelled, illustrating the overlap and differences in tissue-specific genetic architecture between BMI and LUSC. C – G Cell type–specific SNP heritability enrichment for BMI and LUSC across single-cell RNA sequencing datasets from brain, ileum, heart, and colon, estimated using MAGMA-based cell typing. For each tissue, the left panel shows enrichment for BMI and the right panel shows enrichment for LUSC. The y-axis lists cell types (for example, neurons, epithelial cells, eosinophils, CD8⁺ T cells), and the x-axis shows –log₁₀(P) values for the association between cell type–specific expression and SNP heritability. Cell types with P < 0.05 are indicated in red, highlighting those most strongly enriched for the genetic signal of BMI and/or LUSC. BMI body mass index, LUSC lung squamous cell carcinoma, SNP single nucleotide polymorphism, LDSC-SEG linkage disequilibrium score regression applied to specifically expressed genes, MAGMA Multi-marker Analysis of GenoMic Annotation, scRNA-seq single-cell RNA sequencing, GTEx Genotype-Tissue Expression

    Journal: Discover Oncology

    Article Title: Genetic evidence supporting obesity as a risk factor for lung squamous cell carcinoma and the identification of MFAP1 as a shared genetic target

    doi: 10.1007/s12672-026-04793-9

    Figure Lengend Snippet: Tissue- and cell type–specific enrichment of SNP heritability for BMI and LUSC. A Tissue-level SNP heritability enrichment for BMI across 53 GTEx tissues estimated using LDSC-SEG. The x-axis shows tissues grouped by organ system, and the y-axis shows the estimated enrichment coefficient (log-scaled or standardized). Tissues surpassing the significance threshold (FDR-adjusted P < 0.05) are highlighted. B Tissue-level SNP heritability enrichment for LUSC using the same LDSC-SEG framework. The x-axis indicates GTEx tissues and the y-axis indicates enrichment coefficients, as in panel ( A ). Tissues with significant enrichment (FDR-adjusted P < 0.05) are labelled, illustrating the overlap and differences in tissue-specific genetic architecture between BMI and LUSC. C – G Cell type–specific SNP heritability enrichment for BMI and LUSC across single-cell RNA sequencing datasets from brain, ileum, heart, and colon, estimated using MAGMA-based cell typing. For each tissue, the left panel shows enrichment for BMI and the right panel shows enrichment for LUSC. The y-axis lists cell types (for example, neurons, epithelial cells, eosinophils, CD8⁺ T cells), and the x-axis shows –log₁₀(P) values for the association between cell type–specific expression and SNP heritability. Cell types with P < 0.05 are indicated in red, highlighting those most strongly enriched for the genetic signal of BMI and/or LUSC. BMI body mass index, LUSC lung squamous cell carcinoma, SNP single nucleotide polymorphism, LDSC-SEG linkage disequilibrium score regression applied to specifically expressed genes, MAGMA Multi-marker Analysis of GenoMic Annotation, scRNA-seq single-cell RNA sequencing, GTEx Genotype-Tissue Expression

    Article Snippet: The Single-cell RNA sequencing gene expression data were available from https://www.ncbi.nlm.nih.gov/geo/ and [https://singlecell.broadinstitute.org/single_cell](https:/www.singlecell.broadinstitute.org/single_cell) .

    Techniques: Single Cell, RNA Sequencing, Expressing, Marker

    a Gene expression levels (Transcripts Per Million, TPM) of major autoantibody targets identified in paraneoplastic pemphigus, showing a marked enrichment in the skin and other squamous epithelia (data from the GTEx database, v6p.v1.1.8). Each bar comprises stacked boxes, with the width of each box representing the interquartile range of gene expression in the corresponding tissue. b – d Heatmaps showing normalized single-cell transcript expression levels (nTPM), summarized per gene and cell type cluster for selected tissues, highlighting SERPINB3 expression in bronchiolar cells. Single-cell expression data were obtained from the Human Protein Atlas.

    Journal: Communications Medicine

    Article Title: Autoantibody repertoire analysis in paraneoplastic pemphigus reveals novel targets linked to mucocutaneous blistering and bronchiolitis obliterans

    doi: 10.1038/s43856-025-01335-2

    Figure Lengend Snippet: a Gene expression levels (Transcripts Per Million, TPM) of major autoantibody targets identified in paraneoplastic pemphigus, showing a marked enrichment in the skin and other squamous epithelia (data from the GTEx database, v6p.v1.1.8). Each bar comprises stacked boxes, with the width of each box representing the interquartile range of gene expression in the corresponding tissue. b – d Heatmaps showing normalized single-cell transcript expression levels (nTPM), summarized per gene and cell type cluster for selected tissues, highlighting SERPINB3 expression in bronchiolar cells. Single-cell expression data were obtained from the Human Protein Atlas.

    Article Snippet: Single-cell expression data were obtained from the Human Protein Atlas.

    Techniques: Gene Expression, Expressing