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caffeine, s-warfarin, omeprazole, midazolam, simvastatin and cyclosporin compound files from simcyp v21  (Simcyp)

 
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    Simcyp caffeine, s-warfarin, omeprazole, midazolam, simvastatin and cyclosporin compound files from simcyp v21
    Caffeine, S Warfarin, Omeprazole, Midazolam, Simvastatin And Cyclosporin Compound Files From Simcyp V21, supplied by Simcyp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/simcyp+v21/caffeine++s+warfarin++omeprazole++midazolam++simvastatin+and+cyclosporin+compound+files+from+simcyp+v21/pmc11247108-78-12-21
    Average 90 stars, based on 1 article reviews
    caffeine, s-warfarin, omeprazole, midazolam, simvastatin and cyclosporin compound files from simcyp v21 - by Bioz Stars, 2026-10
    90/100 stars

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    Article Title: Evaluating drug interaction potential from cytokine release syndrome using a physiologically based pharmacokinetic model: A case study of teclistamab
    Article Snippet: The IL‐6 model was reconstructed based on literature, , and the caffeine, S‐warfarin, omeprazole, midazolam, simvastatin and cyclosporin compound files from SimCYP v21 were used.



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    Key <t>PBPK</t> modelling steps and components of each clinical study used in model development, refinement, verification and application. BCRP, breast cancer resistance protein; DDI, drug–drug interaction; fu inc , fraction of unbound dersimelagon in in vitro system; K m , Michaelis constant; MAD, multiple ascending dose; OATP, organic anion transporting polypeptide; PBPK, physiologically based pharmacokinetic; PK, pharmacokinetic; QD, once daily; V max , maximum velocity of reaction; V ss , volume of distribution at steady state.
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    Key PBPK modelling steps and components of each clinical study used in model development, refinement, verification and application. BCRP, breast cancer resistance protein; DDI, drug–drug interaction; fu inc , fraction of unbound dersimelagon in in vitro system; K m , Michaelis constant; MAD, multiple ascending dose; OATP, organic anion transporting polypeptide; PBPK, physiologically based pharmacokinetic; PK, pharmacokinetic; QD, once daily; V max , maximum velocity of reaction; V ss , volume of distribution at steady state.

    Journal: British Journal of Clinical Pharmacology

    Article Title: Physiologically based pharmacokinetic modelling to predict potential drug–drug interactions of dersimelagon (MT‐7117)

    doi: 10.1111/bcp.16271

    Figure Lengend Snippet: Key PBPK modelling steps and components of each clinical study used in model development, refinement, verification and application. BCRP, breast cancer resistance protein; DDI, drug–drug interaction; fu inc , fraction of unbound dersimelagon in in vitro system; K m , Michaelis constant; MAD, multiple ascending dose; OATP, organic anion transporting polypeptide; PBPK, physiologically based pharmacokinetic; PK, pharmacokinetic; QD, once daily; V max , maximum velocity of reaction; V ss , volume of distribution at steady state.

    Article Snippet: All simulations were conducted using the Simcyp PBPK Simulator v21 (Certara), which integrates demographic, physiological, genomic and in vitro biochemical data to allow prediction of PK in virtual healthy populations.

    Techniques: In Vitro

    Input parameters of the physiologically based pharmacokinetic model for dersimelagon.

    Journal: British Journal of Clinical Pharmacology

    Article Title: Physiologically based pharmacokinetic modelling to predict potential drug–drug interactions of dersimelagon (MT‐7117)

    doi: 10.1111/bcp.16271

    Figure Lengend Snippet: Input parameters of the physiologically based pharmacokinetic model for dersimelagon.

    Article Snippet: All simulations were conducted using the Simcyp PBPK Simulator v21 (Certara), which integrates demographic, physiological, genomic and in vitro biochemical data to allow prediction of PK in virtual healthy populations.

    Techniques: Binding Assay, Software, Permeability, In Vitro, Inhibition