enzyme kinetics software sigmaplot version 12.5 (SYSTAT)

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SYSTAT enzyme kinetics software sigmaplot version 12.5
Enzyme Kinetics Software Sigmaplot Version 12.5, supplied by SYSTAT, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sigmaplot+12%2E5+software/enzyme+kinetics+module+of+sigmaplot+12+5/pm40517553-105-34-40
Average 90 stars, based on 1 article reviews

enzyme kinetics software sigmaplot version 12.5 - by Bioz Stars, 2026-09

90/100 stars

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Inhibition:

Article Title: Inhibition of cytochrome P450 enzymes and uridine 5'-diphospho-glucuronosyltransferases by vicagrel in human liver microsomes: A prediction of potential drug-drug interactions.
Article Snippet: Vicagrel, an antiplatelet drug candidate targeting platelet P2Y12 receptor and has finished its phase II clinical trial.. The inhibition of six major cytochrome P450 enzymes (P450) (CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, and CYP3A4) and six UDP-glucuronosyltransferases (UGT) (UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A9, and UGT2B7) by vicagrel was evaluated using pooled human liver microsomes and specific probe substrates.. Physiology-based pharmacokinetic (PBPK) simulation was further applied to predict the in vivo drugdrug interaction (DDI) potential between vicagrel and bupropion as well as S-mephenytoin.

Article Title: Metabolite phenotyping of kobusin and identification of glutathione conjugates with kobusin catechol metabolite.
Article Snippet: .. The plots were fitted to the Michaelis-Menten equation [v = Vmax⋅S/(Km + S)], the Hill equation model [v = Vmax⋅Sn/(Kmn + Sn)], or substrate inhibition model [v = Vmax⋅S/(Km + S + S2/Ki)] using enzyme kinetics software (SigmaPlot, version 12.5; Systat Software Inc. San Jose, CA, USA). ..

other:

Article Title: Importance of Rare DPYD Genetic Polymorphisms for 5-Fluorouracil Therapy in the Japanese Population.
Article Snippet: Kinetic data were analyzed using SigmaPlot 12.5 Enzyme Kinetics Module (Systat Software Inc., Chicago, IL, United States); Michaelis constant (Km), maximum velocity (Vmax), and intrinsic clearance (CLint = Vmax/Km) values were determined using the average DPD expression values obtained in triplicate and are expressed as mean ± standard deviation.

Article Title: Importance of Rare DPYD Genetic Polymorphisms for 5-Fluorouracil Therapy in the Japanese Population
Article Snippet: Kinetic data were analyzed using SigmaPlot 12.5 Enzyme Kinetics Module (Systat Software Inc., Chicago, IL, United States); Michaelis constant ( K m ), maximum velocity ( V max ), and intrinsic clearance ( CL int = V max / K m ) values were determined using the average DPD expression values obtained in triplicate and are expressed as mean ± standard deviation.

Article Title: Functional Characterization of 12 Dihydropyrimidinase Allelic Variants in Japanese Individuals for the Prediction of 5-Fluorouracil Treatment-Related Toxicity.
Article Snippet: The drug 5-fluorouracil (5-FU) is the first-choice chemotherapeutic agent against advanced-stage cancers.. However, 10% to 30% of treated patients experience grade 3 to 4 toxicity.. The deficiency of dihydropyrimidinase (DHPase), which catalyzes the second step of the 5-FU degradation pathway, is correlated with the risk of developing toxicity.

Software:

Concentration Assay:

Article Title: Acinetobacter baumannii DacC influences cell shape, biofilm formation and physiological fitness by manifesting DD-carboxypeptidase, and β-lactamase dual-enzyme activities
Article Snippet: .. The data was analysed using the Enzyme Kinetic Module of SIGMAPLOT v13 (Systat Software) to determine the k cat (turnover number) and the K m (substrate concentration at half the maximum velocity). ..

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