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    Tocris ketamine
    ( a ). Schematic illustrating viral transduction strategy and two-photon Ca 2+ imaging of VTA DA neurons in acute brain slices. ( b ). Example 2PLSM image of VTA DA neurons expressing GCaMP6f. Scale bar, 20 µm. ( c ). Spontaneous Ca 2+ oscillations in one neuron with and without <t>ketamine</t> bath application (50 µM). <t>Black,</t> <t>ACSF;</t> blue, with ketamine. ( d ). Power spectral density of Ca 2+ transients for the neuron in ( c ). ( e ). Left, quantification of max power with and without ketamine treatment (n = 410 neurons). Right, quantification of frequency at max power. Paired two-tailed t test, ACSF vs KET, Max power, p = 0.8865, Frequency at max power, p = 0.3779. ( f ). Left, histogram showing the distribution of changes in max power with ketamine application. Right, same but for frequency at max power. n = 410 neurons. ( g ). Schematic illustrating viral transduction strategy and electrophysiological recording of VTA DA neurons in acute brain slices. ( h ). Spontaneous action potentials recorded in one neuron with and without ketamine bath application (50 µM). Black, ACSF; blue, with ketamine. ( i ). Quantification of neuronal firing rate with and without ketamine treatment (n = 9 neurons from three animals). Paired two-tailed t test, ACSF vs KET, p = 0.2561. ( j ). Spontaneous EPSCs recorded in one neuron with and without ketamine bath application (50 µM). Black, ACSF; blue, with ketamine. Holding membrane potential at –70 mV, 10 µM Gabazine in ASCF for both conditions. ( k ). Left, cumulative frequency distribution of sEPSCs amplitudes. Right, quantification of sEPSC amplitude in recorded neurons. Paired two-tailed t test, ACSF vs KET, p = 0.1958. n = 17 neurons from three animals. ( l ). Same as ( k ), but for sEPSCs inter-event intervals (IEI). Paired two-tailed t test, ACSF vs KET, p = 0.8413. ( m ). Spontaneous IPSCs recorded in one neuron with and without ketamine bath application (50 µM). Black, ACSF; blue, with ketamine. Holding membrane potential at –70 mV with high chloride internal solution, 10 µM CNQX in ASCF for both conditions. ( n ). Left, cumulative frequency distribution of sIPSCs amplitudes. Right, quantification of sIPSC amplitude in recorded neurons. Paired two-tailed t test, ACSF vs KET, p = 0.9164. n = 12 neurons from two animals. ( o ). Same as ( n ), but for sIPSCs inter-event intervals (IEI). Paired two-tailed t test, ACSF vs KET, p = 0.5675. Figure 4—source data 1. Numerical data for the graphs in .
    Ketamine, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 111 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/sigma+plot+software+(version+12%2E5/Ketamine+hydrochloride/pmc08211450-343-31-49
    Average 93 stars, based on 111 article reviews
    ketamine - by Bioz Stars, 2026-11
    93/100 stars

    Images

    1) Product Images from "Attenuated dopamine signaling after aversive learning is restored by ketamine to rescue escape actions"

    Article Title: Attenuated dopamine signaling after aversive learning is restored by ketamine to rescue escape actions

    Journal: eLife

    doi: 10.7554/eLife.64041

    ( a ). Schematic illustrating viral transduction strategy and two-photon Ca 2+ imaging of VTA DA neurons in acute brain slices. ( b ). Example 2PLSM image of VTA DA neurons expressing GCaMP6f. Scale bar, 20 µm. ( c ). Spontaneous Ca 2+ oscillations in one neuron with and without ketamine bath application (50 µM). Black, ACSF; blue, with ketamine. ( d ). Power spectral density of Ca 2+ transients for the neuron in ( c ). ( e ). Left, quantification of max power with and without ketamine treatment (n = 410 neurons). Right, quantification of frequency at max power. Paired two-tailed t test, ACSF vs KET, Max power, p = 0.8865, Frequency at max power, p = 0.3779. ( f ). Left, histogram showing the distribution of changes in max power with ketamine application. Right, same but for frequency at max power. n = 410 neurons. ( g ). Schematic illustrating viral transduction strategy and electrophysiological recording of VTA DA neurons in acute brain slices. ( h ). Spontaneous action potentials recorded in one neuron with and without ketamine bath application (50 µM). Black, ACSF; blue, with ketamine. ( i ). Quantification of neuronal firing rate with and without ketamine treatment (n = 9 neurons from three animals). Paired two-tailed t test, ACSF vs KET, p = 0.2561. ( j ). Spontaneous EPSCs recorded in one neuron with and without ketamine bath application (50 µM). Black, ACSF; blue, with ketamine. Holding membrane potential at –70 mV, 10 µM Gabazine in ASCF for both conditions. ( k ). Left, cumulative frequency distribution of sEPSCs amplitudes. Right, quantification of sEPSC amplitude in recorded neurons. Paired two-tailed t test, ACSF vs KET, p = 0.1958. n = 17 neurons from three animals. ( l ). Same as ( k ), but for sEPSCs inter-event intervals (IEI). Paired two-tailed t test, ACSF vs KET, p = 0.8413. ( m ). Spontaneous IPSCs recorded in one neuron with and without ketamine bath application (50 µM). Black, ACSF; blue, with ketamine. Holding membrane potential at –70 mV with high chloride internal solution, 10 µM CNQX in ASCF for both conditions. ( n ). Left, cumulative frequency distribution of sIPSCs amplitudes. Right, quantification of sIPSC amplitude in recorded neurons. Paired two-tailed t test, ACSF vs KET, p = 0.9164. n = 12 neurons from two animals. ( o ). Same as ( n ), but for sIPSCs inter-event intervals (IEI). Paired two-tailed t test, ACSF vs KET, p = 0.5675. Figure 4—source data 1. Numerical data for the graphs in .
    Figure Legend Snippet: ( a ). Schematic illustrating viral transduction strategy and two-photon Ca 2+ imaging of VTA DA neurons in acute brain slices. ( b ). Example 2PLSM image of VTA DA neurons expressing GCaMP6f. Scale bar, 20 µm. ( c ). Spontaneous Ca 2+ oscillations in one neuron with and without ketamine bath application (50 µM). Black, ACSF; blue, with ketamine. ( d ). Power spectral density of Ca 2+ transients for the neuron in ( c ). ( e ). Left, quantification of max power with and without ketamine treatment (n = 410 neurons). Right, quantification of frequency at max power. Paired two-tailed t test, ACSF vs KET, Max power, p = 0.8865, Frequency at max power, p = 0.3779. ( f ). Left, histogram showing the distribution of changes in max power with ketamine application. Right, same but for frequency at max power. n = 410 neurons. ( g ). Schematic illustrating viral transduction strategy and electrophysiological recording of VTA DA neurons in acute brain slices. ( h ). Spontaneous action potentials recorded in one neuron with and without ketamine bath application (50 µM). Black, ACSF; blue, with ketamine. ( i ). Quantification of neuronal firing rate with and without ketamine treatment (n = 9 neurons from three animals). Paired two-tailed t test, ACSF vs KET, p = 0.2561. ( j ). Spontaneous EPSCs recorded in one neuron with and without ketamine bath application (50 µM). Black, ACSF; blue, with ketamine. Holding membrane potential at –70 mV, 10 µM Gabazine in ASCF for both conditions. ( k ). Left, cumulative frequency distribution of sEPSCs amplitudes. Right, quantification of sEPSC amplitude in recorded neurons. Paired two-tailed t test, ACSF vs KET, p = 0.1958. n = 17 neurons from three animals. ( l ). Same as ( k ), but for sEPSCs inter-event intervals (IEI). Paired two-tailed t test, ACSF vs KET, p = 0.8413. ( m ). Spontaneous IPSCs recorded in one neuron with and without ketamine bath application (50 µM). Black, ACSF; blue, with ketamine. Holding membrane potential at –70 mV with high chloride internal solution, 10 µM CNQX in ASCF for both conditions. ( n ). Left, cumulative frequency distribution of sIPSCs amplitudes. Right, quantification of sIPSC amplitude in recorded neurons. Paired two-tailed t test, ACSF vs KET, p = 0.9164. n = 12 neurons from two animals. ( o ). Same as ( n ), but for sIPSCs inter-event intervals (IEI). Paired two-tailed t test, ACSF vs KET, p = 0.5675. Figure 4—source data 1. Numerical data for the graphs in .

    Techniques Used: Transduction, Imaging, Expressing, Two Tailed Test, Membrane

    ( a ). Top, schematic for selected glutamatergic input regions to VTA. Bottom, experimental timeline. ( b ). Summary data showing the percentage of failures after local infusion of ketamine or ACSF in mPFC, and ketamine in PAG, PPTg, and VTA. Two-way ANOVA, Sidak’s multiple comparison test, LH vs LH+ KET, mPFC, p< 0.0001, PAG, p = 0.4965, PPTg, p = 0.9998, VTA, p = 0.9986. LH vs LH+ ACSF (mPFC), p = 0.9993. ( c ). Schematic for viral transduction and VTA photometry recording of Ca 2+ transients with local ketamine delivery in mPFC. ( d ). Left, average Ca 2+ transients (mean ± SEM) in response to foot shocks at the start of induction, at the end of induction, and following local ketamine infusion. Traces are aligned to shock start time (20 trials/animal, 6 animals). Right, quantification of peak Ca 2+ transient amplitude during and after foot shock stimuli across conditions. Both positive and negative values are quantified. n = 6 animals, repeated measures one-way ANOVA, Holm-Sidak’s multiple comparison test, Peak: During shock, F (1.948, 9.739) = 5.547, p = 0.0252, Induction start vs Induction end p = 0.0433, Induction end vs LH + KET, p = 0.0823. After shock, F (1.468, 7.341) = 10.05, p = 0.0105, Induction start vs Induction end, p = 0.0462, Induction end vs LH + KET, p = 0.0147. *p < 0.05, *** p < 0.001, **** p < 0.0001. Error bars reflect SEM. Figure 5—source data 1. Numerical data for the graphs in .
    Figure Legend Snippet: ( a ). Top, schematic for selected glutamatergic input regions to VTA. Bottom, experimental timeline. ( b ). Summary data showing the percentage of failures after local infusion of ketamine or ACSF in mPFC, and ketamine in PAG, PPTg, and VTA. Two-way ANOVA, Sidak’s multiple comparison test, LH vs LH+ KET, mPFC, p< 0.0001, PAG, p = 0.4965, PPTg, p = 0.9998, VTA, p = 0.9986. LH vs LH+ ACSF (mPFC), p = 0.9993. ( c ). Schematic for viral transduction and VTA photometry recording of Ca 2+ transients with local ketamine delivery in mPFC. ( d ). Left, average Ca 2+ transients (mean ± SEM) in response to foot shocks at the start of induction, at the end of induction, and following local ketamine infusion. Traces are aligned to shock start time (20 trials/animal, 6 animals). Right, quantification of peak Ca 2+ transient amplitude during and after foot shock stimuli across conditions. Both positive and negative values are quantified. n = 6 animals, repeated measures one-way ANOVA, Holm-Sidak’s multiple comparison test, Peak: During shock, F (1.948, 9.739) = 5.547, p = 0.0252, Induction start vs Induction end p = 0.0433, Induction end vs LH + KET, p = 0.0823. After shock, F (1.468, 7.341) = 10.05, p = 0.0105, Induction start vs Induction end, p = 0.0462, Induction end vs LH + KET, p = 0.0147. *p < 0.05, *** p < 0.001, **** p < 0.0001. Error bars reflect SEM. Figure 5—source data 1. Numerical data for the graphs in .

    Techniques Used: Comparison, Transduction


    Figure Legend Snippet:

    Techniques Used: Recombinant, Plasmid Preparation, RNAscope, Fluorescence, Multiplex Assay, Software

    Related Articles

    Injection:

    Article Title: Synergistic effects of capsaicin and ketamine on the depression-like behaviors of animals subjected to the chronic unpredictable mild stress protocol.
    Article Snippet: A significant percentage of depression patients are resistant to pharmacological treatments, highlighting the need for novel antidepressant strategies.. Ketamine, an NMDA receptor antagonist, produces rapid antidepressant effects and is effective in treatment-resistant cases, but its association with cognitive and behavioral abnormalities resembling schizophrenia limits broader clinical utility.. Capsaicin, a TRPV1 agonist, alone or combined with standard antidepressants, reduces immobility in the forced swim test (FST) in rodents.

    Saline:

    Article Title: Sex specific effects of ketamine, but not other glutamate receptor modulators, on ethanol self-administration and reinstatement of ethanol seeking in rats.
    Article Snippet: use disorder (AUD), with individuals diagnosed with a substance use disorder being nearly three times as likely to have major depression as well (Conway et al. 2006).. This pattern is especially evident in women, who are nearly twice as likely to have both disorders compared to men (Bradizza et al. 2006).. Treatment of either of these disorders alone is difficult, as 30–50% of patients with major depressive disorder do not respond to traditional treatments (Fava et al. 2003; McIntyre and Jain 2024), and relapse rates in individuals with alcohol dependence have been shown to be as high as 80% (Hunt et al. 1971), though treatment significantly reduces these rates (Moos et al. 2006).

    Article Title: Heightened anxiety with distinct prefrontal substrates is differentially sensitive to the anxiolytics, citalopram and ketamine: Prefrontal substrates and anxiolytic sensitivity.
    Article Snippet: .. Central administration of racemic ketamine (0.5 μg/μL, Tocris, UK), dissolved in sterile saline, was infused in 1 μL for a 24 hr pretreatment to intrusion as used previously (29). ..

    Article Title: Heightened anxiety with distinct prefrontal substrates is differentially sensitive to the anxiolytics, citalopram and ketamine: Prefrontal substrates and anxiolytic sensitivity.
    Article Snippet: .. Ketamine (1 mg/kg, dissolved in sterile saline, Tocris, UK) was administered sub-acutely for a 24 hr pretreatment to intrusion. ..

    Suspension:

    Article Title: Depression-like effects induced by chronic unpredictable mild stress in mice are rapidly reversed by a partial negative allosteric modulator of mGlu 5 receptor, M-5MPEP
    Article Snippet: .. M-5MPEP and (S) -(+)-ketamine hydrochloride (Tocris Cookson, Ltd., Bristol, UK), UK) were diluted in a suspension of 0.5% methylcellulose/0.9% NaCl, which was used as a vehicle. ..

    Transfection:

    Article Title: Ketamine inhibition of SARS-CoV-2 replication in astrocytes is associated with COVID-19 disease severity in a variant-dependent manner
    Article Snippet: Twenty-four hours after seeding, astrocytes were transfected with pGBW-m4134157 plasmid encoding for viral protein SARS-CoV-2 nsp6 protein with HA-Tag or pSBL_DK186 plasmid encoding for insert SARS-CoV-2 3a protein fused to EGFP using FuGENE transfection reagent (Promega, Madison, USA) according to the manufacturer’s instructions (1 μg/coverslip of DNA). .. After transfection, astrocytes were incubated at 37°C for 24 h or 48 h. In some experiments, on transfection, astrocytes were supplied with growth medium containing DGAT1 and DGAT2 inhibitors T863 (10 μM) and PF-06424439 (10 μM), respectively, to prevent biogenesis of LD, or with growth medium containing ketamine (10 μM; Tocris Bioscience, Bristol, UK) and incubated at 37°C for 24 h. ..

    Article Title: Heightened anxiety with distinct prefrontal substrates is differentially sensitive to the anxiolytics, citalopram and ketamine: Prefrontal substrates and anxiolytic sensitivity.
    Article Snippet: .. Antibody Not Applicable Bacterial or Viral Strain Not Applicable Biological Sample postmortem brain tissue This paper Cell Line Not Applicable Chemical Compound or Drug dihydrokainic acid (DHK) Tocris Cat # 0111, CAS 52497-36-6 Chemical Compound or Drug Muscimol Sigma-Aldrich Cat # M1523, CAS 2763-96-4 Chemical Compound or Drug Baclofen Sigma-Aldrich Cat # BP028, CAS 1134-47-0 Chemical Compound or Drug Citalopram Hbr Tocris Cat # 1427, CAS 59729-32-7 Chemical Compound or Drug Ketamine HCl Tocris Cat # 3131, CAS 1867-66-9 Commercial Assay Or Kit Not Applicable Deposited Data; Public Database Manuscript_dataset This paper DOI: 10.17632/vky7vm6pfh.1 Genetic Reagent Not Applicable Organism/Strain common marmoset (Callithrix jacchus ) University of Cambridge Marmoset Breeding ColonyN/A Peptide, Recombinant Protein Not Applicable Recombinant DNA Not Applicable Sequence-Based Reagent Not Applicable Software; Algorithm GraphPad Prism GraphPad RRID:SCR_002798 Software; Algorithm Microsoft Excel Microsoft RRID:SCR_016137 Software; Algorithm Rstudio Rstudio RRID:SCR_000432 Software; Algorithm Syrinx Dr. John Burt https://syrinxpc.com/ Software; Algorithm Jwatcher University of California at Los Angeles; California; USARRID:SCR_017595 Transfected Construct Not Applicable Other KEY RESOURCES TABLE Jo urn al Pr e-p roo f Region Blocks 1 + 2: Peripheral Block 3: Intracerebral Subject:Symbol Sex # of MRI scans prior to inclusion vmPFC-14 OFC-11 SSRI KET SSRI KET 1 F 0 ✓ ✓ ✓ ✓ ✓ 2 M 0 ✓ ✓ 3 F 0 ✓ ✓ 4 M 0 ✓ ✓ ✓ ✓ ✓ 5 F 1 ✓ ✓ ✓ ✓ 6 M 0 ✓ ✓ ✓ ✓ ✓ 7 F 4 ✓ ✓ ✓ 8 M 5 ✓ ✓ ✓ ✓ 9 M 0 ✓ ✓ ✓ ✓ ✓ 10 F 0 ✓ ✓ ✓ 11 F 0 ✓ ✓ ✓ ✓ ✓ 12 M 0 ✓ ✓ ✓ ✓ ✓ 13 M 4 ✓ ✓ ✓ ✓ ✓ 14 F 4 ✓ ✓ ✓ ✓ ✓ Table 1: Subject inclusion in all experimental blocks of the study. ..

    Incubation:

    Article Title: Ketamine inhibition of SARS-CoV-2 replication in astrocytes is associated with COVID-19 disease severity in a variant-dependent manner
    Article Snippet: Twenty-four hours after seeding, astrocytes were transfected with pGBW-m4134157 plasmid encoding for viral protein SARS-CoV-2 nsp6 protein with HA-Tag or pSBL_DK186 plasmid encoding for insert SARS-CoV-2 3a protein fused to EGFP using FuGENE transfection reagent (Promega, Madison, USA) according to the manufacturer’s instructions (1 μg/coverslip of DNA). .. After transfection, astrocytes were incubated at 37°C for 24 h or 48 h. In some experiments, on transfection, astrocytes were supplied with growth medium containing DGAT1 and DGAT2 inhibitors T863 (10 μM) and PF-06424439 (10 μM), respectively, to prevent biogenesis of LD, or with growth medium containing ketamine (10 μM; Tocris Bioscience, Bristol, UK) and incubated at 37°C for 24 h. ..

    Recombinant:

    Article Title: Heightened anxiety with distinct prefrontal substrates is differentially sensitive to the anxiolytics, citalopram and ketamine: Prefrontal substrates and anxiolytic sensitivity.
    Article Snippet: .. Antibody Not Applicable Bacterial or Viral Strain Not Applicable Biological Sample postmortem brain tissue This paper Cell Line Not Applicable Chemical Compound or Drug dihydrokainic acid (DHK) Tocris Cat # 0111, CAS 52497-36-6 Chemical Compound or Drug Muscimol Sigma-Aldrich Cat # M1523, CAS 2763-96-4 Chemical Compound or Drug Baclofen Sigma-Aldrich Cat # BP028, CAS 1134-47-0 Chemical Compound or Drug Citalopram Hbr Tocris Cat # 1427, CAS 59729-32-7 Chemical Compound or Drug Ketamine HCl Tocris Cat # 3131, CAS 1867-66-9 Commercial Assay Or Kit Not Applicable Deposited Data; Public Database Manuscript_dataset This paper DOI: 10.17632/vky7vm6pfh.1 Genetic Reagent Not Applicable Organism/Strain common marmoset (Callithrix jacchus ) University of Cambridge Marmoset Breeding ColonyN/A Peptide, Recombinant Protein Not Applicable Recombinant DNA Not Applicable Sequence-Based Reagent Not Applicable Software; Algorithm GraphPad Prism GraphPad RRID:SCR_002798 Software; Algorithm Microsoft Excel Microsoft RRID:SCR_016137 Software; Algorithm Rstudio Rstudio RRID:SCR_000432 Software; Algorithm Syrinx Dr. John Burt https://syrinxpc.com/ Software; Algorithm Jwatcher University of California at Los Angeles; California; USARRID:SCR_017595 Transfected Construct Not Applicable Other KEY RESOURCES TABLE Jo urn al Pr e-p roo f Region Blocks 1 + 2: Peripheral Block 3: Intracerebral Subject:Symbol Sex # of MRI scans prior to inclusion vmPFC-14 OFC-11 SSRI KET SSRI KET 1 F 0 ✓ ✓ ✓ ✓ ✓ 2 M 0 ✓ ✓ 3 F 0 ✓ ✓ 4 M 0 ✓ ✓ ✓ ✓ ✓ 5 F 1 ✓ ✓ ✓ ✓ 6 M 0 ✓ ✓ ✓ ✓ ✓ 7 F 4 ✓ ✓ ✓ 8 M 5 ✓ ✓ ✓ ✓ 9 M 0 ✓ ✓ ✓ ✓ ✓ 10 F 0 ✓ ✓ ✓ 11 F 0 ✓ ✓ ✓ ✓ ✓ 12 M 0 ✓ ✓ ✓ ✓ ✓ 13 M 4 ✓ ✓ ✓ ✓ ✓ 14 F 4 ✓ ✓ ✓ ✓ ✓ Table 1: Subject inclusion in all experimental blocks of the study. ..

    Sequencing:

    Article Title: Heightened anxiety with distinct prefrontal substrates is differentially sensitive to the anxiolytics, citalopram and ketamine: Prefrontal substrates and anxiolytic sensitivity.
    Article Snippet: .. Antibody Not Applicable Bacterial or Viral Strain Not Applicable Biological Sample postmortem brain tissue This paper Cell Line Not Applicable Chemical Compound or Drug dihydrokainic acid (DHK) Tocris Cat # 0111, CAS 52497-36-6 Chemical Compound or Drug Muscimol Sigma-Aldrich Cat # M1523, CAS 2763-96-4 Chemical Compound or Drug Baclofen Sigma-Aldrich Cat # BP028, CAS 1134-47-0 Chemical Compound or Drug Citalopram Hbr Tocris Cat # 1427, CAS 59729-32-7 Chemical Compound or Drug Ketamine HCl Tocris Cat # 3131, CAS 1867-66-9 Commercial Assay Or Kit Not Applicable Deposited Data; Public Database Manuscript_dataset This paper DOI: 10.17632/vky7vm6pfh.1 Genetic Reagent Not Applicable Organism/Strain common marmoset (Callithrix jacchus ) University of Cambridge Marmoset Breeding ColonyN/A Peptide, Recombinant Protein Not Applicable Recombinant DNA Not Applicable Sequence-Based Reagent Not Applicable Software; Algorithm GraphPad Prism GraphPad RRID:SCR_002798 Software; Algorithm Microsoft Excel Microsoft RRID:SCR_016137 Software; Algorithm Rstudio Rstudio RRID:SCR_000432 Software; Algorithm Syrinx Dr. John Burt https://syrinxpc.com/ Software; Algorithm Jwatcher University of California at Los Angeles; California; USARRID:SCR_017595 Transfected Construct Not Applicable Other KEY RESOURCES TABLE Jo urn al Pr e-p roo f Region Blocks 1 + 2: Peripheral Block 3: Intracerebral Subject:Symbol Sex # of MRI scans prior to inclusion vmPFC-14 OFC-11 SSRI KET SSRI KET 1 F 0 ✓ ✓ ✓ ✓ ✓ 2 M 0 ✓ ✓ 3 F 0 ✓ ✓ 4 M 0 ✓ ✓ ✓ ✓ ✓ 5 F 1 ✓ ✓ ✓ ✓ 6 M 0 ✓ ✓ ✓ ✓ ✓ 7 F 4 ✓ ✓ ✓ 8 M 5 ✓ ✓ ✓ ✓ 9 M 0 ✓ ✓ ✓ ✓ ✓ 10 F 0 ✓ ✓ ✓ 11 F 0 ✓ ✓ ✓ ✓ ✓ 12 M 0 ✓ ✓ ✓ ✓ ✓ 13 M 4 ✓ ✓ ✓ ✓ ✓ 14 F 4 ✓ ✓ ✓ ✓ ✓ Table 1: Subject inclusion in all experimental blocks of the study. ..

    Software:

    Article Title: Heightened anxiety with distinct prefrontal substrates is differentially sensitive to the anxiolytics, citalopram and ketamine: Prefrontal substrates and anxiolytic sensitivity.
    Article Snippet: .. Antibody Not Applicable Bacterial or Viral Strain Not Applicable Biological Sample postmortem brain tissue This paper Cell Line Not Applicable Chemical Compound or Drug dihydrokainic acid (DHK) Tocris Cat # 0111, CAS 52497-36-6 Chemical Compound or Drug Muscimol Sigma-Aldrich Cat # M1523, CAS 2763-96-4 Chemical Compound or Drug Baclofen Sigma-Aldrich Cat # BP028, CAS 1134-47-0 Chemical Compound or Drug Citalopram Hbr Tocris Cat # 1427, CAS 59729-32-7 Chemical Compound or Drug Ketamine HCl Tocris Cat # 3131, CAS 1867-66-9 Commercial Assay Or Kit Not Applicable Deposited Data; Public Database Manuscript_dataset This paper DOI: 10.17632/vky7vm6pfh.1 Genetic Reagent Not Applicable Organism/Strain common marmoset (Callithrix jacchus ) University of Cambridge Marmoset Breeding ColonyN/A Peptide, Recombinant Protein Not Applicable Recombinant DNA Not Applicable Sequence-Based Reagent Not Applicable Software; Algorithm GraphPad Prism GraphPad RRID:SCR_002798 Software; Algorithm Microsoft Excel Microsoft RRID:SCR_016137 Software; Algorithm Rstudio Rstudio RRID:SCR_000432 Software; Algorithm Syrinx Dr. John Burt https://syrinxpc.com/ Software; Algorithm Jwatcher University of California at Los Angeles; California; USARRID:SCR_017595 Transfected Construct Not Applicable Other KEY RESOURCES TABLE Jo urn al Pr e-p roo f Region Blocks 1 + 2: Peripheral Block 3: Intracerebral Subject:Symbol Sex # of MRI scans prior to inclusion vmPFC-14 OFC-11 SSRI KET SSRI KET 1 F 0 ✓ ✓ ✓ ✓ ✓ 2 M 0 ✓ ✓ 3 F 0 ✓ ✓ 4 M 0 ✓ ✓ ✓ ✓ ✓ 5 F 1 ✓ ✓ ✓ ✓ 6 M 0 ✓ ✓ ✓ ✓ ✓ 7 F 4 ✓ ✓ ✓ 8 M 5 ✓ ✓ ✓ ✓ 9 M 0 ✓ ✓ ✓ ✓ ✓ 10 F 0 ✓ ✓ ✓ 11 F 0 ✓ ✓ ✓ ✓ ✓ 12 M 0 ✓ ✓ ✓ ✓ ✓ 13 M 4 ✓ ✓ ✓ ✓ ✓ 14 F 4 ✓ ✓ ✓ ✓ ✓ Table 1: Subject inclusion in all experimental blocks of the study. ..

    Construct:

    Article Title: Heightened anxiety with distinct prefrontal substrates is differentially sensitive to the anxiolytics, citalopram and ketamine: Prefrontal substrates and anxiolytic sensitivity.
    Article Snippet: .. Antibody Not Applicable Bacterial or Viral Strain Not Applicable Biological Sample postmortem brain tissue This paper Cell Line Not Applicable Chemical Compound or Drug dihydrokainic acid (DHK) Tocris Cat # 0111, CAS 52497-36-6 Chemical Compound or Drug Muscimol Sigma-Aldrich Cat # M1523, CAS 2763-96-4 Chemical Compound or Drug Baclofen Sigma-Aldrich Cat # BP028, CAS 1134-47-0 Chemical Compound or Drug Citalopram Hbr Tocris Cat # 1427, CAS 59729-32-7 Chemical Compound or Drug Ketamine HCl Tocris Cat # 3131, CAS 1867-66-9 Commercial Assay Or Kit Not Applicable Deposited Data; Public Database Manuscript_dataset This paper DOI: 10.17632/vky7vm6pfh.1 Genetic Reagent Not Applicable Organism/Strain common marmoset (Callithrix jacchus ) University of Cambridge Marmoset Breeding ColonyN/A Peptide, Recombinant Protein Not Applicable Recombinant DNA Not Applicable Sequence-Based Reagent Not Applicable Software; Algorithm GraphPad Prism GraphPad RRID:SCR_002798 Software; Algorithm Microsoft Excel Microsoft RRID:SCR_016137 Software; Algorithm Rstudio Rstudio RRID:SCR_000432 Software; Algorithm Syrinx Dr. John Burt https://syrinxpc.com/ Software; Algorithm Jwatcher University of California at Los Angeles; California; USARRID:SCR_017595 Transfected Construct Not Applicable Other KEY RESOURCES TABLE Jo urn al Pr e-p roo f Region Blocks 1 + 2: Peripheral Block 3: Intracerebral Subject:Symbol Sex # of MRI scans prior to inclusion vmPFC-14 OFC-11 SSRI KET SSRI KET 1 F 0 ✓ ✓ ✓ ✓ ✓ 2 M 0 ✓ ✓ 3 F 0 ✓ ✓ 4 M 0 ✓ ✓ ✓ ✓ ✓ 5 F 1 ✓ ✓ ✓ ✓ 6 M 0 ✓ ✓ ✓ ✓ ✓ 7 F 4 ✓ ✓ ✓ 8 M 5 ✓ ✓ ✓ ✓ 9 M 0 ✓ ✓ ✓ ✓ ✓ 10 F 0 ✓ ✓ ✓ 11 F 0 ✓ ✓ ✓ ✓ ✓ 12 M 0 ✓ ✓ ✓ ✓ ✓ 13 M 4 ✓ ✓ ✓ ✓ ✓ 14 F 4 ✓ ✓ ✓ ✓ ✓ Table 1: Subject inclusion in all experimental blocks of the study. ..

    Blocking Assay:

    Article Title: Heightened anxiety with distinct prefrontal substrates is differentially sensitive to the anxiolytics, citalopram and ketamine: Prefrontal substrates and anxiolytic sensitivity.
    Article Snippet: .. Antibody Not Applicable Bacterial or Viral Strain Not Applicable Biological Sample postmortem brain tissue This paper Cell Line Not Applicable Chemical Compound or Drug dihydrokainic acid (DHK) Tocris Cat # 0111, CAS 52497-36-6 Chemical Compound or Drug Muscimol Sigma-Aldrich Cat # M1523, CAS 2763-96-4 Chemical Compound or Drug Baclofen Sigma-Aldrich Cat # BP028, CAS 1134-47-0 Chemical Compound or Drug Citalopram Hbr Tocris Cat # 1427, CAS 59729-32-7 Chemical Compound or Drug Ketamine HCl Tocris Cat # 3131, CAS 1867-66-9 Commercial Assay Or Kit Not Applicable Deposited Data; Public Database Manuscript_dataset This paper DOI: 10.17632/vky7vm6pfh.1 Genetic Reagent Not Applicable Organism/Strain common marmoset (Callithrix jacchus ) University of Cambridge Marmoset Breeding ColonyN/A Peptide, Recombinant Protein Not Applicable Recombinant DNA Not Applicable Sequence-Based Reagent Not Applicable Software; Algorithm GraphPad Prism GraphPad RRID:SCR_002798 Software; Algorithm Microsoft Excel Microsoft RRID:SCR_016137 Software; Algorithm Rstudio Rstudio RRID:SCR_000432 Software; Algorithm Syrinx Dr. John Burt https://syrinxpc.com/ Software; Algorithm Jwatcher University of California at Los Angeles; California; USARRID:SCR_017595 Transfected Construct Not Applicable Other KEY RESOURCES TABLE Jo urn al Pr e-p roo f Region Blocks 1 + 2: Peripheral Block 3: Intracerebral Subject:Symbol Sex # of MRI scans prior to inclusion vmPFC-14 OFC-11 SSRI KET SSRI KET 1 F 0 ✓ ✓ ✓ ✓ ✓ 2 M 0 ✓ ✓ 3 F 0 ✓ ✓ 4 M 0 ✓ ✓ ✓ ✓ ✓ 5 F 1 ✓ ✓ ✓ ✓ 6 M 0 ✓ ✓ ✓ ✓ ✓ 7 F 4 ✓ ✓ ✓ 8 M 5 ✓ ✓ ✓ ✓ 9 M 0 ✓ ✓ ✓ ✓ ✓ 10 F 0 ✓ ✓ ✓ 11 F 0 ✓ ✓ ✓ ✓ ✓ 12 M 0 ✓ ✓ ✓ ✓ ✓ 13 M 4 ✓ ✓ ✓ ✓ ✓ 14 F 4 ✓ ✓ ✓ ✓ ✓ Table 1: Subject inclusion in all experimental blocks of the study. ..

    Magnetic Resonance Imaging:

    Article Title: Heightened anxiety with distinct prefrontal substrates is differentially sensitive to the anxiolytics, citalopram and ketamine: Prefrontal substrates and anxiolytic sensitivity.
    Article Snippet: .. Antibody Not Applicable Bacterial or Viral Strain Not Applicable Biological Sample postmortem brain tissue This paper Cell Line Not Applicable Chemical Compound or Drug dihydrokainic acid (DHK) Tocris Cat # 0111, CAS 52497-36-6 Chemical Compound or Drug Muscimol Sigma-Aldrich Cat # M1523, CAS 2763-96-4 Chemical Compound or Drug Baclofen Sigma-Aldrich Cat # BP028, CAS 1134-47-0 Chemical Compound or Drug Citalopram Hbr Tocris Cat # 1427, CAS 59729-32-7 Chemical Compound or Drug Ketamine HCl Tocris Cat # 3131, CAS 1867-66-9 Commercial Assay Or Kit Not Applicable Deposited Data; Public Database Manuscript_dataset This paper DOI: 10.17632/vky7vm6pfh.1 Genetic Reagent Not Applicable Organism/Strain common marmoset (Callithrix jacchus ) University of Cambridge Marmoset Breeding ColonyN/A Peptide, Recombinant Protein Not Applicable Recombinant DNA Not Applicable Sequence-Based Reagent Not Applicable Software; Algorithm GraphPad Prism GraphPad RRID:SCR_002798 Software; Algorithm Microsoft Excel Microsoft RRID:SCR_016137 Software; Algorithm Rstudio Rstudio RRID:SCR_000432 Software; Algorithm Syrinx Dr. John Burt https://syrinxpc.com/ Software; Algorithm Jwatcher University of California at Los Angeles; California; USARRID:SCR_017595 Transfected Construct Not Applicable Other KEY RESOURCES TABLE Jo urn al Pr e-p roo f Region Blocks 1 + 2: Peripheral Block 3: Intracerebral Subject:Symbol Sex # of MRI scans prior to inclusion vmPFC-14 OFC-11 SSRI KET SSRI KET 1 F 0 ✓ ✓ ✓ ✓ ✓ 2 M 0 ✓ ✓ 3 F 0 ✓ ✓ 4 M 0 ✓ ✓ ✓ ✓ ✓ 5 F 1 ✓ ✓ ✓ ✓ 6 M 0 ✓ ✓ ✓ ✓ ✓ 7 F 4 ✓ ✓ ✓ 8 M 5 ✓ ✓ ✓ ✓ 9 M 0 ✓ ✓ ✓ ✓ ✓ 10 F 0 ✓ ✓ ✓ 11 F 0 ✓ ✓ ✓ ✓ ✓ 12 M 0 ✓ ✓ ✓ ✓ ✓ 13 M 4 ✓ ✓ ✓ ✓ ✓ 14 F 4 ✓ ✓ ✓ ✓ ✓ Table 1: Subject inclusion in all experimental blocks of the study. ..

    Sterility:

    Article Title: Heightened anxiety with distinct prefrontal substrates is differentially sensitive to the anxiolytics, citalopram and ketamine: Prefrontal substrates and anxiolytic sensitivity.
    Article Snippet: .. Central administration of racemic ketamine (0.5 μg/μL, Tocris, UK), dissolved in sterile saline, was infused in 1 μL for a 24 hr pretreatment to intrusion as used previously (29). ..

    Article Title: Heightened anxiety with distinct prefrontal substrates is differentially sensitive to the anxiolytics, citalopram and ketamine: Prefrontal substrates and anxiolytic sensitivity.
    Article Snippet: .. Ketamine (1 mg/kg, dissolved in sterile saline, Tocris, UK) was administered sub-acutely for a 24 hr pretreatment to intrusion. ..



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