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megalign program  (DYNASTAR Inc)

 
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    Structured Review

    DYNASTAR Inc megalign program
    PDZ domains of the NHERF family were defined using ScanSite MotifScan. The 12 human NHERF family PDZ domains were individually analysed for sequence relationship by the <t>MegAlign</t> program (DynaStar, Inc.). The domains were grouped by closest relationships. Relationship with C. elegans and D. melanogaster proteins were also analysed by MegAlign. All protein names and sequences were obtained from NCB1. C. elegans has two PDZ domain-containing proteins that are related to the NHERF family. CO1F6.6 contains one PDZ domain while 4J893 contains two PDZ domains, one identical to that in CO1F6.6 and the other 5% identical. This suggests that the second PDZ domain of 4J893 may have evolved by gene duplication. Each of the two worm PDZ domains is a precursor to certain groups of PDZ domains of the human NHERF family. The D. melanogaster proteins CG10939-PA and CG32758-PA each contain one PDZ domain (10% identical to each other) and are precursors to the human NHERF family.
    Megalign Program, supplied by DYNASTAR Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/sequence+analysis+software+megalign+program/pmc01474160-47-15-17?v=DYNASTAR+Inc
    Average 90 stars, based on 1 article reviews
    megalign program - by Bioz Stars, 2026-08
    90/100 stars

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    1) Product Images from "NHERF family and NHE3 regulation"

    Article Title: NHERF family and NHE3 regulation

    Journal:

    doi: 10.1113/jphysiol.2005.090399

    PDZ domains of the NHERF family were defined using ScanSite MotifScan. The 12 human NHERF family PDZ domains were individually analysed for sequence relationship by the MegAlign program (DynaStar, Inc.). The domains were grouped by closest relationships. Relationship with C. elegans and D. melanogaster proteins were also analysed by MegAlign. All protein names and sequences were obtained from NCB1. C. elegans has two PDZ domain-containing proteins that are related to the NHERF family. CO1F6.6 contains one PDZ domain while 4J893 contains two PDZ domains, one identical to that in CO1F6.6 and the other 5% identical. This suggests that the second PDZ domain of 4J893 may have evolved by gene duplication. Each of the two worm PDZ domains is a precursor to certain groups of PDZ domains of the human NHERF family. The D. melanogaster proteins CG10939-PA and CG32758-PA each contain one PDZ domain (10% identical to each other) and are precursors to the human NHERF family.
    Figure Legend Snippet: PDZ domains of the NHERF family were defined using ScanSite MotifScan. The 12 human NHERF family PDZ domains were individually analysed for sequence relationship by the MegAlign program (DynaStar, Inc.). The domains were grouped by closest relationships. Relationship with C. elegans and D. melanogaster proteins were also analysed by MegAlign. All protein names and sequences were obtained from NCB1. C. elegans has two PDZ domain-containing proteins that are related to the NHERF family. CO1F6.6 contains one PDZ domain while 4J893 contains two PDZ domains, one identical to that in CO1F6.6 and the other 5% identical. This suggests that the second PDZ domain of 4J893 may have evolved by gene duplication. Each of the two worm PDZ domains is a precursor to certain groups of PDZ domains of the human NHERF family. The D. melanogaster proteins CG10939-PA and CG32758-PA each contain one PDZ domain (10% identical to each other) and are precursors to the human NHERF family.

    Techniques Used: Sequencing



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