scrnaseq data (Allen Institute for Brain Science)
90
Structured Review
Allen Institute for Brain Science
scrnaseq data
Scrnaseq Data, supplied by Allen Institute for Brain Science, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/scrna+seq+data+analysis/scrna+seq+data/pmc09089861-232-2-16
Average 90 stars, based on 1 article reviews
Scrnaseq Data, supplied by Allen Institute for Brain Science, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/scrna+seq+data+analysis/scrna+seq+data/pmc09089861-232-2-16
Average 90 stars, based on 1 article reviews
scrnaseq data - by Bioz Stars,
2026-09
90/100 stars
Images
1) Product Images from "Cell type-specific mechanisms of information transfer in data-driven biophysical models of hippocampal CA3 principal neurons"
Article Title: Cell type-specific mechanisms of information transfer in data-driven biophysical models of hippocampal CA3 principal neurons
Journal: PLoS Computational Biology
doi: 10.1371/journal.pcbi.1010071
Figure Legend Snippet: (A) Bidimensional representation of parameter values transformed using UMAP: each dot represents one individual, and closed lines indicate the convex hulls associated with all the individuals obtained with a given morphology (color-coded accordingly to both the convex hull and the points contained in it). (B) UMAP projection and clustering of CA3 excitatory neurons based on scRNAseq data. Using the Leiden clustering algorithm with a resolution of 0.65 delineated the primary division in the CA3 principal neuron population. Note that CA3 principal cells are primarily composed of a larger population of cells (cluster 1, black) and a second minority population (cluster 2, red). (C) Violin plots of the distributions of maximal conductance values for four different classes of ion channels (potassium, calcium, sodium and hyperpolarization-activated) for the model cells included in the analysis, normalized over the range of allowed variability of each parameter as reported in (black and red indicate thorny and a-thorny cells, respectively). Dashed lines indicate the median of the population, while the upper and lower dotted lines represent the 25th and 75th percentile of the distributions. Most parameter distributions were significantly different between the two cell-types (non-parametric Kolmogorov-Smirnov test: * p < 0.05, ** p < 0.01, *** p < 0.001). For the remaining parameters see . (D) Expression levels for cells belonging to cluster 1 (black) or cluster 2 (red) for analogous classes of ion channel genes as shown in (C). Note that expression levels for most Na channel genes were not significantly different while Ca and K channel genes were significantly differentially expressed between the two clusters (non-parametric Kolmogorov-Smirnov test: * p < 0.05, ** p < 0.01, *** p < 0.001).
Techniques Used: Transformation Assay, Expressing
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