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Johns Hopkins HealthCare rnaseq database

Patients with high expression of HPV16 E5 have <t>decreased</t> <t>HLA</t> expression associated with worse disease-free survival. A, B) mRNA expression analyzed by <t>RNAseq</t> in HNSCC from normal, E245 high, and E67 high patients in Johns Hopkins University (JHU) cohort. (Normal; n = 25, E245 high: n = 26, E67 high: n = 10) (A) Correlation analysis of HPV16 E5 expression and HLA-subtype or TAP expression (n = 36, Spearman’s correlation coefficient) (B) Patients were assigned to 3 groups based on the mRNA expression level of HLA (low, average, and high). Patients with low and high expression of HLA are shown. (Chi-square test and residual analysis) C) Disease-free survival and overall survival of patients in JHU cohort. Patients were assigned to groups based on E5 and HLA expression level.

Rnaseq Database, supplied by Johns Hopkins HealthCare, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rna-seq+database/rnaseq+database/pmc07024675-319-21-32
Average 90 stars, based on 1 article reviews

rnaseq database - by Bioz Stars, 2026-10

90/100 stars

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Article Title: HPV16 E5 Mediates Resistance to PD-L1 Blockade and can be targeted with Rimantadine in Head and Neck Cancer

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-19-1771

Patients with high expression of HPV16 E5 have decreased HLA expression associated with worse disease-free survival. A, B) mRNA expression analyzed by RNAseq in HNSCC from normal, E245 high, and E67 high patients in Johns Hopkins University (JHU) cohort. (Normal; n = 25, E245 high: n = 26, E67 high: n = 10) (A) Correlation analysis of HPV16 E5 expression and HLA-subtype or TAP expression (n = 36, Spearman’s correlation coefficient) (B) Patients were assigned to 3 groups based on the mRNA expression level of HLA (low, average, and high). Patients with low and high expression of HLA are shown. (Chi-square test and residual analysis) C) Disease-free survival and overall survival of patients in JHU cohort. Patients were assigned to groups based on E5 and HLA expression level.

Figure Legend Snippet: Patients with high expression of HPV16 E5 have decreased HLA expression associated with worse disease-free survival. A, B) mRNA expression analyzed by RNAseq in HNSCC from normal, E245 high, and E67 high patients in Johns Hopkins University (JHU) cohort. (Normal; n = 25, E245 high: n = 26, E67 high: n = 10) (A) Correlation analysis of HPV16 E5 expression and HLA-subtype or TAP expression (n = 36, Spearman’s correlation coefficient) (B) Patients were assigned to 3 groups based on the mRNA expression level of HLA (low, average, and high). Patients with low and high expression of HLA are shown. (Chi-square test and residual analysis) C) Disease-free survival and overall survival of patients in JHU cohort. Patients were assigned to groups based on E5 and HLA expression level.

Techniques Used: Expressing

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Article Title: HPV16 E5 Mediates Resistance to PD-L1 Blockade and can be targeted with Rimantadine in Head and Neck Cancer
Article Snippet: .. In order to evaluate whether HPV E5 has an effect on HLA expression in human tumors, we analyzed a prospectively collected RNAseq database of 35 HNSCC patient tumors and 25 healthy volunteers [Johns Hopkins University (JHU) cohort] ( Supp Table 1 ). ..

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