tcga rnaseq data (GraphPad Software Inc)
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Tcga Rnaseq Data, supplied by GraphPad Software Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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1) Product Images from "Duchenne muscular dystrophy gene expression is an independent prognostic marker for IDH mutant low-grade glioma"
Article Title: Duchenne muscular dystrophy gene expression is an independent prognostic marker for IDH mutant low-grade glioma
Journal: Scientific Reports
doi: 10.1038/s41598-022-07223-2
Figure Legend Snippet: High DMD expression is significantly associated with poor survival in LGG. ( a ) TCGA RNAseq data from WHO grade II LGG cases was dichotomised into high (blue) and low (red) DMD expressing groups and survival analysis performed in GraphPad using the log-rank test. Tumour subtype analysis was also performed. Numbers in brackets are median overall survival times in months. ( b ) Forest plot revealing the log-rank hazard ratio with 95% confidence intervals and number of patients for each group. A astrocytoma, OD oligodendroglioma, NOS not otherwise specified.
Techniques Used: Expressing
Figure Legend Snippet: WGCNA of the TCGA WHO grade II LGG dataset identified a network of 882 genes divided into five co-expression modules. ( a ) Gene dendrogram. Colours are randomly assigned except grey which represents areas unassigned to a module. ( b ) Networks of the top 20 genes for the entire network and each module individually. ( c ) Visualisation of the GO enrichment analysis for each module; heatmap was produced in GraphPad. ( d ) Venn analysis to identify common genes returned by both WGCNA and DEG analysis.
Techniques Used: Expressing, Produced
Figure Legend Snippet: The expression of multiple DMD gene products are significantly associated with LGG survival outcomes. ( a ) LGG TCGA RNAseq data for each DMD isoform was dichotomised into high (blue) and low (red) expression groups and survival analysis performed in GraphPad using the log-rank test. Numbers in brackets are median overall survival times in months. ( b ) Kaplan–Meier survival curves for high (blue) vs low (red) Dp71, Dp71ab or Dp427m expression for each IDH mutation status group were compared. Numbers in brackets are median overall survival times in months. The tables provide the log-rank test P values for each planned comparison; the alpha value was adjusted to 0.017 to correct for multiple testing.
Techniques Used: Expressing, Mutagenesis, Comparison
Related Articles
Expressing:Article Title: Duchenne muscular dystrophy gene expression is an independent prognostic marker for IDH mutant low-grade glioma Article Snippet: .. Figure 1 High DMD expression is significantly associated with poor survival in LGG. ( a ) RNA sequencing:Article Title: Duchenne muscular dystrophy gene expression is an independent prognostic marker for IDH mutant low-grade glioma Article Snippet: .. Figure 1 High DMD expression is significantly associated with poor survival in LGG. ( a ) |

