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automated patch clamp (apc) system qpatch 48 x  (Sophion Bioscience)

 
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    Sophion Bioscience automated patch clamp (apc) system qpatch 48 x
    Automated Patch Clamp (Apc) System Qpatch 48 X, supplied by Sophion Bioscience, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/qpatch+automated+patch-clamp+system/automated+patch+clamp/pm39637404-646-5-8
    Average 90 stars, based on 1 article reviews
    automated patch clamp (apc) system qpatch 48 x - by Bioz Stars, 2026-10
    90/100 stars

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    Related Articles

    Patch Clamp:

    Article Title: Advances in ion channel high throughput screening: where are we in 2023?
    Article Snippet: .. Declaration of interest D Bell is an employee of Sophion Bioscience A/S who sell automated patch clamp platforms. ..

    Article Title: In vivo neutralization of coral snake venoms with an oligoclonal nanobody mixture in a murine challenge model
    Article Snippet: .. Patch Clamp data was analyzed with Sophion Analyzer v6.6.70 (Sophion Bioscience) and GraphPad Prism v10. .. BLI data was processed and analyzed using Octet® Analysis Studio 12.2.2.26 (ForteBio) and GraphPad Prism v10.

    Article Title: Selectively Antagonizing the NOD1-Mediated Inflammatory Signaling Pathway Mitigates the Gastric Inflammation Induced by Helicobacter pylori Infection.
    Article Snippet: Helicobacter pylori (H. pylori) infection is characterized by the complex interplay between H. pylori and gastric disorders.. It has been established that NOD1 can be activated by the peptidoglycan (PGN) present in the cell wall of H. pylori, serving as a key mediator of inflammation and initiating the RIP2/NF-κB and MAPK inflammatory signaling pathways.. In this article, we reported on the development of a 2chloroquinazolin-4-ol derivative 66 as a potent and selective antagonist of both human and mouse NOD1, which effectively inhibited the expression of inflammatory cytokines (IL-6, TNF-α) and chemokines (CXCL1, CXCL8) in immune and epithelial cells, as well as inflammatory cytokines (KC, IL-6) in a H. pylori-induced murine model of gastritis following oral administration.

    Article Title: Fused ring derivative having MGAT-2 inhibitory activity
    Article Snippet: .. After a cell was retained at a membrane potential of −80 mV by whole cell patch clamp method using an automated patch clamp system (QPatch; Sophion BIoscience A/S), IKr induced by application of a leak potential of −50 mV followed by depolarization pulse stimulation at +20 mV for 2 seconds and, further, repolarization pulse stimulation at −50 mV for 2 seconds, was recorded. .. After a cell was retained at a membrane potential of −80 mV by whole cell patch clamp method using an automated patch clamp system (QPatch; Sophion BIoscience A/S), IKr induced by application of a leak potential of −50 mV followed by depolarization pulse stimulation at +20 mV for 2 seconds and, further, repolarization pulse stimulation at −50 mV for 2 seconds, was recorded.

    other:

    Article Title: Recent Advances in Ionic Mechanisms in Pituitary Cells: Implications for Electrophysiological and Electropharmacological Research
    Article Snippet: Another advanced and innovative technique, such as the automatic patch-clamp technique provided by Sophion Bioscience ( http://sophion.com , accessed on 14 April 2025), is also an alternative option for conducting cell electrophysiology studies on pituitary cells.

    Article Title: Calcineurin regulates aldosterone production via dephosphorylation of NFATC4.
    Article Snippet: We would also like to thank Sophion Bioscience for their support with automated patch-clamping.

    Article Title: Recent Advances in Ionic Mechanisms in Pituitary Cells: Implications for Electrophysiological and Electropharmacological Research.
    Article Snippet: Another advanced and innovative technique, such as the automatic patch-clamp technique provided by Sophion Bioscience (http://sophion.com, accessed on 14 April 2025), is also an alternative option for conducting cell electrophysiology studies on pituitary cells.

    Article Title: Carbazole and tetrahydro-carboline derivatives as dopamine D 3 receptor antagonists with the multiple antipsychotic-like properties
    Article Snippet: The tail currents of hERG channel were evaluated using the Q-patch automated patch clamp platform (Sophion Bioscience, Denmark).

    Membrane:

    Article Title: Fused ring derivative having MGAT-2 inhibitory activity
    Article Snippet: .. After a cell was retained at a membrane potential of −80 mV by whole cell patch clamp method using an automated patch clamp system (QPatch; Sophion BIoscience A/S), IKr induced by application of a leak potential of −50 mV followed by depolarization pulse stimulation at +20 mV for 2 seconds and, further, repolarization pulse stimulation at −50 mV for 2 seconds, was recorded. .. After a cell was retained at a membrane potential of −80 mV by whole cell patch clamp method using an automated patch clamp system (QPatch; Sophion BIoscience A/S), IKr induced by application of a leak potential of −50 mV followed by depolarization pulse stimulation at +20 mV for 2 seconds and, further, repolarization pulse stimulation at −50 mV for 2 seconds, was recorded.



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    Na v channel compound profile assessed on the Qube or Qpatch*. Ten-point titrations in the Qube automated patch-clamp assay determined MSD199 to be a potent and selective compound (IC 50 = 4.7 ± 0.8 nM, mean ± SD). MSD199 potency was too weak to calculate for all other Na v isoforms except Na v 1.4, which was 1781-fold shifted to 8370 nM mean IC 50 ± 1429.

    Journal: Pain

    Article Title: Analgesia and peripheral c-fiber modulation by selective Na v 1.8 inhibition in rhesus

    doi: 10.1097/j.pain.0000000000003404

    Figure Lengend Snippet: Na v channel compound profile assessed on the Qube or Qpatch*. Ten-point titrations in the Qube automated patch-clamp assay determined MSD199 to be a potent and selective compound (IC 50 = 4.7 ± 0.8 nM, mean ± SD). MSD199 potency was too weak to calculate for all other Na v isoforms except Na v 1.4, which was 1781-fold shifted to 8370 nM mean IC 50 ± 1429.

    Article Snippet: Qube voltage-clamp experiments were performed using human embryonic kidney (HEK) 293 cell lines or Chinese Hamster Ovary cell lines stably expressing either human Na v 1.1, Na v 1.2, Na v 1.3, Na v 1.4, Na v 1.5, Na v 1.6, Na v 1.7, Na v 1.8, or Na v 1.9 on the Qube or Qpatch automated patch-clamp platforms (Sophion Bioscience A/S, Ballerup, Denmark).

    Techniques: Patch Clamp