pulse (v8.65) software (HEKA Elektronik)
90
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HEKA Elektronik
pulse (v8.65) software
Pulse (V8.65) Software, supplied by HEKA Elektronik, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/pulse+software/pulse++v8+65++software/pmc04415010-105-24-27
Average 90 stars, based on 1 article reviews
Pulse (V8.65) Software, supplied by HEKA Elektronik, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/pulse+software/pulse++v8+65++software/pmc04415010-105-24-27
Average 90 stars, based on 1 article reviews
pulse (v8.65) software - by Bioz Stars,
2026-09
90/100 stars
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Patch Clamp:Article Title: Synthesis and biological evaluation of fluoro-substituted 3,4-dihydroquinazoline derivatives for cytotoxic and analgesic effects. Article Snippet: page 1 / 21 KYS05090S, a series of new fluoro-substituted 3,4-dihydroquinazoline derivatives was prepared and evaluated for T-type calcium channel (Cav3.2) block, cytotoxic effects and liver microsomal stability.. Among them, compound 8h (KCP10068F) containing 4-fluorobenzyl amide potently blocked Cav3.2 currents (>90 % inhibition) at 10 μM concentration and exhibited cytotoxic effect (IC50 = 5.9 μM) in A549 non-small cell lung cancer cells that was comparable to KYS05090S.. Furthermore, 8h showed approximately a 2-fold increase in liver metabolic stability in rat and human species compared to KYS05090S. Article Title: Binding mechanism investigations guiding the synthesis of novel condensed 1,4-dihydropyridine derivatives with L-/T-type calcium channel blocking activity Article Snippet: Accepted Manuscript Binding mechanism investigations guiding the synthesis of novel condensed 1,4- dihydropyridine derivatives with L-/T-type calcium channel blocking activity David Schaller, Miyase Gözde Gündüz, Fang Xiong Zhang, Gerald W. Zamponi, Gerhard Wolber PII: S0223-5234(18)30445-8 DOI: 10.1016/j.ejmech.2018.05.032 Reference: EJMECH 10443 To appear in: European Journal of Medicinal Chemistry Received Date: 13 April 2018 Revised Date: 14 May 2018 Accepted Date: 20 May 2018 Please cite this article as: D. Schaller, Miyase.Gö.. Gündüz, F.X.. Zhang, G.W. Article Title: Synthesis and biological evaluation of novel N3- substituted dihydropyrimidine derivatives as T-type calcium channel blockers and their efficacy as analgesics in mouse models of inflammatory pain Article Snippet: Low-voltage-activated calcium channels are important regulators of neurotransmission and membrane ion conductance.. A plethora of intracellular events rely on their modulation.. Accordingly, they are implicated in many disorders including epilepsy, Parkinson's disease, pain and other neurological diseases. Article Title: Structural optimization, synthesis and in vitro synergistic anticancer activities of combinations of new N3-substituted dihydropyrimidine calcium channel blockers with cisplatin and etoposide. Article Snippet: T-type calcium channels are considered potential drug targets to combat cancer.. Combining T-type calcium channel blockers with conventional chemotherapy drugs represents a promising strategy towards successful cancer treatment.. From this perspective, we report in this study the design and synthesis of a novel series of N3sustituted dihydropyrimidines (DHPMs) as anticancer adjuvants to cisplatin (Cis) and etoposide (Eto). Article Title: Synthesis of some new C2 substituted dihydropyrimidines and their electrophysiological evaluation as L-/T-type calcium channel blockers. Article Snippet: Drugs targeting different calcium channel subtypes have strong therapeutic potential for future drug development for cardiovascular disorders, neuropsychiatric diseases and cancer.. This study aims to design and synthesize a new series of C2 substituted dihydropyrimidines to mimic the structure features of third generation long acting dihydropyridine calcium channel blockers and dihydropyrimidines analogues.. The target compounds have been evaluated as blockers for CaV1.2 and CaV3.2 utilizing the whole-cell patch clamp technique. Article Title: The terpenes camphene and alpha-bisabolol inhibit inflammatory and neuropathic pain via Cav3.2 T-type calcium channels Article Snippet: The patch clamp recordings were performed by an EPC 10 amplifier linked to a personal computer equipped with Article Title: Design, synthesis and pharmacological evaluation of some substituted dihydropyrimidines with L-/T-type calcium channel blocking activities. Article Snippet: New dihydropyrimidines bearing various lipophilic pharmacophores and functionalities at position 3 were designed and synthesized.. The basic framework of the new compounds was designed to maintain the main structural requirements for calcium channel blocking activity of the known dihydropyridines and dihydropyrimidines calcium channel blockers.. The newly synthesized compounds were evaluated as antagonists for CaV1.2 and CaV3.2 using the whole-cell patch clamp technique. Article Title: Effect of the T-type channel blocker KYS-05090S in mouse models of acute and neuropathic pain. Article Snippet: T-type channels are important contributors to the initiation and the maintenance of chronic pain states.. Blocking T-type channels is therefore a possible therapeutic strategy for relieving pain.. Here, we report the Cav3.2 T-type channel blocking action of a previously reported small organic molecule, KYS-05090S. Software:Article Title: Synthesis and biological evaluation of fluoro-substituted 3,4-dihydroquinazoline derivatives for cytotoxic and analgesic effects. Article Snippet: page 1 / 21 KYS05090S, a series of new fluoro-substituted 3,4-dihydroquinazoline derivatives was prepared and evaluated for T-type calcium channel (Cav3.2) block, cytotoxic effects and liver microsomal stability.. Among them, compound 8h (KCP10068F) containing 4-fluorobenzyl amide potently blocked Cav3.2 currents (>90 % inhibition) at 10 μM concentration and exhibited cytotoxic effect (IC50 = 5.9 μM) in A549 non-small cell lung cancer cells that was comparable to KYS05090S.. Furthermore, 8h showed approximately a 2-fold increase in liver metabolic stability in rat and human species compared to KYS05090S. Article Title: Binding mechanism investigations guiding the synthesis of novel condensed 1,4-dihydropyridine derivatives with L-/T-type calcium channel blocking activity Article Snippet: Accepted Manuscript Binding mechanism investigations guiding the synthesis of novel condensed 1,4- dihydropyridine derivatives with L-/T-type calcium channel blocking activity David Schaller, Miyase Gözde Gündüz, Fang Xiong Zhang, Gerald W. Zamponi, Gerhard Wolber PII: S0223-5234(18)30445-8 DOI: 10.1016/j.ejmech.2018.05.032 Reference: EJMECH 10443 To appear in: European Journal of Medicinal Chemistry Received Date: 13 April 2018 Revised Date: 14 May 2018 Accepted Date: 20 May 2018 Please cite this article as: D. Schaller, Miyase.Gö.. Gündüz, F.X.. Zhang, G.W. Article Title: Synthesis and biological evaluation of novel N3- substituted dihydropyrimidine derivatives as T-type calcium channel blockers and their efficacy as analgesics in mouse models of inflammatory pain Article Snippet: Low-voltage-activated calcium channels are important regulators of neurotransmission and membrane ion conductance.. A plethora of intracellular events rely on their modulation.. Accordingly, they are implicated in many disorders including epilepsy, Parkinson's disease, pain and other neurological diseases. Article Title: Structural optimization, synthesis and in vitro synergistic anticancer activities of combinations of new N3-substituted dihydropyrimidine calcium channel blockers with cisplatin and etoposide. Article Snippet: T-type calcium channels are considered potential drug targets to combat cancer.. Combining T-type calcium channel blockers with conventional chemotherapy drugs represents a promising strategy towards successful cancer treatment.. From this perspective, we report in this study the design and synthesis of a novel series of N3sustituted dihydropyrimidines (DHPMs) as anticancer adjuvants to cisplatin (Cis) and etoposide (Eto). Article Title: Synthesis of some new C2 substituted dihydropyrimidines and their electrophysiological evaluation as L-/T-type calcium channel blockers. Article Snippet: Drugs targeting different calcium channel subtypes have strong therapeutic potential for future drug development for cardiovascular disorders, neuropsychiatric diseases and cancer.. This study aims to design and synthesize a new series of C2 substituted dihydropyrimidines to mimic the structure features of third generation long acting dihydropyridine calcium channel blockers and dihydropyrimidines analogues.. The target compounds have been evaluated as blockers for CaV1.2 and CaV3.2 utilizing the whole-cell patch clamp technique. Article Title: The terpenes camphene and alpha-bisabolol inhibit inflammatory and neuropathic pain via Cav3.2 T-type calcium channels Article Snippet: The patch clamp recordings were performed by an EPC 10 amplifier linked to a personal computer equipped with Article Title: Design, synthesis and pharmacological evaluation of some substituted dihydropyrimidines with L-/T-type calcium channel blocking activities. Article Snippet: New dihydropyrimidines bearing various lipophilic pharmacophores and functionalities at position 3 were designed and synthesized.. The basic framework of the new compounds was designed to maintain the main structural requirements for calcium channel blocking activity of the known dihydropyridines and dihydropyrimidines calcium channel blockers.. The newly synthesized compounds were evaluated as antagonists for CaV1.2 and CaV3.2 using the whole-cell patch clamp technique. Article Title: Effect of the T-type channel blocker KYS-05090S in mouse models of acute and neuropathic pain. Article Snippet: T-type channels are important contributors to the initiation and the maintenance of chronic pain states.. Blocking T-type channels is therefore a possible therapeutic strategy for relieving pain.. Here, we report the Cav3.2 T-type channel blocking action of a previously reported small organic molecule, KYS-05090S. |