Journal: Nature Communications
Article Title: Daytime eating during simulated night work mitigates changes in cardiovascular risk factors: secondary analyses of a randomized controlled trial
doi: 10.1038/s41467-025-57846-y
Figure Lengend Snippet: The meal timing intervention significantly modified the impact of simulated night work on pNN50 ( A , B ), RMSSD ( C , D ), LF/HF ( E , F ) and PAI-1 ( G , H ) levels. For all results, cosinor mixed-model analyses were used, and the interaction of meal timing group vs. pre/post simulated night work is reported in the figures. Cosine curves make use of precise circadian phase of each measurement for each participant. Circles indicate data grouped into 15°-circadian windows (~1-hour resolution, except for PAI-1 that is presented with 2-h resolution) with SEM error bars and the top x axes were scaled to the approximate group-averaged clock time of the circadian CBT minimum (reflected by 0 o ) for reference (i.e., relative clock time). Data correspond to the average (mean ± SEM) across participants per pre/post simulated night work condition and per meal timing group ( n = 10 in the NMC group and n = 9 in the DMI group).
Article Snippet: To control overall type I error in null hypothesis testing when conducting multiple comparisons, P -values from the mixed-model analysis were adjusted using False Discovery Rates ( p FDR) (PROC MULTTEST, SAS) for the primary (i.e., pNN50, RMSSD, LF/HF ratio) and secondary (PAI-1) cardiovascular outcomes.
Techniques: Modification