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nav1 6 positive allosteric modulator potx  (MedChemExpress)


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    MedChemExpress nav1 6 positive allosteric modulator potx
    Nav1 6 Positive Allosteric Modulator Potx, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/position+module/Poneratoxin/pm41284713-298-27-36
    Average 93 stars, based on 2 article reviews
    nav1 6 positive allosteric modulator potx - by Bioz Stars, 2026-11
    93/100 stars

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    Related Articles

    Saline:

    Article Title: Amyloid precursor protein modulates cerebellar Purkinje cell activity and motor function through regulation of Nav1.6 currents.
    Article Snippet: .. Following a minimum recovery period of 4 days, mice received microinjections of either saline (0.5 μl/lateral), the Nav1.6 blocker 4,9-ahTTX (200 nM, 0.5 μl/lateral; MCE), or the Nav1.6 positive allosteric modulator PoTX (20 pM; 0.5 μl/lateral, MCE, HY-P10234A) 20 min before behavioral testing. .. Drug infusion into the cerebellar cortex was performed over 5 min using blunted microliter syringes (Hamilton, 1 μl, 25 gauge), extending 0.2 mm beyond the guide cannula tip.

    Article Title: Amyloid precursor protein modulates cerebellar Purkinje cell activity and motor function through regulation of Nav1.6 currents
    Article Snippet: .. Following a minimum recovery period of 4 days, mice received microinjections of either saline (0.5 μl/lateral), the Nav1.6 blocker 4,9-ahTTX (200 nM, 0.5 μl/lateral; MCE), or the Nav1.6 positive allosteric modulator PoTX (20 pM; 0.5 μl/lateral, MCE, HY-P10234A) 20 min before behavioral testing. .. Drug infusion into the cerebellar cortex was performed over 5 min using blunted microliter syringes (Hamilton, 1 μl, 25 gauge), extending 0.2 mm beyond the guide cannula tip.

    other:

    Article Title: Poneratoxin as a key tool for investigating the relationship between sodium channel hypersensitivity and impaired nerve cell function
    Article Snippet: Poneratoxin (product number: HY- P10234 ), ouabain (HY-B0542), veratridine (HY-N6691) were purchased from MedChemExpress (USA).



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    Potentiating SK channels restores normal NMDAR integration in Grin1 Y647S +/− mice (A) Schematic of potential mechanism showing impaired negative feedback in Y647S +/− neurons due to insufficient Ca 2+ influx compared to WT and the effect of NS309 in boosting SK channel Ca 2+ sensitivity, thereby restoring negative feedback in Y647S +/− neurons. (B) Average NMDAR plateau potential in Y647S +/− neurons at 70 μA with extended tail indicated by red arrow. Application of 10 μM NS309 to the slice restores normal duration and terminates the NMDAR plateau potential in Y647S +/− (Y647S +/− + NS309). (Inset) Restoration of plateau potential duration by NS309 at increasing stimulus intensities in a Y647S +/− neuron. (C) Total width of the NMDAR plateau potential in WT, Y647S +/− , and Y647S +/− + NS309 neurons (∗∗ p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗ p < 10 −4 , Tukey’s post hoc. Black stars: WT vs. Y647S +/− , purple stars: Y647S +/− vs. Y647S +/− + NS309). (D) SK2 channel blocker (Leidab7, 100 nM) prevents NS309 from reducing plateau potential duration in Y647S +/− neurons. (E) Normalized NMDAR plateau width in Y647S +/− neurons with the addition of NS309 and NS309+SK2 blockers (∗ p < 0.05, Sidak’s post hoc).

    Journal: iScience

    Article Title: Context-dependent NMDA receptor dysfunction predicts seizure treatment in mice with human GluN1 variant

    doi: 10.1016/j.isci.2025.114301

    Figure Lengend Snippet: Potentiating SK channels restores normal NMDAR integration in Grin1 Y647S +/− mice (A) Schematic of potential mechanism showing impaired negative feedback in Y647S +/− neurons due to insufficient Ca 2+ influx compared to WT and the effect of NS309 in boosting SK channel Ca 2+ sensitivity, thereby restoring negative feedback in Y647S +/− neurons. (B) Average NMDAR plateau potential in Y647S +/− neurons at 70 μA with extended tail indicated by red arrow. Application of 10 μM NS309 to the slice restores normal duration and terminates the NMDAR plateau potential in Y647S +/− (Y647S +/− + NS309). (Inset) Restoration of plateau potential duration by NS309 at increasing stimulus intensities in a Y647S +/− neuron. (C) Total width of the NMDAR plateau potential in WT, Y647S +/− , and Y647S +/− + NS309 neurons (∗∗ p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗ p < 10 −4 , Tukey’s post hoc. Black stars: WT vs. Y647S +/− , purple stars: Y647S +/− vs. Y647S +/− + NS309). (D) SK2 channel blocker (Leidab7, 100 nM) prevents NS309 from reducing plateau potential duration in Y647S +/− neurons. (E) Normalized NMDAR plateau width in Y647S +/− neurons with the addition of NS309 and NS309+SK2 blockers (∗ p < 0.05, Sidak’s post hoc).

    Article Snippet: SK channel positive allosteric modulator NS309 (10 μM, Tocris ) was included in a subset of experiments to restore appropriate duration of dendritic integration in Y647S +/− mice.

    Techniques: