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apoptosis protein arrays human phospho kinase  (R&D Systems)


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    R&D Systems apoptosis protein arrays human phospho kinase
    Figure 3: CUDC-101 inhibits ATC cell proliferation, and induces cell cycle arrest and <t>apoptosis.</t> (A) Basal expression of HDAC1, HDAC2 and EGFR in ATC cell lines. (B) Cell proliferation assay. Error bars are mean ± SD. (C) Cell cycle analysis after 24 hours of treatment. (D) The Caspase-Glo 3/7 assay after 48 hours of treatment with CUDC-101. *p < 0.05, **p < 0.01, ***p < 0.001. NS, no significant difference.
    Apoptosis Protein Arrays Human Phospho Kinase, supplied by R&D Systems, used in various techniques. Bioz Stars score: 96/100, based on 213 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/phospho-specific+protein+microarray+analysis/pm25940539-166-2-39?v=R%26D+Systems
    Average 96 stars, based on 213 article reviews
    apoptosis protein arrays human phospho kinase - by Bioz Stars, 2026-08
    96/100 stars

    Images

    1) Product Images from "Dual inhibition of HDAC and EGFR signaling with CUDC-101 induces potent suppression of tumor growth and metastasis in anaplastic thyroid cancer."

    Article Title: Dual inhibition of HDAC and EGFR signaling with CUDC-101 induces potent suppression of tumor growth and metastasis in anaplastic thyroid cancer.

    Journal: Oncotarget

    doi: 10.18632/oncotarget.3268

    Figure 3: CUDC-101 inhibits ATC cell proliferation, and induces cell cycle arrest and apoptosis. (A) Basal expression of HDAC1, HDAC2 and EGFR in ATC cell lines. (B) Cell proliferation assay. Error bars are mean ± SD. (C) Cell cycle analysis after 24 hours of treatment. (D) The Caspase-Glo 3/7 assay after 48 hours of treatment with CUDC-101. *p < 0.05, **p < 0.01, ***p < 0.001. NS, no significant difference.
    Figure Legend Snippet: Figure 3: CUDC-101 inhibits ATC cell proliferation, and induces cell cycle arrest and apoptosis. (A) Basal expression of HDAC1, HDAC2 and EGFR in ATC cell lines. (B) Cell proliferation assay. Error bars are mean ± SD. (C) Cell cycle analysis after 24 hours of treatment. (D) The Caspase-Glo 3/7 assay after 48 hours of treatment with CUDC-101. *p < 0.05, **p < 0.01, ***p < 0.001. NS, no significant difference.

    Techniques Used: Expressing, Proliferation Assay, Cell Cycle Assay, Caspase-Glo Assay

    Figure 5: Protein targets of CUDC-101 in ATC cells. (A) CUDC-101 inhibits HDACs and MAPK in ATC cells. (B) Targets of CUDC-101 identified by phospho-kinase array. Phospho-kinase arrays were performed using cell lysates treated with and without CUDC-101. Shown are those proteins that were altered with CUDC-101 treatment in both ATC cell lines with > 1.5-fold difference. (C) Differentially expressed apoptotic proteins with and without CUDC-101 treatment. Apoptosis arrays were performed. Shown are those proteins that were altered with CUDC-101 treatment in both ATC cell lines with > 1.5-fold difference. For A–C, ATC cells were treated with the vehicle or CUDC-101 at 1.1 μM for 24 hours. (D) CUDC-101 reduces the expression of survivin, XIAP, and β-catenin. Cells were treated with the vehicle or CUDC-101 for 24 hours.
    Figure Legend Snippet: Figure 5: Protein targets of CUDC-101 in ATC cells. (A) CUDC-101 inhibits HDACs and MAPK in ATC cells. (B) Targets of CUDC-101 identified by phospho-kinase array. Phospho-kinase arrays were performed using cell lysates treated with and without CUDC-101. Shown are those proteins that were altered with CUDC-101 treatment in both ATC cell lines with > 1.5-fold difference. (C) Differentially expressed apoptotic proteins with and without CUDC-101 treatment. Apoptosis arrays were performed. Shown are those proteins that were altered with CUDC-101 treatment in both ATC cell lines with > 1.5-fold difference. For A–C, ATC cells were treated with the vehicle or CUDC-101 at 1.1 μM for 24 hours. (D) CUDC-101 reduces the expression of survivin, XIAP, and β-catenin. Cells were treated with the vehicle or CUDC-101 for 24 hours.

    Techniques Used: Expressing



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    Image Search Results


    Effect of Lem4 on tyrosine phosphorylation of signal proteins in HEK293T cell line, as detected by tyrosine phosphorylation ProArray (Full Moon BioSystems). Phosphorylation levels were increased by at least 30% at 30 sites and decreased by at least 30% at four sites in the cells overexpressing Lem4-GFP. Red dashed line indicates the level of phosphorylation in the control GFP-expressing cell line.

    Journal: The Journal of Biological Chemistry

    Article Title: Legionella pneumophila effector Lem4 is a membrane-associated protein tyrosine phosphatase

    doi: 10.1074/jbc.RA118.003845

    Figure Lengend Snippet: Effect of Lem4 on tyrosine phosphorylation of signal proteins in HEK293T cell line, as detected by tyrosine phosphorylation ProArray (Full Moon BioSystems). Phosphorylation levels were increased by at least 30% at 30 sites and decreased by at least 30% at four sites in the cells overexpressing Lem4-GFP. Red dashed line indicates the level of phosphorylation in the control GFP-expressing cell line.

    Article Snippet: Phospho-specific protein microarray analysis Tyrosine phosphorylation ProArray was purchased from Full Moon Biosystems (Sunnyvale, CA).

    Techniques: Phospho-proteomics, Control, Expressing