selective pi3k p110 α inhibitor pi 103 (Selleck Chemicals)
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selective pi3k p110 α inhibitor pi 103
Selective Pi3k P110 α Inhibitor Pi 103, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 94/100, based on 158 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/phapi/PI-103/pmc04622552-24-1-15
Average 94 stars, based on 158 article reviews
Selective Pi3k P110 α Inhibitor Pi 103, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 94/100, based on 158 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/phapi/PI-103/pmc04622552-24-1-15
Average 94 stars, based on 158 article reviews
selective pi3k p110 α inhibitor pi 103 - by Bioz Stars,
2026-09
94/100 stars
Images
1) Product Images from "Overexpression of PI3K p110α contributes to acquired resistance to MET inhibitor, in MET-amplified SNU-5 gastric xenografts"
Article Title: Overexpression of PI3K p110α contributes to acquired resistance to MET inhibitor, in MET-amplified SNU-5 gastric xenografts
Journal: Drug Design, Development and Therapy
doi: 10.2147/DDDT.S89410
Figure Legend Snippet: Establishment of MET inhibitor-resistant human gastric cancer model in vivo. Notes: ( A ) Nude mice-bearing SNU-5 tumors were once-daily orally dosed with 10 mg/kg PHA665752 for up to 26 weeks. Tumor volume was monitored twice weekly. ( B ) Nude mice-bearing SNU-5 tumors after 26 weeks treatment. ( C ) Tumors were resected from nude mice. ( D ) The expression level of PI3K p110α , β , γ , p-MET, PTEN, and DNA-PK were analyzed by Western blotting in parental and PHA665752-resistant SNU-5 xenografts.
Techniques Used: In Vivo, Expressing, Western Blot
Figure Legend Snippet: Antitumor effects of PHA665752 in combination with PI-103 in PHA665752-resistant SNU-5 xenografts. Notes: ( A ) Nude mice-bearing resistant SNU-5 tumors were orally dosed with 10 mg/kg PHA665752 once daily or/and 5 mg/kg PI-103 once daily by oral administration for 3 weeks, respectively. The tumor volumes were monitored twice weekly. ( B ) Mice were killed using CO 2 on the last day of efficacy. ( C ) Tumor weight was measured on the last day of efficacy. ( D ) Body weights of mice were monitored in the indicated day during the efficacy study. ( E ) Effects of PHA665752 or/and PI-103 on signaling transduction pathways between parental and PHA665752-resistant SNU-5 xenografts model. The expression level of p-MET, p-AKT, p-ERK, p-S6, p110 α , β, γ, DNA-PK, PTEN, and p53 were analyzed by Western blotting in parental and PHA665752-resistant SNU-5 xenografts after exposing to PHA665752 or/and PI-103. Mean ± SD, n=10. ** P <0.01 vs vehicle group. Abbreviation: SD, standard deviation.
Techniques Used: Transduction, Expressing, Western Blot, Standard Deviation
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