parameter logistic fitting (Dotmatics Limited)
86
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Dotmatics Limited
parameter logistic fitting
Parameter Logistic Fitting, supplied by Dotmatics Limited, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/parameter+logistic+fitting/4+fitting+logistic+parameter/pm41887113-346-7-11
Average 86 stars, based on 1 article reviews
Parameter Logistic Fitting, supplied by Dotmatics Limited, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/parameter+logistic+fitting/4+fitting+logistic+parameter/pm41887113-346-7-11
Average 86 stars, based on 1 article reviews
parameter logistic fitting - by Bioz Stars,
2026-10
86/100 stars
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other:Article Title: Discovery of orally bioavailable N-acylated remdesivir derivatives with potent broad-spectrum antiviral activity. Article Snippet: Remdesivir (RDV), a nucleoside analog targeting viral RNA-dependent RNA polymerase (RdRp), suffers from critical limitations including low oral bioavailability, plasma instability, and reliance on intravenous administration, hindering its clinical utility.. To address these issues, we designed and synthesized 28 novel N-acylated derivatives by modifying the amino group on remdesivir's triazine ring.. The lead compound 4f exhibited potent anti-SARS-CoV-2 activity (EC50 = 0.0862 μM) in Vero E6 cells, comparable to remdesivir (EC50 = 0.0459 μM), with reduced cytotoxicity (CC50 = 15.6 μM, SI = 181.0). Article Title: Antiviral activities of phenylalanine derivatives carrying carboxylic acid bioisosteres against chikungunya and parainfluenza virus type 3. Article Snippet: Pathogenic RNA viruses from various virus families represent substantial public health hazards.. Specific antiviral drugs effective against most RNA virus infections have not yet been developed.. In this study, it was aimed to investigate the broad-spectrum antiviral activities of phenylalanine derivatives designed by replacing the carboxylic acid moiety with various bioisosteres such as nitrile, hydroxamidine and 5-oxo/thioxo-1,2,4-oxadiazole. |