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optrode array  (Bio-Signal Technologies)

 
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    Bio-Signal Technologies optrode array
    a Timeline of the approach-avoidance conflict test during single-unit recordings from photoidentified aPVT CRF neurons. b Diagram showing the injection of viral mix containing AAV-CRF-Cre and AAV-ChR2-DIO, and the implantation of <t>optrode</t> in aPVT. c – e Photoidentification of aPVT CRF neurons. c Representative aPVT CRF neuron responsive to laser illumination ( Z -score >3.29, P < 0.001, red dotted line, see details in Methods). d Cells with photoresponse latencies <12 ms were classified as aPVT CRF neurons (black bars, n = 26 out of 96 recorded neurons), whereas cells with photoresponse latencies >12 ms (white bars, n = 5 neurons) or non-responsive to the laser ( n = 65 neurons, not shown) were classified as non-identified aPVT neurons (aPVT non-ident , n = 70 out of 96 recorded neurons). e Raster plot and firing rate of a representative aPVT CRF neuron responding to a 5 Hz train of laser stimulation. Inset: Raster plot and firing rate time-locked for laser onset. Vertical blue bars: laser onset. Bins of 1 ms. f Relative frequency histogram showing the baseline firing rate of aPVT CRF neurons and aPVT non-identif neurons. g (Top) Schematic of the food-cue-evoked responses. (Bottom) Percentage of aPVT CRF and aPVT non-ident neurons that were responsive to food cues (green bars) before (left) and during the conflict (right). aPVT CRF neurons showed more food-cue responses during the conflict test, when compared to aPVT non-ident neurons (Fisher’s exact test; aPVT CRF neurons: 39%, 10 out of 26; aPVT non-ident neurons: 15%, 11 out of 70 neurons, P = 0.039). h – i Average peristimulus time histograms of all photoidentified aPVT CRF neurons showing h excitatory or i inhibitory food-cue responses during the conflict (red or blue bars, respectively) or the same neurons before the conflict (gray bars). j (Top) Schematic of the spontaneous activity recordings. (Bottom) Percentage of aPVT CRF and aPVT non-ident neurons that changed their baseline spontaneous activity (30 s pre vs. 30 s post) exclusively in food-seeking phase, cat odor phase, conflict phase (30 min), in more than one phase (nonselective), or did not change. No differences were observed between the two groups (Fisher’s exact test, all P ’s > 0.05). k (Top) Schematic of the recordings during lever presses-evoked responses. (Bottom) Percentage of aPVT CRF and aPVT non-ident neurons that were responsive to lever presses (pink bars) before the conflict phase. l (Top) Schematic of the recordings during dish-entry-evoked responses. (Bottom) Percentage of aPVT CRF and aPVT non-ident neurons that were responsive to rewarded dish entries (orange bars) before the conflict phase. No differences were observed between the two groups (Fisher’s exact test, all P ’s > 0.05). A total of eight rats were used.
    Optrode Array, supplied by Bio-Signal Technologies, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Images

    1) Product Images from "A hypothalamic-thalamostriatal circuit that controls approach-avoidance conflict in rats"

    Article Title: A hypothalamic-thalamostriatal circuit that controls approach-avoidance conflict in rats

    Journal: Nature Communications

    doi: 10.1038/s41467-021-22730-y

    a Timeline of the approach-avoidance conflict test during single-unit recordings from photoidentified aPVT CRF neurons. b Diagram showing the injection of viral mix containing AAV-CRF-Cre and AAV-ChR2-DIO, and the implantation of optrode in aPVT. c – e Photoidentification of aPVT CRF neurons. c Representative aPVT CRF neuron responsive to laser illumination ( Z -score >3.29, P < 0.001, red dotted line, see details in Methods). d Cells with photoresponse latencies <12 ms were classified as aPVT CRF neurons (black bars, n = 26 out of 96 recorded neurons), whereas cells with photoresponse latencies >12 ms (white bars, n = 5 neurons) or non-responsive to the laser ( n = 65 neurons, not shown) were classified as non-identified aPVT neurons (aPVT non-ident , n = 70 out of 96 recorded neurons). e Raster plot and firing rate of a representative aPVT CRF neuron responding to a 5 Hz train of laser stimulation. Inset: Raster plot and firing rate time-locked for laser onset. Vertical blue bars: laser onset. Bins of 1 ms. f Relative frequency histogram showing the baseline firing rate of aPVT CRF neurons and aPVT non-identif neurons. g (Top) Schematic of the food-cue-evoked responses. (Bottom) Percentage of aPVT CRF and aPVT non-ident neurons that were responsive to food cues (green bars) before (left) and during the conflict (right). aPVT CRF neurons showed more food-cue responses during the conflict test, when compared to aPVT non-ident neurons (Fisher’s exact test; aPVT CRF neurons: 39%, 10 out of 26; aPVT non-ident neurons: 15%, 11 out of 70 neurons, P = 0.039). h – i Average peristimulus time histograms of all photoidentified aPVT CRF neurons showing h excitatory or i inhibitory food-cue responses during the conflict (red or blue bars, respectively) or the same neurons before the conflict (gray bars). j (Top) Schematic of the spontaneous activity recordings. (Bottom) Percentage of aPVT CRF and aPVT non-ident neurons that changed their baseline spontaneous activity (30 s pre vs. 30 s post) exclusively in food-seeking phase, cat odor phase, conflict phase (30 min), in more than one phase (nonselective), or did not change. No differences were observed between the two groups (Fisher’s exact test, all P ’s > 0.05). k (Top) Schematic of the recordings during lever presses-evoked responses. (Bottom) Percentage of aPVT CRF and aPVT non-ident neurons that were responsive to lever presses (pink bars) before the conflict phase. l (Top) Schematic of the recordings during dish-entry-evoked responses. (Bottom) Percentage of aPVT CRF and aPVT non-ident neurons that were responsive to rewarded dish entries (orange bars) before the conflict phase. No differences were observed between the two groups (Fisher’s exact test, all P ’s > 0.05). A total of eight rats were used.
    Figure Legend Snippet: a Timeline of the approach-avoidance conflict test during single-unit recordings from photoidentified aPVT CRF neurons. b Diagram showing the injection of viral mix containing AAV-CRF-Cre and AAV-ChR2-DIO, and the implantation of optrode in aPVT. c – e Photoidentification of aPVT CRF neurons. c Representative aPVT CRF neuron responsive to laser illumination ( Z -score >3.29, P < 0.001, red dotted line, see details in Methods). d Cells with photoresponse latencies <12 ms were classified as aPVT CRF neurons (black bars, n = 26 out of 96 recorded neurons), whereas cells with photoresponse latencies >12 ms (white bars, n = 5 neurons) or non-responsive to the laser ( n = 65 neurons, not shown) were classified as non-identified aPVT neurons (aPVT non-ident , n = 70 out of 96 recorded neurons). e Raster plot and firing rate of a representative aPVT CRF neuron responding to a 5 Hz train of laser stimulation. Inset: Raster plot and firing rate time-locked for laser onset. Vertical blue bars: laser onset. Bins of 1 ms. f Relative frequency histogram showing the baseline firing rate of aPVT CRF neurons and aPVT non-identif neurons. g (Top) Schematic of the food-cue-evoked responses. (Bottom) Percentage of aPVT CRF and aPVT non-ident neurons that were responsive to food cues (green bars) before (left) and during the conflict (right). aPVT CRF neurons showed more food-cue responses during the conflict test, when compared to aPVT non-ident neurons (Fisher’s exact test; aPVT CRF neurons: 39%, 10 out of 26; aPVT non-ident neurons: 15%, 11 out of 70 neurons, P = 0.039). h – i Average peristimulus time histograms of all photoidentified aPVT CRF neurons showing h excitatory or i inhibitory food-cue responses during the conflict (red or blue bars, respectively) or the same neurons before the conflict (gray bars). j (Top) Schematic of the spontaneous activity recordings. (Bottom) Percentage of aPVT CRF and aPVT non-ident neurons that changed their baseline spontaneous activity (30 s pre vs. 30 s post) exclusively in food-seeking phase, cat odor phase, conflict phase (30 min), in more than one phase (nonselective), or did not change. No differences were observed between the two groups (Fisher’s exact test, all P ’s > 0.05). k (Top) Schematic of the recordings during lever presses-evoked responses. (Bottom) Percentage of aPVT CRF and aPVT non-ident neurons that were responsive to lever presses (pink bars) before the conflict phase. l (Top) Schematic of the recordings during dish-entry-evoked responses. (Bottom) Percentage of aPVT CRF and aPVT non-ident neurons that were responsive to rewarded dish entries (orange bars) before the conflict phase. No differences were observed between the two groups (Fisher’s exact test, all P ’s > 0.05). A total of eight rats were used.

    Techniques Used: Injection, Activity Assay

    Related Articles

    Injection:

    Article Title: A hypothalamic-thalamostriatal circuit that controls approach-avoidance conflict in rats
    Article Snippet: For photoidentification of aPVT CRF neurons, an optrode array (32 channels, 200 nm core, Bio-Signal) was implanted at the same coordinates described above.

    Activity Assay:

    Article Title: A hypothalamic-thalamostriatal circuit that controls approach-avoidance conflict in rats
    Article Snippet: For photoidentification of aPVT CRF neurons, an optrode array (32 channels, 200 nm core, Bio-Signal) was implanted at the same coordinates described above.



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    Image Search Results


    Experimental setup and ultrasound parameter. (A) Experimental setup of intracranial electrodes for recording multi-region signals, optical fiber for activating specific type of neurons and 128-element random array ultrasound transducer. The 64-channel optrode was inserted into left somatosensory cortex (S1) and 32-channel electrode was inserted into left posteromedial of the thalamus (POm). Vibration-tactile stimulation was applied to the right hind paw. (B) Ultrasound parameters used in this study. The inter-sonication interval (ISI) was set at 2.5s with 10% jitter to avoid neuronal adaptation to fixed ISI. Ultrasound duration (UD) was set at 100ms with vibration stimulation or 67ms for tFUS only. Pulse repetitive frequencies (PRFs) and duty cycles (DCs) tested in this study were 30Hz with 0.6%DC and 3000Hz with 60% DC. Pulse durations (PD) were calculated by PRF*DCs. (C-D) Ex-vivo hydrophone peak-to-peak pressure amplitude z-axis (upper) and y-axis (bottom) scan at the estimated targeted brain region with low pressure (C, ∼98kPa) and high pressure (D, ∼163kPa).

    Journal: bioRxiv

    Article Title: Cell-Type-Specific Bidirectional Modulation of the Cortico–Thalamo–Cortical Sensory Pathway by Transcranial Focused Ultrasound (tFUS)

    doi: 10.64898/2026.03.23.713540

    Figure Lengend Snippet: Experimental setup and ultrasound parameter. (A) Experimental setup of intracranial electrodes for recording multi-region signals, optical fiber for activating specific type of neurons and 128-element random array ultrasound transducer. The 64-channel optrode was inserted into left somatosensory cortex (S1) and 32-channel electrode was inserted into left posteromedial of the thalamus (POm). Vibration-tactile stimulation was applied to the right hind paw. (B) Ultrasound parameters used in this study. The inter-sonication interval (ISI) was set at 2.5s with 10% jitter to avoid neuronal adaptation to fixed ISI. Ultrasound duration (UD) was set at 100ms with vibration stimulation or 67ms for tFUS only. Pulse repetitive frequencies (PRFs) and duty cycles (DCs) tested in this study were 30Hz with 0.6%DC and 3000Hz with 60% DC. Pulse durations (PD) were calculated by PRF*DCs. (C-D) Ex-vivo hydrophone peak-to-peak pressure amplitude z-axis (upper) and y-axis (bottom) scan at the estimated targeted brain region with low pressure (C, ∼98kPa) and high pressure (D, ∼163kPa).

    Article Snippet: A 64-channel Optrode (A1×64-Edge-6mm-22.5-177-OXA64LP, Neuronexus, Ann Arbor, MI, USA) was inserted into S1 from the left side (angle: 40°) to make sure the signals were recorded from the virus injection site.

    Techniques: Sonication, Ex Vivo