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nonlinear iterative curve-fitting computer program pharmkit  (Sanyal Biotechnology)

 
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    Sanyal Biotechnology nonlinear iterative curve-fitting computer program pharmkit
    Nonlinear Iterative Curve Fitting Computer Program Pharmkit, supplied by Sanyal Biotechnology, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/nonlinear+curve+fitting+computer+program/non+linear+modelling+programme+pharmkit/pm26363987-68-33-38
    Average 90 stars, based on 1 article reviews
    nonlinear iterative curve-fitting computer program pharmkit - by Bioz Stars, 2026-09
    90/100 stars

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    Article Title: Pharmacokinetics and tissue residues of pefloxacin and its metabolite norfloxacin in broiler chickens.
    Article Snippet: The pharmacokinetics of pefloxacin and its active metabolite norfloxacin were investigated in chickens after a single oral administration of pefloxacin at a dosage of 10 mg/kg.. To characterise the residue pattern, another group of chickens was given 10 mg of pefloxacin/kg body once daily for 4 d by oral route; the tissue concentrations of pefloxacin and norfloxacin were determined at 1, 5 and 10 d after the last administration of the drug.. The concentrations of pefloxacin and norfloxacin in plasma and tissues were determined by HPLC assay.

    Article Title: Comparative plasma pharmacokinetics of meloxicam in sheep and goats following intravenous administration.
    Article Snippet: Meloxicam, a novel cyclooxygenase-2 selective nonsteroidal anti-inflammatory drug (NSAID), has been used extensively in humans and recently in some domestic animal species.. Although it is an attractive NSAID for use in small ruminants, meloxicam pharmacokinetics have not been investigated in sheep and goats and this information is essential for rational therapeutic use of the drug in these species.. In this investigation, comparative pharmacokinetic properties of meloxicam were studied in sheep and goats after a single intravenous dose of 0.5 mg kg body mass.

    Article Title: Impact of aflatoxin B1 on the pharmacokinetic disposition of enrofloxacin in broiler chickens.
    Article Snippet: Accepted Manuscript Title: Impact of aflatoxin B1 on the pharmacokinetic disposition of enrofloxacin in broiler chickens Author: Starling Kalpana G. Srinivasa.. Rao Jitendra K. Malik PII: S1382-6689(15)30067-3 DOI: http://dx.doi.org/doi:10.1016/j.etap.2015.08.023 Reference: ENVTOX 2334 To appear in: Environmental Toxicology and Pharmacology Received date: 3-3-2015 Revised date: 21-8-2015 Accepted date: 23-8-2015 Please cite this article as: Kalpana, S., Rao, G.Sa., Malik, J.K.,Impact of aflatoxin B1 on the pharmacokinetic disposition of enrofloxacin in broiler chickens, Environmental Toxicology and Pharmacology (2015), http://dx.doi.org/10.1016/j.etap.2015.08.023 This is a PDF file of an unedited manuscript that has been accepted for publication.. As a service to our customers we are providing this early version of the manuscript.

    Article Title: Diet-induced modulation of pharmacokinetics of albendazole in Sahiwal cattle
    Article Snippet: The influence of diet type and pre-treatment fasting on the kinetic disposition of albendazole was evaluated in Sahiwal heifers following oral and intra-ruminal administration of the drug.. The anthelmintically active moiety albendazole sulphoxide appeared early and was eliminated early in cattle offered green fodder, with decreased maximum concentration (Cmax) and area under concentration–time curve (AUC) when the drug was administered both through oral and intra-ruminal routes.. Further, the elimination half-life (t1 2 b) revealed significantly increased values for albendazole sulphoxide in cattle administered albendazole through the intra-ruminal route.

    Clinical Proteomics:

    Article Title: Effects of subchronic malathion exposure on the pharmacokinetic disposition of pefloxacin.
    Article Snippet: Malathion is one of the most extensively used organophosphorus pesticides applied in agriculture, mosquito eradication and in the control of animal ectoparasites and human body lice.. The widespread use of malathion has raised concern over its potential to cause untoward health effects in humans, animals and birds.. Malathion inhibits cytochrome P450 monooxygenases and has the potential to alter pharmacokinetic profiles of therapeutic agents that are metabolized in the liver.

    Article Title: Interactive alterations of arsenic and malathion in the disposition kinetics of pefloxacin.
    Article Snippet: Assessment of deleterious effects produced by concurrent exposure to commonly encountered chemicals is of great concern to find out toxicological consequences arising as a result of their interactions and for a more comprehensive management of chemical-induced untoward effects.. The naturally occurring heavy metal arsenic is present in food and water.. Malathion is one of the most widely used pesticides in agriculture and public health practices worldwide.

    Article Title: Pharmacokinetics and bioavailability of nimesulide in goats.
    Article Snippet: The pharmacokinetic properties and bioavailability of cyclooxygenase (COX)-2 selective nonsteroidal anti-inflammatory drug nimesulide were investigated in female goats following intravenous (i.v.) and intramuscular (i.m.) administration at a dose of 4 mg/kg BW.. Blood samples were collected by jugular venipuncture at predetermined times after drug administration.. Plasma concentrations of nimesulide were determined by a validated high-performance liquid chromatography method.

    Concentration Assay:

    Article Title: Effects of subchronic malathion exposure on the pharmacokinetic disposition of pefloxacin.
    Article Snippet: Malathion is one of the most extensively used organophosphorus pesticides applied in agriculture, mosquito eradication and in the control of animal ectoparasites and human body lice.. The widespread use of malathion has raised concern over its potential to cause untoward health effects in humans, animals and birds.. Malathion inhibits cytochrome P450 monooxygenases and has the potential to alter pharmacokinetic profiles of therapeutic agents that are metabolized in the liver.

    Article Title: Interactive alterations of arsenic and malathion in the disposition kinetics of pefloxacin.
    Article Snippet: Assessment of deleterious effects produced by concurrent exposure to commonly encountered chemicals is of great concern to find out toxicological consequences arising as a result of their interactions and for a more comprehensive management of chemical-induced untoward effects.. The naturally occurring heavy metal arsenic is present in food and water.. Malathion is one of the most widely used pesticides in agriculture and public health practices worldwide.

    Article Title: Efficacy of pharmacokinetic interactions between piperonyl butoxide and albendazole against gastrointestinal nematodiasis in goats
    Article Snippet: To test the hypothesis that modulation of hepatic microsomal sulphoxidation and sulphonation by the cytochrome P450 inhibitor piperonyl butoxide could increase bioavailability of albendazole, the present study was undertaken to understand the pharmacokinetics of albendazole in goats at a dose of 7.5 mg kg body weight with and without co-administration with piperonyl butoxide at 63.0 mg kg body weight.. Plasma albendazole sulphoxide metabolite, the anthelmintically active moiety, reached its maximum concentration of 0.322 ^ 0.045mg ml and 0.384 ^ 0.013mg ml at 18 h and 24 h after administration of albendazole alone and co-administration of albendazole with piperonyl butoxide, respectively.. Analysis of the data revealed statistically increased albendazole sulphoxide levels at 24 (P , 0.001), 30 (P , 0.001) and 36 h (P , 0.01) after administration of albendazole with piperonyl butoxide, with statistically increased levels of albendazole sulphone at 24, 30 and 48 h after administration.

    Article Title: Pharmacokinetics and bioavailability of nimesulide in goats.
    Article Snippet: The pharmacokinetic properties and bioavailability of cyclooxygenase (COX)-2 selective nonsteroidal anti-inflammatory drug nimesulide were investigated in female goats following intravenous (i.v.) and intramuscular (i.m.) administration at a dose of 4 mg/kg BW.. Blood samples were collected by jugular venipuncture at predetermined times after drug administration.. Plasma concentrations of nimesulide were determined by a validated high-performance liquid chromatography method.

    Software:

    Article Title: Effects of subchronic malathion exposure on the pharmacokinetic disposition of pefloxacin.
    Article Snippet: Malathion is one of the most extensively used organophosphorus pesticides applied in agriculture, mosquito eradication and in the control of animal ectoparasites and human body lice.. The widespread use of malathion has raised concern over its potential to cause untoward health effects in humans, animals and birds.. Malathion inhibits cytochrome P450 monooxygenases and has the potential to alter pharmacokinetic profiles of therapeutic agents that are metabolized in the liver.



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