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single-hit multitarget model  (MultiTarget Pharmaceuticals)

 
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    MultiTarget Pharmaceuticals single-hit multitarget model
    Single Hit Multitarget Model, supplied by MultiTarget Pharmaceuticals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/multitarget-+single-hitting+model/single+hit+multitarget+model/pmc11995309-90-8-7
    Average 90 stars, based on 1 article reviews
    single-hit multitarget model - by Bioz Stars, 2026-11
    90/100 stars

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    Article Title: MXene-based nanosheet for enhanced glioma therapy via photonic hyperthermia to boost the abscopal effect of radioimmunotherapy
    Article Snippet: Based on the sensitization enhancement ratio (SER) calculated via a multitarget single-hit model was 1.08 (Fig. ), indicating the preferable radiosensitization effect of APMP.

    Article Title: Camouflaged Nanozymes with Oxidation‐Promoting Activities Triggering Ferroptosis for Radio‐Immunotherapy
    Article Snippet: Furthermore, a clonogenic formation assay was performed to evaluate the effects of the treatments on cell survival, with the results fitted via a “multitarget single‐hit” model. As depicted in Figure , RT alone moderately reduced 4T1 cell survival, but adding MPP@CM significantly increased the inhibition rate.

    Article Title: Targeting ATM enhances radiation sensitivity of colorectal cancer by Potentiating radiation-induced cell death and antitumor immunity.
    Article Snippet: Radiobiological parameters such as SF2 (the survival fraction at 2 Gy), D0 (the dose reducing the survival rate by 37%), and Dq (the capacity of cells to repair sublethal damage) were calculated using the multitarget single-hit model.

    Article Title: IGF2BP2 regulates gastric cancer radiotherapy resistance through HIF1α-mediated glycolysis
    Article Snippet: The data were analyzed using the multitarget single-hit model: SF = 1 − (1 − exp(−D/D 0 )) n , where Dq = D 0 × ln( N ).

    Article Title: Arsenic enhances cervical cancer cell radiosensitivity by suppressing the DNA damage repair pathway
    Article Snippet: The radiation sensitizer enhancement ratio (SER) was calculated using the multitarget single-hit model as follows: SF = 1 − (1 − e −D/D0 ) N , where D is the radiation dose, and D0 is the lethal dose; meanwhile, the quasithreshold dose (Dq) was calculated as follows: Dq = D 0 logN, where N is the extrapolation number.

    Article Title: IGF2BP2 regulates gastric cancer radiotherapy resistance through HIF1α-mediated glycolysis
    Article Snippet: We fitted survival curves ( ) using the multitarget single-hit model based on the clonogenic assay data and generated a table of radiobiological parameters ( ).

    Generated:

    Article Title: m6A-modified circCREBBP enhances radiosensitivity of esophageal squamous cell carcinoma by reducing the stability of MYC through interaction with IGF2BP3.
    Article Snippet: Substantial evidence has showed a close relationship between circRNAs and m6A modification in tumorigenesis and development.. However, limited research has explored the regulatory role and underlying mechanism of m6A-modified circRNAs in regulating the radiosensitivity of esophageal squamous cell carcinoma (ESCC).. The aim of this study was to clarify the molecular pathway by which m6A-modified circCREBBP enhances the radiosensitivity of ESCC.

    Colony Assay:

    Article Title: m6A-modified circCREBBP enhances radiosensitivity of esophageal squamous cell carcinoma by reducing the stability of MYC through interaction with IGF2BP3.
    Article Snippet: Substantial evidence has showed a close relationship between circRNAs and m6A modification in tumorigenesis and development.. However, limited research has explored the regulatory role and underlying mechanism of m6A-modified circRNAs in regulating the radiosensitivity of esophageal squamous cell carcinoma (ESCC).. The aim of this study was to clarify the molecular pathway by which m6A-modified circCREBBP enhances the radiosensitivity of ESCC.



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