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METTLER TOLEDO toledo sfc-multigram system
Toledo Sfc Multigram System, supplied by METTLER TOLEDO, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/multigram/toledo+multigram+iii+system+sfc/pm40198752-206-23-23
Average 90 stars, based on 1 article reviews
toledo sfc-multigram system - by Bioz Stars, 2026-10
90/100 stars

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Article Title: Benzothiazole compounds for the treatment of autoimmune diseases
Article Snippet: Waters AutoP purification System (Sample Manager 2767, Pump 2525, Detector: Micromass ZQ and UV 2487, solvent system: acetonitrile and 0.1% ammonium hydroxide in water; acetonitrile and 0.1% FA in water or acetonitrile and 0.1% TFA in water).

Article Title: Piperazine compounds for the treatment of autoimmune disease
Article Snippet: Intermediates and final compounds were purified by preparative HPLC on reversed phase column using XBridge Prep-C18 (5 μm, OBDTM 30×100 mm) column, SunFire Prep-C18 (5 μm, OBD 30×100 mm) column, Phenomenex Synergi-C18 (10 μm, 25×150 mm) or Phenomenex Gemini-C18 (10 μm, 25×150 mm).

Article Title: Discovery of Naphthyridinone Derivatives as Selective and Potent PKMYT1 Inhibitors with Antitumor Efficacy.
Article Snippet: PKMYT1 is a crucial regulator of the cell cycle, particularly involved in the G2/M transition through the inhibitory phosphorylation of CDK1, and is a promising therapeutic target for cancer therapy.. Data mining in the Roche kinome screen database identified a hit characterized by 100% PKMYT1 inhibitory activity at a 10 μM concentration, which was further validated with a PKMYT1 enzymatic assay showing double-digit nanomolar potency.. The hit featured a quinolinone central core and a phenol headgroup.

Article Title: Methods of synthesizing pyrazine compounds
Article Snippet: For SFC chiral separation, intermediates were separated by chiral column (Daicel chiralpak IC, 5 μm, 30×250 mm) using Mettler Toledo SFC-Multigram III system, solvent system: 95% CO2 and 5% IPA (0.5% TEA in IPA), back pressure 100 bar, detection UV@254 nm.

Article Title: 6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
Article Snippet: For SFC chiral separation, intermediates were separated by chiral column (Daicel chiralpak IC, 5 μm, 30×250 mm) column using Mettler Toledo SFC-Multigram III system, solvent system: 95% CO2 and 5% IPA (0.5% TEA in IPA), back pressure 100 bar, detection UV@ 254 nm.

Article Title: 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
Article Snippet: For SFC chiral separation, intermediates were separated by chiral column (Daicel chiralpak IC, 5 μm, 30×250 mm) column using Mettler Toledo SFC-Multigram III system, solvent system: 95% CO2 and 5% IPA (0.5% TEA in IPA), back pressure 100 bar, detection UV@ 254 nm.

Article Title: Aminocarbamoyl compounds for the treatment of viral infections
Article Snippet: LC/MS spectra were obtained using a Waters UPLC-SQD Mass.

Indirect Immunoperoxidase Assay:

Article Title: Benzothiazole compounds for the treatment of autoimmune diseases
Article Snippet: Waters AutoP purification System (Sample Manager 2767, Pump 2525, Detector: Micromass ZQ and UV 2487, solvent system: acetonitrile and 0.1% ammonium hydroxide in water; acetonitrile and 0.1% FA in water or acetonitrile and 0.1% TFA in water).

Article Title: Piperazine compounds for the treatment of autoimmune disease
Article Snippet: Intermediates and final compounds were purified by preparative HPLC on reversed phase column using XBridge Prep-C18 (5 μm, OBDTM 30×100 mm) column, SunFire Prep-C18 (5 μm, OBD 30×100 mm) column, Phenomenex Synergi-C18 (10 μm, 25×150 mm) or Phenomenex Gemini-C18 (10 μm, 25×150 mm).

Article Title: Discovery of Naphthyridinone Derivatives as Selective and Potent PKMYT1 Inhibitors with Antitumor Efficacy.
Article Snippet: PKMYT1 is a crucial regulator of the cell cycle, particularly involved in the G2/M transition through the inhibitory phosphorylation of CDK1, and is a promising therapeutic target for cancer therapy.. Data mining in the Roche kinome screen database identified a hit characterized by 100% PKMYT1 inhibitory activity at a 10 μM concentration, which was further validated with a PKMYT1 enzymatic assay showing double-digit nanomolar potency.. The hit featured a quinolinone central core and a phenol headgroup.

Article Title: Methods of synthesizing pyrazine compounds
Article Snippet: For SFC chiral separation, intermediates were separated by chiral column (Daicel chiralpak IC, 5 μm, 30×250 mm) using Mettler Toledo SFC-Multigram III system, solvent system: 95% CO2 and 5% IPA (0.5% TEA in IPA), back pressure 100 bar, detection UV@254 nm.

Article Title: 6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
Article Snippet: For SFC chiral separation, intermediates were separated by chiral column (Daicel chiralpak IC, 5 μm, 30×250 mm) column using Mettler Toledo SFC-Multigram III system, solvent system: 95% CO2 and 5% IPA (0.5% TEA in IPA), back pressure 100 bar, detection UV@ 254 nm.

Article Title: 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
Article Snippet: For SFC chiral separation, intermediates were separated by chiral column (Daicel chiralpak IC, 5 μm, 30×250 mm) column using Mettler Toledo SFC-Multigram III system, solvent system: 95% CO2 and 5% IPA (0.5% TEA in IPA), back pressure 100 bar, detection UV@ 254 nm.

Article Title: Aminocarbamoyl compounds for the treatment of viral infections
Article Snippet: LC/MS spectra were obtained using a Waters UPLC-SQD Mass.



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