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proteome profiler mouse adipokine array kit  (R&D Systems)


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    R&D Systems proteome profiler mouse adipokine array kit
    Genetic deletion of the Sele gene reduces inflammation, lipolysis, and proinflammatory <t>adipokine</t> secretion in adipose tissue from HFD + AdCxcl1 -induced NASH. WT (n = 4–7) and Sele KO (n = 4–7) were subjected to 3-month HFD feeding plus Ad Cxcl1 to induce NASH. Sera and epididymal adipose tissues were collected and analyzed. ( A ) MPO and F4/80 immunostaining of adipose tissues. ( B , C , and E ) RT-qPCR of adipose tissues. ( D ) Determination of serum FFAs. ( F ) Determination of serum proinflammatory adipokines. ∗ P < .05.
    Proteome Profiler Mouse Adipokine Array Kit, supplied by R&D Systems, used in various techniques. Bioz Stars score: 94/100, based on 74 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/mouse+proteome+profiler+array/Proteome+Profiler+Mouse+Adipokine+Array+Kit/pmc08593619-229-1-7
    Average 94 stars, based on 74 article reviews
    proteome profiler mouse adipokine array kit - by Bioz Stars, 2026-11
    94/100 stars

    Images

    1) Product Images from "E-Selectin-Dependent Inflammation and Lipolysis in Adipose Tissue Exacerbate Steatosis-to-NASH Progression via S100A8/9"

    Article Title: E-Selectin-Dependent Inflammation and Lipolysis in Adipose Tissue Exacerbate Steatosis-to-NASH Progression via S100A8/9

    Journal: Cellular and Molecular Gastroenterology and Hepatology

    doi: 10.1016/j.jcmgh.2021.08.002

    Genetic deletion of the Sele gene reduces inflammation, lipolysis, and proinflammatory adipokine secretion in adipose tissue from HFD + AdCxcl1 -induced NASH. WT (n = 4–7) and Sele KO (n = 4–7) were subjected to 3-month HFD feeding plus Ad Cxcl1 to induce NASH. Sera and epididymal adipose tissues were collected and analyzed. ( A ) MPO and F4/80 immunostaining of adipose tissues. ( B , C , and E ) RT-qPCR of adipose tissues. ( D ) Determination of serum FFAs. ( F ) Determination of serum proinflammatory adipokines. ∗ P < .05.
    Figure Legend Snippet: Genetic deletion of the Sele gene reduces inflammation, lipolysis, and proinflammatory adipokine secretion in adipose tissue from HFD + AdCxcl1 -induced NASH. WT (n = 4–7) and Sele KO (n = 4–7) were subjected to 3-month HFD feeding plus Ad Cxcl1 to induce NASH. Sera and epididymal adipose tissues were collected and analyzed. ( A ) MPO and F4/80 immunostaining of adipose tissues. ( B , C , and E ) RT-qPCR of adipose tissues. ( D ) Determination of serum FFAs. ( F ) Determination of serum proinflammatory adipokines. ∗ P < .05.

    Techniques Used: Immunostaining, Quantitative RT-PCR

    Inhibition of S100A9 ameliorates liver damage and inflammation in NASH by lowering lipolysis and adipokines in adipose tissue. WT mice were subjected to 4-month HFD feeding, followed by injection of Ad Cxcl1 and treatment with 2 different doses of PAQ: 10 μg/kg (PAQ10) (n = 7) or 20 μg/kg (PAQ20) (n = 6), or vehicle control (VC) (n = 5). Serum, liver, and adipose tissues were collected and analyzed. ( A ) Schematics for the administration of PAQ to HFD +Ad Cxcl1 -challenged mice. ( B ) Serum ALT and AST levels. ( C and D ) RT-qPCR of liver tissues. ( E and F ) RT-qPCR of adipose tissues. ( G and H ) Determination of serum FFAs and serum resistin. ( I ) RT-qPCR analyses of differentiated preadipocytes exposed to vehicle control or S100A8/A9. ( J ) Schematic illustration of the proposed role of E-selectin and S100A8/A9 in the liver and adipose tissue during neutrophil-induced NASH. ∗ P < .05.
    Figure Legend Snippet: Inhibition of S100A9 ameliorates liver damage and inflammation in NASH by lowering lipolysis and adipokines in adipose tissue. WT mice were subjected to 4-month HFD feeding, followed by injection of Ad Cxcl1 and treatment with 2 different doses of PAQ: 10 μg/kg (PAQ10) (n = 7) or 20 μg/kg (PAQ20) (n = 6), or vehicle control (VC) (n = 5). Serum, liver, and adipose tissues were collected and analyzed. ( A ) Schematics for the administration of PAQ to HFD +Ad Cxcl1 -challenged mice. ( B ) Serum ALT and AST levels. ( C and D ) RT-qPCR of liver tissues. ( E and F ) RT-qPCR of adipose tissues. ( G and H ) Determination of serum FFAs and serum resistin. ( I ) RT-qPCR analyses of differentiated preadipocytes exposed to vehicle control or S100A8/A9. ( J ) Schematic illustration of the proposed role of E-selectin and S100A8/A9 in the liver and adipose tissue during neutrophil-induced NASH. ∗ P < .05.

    Techniques Used: Inhibition, Injection, Control, Quantitative RT-PCR

    Related Articles

    Enzyme-linked Immunosorbent Assay:

    Article Title: An iron-regulated methionine redox axis governs adipose browning and cancer cachexia.
    Article Snippet: .. Prepared samples were assayed using the procedures described in the R&D Systems Proteome Profiler mouse adipokine array kit, the Proteome Profiler mouse XL cytokine array and the mouse insulin ELISA kit according to the manufacturer’s instructions. ..

    Article Title: The cardiac METTL3/m6A pathway regulates the systemic response to Western diet
    Article Snippet: .. Circulating obesogenic factors were analyzed on plasma collected from mice following the manufacturer’s instructions for the Mouse Adipokine Array Kit (ARY013, R&D Systems, Bio-Techne) or FGF1 ELISA (ab223587, Abcam). ..

    Selection:

    Article Title: Paracrine Signaling by Distinct Adipose Tissue Depots Regulate Fibroblast Mechanobiology and Functional Heterogeneity.
    Article Snippet: Purpose Adipose tissues have long been recognized for their diverse endocrine functions that serve to regulate tissue homeostasis.. Although adipose depot-specific secretory profiles can differentially regulate fibroblast fate and fibrotic tissue remodeling, systematic investigation of how adipose depots of varying phenotypes influence fibroblast mechanobiology remains lacking Methods By integrating secretome profiling with functional and mechanobiological assays in a controlled adipose-fibroblast coculture platform, we mechanistically investigate how canonical brown (BAT), white (WAT), and beige adipose tissues (thoracic and abdominal perivascular adipose tissue; T-PVAT and A-PVAT, respectively) govern fibroblast-to-myofibroblast transition (FMT) through depot-specific paracrine signaling.. Results Thermogenic depots (BAT and T-PVAT) enhance fibroblast proliferation, collagen deposition, and stiffness (1.9fold increase in single cell modulus; p < 0.0001) alongside specific adipokines that regulate metabolism (ANGPTL3, FGF1) and inhibit calcification (Fetuin A).

    Clinical Proteomics:

    Article Title: The cardiac METTL3/m6A pathway regulates the systemic response to Western diet
    Article Snippet: .. Circulating obesogenic factors were analyzed on plasma collected from mice following the manufacturer’s instructions for the Mouse Adipokine Array Kit (ARY013, R&D Systems, Bio-Techne) or FGF1 ELISA (ab223587, Abcam). ..

    Incubation:

    Article Title: The microRNA miR-30a blocks adipose tissue fibrosis accumulation in obesity
    Article Snippet: Antibodies used in this study include: HSP90 (Cell 515 Signaling #4877), PPARg (Cell Signaling #2443), ADIPOQ (GeneTex #GTX112777), 516 UCP1 (Abcam ab10983), CYCS (Cell Signaling #4280), Cre (Cell Signaling #15036), 517 FABP4 (Genetex #116036), PAI-1 (Novus NBP19223), COL1A1 (Genetex #112731), and 518 b-actin (Sigma #A5441). .. For tissue cytokine analysis, tissue lysates from four samples 519 were pooled (125 μg/sample) and incubated with membranes from the Proteome Profiler 520 Mouse Adipokine Array Kit (R&D Systems #ARY013). ..

    Article Title: The microRNA miR-30a blocks adipose tissue fibrosis accumulation in obesity
    Article Snippet: Antibodies used in this study include HSP90 (Cell Signaling Technology, 4877), PPARg (Cell Signaling Technology, 2443), ADIPOQ (GeneTex, GTX112777), UCP1 (Abcam, ab10983), CYCS (Cell Signaling Technology, 4280), Cre (Cell Signaling Technology, 15036), FABP4 (Genetex, 116036), PAI-1 (Novus, NBP19223), COL1A1 (Genetex, 112731), and β-actin (MilliporeSigma, A5441). .. For tissue cytokine analysis, tissue lysates from 4 samples were pooled (125 μg/sample) and incubated with membranes from the Proteome Profiler Mouse Adipokine Array Kit (R&D Systems, ARY013). .. Mice were fed a 60% HFD (Bio-Serv) for 12–18 weeks before phenotyping.



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    Image Search Results


    Cytokine profiling showed significantly elevated levels of (A) CXCL10/IP-10 (1.37-fold increase; p < 0.0001, n = 3) and TIMP-1 (1.35-fold increase; p < 0.0001, n = 3) in the CD38-OE group compared to the CD38-WT group, and (B) ICAM-1, with a 1.15-fold increase compared to the CD38-WT group and a 1.34-fold increase compared to the control group (p < 0.0002, n = 3). No significant changes were observed in SDF-1/CXCL12 expression. (n = 3). These molecules were highlighted for their notable, yet relatively understudied, roles in GBM progression and tumor microenvironment modulation compared to other cytokines in the panel, which have more established functions in cancer biology. One-way ANOVA with Tukey’s post-hoc, *p < 0.0001, **p < 0.0002.

    Journal: Translational Oncology

    Article Title: CD38 overexpression drives glioblastoma progression via L1CAM/ICAM1/JAK-STAT-Driven tumor microenvironment rewiring

    doi: 10.1016/j.tranon.2026.102758

    Figure Lengend Snippet: Cytokine profiling showed significantly elevated levels of (A) CXCL10/IP-10 (1.37-fold increase; p < 0.0001, n = 3) and TIMP-1 (1.35-fold increase; p < 0.0001, n = 3) in the CD38-OE group compared to the CD38-WT group, and (B) ICAM-1, with a 1.15-fold increase compared to the CD38-WT group and a 1.34-fold increase compared to the control group (p < 0.0002, n = 3). No significant changes were observed in SDF-1/CXCL12 expression. (n = 3). These molecules were highlighted for their notable, yet relatively understudied, roles in GBM progression and tumor microenvironment modulation compared to other cytokines in the panel, which have more established functions in cancer biology. One-way ANOVA with Tukey’s post-hoc, *p < 0.0001, **p < 0.0002.

    Article Snippet: For cytokine profiling, the Mouse Cytokine Array Panel A (Catalog #ARY006, R&D Systems, USA) was used according to the manufacturer’s instructions (Supplementary Table).

    Techniques: Control, Expressing