Review




Structured Review

Arraystar inc microarray analyses service
Heroin self-administration as a tool to identify heroin-responsive circRNAs in the OFC. ( A ) Schematic overview of experimental timeline. Male and female rats underwent self-administration of 0.03mg/kg/infusion of heroin or saline and were then euthanized for molecular analyses of circRNA expression in the OFC. OFC RNA from a subset of male rats was used for circRNA <t>microarray</t> analyses. Differentially regulated circRNAs were validated in all male rats and further examined in female rats. ( B – G ) Heroin and saline self-administration in male ( B – D ) and female ( E – G ) rats. Displayed are the number of infusions ( B , E ) and active or inactive lever presses for heroin ( C , F ) or saline animals ( D , G ). Error ± S.E.M. * p < 0.05; ** p < 0.01; **** p < 0.0001. Male N = 21/group; Female N = 14 saline, 13 heroin.
Microarray Analyses Service, supplied by Arraystar inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/microarray+service/microarray+analysis+services/pmc08836038-93-18-23
Average 90 stars, based on 1 article reviews
microarray analyses service - by Bioz Stars, 2026-09
90/100 stars

Images

1) Product Images from "Heroin Regulates Orbitofrontal Circular RNAs"

Article Title: Heroin Regulates Orbitofrontal Circular RNAs

Journal: International Journal of Molecular Sciences

doi: 10.3390/ijms23031453

Heroin self-administration as a tool to identify heroin-responsive circRNAs in the OFC. ( A ) Schematic overview of experimental timeline. Male and female rats underwent self-administration of 0.03mg/kg/infusion of heroin or saline and were then euthanized for molecular analyses of circRNA expression in the OFC. OFC RNA from a subset of male rats was used for circRNA microarray analyses. Differentially regulated circRNAs were validated in all male rats and further examined in female rats. ( B – G ) Heroin and saline self-administration in male ( B – D ) and female ( E – G ) rats. Displayed are the number of infusions ( B , E ) and active or inactive lever presses for heroin ( C , F ) or saline animals ( D , G ). Error ± S.E.M. * p < 0.05; ** p < 0.01; **** p < 0.0001. Male N = 21/group; Female N = 14 saline, 13 heroin.
Figure Legend Snippet: Heroin self-administration as a tool to identify heroin-responsive circRNAs in the OFC. ( A ) Schematic overview of experimental timeline. Male and female rats underwent self-administration of 0.03mg/kg/infusion of heroin or saline and were then euthanized for molecular analyses of circRNA expression in the OFC. OFC RNA from a subset of male rats was used for circRNA microarray analyses. Differentially regulated circRNAs were validated in all male rats and further examined in female rats. ( B – G ) Heroin and saline self-administration in male ( B – D ) and female ( E – G ) rats. Displayed are the number of infusions ( B , E ) and active or inactive lever presses for heroin ( C , F ) or saline animals ( D , G ). Error ± S.E.M. * p < 0.05; ** p < 0.01; **** p < 0.0001. Male N = 21/group; Female N = 14 saline, 13 heroin.

Techniques Used: Saline, Expressing, Microarray

Heroin-associated circRNAs are derived from genes distributed across the genome and are mostly exonic. ( A ) Volcano plot depicting differentially expressed circRNAs in the OFC after heroin self-administration, as measured by microarray analyses. Red dots indicate circRNAs that meet statistical criteria for significantly different compared to saline. Grey dots represent circRNAs that are not statistically different between heroin and saline. ( B ) Genomic size in base pairs (bp) of each circRNA differentially expressed between heroin and saline animals, as indicated by the beginning and end position of the circRNA’s backsplice junction. ( C ). Chromosomal location of each differentially regulated circRNA. ( D ) Pie graph depicting the proportions of heroin-associated circRNAs that are exonic, intergenic, or sense overlapping. ( E , F ) Results from gene ontology analyses ( E ) and KEGG pathway analyses ( F ) indicating the terms significantly enriched from the gene list of linear mRNAs that give rise to differentially expressed heroin-associated circRNAs. For each term, the genes identified in the microarray analysis that belong to the term list are indicated. ( G ) List of repeat heroin-associated circRNAs that are derived from the same linear gene.
Figure Legend Snippet: Heroin-associated circRNAs are derived from genes distributed across the genome and are mostly exonic. ( A ) Volcano plot depicting differentially expressed circRNAs in the OFC after heroin self-administration, as measured by microarray analyses. Red dots indicate circRNAs that meet statistical criteria for significantly different compared to saline. Grey dots represent circRNAs that are not statistically different between heroin and saline. ( B ) Genomic size in base pairs (bp) of each circRNA differentially expressed between heroin and saline animals, as indicated by the beginning and end position of the circRNA’s backsplice junction. ( C ). Chromosomal location of each differentially regulated circRNA. ( D ) Pie graph depicting the proportions of heroin-associated circRNAs that are exonic, intergenic, or sense overlapping. ( E , F ) Results from gene ontology analyses ( E ) and KEGG pathway analyses ( F ) indicating the terms significantly enriched from the gene list of linear mRNAs that give rise to differentially expressed heroin-associated circRNAs. For each term, the genes identified in the microarray analysis that belong to the term list are indicated. ( G ) List of repeat heroin-associated circRNAs that are derived from the same linear gene.

Techniques Used: Derivative Assay, Microarray, Saline

A predicted circRNA–miRNA network in the OFC associated with heroin exposure. ( A ) List of miRNAs predicted to target at least 3 heroin-associated circRNAs identified in the microarray analysis. Highlighted miRNAs target circRNAs validated with qPCR. ( B ) Pathway analysis of the target genes of miRNAs listed in ( A ). For each significant pathway, the number of miRNAs that target the pathway is listed, as well as the number of genes in the pathway that the miRNAs target.
Figure Legend Snippet: A predicted circRNA–miRNA network in the OFC associated with heroin exposure. ( A ) List of miRNAs predicted to target at least 3 heroin-associated circRNAs identified in the microarray analysis. Highlighted miRNAs target circRNAs validated with qPCR. ( B ) Pathway analysis of the target genes of miRNAs listed in ( A ). For each significant pathway, the number of miRNAs that target the pathway is listed, as well as the number of genes in the pathway that the miRNAs target.

Techniques Used: Microarray



Similar Products

90
Miltenyi Biotec biotech microarray service
Biotech Microarray Service, supplied by Miltenyi Biotec, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/microarray+service/agilent+human+genome+oligo+microarrays/pm37835445-42-7-9
Average 90 stars, based on 1 article reviews
biotech microarray service - by Bioz Stars, 2026-09
90/100 stars
  Buy from Supplier

90
Annoroad Gene Technology Co Ltd mirna microarray service
Mirna Microarray Service, supplied by Annoroad Gene Technology Co Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/microarray+service/mirna+microarray+service/pmc11441009-124-21-18
Average 90 stars, based on 1 article reviews
mirna microarray service - by Bioz Stars, 2026-09
90/100 stars
  Buy from Supplier

90
PEPperPRINT gmbh peppermap (trademark) peptide microarray contract analysis service
Peppermap (Trademark) Peptide Microarray Contract Analysis Service, supplied by PEPperPRINT gmbh, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/microarray+service/pepperchip+peptide+microarrays/us11970549-570-10-9
Average 90 stars, based on 1 article reviews
peppermap (trademark) peptide microarray contract analysis service - by Bioz Stars, 2026-09
90/100 stars
  Buy from Supplier

90
Arraystar inc microarray analysis services
Microarray Analysis Services, supplied by Arraystar inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/microarray+service/microarray+analysis+services/pm38565538-303-22-27
Average 90 stars, based on 1 article reviews
microarray analysis services - by Bioz Stars, 2026-09
90/100 stars
  Buy from Supplier

90
Arraystar inc microarrays service
CircRNA profiles in BALF EVs, serum EVs and BALF cells. Three mice were used in this experiment. BALF and serum were collected and pooled after exposure to PBS or LPS (1µg/mouse) or HCl (0.1N) for 24h. EVs were separated using ultracentrifugation as previously described . RNA was isolated from the EVs and subjected to circRNA <t>microarrays</t> by Arraystar Inc (Rockville, MD). Heatmap of the circRNA arrays in EVs obtained from BALF in the absence and presence of noxious stimuli. (A) BALF EVs obtained from mice that were exposed to PBS or LPS. (B) BALF EVs obtained from mice that were exposed to PBS or HCL. (C) the changes of EV-cargo circRNA profiles between non-infectious stimuli (HCL) and endotoxin (LPS) were expressed in Log2 fold change. (D) A representative picture showing the histological changes was presented here. The inflammatory score was determined by a double-blinded examiner using five lung sections per mouse, and three mice per treatment. The mean value is graphed and presented. ***p<0.05.
Microarrays Service, supplied by Arraystar inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/microarray+service/microarray+analysis+services/pmc11024224-86-5-11
Average 90 stars, based on 1 article reviews
microarrays service - by Bioz Stars, 2026-09
90/100 stars
  Buy from Supplier

90
LC Sciences microarray services
CircRNA profiles in BALF EVs, serum EVs and BALF cells. Three mice were used in this experiment. BALF and serum were collected and pooled after exposure to PBS or LPS (1µg/mouse) or HCl (0.1N) for 24h. EVs were separated using ultracentrifugation as previously described . RNA was isolated from the EVs and subjected to circRNA <t>microarrays</t> by Arraystar Inc (Rockville, MD). Heatmap of the circRNA arrays in EVs obtained from BALF in the absence and presence of noxious stimuli. (A) BALF EVs obtained from mice that were exposed to PBS or LPS. (B) BALF EVs obtained from mice that were exposed to PBS or HCL. (C) the changes of EV-cargo circRNA profiles between non-infectious stimuli (HCL) and endotoxin (LPS) were expressed in Log2 fold change. (D) A representative picture showing the histological changes was presented here. The inflammatory score was determined by a double-blinded examiner using five lung sections per mouse, and three mice per treatment. The mean value is graphed and presented. ***p<0.05.
Microarray Services, supplied by LC Sciences, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/microarray+service/microarray+service/pm38401394-64-16-18
Average 90 stars, based on 1 article reviews
microarray services - by Bioz Stars, 2026-09
90/100 stars
  Buy from Supplier

90
Fisher Scientific microarray services
CircRNA profiles in BALF EVs, serum EVs and BALF cells. Three mice were used in this experiment. BALF and serum were collected and pooled after exposure to PBS or LPS (1µg/mouse) or HCl (0.1N) for 24h. EVs were separated using ultracentrifugation as previously described . RNA was isolated from the EVs and subjected to circRNA <t>microarrays</t> by Arraystar Inc (Rockville, MD). Heatmap of the circRNA arrays in EVs obtained from BALF in the absence and presence of noxious stimuli. (A) BALF EVs obtained from mice that were exposed to PBS or LPS. (B) BALF EVs obtained from mice that were exposed to PBS or HCL. (C) the changes of EV-cargo circRNA profiles between non-infectious stimuli (HCL) and endotoxin (LPS) were expressed in Log2 fold change. (D) A representative picture showing the histological changes was presented here. The inflammatory score was determined by a double-blinded examiner using five lung sections per mouse, and three mice per treatment. The mean value is graphed and presented. ***p<0.05.
Microarray Services, supplied by Fisher Scientific, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/microarray+service/microarray+analysis/pm38261515-291-9-6
Average 90 stars, based on 1 article reviews
microarray services - by Bioz Stars, 2026-09
90/100 stars
  Buy from Supplier

90
Macrogen microarray analysis service
CircRNA profiles in BALF EVs, serum EVs and BALF cells. Three mice were used in this experiment. BALF and serum were collected and pooled after exposure to PBS or LPS (1µg/mouse) or HCl (0.1N) for 24h. EVs were separated using ultracentrifugation as previously described . RNA was isolated from the EVs and subjected to circRNA <t>microarrays</t> by Arraystar Inc (Rockville, MD). Heatmap of the circRNA arrays in EVs obtained from BALF in the absence and presence of noxious stimuli. (A) BALF EVs obtained from mice that were exposed to PBS or LPS. (B) BALF EVs obtained from mice that were exposed to PBS or HCL. (C) the changes of EV-cargo circRNA profiles between non-infectious stimuli (HCL) and endotoxin (LPS) were expressed in Log2 fold change. (D) A representative picture showing the histological changes was presented here. The inflammatory score was determined by a double-blinded examiner using five lung sections per mouse, and three mice per treatment. The mean value is graphed and presented. ***p<0.05.
Microarray Analysis Service, supplied by Macrogen, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/microarray+service/microarray+services/pm37436601-30-28-31
Average 90 stars, based on 1 article reviews
microarray analysis service - by Bioz Stars, 2026-09
90/100 stars
  Buy from Supplier

90
NeoScience Co Ltd microarray services
CircRNA profiles in BALF EVs, serum EVs and BALF cells. Three mice were used in this experiment. BALF and serum were collected and pooled after exposure to PBS or LPS (1µg/mouse) or HCl (0.1N) for 24h. EVs were separated using ultracentrifugation as previously described . RNA was isolated from the EVs and subjected to circRNA <t>microarrays</t> by Arraystar Inc (Rockville, MD). Heatmap of the circRNA arrays in EVs obtained from BALF in the absence and presence of noxious stimuli. (A) BALF EVs obtained from mice that were exposed to PBS or LPS. (B) BALF EVs obtained from mice that were exposed to PBS or HCL. (C) the changes of EV-cargo circRNA profiles between non-infectious stimuli (HCL) and endotoxin (LPS) were expressed in Log2 fold change. (D) A representative picture showing the histological changes was presented here. The inflammatory score was determined by a double-blinded examiner using five lung sections per mouse, and three mice per treatment. The mean value is graphed and presented. ***p<0.05.
Microarray Services, supplied by NeoScience Co Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/microarray+service/microarray+services/pm37755545-77-13-7
Average 90 stars, based on 1 article reviews
microarray services - by Bioz Stars, 2026-09
90/100 stars
  Buy from Supplier

Image Search Results


CircRNA profiles in BALF EVs, serum EVs and BALF cells. Three mice were used in this experiment. BALF and serum were collected and pooled after exposure to PBS or LPS (1µg/mouse) or HCl (0.1N) for 24h. EVs were separated using ultracentrifugation as previously described . RNA was isolated from the EVs and subjected to circRNA microarrays by Arraystar Inc (Rockville, MD). Heatmap of the circRNA arrays in EVs obtained from BALF in the absence and presence of noxious stimuli. (A) BALF EVs obtained from mice that were exposed to PBS or LPS. (B) BALF EVs obtained from mice that were exposed to PBS or HCL. (C) the changes of EV-cargo circRNA profiles between non-infectious stimuli (HCL) and endotoxin (LPS) were expressed in Log2 fold change. (D) A representative picture showing the histological changes was presented here. The inflammatory score was determined by a double-blinded examiner using five lung sections per mouse, and three mice per treatment. The mean value is graphed and presented. ***p<0.05.

Journal: Frontiers in Immunology

Article Title: Altered circular RNA expressions in extracellular vesicles from bronchoalveolar lavage fluids in mice after bacterial infections

doi: 10.3389/fimmu.2024.1354676

Figure Lengend Snippet: CircRNA profiles in BALF EVs, serum EVs and BALF cells. Three mice were used in this experiment. BALF and serum were collected and pooled after exposure to PBS or LPS (1µg/mouse) or HCl (0.1N) for 24h. EVs were separated using ultracentrifugation as previously described . RNA was isolated from the EVs and subjected to circRNA microarrays by Arraystar Inc (Rockville, MD). Heatmap of the circRNA arrays in EVs obtained from BALF in the absence and presence of noxious stimuli. (A) BALF EVs obtained from mice that were exposed to PBS or LPS. (B) BALF EVs obtained from mice that were exposed to PBS or HCL. (C) the changes of EV-cargo circRNA profiles between non-infectious stimuli (HCL) and endotoxin (LPS) were expressed in Log2 fold change. (D) A representative picture showing the histological changes was presented here. The inflammatory score was determined by a double-blinded examiner using five lung sections per mouse, and three mice per treatment. The mean value is graphed and presented. ***p<0.05.

Article Snippet: For the circRNA profiling using microarrays, we used the service from Arraystar (Rockville, MD).

Techniques: Isolation