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protein 1 micro ct microcomputed tomography md molecular dynamics nrf2 nuclear factor erythroid 2 related factor 2 nqo1  (Molecular Dynamics Inc)

 
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    Molecular Dynamics Inc protein 1 micro ct microcomputed tomography md molecular dynamics nrf2 nuclear factor erythroid 2 related factor 2 nqo1
    Protein 1 Micro Ct Microcomputed Tomography Md Molecular Dynamics Nrf2 Nuclear Factor Erythroid 2 Related Factor 2 Nqo1, supplied by Molecular Dynamics Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 86 stars, based on 1 article reviews
    protein 1 micro ct microcomputed tomography md molecular dynamics nrf2 nuclear factor erythroid 2 related factor 2 nqo1 - by Bioz Stars, 2026-10
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    Blocking Assay:

    Article Title: In silico assessment of neuromuscular blocking agents and fluoroquinolones as ligands of the Mas-related G protein-coupled receptor X2.
    Article Snippet: .. CIP Ciprofloxacin DHR Drug hypersensitivity reaction FQ Fluoroquinolone LAU Laudanosine LEV Levofloxacin MD Molecular dynamics MM/PBSA Molecular mechanics Poisson–Boltzmann surface area (method) MOX Moxifloxacin MRGPRX2 Mas-related G protein-coupled receptor X2 NMBA Neuromuscular blocking agent Hubert Rybka and Alicja Dziadowiec co-first authorship. ..

    Concentration Assay:

    Article Title: CAMPER: mechanistic artificial intelligence for designing peptides that target MRSA persisters.
    Article Snippet: Abbreviation Definition AI artificial intelligence AMPs antimicrobial peptides AMR antimicrobial resistance ANOVA analysis of variance APD Antimicrobial Peptide Database ATP adenosine triphosphate AUC area under the curve BCECF 2′,7′-Bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein BUN blood urea nitrogen CD circular dichroism CDC Centers for Disease Control and Prevention cDNA complementary DNA CFU Colony Forming Units CG coarse-grained cryo-EM cryo-electron microscopy Dab diaminobutyric acid Dap diaminopimelic acid DBAASP Database of Antimicrobial Activity and Structure of Peptides DCFH-DA 2′,7′-dichlorofluorescein diacetate DMEM Dulbecco's modified eagle medium DOPC 1,2-Dioleoyl-sn-glycero-3-phosphocholine DOPG dioleoylphosphatidylglycerol GRAVY Grand Average of Hydropathy HaCaT human keratinocytes HKC-8 human kidney cortical cells HPC High-Performance Computing HSQC Heteronuclear Single Quantum Coherence IFN-γ Interferon gamma IL-1β Interleukin-1 beta IL-6 Interleukin 6 LD50 lethal dose, 50% LogP octanol-water partition coefficient LPG lysylphosphatidylglycerol MBEC50 Minimal Biofilm Eradication Concentration 50%. .. MCP-1 Monocyte Chemoattractant Protein-1 AR TI CL E IN P RE SS Abbreviation Definition MD Molecular Dynamics MIC minimal inhibitory concentration ML machine learning MOA mode of action MRSA methicillin-resistant Staphylococcus aureus NMR Nuclear Magnetic Resonance NOESY Nuclear Overhauser Effect Spectroscopy NTML Nebraska Transposon Mutant Library OD600 optical density at 600 nm Orn ornithine PBS phosphate-buffered saline PCR polymerase chain reaction PG phosphatidylglycerol PI propidium iodide PMF proton motive force QSAR quantitative-structure activity relationship RF random forest RNA-seq RNA sequencing ROS reactive oxygen species S. aureus Staphylococcus aureus SDS sodium dodecyl sulfate SEM Scanning electron microscopy TNF-α Tumor Necrosis Factor alpha TOCSY Total Correlation Spectroscopy TPSA topological polar surface area TSA tryptic soy agar TSB tryptic soy broth VRSA vancomycin-resistant S. aureus AR TI CL E IN P RE SS .. MCP-1 Monocyte Chemoattractant Protein-1 AR TI CL E IN P RE SS Abbreviation Definition MD Molecular Dynamics MIC minimal inhibitory concentration ML machine learning MOA mode of action MRSA methicillin-resistant Staphylococcus aureus NMR Nuclear Magnetic Resonance NOESY Nuclear Overhauser Effect Spectroscopy NTML Nebraska Transposon Mutant Library OD600 optical density at 600 nm Orn ornithine PBS phosphate-buffered saline PCR polymerase chain reaction PG phosphatidylglycerol PI propidium iodide PMF proton motive force QSAR quantitative-structure activity relationship RF random forest RNA-seq RNA sequencing ROS reactive oxygen species S. aureus Staphylococcus aureus SDS sodium dodecyl sulfate SEM Scanning electron microscopy TNF-α Tumor Necrosis Factor alpha TOCSY Total Correlation Spectroscopy TPSA topological polar surface area TSA tryptic soy agar TSB tryptic soy broth VRSA vancomycin-resistant S. aureus AR TI CL E IN P RE SS

    Nuclear Magnetic Resonance:

    Article Title: CAMPER: mechanistic artificial intelligence for designing peptides that target MRSA persisters.
    Article Snippet: Abbreviation Definition AI artificial intelligence AMPs antimicrobial peptides AMR antimicrobial resistance ANOVA analysis of variance APD Antimicrobial Peptide Database ATP adenosine triphosphate AUC area under the curve BCECF 2′,7′-Bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein BUN blood urea nitrogen CD circular dichroism CDC Centers for Disease Control and Prevention cDNA complementary DNA CFU Colony Forming Units CG coarse-grained cryo-EM cryo-electron microscopy Dab diaminobutyric acid Dap diaminopimelic acid DBAASP Database of Antimicrobial Activity and Structure of Peptides DCFH-DA 2′,7′-dichlorofluorescein diacetate DMEM Dulbecco's modified eagle medium DOPC 1,2-Dioleoyl-sn-glycero-3-phosphocholine DOPG dioleoylphosphatidylglycerol GRAVY Grand Average of Hydropathy HaCaT human keratinocytes HKC-8 human kidney cortical cells HPC High-Performance Computing HSQC Heteronuclear Single Quantum Coherence IFN-γ Interferon gamma IL-1β Interleukin-1 beta IL-6 Interleukin 6 LD50 lethal dose, 50% LogP octanol-water partition coefficient LPG lysylphosphatidylglycerol MBEC50 Minimal Biofilm Eradication Concentration 50%. .. MCP-1 Monocyte Chemoattractant Protein-1 AR TI CL E IN P RE SS Abbreviation Definition MD Molecular Dynamics MIC minimal inhibitory concentration ML machine learning MOA mode of action MRSA methicillin-resistant Staphylococcus aureus NMR Nuclear Magnetic Resonance NOESY Nuclear Overhauser Effect Spectroscopy NTML Nebraska Transposon Mutant Library OD600 optical density at 600 nm Orn ornithine PBS phosphate-buffered saline PCR polymerase chain reaction PG phosphatidylglycerol PI propidium iodide PMF proton motive force QSAR quantitative-structure activity relationship RF random forest RNA-seq RNA sequencing ROS reactive oxygen species S. aureus Staphylococcus aureus SDS sodium dodecyl sulfate SEM Scanning electron microscopy TNF-α Tumor Necrosis Factor alpha TOCSY Total Correlation Spectroscopy TPSA topological polar surface area TSA tryptic soy agar TSB tryptic soy broth VRSA vancomycin-resistant S. aureus AR TI CL E IN P RE SS .. MCP-1 Monocyte Chemoattractant Protein-1 AR TI CL E IN P RE SS Abbreviation Definition MD Molecular Dynamics MIC minimal inhibitory concentration ML machine learning MOA mode of action MRSA methicillin-resistant Staphylococcus aureus NMR Nuclear Magnetic Resonance NOESY Nuclear Overhauser Effect Spectroscopy NTML Nebraska Transposon Mutant Library OD600 optical density at 600 nm Orn ornithine PBS phosphate-buffered saline PCR polymerase chain reaction PG phosphatidylglycerol PI propidium iodide PMF proton motive force QSAR quantitative-structure activity relationship RF random forest RNA-seq RNA sequencing ROS reactive oxygen species S. aureus Staphylococcus aureus SDS sodium dodecyl sulfate SEM Scanning electron microscopy TNF-α Tumor Necrosis Factor alpha TOCSY Total Correlation Spectroscopy TPSA topological polar surface area TSA tryptic soy agar TSB tryptic soy broth VRSA vancomycin-resistant S. aureus AR TI CL E IN P RE SS

    Article Title: Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction.
    Article Snippet: .. Overall, MTMs are membrane-bound and dephosphorylate phosphatidyl-inositol-3-monophosphate (PI(3)P) and − 3, Abbreviations aa amino acid Ab antibody AKT protein kinase B APC adenomatous polyposis coli CC coiled coil CD circular dichroism CEA carcinoembryonic antigen CRC colorectal cancer EGF(R) epidermal growth factor (receptor) ERK1/2 extracellular signal-regulated kinase-1/2 EV empty vector FCS fetal calf serum FFPE formalin-fixed-paraffin-embedded FI fluorescence intensity FL full-length FOS FBJ murine osteosarcoma viral oncogene homologue GAP GTPase activating protein GD globular domain GDS guanine nucleotide dissociation factor GEF guanine nucleotide exchange factor GFP green fluorescence protein GI gastrointestinal H&E haematoxylin&eosin HSP90 heat shock protein 90 HCS catalytical site (MTMs) HVR hypervariable region IB immunoblotting IF immunofluorescence IHC immunohistochemistry Ins(1,3)P2 inositol-1,3-bisphosphate KCA3.1 calcium-activated potassium channel SK4 K-RAS Kirsten rat sarcoma viral oncogene homologue M7-CC514-554 recombinant MTMR7-CC mimicry protein MD molecular dynamics MEK1/2 mitogen-activated kinase kinase-1/2 MT synthetic MTMR7-CC mimicry peptide MTM myotubularin MTMR7 myotubularin-related-protein-7 MRI magnetic resonance imaging mTOR mechanistic target of rapamycin kinase NMR nuclear magnetic resonance OD optical density PET/CT positron emission tomography/computed tomography PH plextrin homology (domain) PI phosphatidyl-inositol PI3K phosphoinositide-3-kinase PI(3)P phosphatidyl-inositol-3-monophosphate PI(3,5)P2 phosphatidyl-inositol-3,5-bisphosphate PIP phosphoinositide PLC phospholipase C PS phosphatidylserine PTP protein tyrosine phosphatase RAF proto-oncogene serine/threonine-protein kinase RAB Ras-related protein RAL Ras-like proto-oncogene S6RP S6 ribosomal protein SC scrambled control peptide SCF subcellular fractionation SID SET-interaction domain SOS Son of Sevenless Homologue SRE serum-response element SV40 simian virus-40 t time TAg large T-antigen UT untreated (control) VC vehicle control WT wild-type P. Weidner et al. Cancer Letters 588 (2024) 216783 5-bisphosphate (PI(3,5)P2) at the 3′-position [18]. ..

    Spectroscopy:

    Article Title: CAMPER: mechanistic artificial intelligence for designing peptides that target MRSA persisters.
    Article Snippet: Abbreviation Definition AI artificial intelligence AMPs antimicrobial peptides AMR antimicrobial resistance ANOVA analysis of variance APD Antimicrobial Peptide Database ATP adenosine triphosphate AUC area under the curve BCECF 2′,7′-Bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein BUN blood urea nitrogen CD circular dichroism CDC Centers for Disease Control and Prevention cDNA complementary DNA CFU Colony Forming Units CG coarse-grained cryo-EM cryo-electron microscopy Dab diaminobutyric acid Dap diaminopimelic acid DBAASP Database of Antimicrobial Activity and Structure of Peptides DCFH-DA 2′,7′-dichlorofluorescein diacetate DMEM Dulbecco's modified eagle medium DOPC 1,2-Dioleoyl-sn-glycero-3-phosphocholine DOPG dioleoylphosphatidylglycerol GRAVY Grand Average of Hydropathy HaCaT human keratinocytes HKC-8 human kidney cortical cells HPC High-Performance Computing HSQC Heteronuclear Single Quantum Coherence IFN-γ Interferon gamma IL-1β Interleukin-1 beta IL-6 Interleukin 6 LD50 lethal dose, 50% LogP octanol-water partition coefficient LPG lysylphosphatidylglycerol MBEC50 Minimal Biofilm Eradication Concentration 50%. .. MCP-1 Monocyte Chemoattractant Protein-1 AR TI CL E IN P RE SS Abbreviation Definition MD Molecular Dynamics MIC minimal inhibitory concentration ML machine learning MOA mode of action MRSA methicillin-resistant Staphylococcus aureus NMR Nuclear Magnetic Resonance NOESY Nuclear Overhauser Effect Spectroscopy NTML Nebraska Transposon Mutant Library OD600 optical density at 600 nm Orn ornithine PBS phosphate-buffered saline PCR polymerase chain reaction PG phosphatidylglycerol PI propidium iodide PMF proton motive force QSAR quantitative-structure activity relationship RF random forest RNA-seq RNA sequencing ROS reactive oxygen species S. aureus Staphylococcus aureus SDS sodium dodecyl sulfate SEM Scanning electron microscopy TNF-α Tumor Necrosis Factor alpha TOCSY Total Correlation Spectroscopy TPSA topological polar surface area TSA tryptic soy agar TSB tryptic soy broth VRSA vancomycin-resistant S. aureus AR TI CL E IN P RE SS .. MCP-1 Monocyte Chemoattractant Protein-1 AR TI CL E IN P RE SS Abbreviation Definition MD Molecular Dynamics MIC minimal inhibitory concentration ML machine learning MOA mode of action MRSA methicillin-resistant Staphylococcus aureus NMR Nuclear Magnetic Resonance NOESY Nuclear Overhauser Effect Spectroscopy NTML Nebraska Transposon Mutant Library OD600 optical density at 600 nm Orn ornithine PBS phosphate-buffered saline PCR polymerase chain reaction PG phosphatidylglycerol PI propidium iodide PMF proton motive force QSAR quantitative-structure activity relationship RF random forest RNA-seq RNA sequencing ROS reactive oxygen species S. aureus Staphylococcus aureus SDS sodium dodecyl sulfate SEM Scanning electron microscopy TNF-α Tumor Necrosis Factor alpha TOCSY Total Correlation Spectroscopy TPSA topological polar surface area TSA tryptic soy agar TSB tryptic soy broth VRSA vancomycin-resistant S. aureus AR TI CL E IN P RE SS

    Mutagenesis:

    Article Title: CAMPER: mechanistic artificial intelligence for designing peptides that target MRSA persisters.
    Article Snippet: Abbreviation Definition AI artificial intelligence AMPs antimicrobial peptides AMR antimicrobial resistance ANOVA analysis of variance APD Antimicrobial Peptide Database ATP adenosine triphosphate AUC area under the curve BCECF 2′,7′-Bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein BUN blood urea nitrogen CD circular dichroism CDC Centers for Disease Control and Prevention cDNA complementary DNA CFU Colony Forming Units CG coarse-grained cryo-EM cryo-electron microscopy Dab diaminobutyric acid Dap diaminopimelic acid DBAASP Database of Antimicrobial Activity and Structure of Peptides DCFH-DA 2′,7′-dichlorofluorescein diacetate DMEM Dulbecco's modified eagle medium DOPC 1,2-Dioleoyl-sn-glycero-3-phosphocholine DOPG dioleoylphosphatidylglycerol GRAVY Grand Average of Hydropathy HaCaT human keratinocytes HKC-8 human kidney cortical cells HPC High-Performance Computing HSQC Heteronuclear Single Quantum Coherence IFN-γ Interferon gamma IL-1β Interleukin-1 beta IL-6 Interleukin 6 LD50 lethal dose, 50% LogP octanol-water partition coefficient LPG lysylphosphatidylglycerol MBEC50 Minimal Biofilm Eradication Concentration 50%. .. MCP-1 Monocyte Chemoattractant Protein-1 AR TI CL E IN P RE SS Abbreviation Definition MD Molecular Dynamics MIC minimal inhibitory concentration ML machine learning MOA mode of action MRSA methicillin-resistant Staphylococcus aureus NMR Nuclear Magnetic Resonance NOESY Nuclear Overhauser Effect Spectroscopy NTML Nebraska Transposon Mutant Library OD600 optical density at 600 nm Orn ornithine PBS phosphate-buffered saline PCR polymerase chain reaction PG phosphatidylglycerol PI propidium iodide PMF proton motive force QSAR quantitative-structure activity relationship RF random forest RNA-seq RNA sequencing ROS reactive oxygen species S. aureus Staphylococcus aureus SDS sodium dodecyl sulfate SEM Scanning electron microscopy TNF-α Tumor Necrosis Factor alpha TOCSY Total Correlation Spectroscopy TPSA topological polar surface area TSA tryptic soy agar TSB tryptic soy broth VRSA vancomycin-resistant S. aureus AR TI CL E IN P RE SS .. MCP-1 Monocyte Chemoattractant Protein-1 AR TI CL E IN P RE SS Abbreviation Definition MD Molecular Dynamics MIC minimal inhibitory concentration ML machine learning MOA mode of action MRSA methicillin-resistant Staphylococcus aureus NMR Nuclear Magnetic Resonance NOESY Nuclear Overhauser Effect Spectroscopy NTML Nebraska Transposon Mutant Library OD600 optical density at 600 nm Orn ornithine PBS phosphate-buffered saline PCR polymerase chain reaction PG phosphatidylglycerol PI propidium iodide PMF proton motive force QSAR quantitative-structure activity relationship RF random forest RNA-seq RNA sequencing ROS reactive oxygen species S. aureus Staphylococcus aureus SDS sodium dodecyl sulfate SEM Scanning electron microscopy TNF-α Tumor Necrosis Factor alpha TOCSY Total Correlation Spectroscopy TPSA topological polar surface area TSA tryptic soy agar TSB tryptic soy broth VRSA vancomycin-resistant S. aureus AR TI CL E IN P RE SS

    Saline:

    Article Title: CAMPER: mechanistic artificial intelligence for designing peptides that target MRSA persisters.
    Article Snippet: Abbreviation Definition AI artificial intelligence AMPs antimicrobial peptides AMR antimicrobial resistance ANOVA analysis of variance APD Antimicrobial Peptide Database ATP adenosine triphosphate AUC area under the curve BCECF 2′,7′-Bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein BUN blood urea nitrogen CD circular dichroism CDC Centers for Disease Control and Prevention cDNA complementary DNA CFU Colony Forming Units CG coarse-grained cryo-EM cryo-electron microscopy Dab diaminobutyric acid Dap diaminopimelic acid DBAASP Database of Antimicrobial Activity and Structure of Peptides DCFH-DA 2′,7′-dichlorofluorescein diacetate DMEM Dulbecco's modified eagle medium DOPC 1,2-Dioleoyl-sn-glycero-3-phosphocholine DOPG dioleoylphosphatidylglycerol GRAVY Grand Average of Hydropathy HaCaT human keratinocytes HKC-8 human kidney cortical cells HPC High-Performance Computing HSQC Heteronuclear Single Quantum Coherence IFN-γ Interferon gamma IL-1β Interleukin-1 beta IL-6 Interleukin 6 LD50 lethal dose, 50% LogP octanol-water partition coefficient LPG lysylphosphatidylglycerol MBEC50 Minimal Biofilm Eradication Concentration 50%. .. MCP-1 Monocyte Chemoattractant Protein-1 AR TI CL E IN P RE SS Abbreviation Definition MD Molecular Dynamics MIC minimal inhibitory concentration ML machine learning MOA mode of action MRSA methicillin-resistant Staphylococcus aureus NMR Nuclear Magnetic Resonance NOESY Nuclear Overhauser Effect Spectroscopy NTML Nebraska Transposon Mutant Library OD600 optical density at 600 nm Orn ornithine PBS phosphate-buffered saline PCR polymerase chain reaction PG phosphatidylglycerol PI propidium iodide PMF proton motive force QSAR quantitative-structure activity relationship RF random forest RNA-seq RNA sequencing ROS reactive oxygen species S. aureus Staphylococcus aureus SDS sodium dodecyl sulfate SEM Scanning electron microscopy TNF-α Tumor Necrosis Factor alpha TOCSY Total Correlation Spectroscopy TPSA topological polar surface area TSA tryptic soy agar TSB tryptic soy broth VRSA vancomycin-resistant S. aureus AR TI CL E IN P RE SS .. MCP-1 Monocyte Chemoattractant Protein-1 AR TI CL E IN P RE SS Abbreviation Definition MD Molecular Dynamics MIC minimal inhibitory concentration ML machine learning MOA mode of action MRSA methicillin-resistant Staphylococcus aureus NMR Nuclear Magnetic Resonance NOESY Nuclear Overhauser Effect Spectroscopy NTML Nebraska Transposon Mutant Library OD600 optical density at 600 nm Orn ornithine PBS phosphate-buffered saline PCR polymerase chain reaction PG phosphatidylglycerol PI propidium iodide PMF proton motive force QSAR quantitative-structure activity relationship RF random forest RNA-seq RNA sequencing ROS reactive oxygen species S. aureus Staphylococcus aureus SDS sodium dodecyl sulfate SEM Scanning electron microscopy TNF-α Tumor Necrosis Factor alpha TOCSY Total Correlation Spectroscopy TPSA topological polar surface area TSA tryptic soy agar TSB tryptic soy broth VRSA vancomycin-resistant S. aureus AR TI CL E IN P RE SS

    Article Title: AI and pharmacophore-based screening, molecular docking, and dynamic simulation for identification of CDK6 inhibitors to combat NSCLC.
    Article Snippet: The overactivated CDK6/Cyclin D3 complex is considered to be associated with poor prognosis in patients with NSCLC, thus developing CDK6/Cyclin D3 inhibitors is expected to provide new options for NSCLC patients.. This study successfully utilized a mixed virtual screening workflow based on artificial intelligence, pharmacophores, and docking to rapidly identify multiple CDK6/Cyclin D3 inhibitors from a compound library consisting of 12,563 compounds, achieving a hit rate of over 40% (2 out of 5 selected candidate compounds).. Among these, compound 2 exhibited the most potent CDK6/Cyclin D3 inhibitory activity, with an IC50 value of 38.6 nM, comparable to CDK6 inhibitors in clinical trial phases.

    Article Title: The Protective Effects and Material Basis of Astragalus membranaceus in the Prevention and Treatment of Radiation-Induced Lung Injury via Modulation of the Keap1-Nrf2 Signaling Pathway.
    Article Snippet: This is a PDF of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability.. This version will undergo additional copyediting, typesetting and review before it is published in its final form.. As such, this version is no longer the Accepted Manuscript, but it is not yet the definitive Version of Record; we are providing this early version to give early visibility of the article.

    Polymerase Chain Reaction:

    Article Title: CAMPER: mechanistic artificial intelligence for designing peptides that target MRSA persisters.
    Article Snippet: Abbreviation Definition AI artificial intelligence AMPs antimicrobial peptides AMR antimicrobial resistance ANOVA analysis of variance APD Antimicrobial Peptide Database ATP adenosine triphosphate AUC area under the curve BCECF 2′,7′-Bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein BUN blood urea nitrogen CD circular dichroism CDC Centers for Disease Control and Prevention cDNA complementary DNA CFU Colony Forming Units CG coarse-grained cryo-EM cryo-electron microscopy Dab diaminobutyric acid Dap diaminopimelic acid DBAASP Database of Antimicrobial Activity and Structure of Peptides DCFH-DA 2′,7′-dichlorofluorescein diacetate DMEM Dulbecco's modified eagle medium DOPC 1,2-Dioleoyl-sn-glycero-3-phosphocholine DOPG dioleoylphosphatidylglycerol GRAVY Grand Average of Hydropathy HaCaT human keratinocytes HKC-8 human kidney cortical cells HPC High-Performance Computing HSQC Heteronuclear Single Quantum Coherence IFN-γ Interferon gamma IL-1β Interleukin-1 beta IL-6 Interleukin 6 LD50 lethal dose, 50% LogP octanol-water partition coefficient LPG lysylphosphatidylglycerol MBEC50 Minimal Biofilm Eradication Concentration 50%. .. MCP-1 Monocyte Chemoattractant Protein-1 AR TI CL E IN P RE SS Abbreviation Definition MD Molecular Dynamics MIC minimal inhibitory concentration ML machine learning MOA mode of action MRSA methicillin-resistant Staphylococcus aureus NMR Nuclear Magnetic Resonance NOESY Nuclear Overhauser Effect Spectroscopy NTML Nebraska Transposon Mutant Library OD600 optical density at 600 nm Orn ornithine PBS phosphate-buffered saline PCR polymerase chain reaction PG phosphatidylglycerol PI propidium iodide PMF proton motive force QSAR quantitative-structure activity relationship RF random forest RNA-seq RNA sequencing ROS reactive oxygen species S. aureus Staphylococcus aureus SDS sodium dodecyl sulfate SEM Scanning electron microscopy TNF-α Tumor Necrosis Factor alpha TOCSY Total Correlation Spectroscopy TPSA topological polar surface area TSA tryptic soy agar TSB tryptic soy broth VRSA vancomycin-resistant S. aureus AR TI CL E IN P RE SS .. MCP-1 Monocyte Chemoattractant Protein-1 AR TI CL E IN P RE SS Abbreviation Definition MD Molecular Dynamics MIC minimal inhibitory concentration ML machine learning MOA mode of action MRSA methicillin-resistant Staphylococcus aureus NMR Nuclear Magnetic Resonance NOESY Nuclear Overhauser Effect Spectroscopy NTML Nebraska Transposon Mutant Library OD600 optical density at 600 nm Orn ornithine PBS phosphate-buffered saline PCR polymerase chain reaction PG phosphatidylglycerol PI propidium iodide PMF proton motive force QSAR quantitative-structure activity relationship RF random forest RNA-seq RNA sequencing ROS reactive oxygen species S. aureus Staphylococcus aureus SDS sodium dodecyl sulfate SEM Scanning electron microscopy TNF-α Tumor Necrosis Factor alpha TOCSY Total Correlation Spectroscopy TPSA topological polar surface area TSA tryptic soy agar TSB tryptic soy broth VRSA vancomycin-resistant S. aureus AR TI CL E IN P RE SS

    Article Title: The Protective Effects and Material Basis of Astragalus membranaceus in the Prevention and Treatment of Radiation-Induced Lung Injury via Modulation of the Keap1-Nrf2 Signaling Pathway.
    Article Snippet: This is a PDF of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability.. This version will undergo additional copyediting, typesetting and review before it is published in its final form.. As such, this version is no longer the Accepted Manuscript, but it is not yet the definitive Version of Record; we are providing this early version to give early visibility of the article.

    Peptide Mass Fingerprinting:

    Article Title: CAMPER: mechanistic artificial intelligence for designing peptides that target MRSA persisters.
    Article Snippet: Abbreviation Definition AI artificial intelligence AMPs antimicrobial peptides AMR antimicrobial resistance ANOVA analysis of variance APD Antimicrobial Peptide Database ATP adenosine triphosphate AUC area under the curve BCECF 2′,7′-Bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein BUN blood urea nitrogen CD circular dichroism CDC Centers for Disease Control and Prevention cDNA complementary DNA CFU Colony Forming Units CG coarse-grained cryo-EM cryo-electron microscopy Dab diaminobutyric acid Dap diaminopimelic acid DBAASP Database of Antimicrobial Activity and Structure of Peptides DCFH-DA 2′,7′-dichlorofluorescein diacetate DMEM Dulbecco's modified eagle medium DOPC 1,2-Dioleoyl-sn-glycero-3-phosphocholine DOPG dioleoylphosphatidylglycerol GRAVY Grand Average of Hydropathy HaCaT human keratinocytes HKC-8 human kidney cortical cells HPC High-Performance Computing HSQC Heteronuclear Single Quantum Coherence IFN-γ Interferon gamma IL-1β Interleukin-1 beta IL-6 Interleukin 6 LD50 lethal dose, 50% LogP octanol-water partition coefficient LPG lysylphosphatidylglycerol MBEC50 Minimal Biofilm Eradication Concentration 50%. .. MCP-1 Monocyte Chemoattractant Protein-1 AR TI CL E IN P RE SS Abbreviation Definition MD Molecular Dynamics MIC minimal inhibitory concentration ML machine learning MOA mode of action MRSA methicillin-resistant Staphylococcus aureus NMR Nuclear Magnetic Resonance NOESY Nuclear Overhauser Effect Spectroscopy NTML Nebraska Transposon Mutant Library OD600 optical density at 600 nm Orn ornithine PBS phosphate-buffered saline PCR polymerase chain reaction PG phosphatidylglycerol PI propidium iodide PMF proton motive force QSAR quantitative-structure activity relationship RF random forest RNA-seq RNA sequencing ROS reactive oxygen species S. aureus Staphylococcus aureus SDS sodium dodecyl sulfate SEM Scanning electron microscopy TNF-α Tumor Necrosis Factor alpha TOCSY Total Correlation Spectroscopy TPSA topological polar surface area TSA tryptic soy agar TSB tryptic soy broth VRSA vancomycin-resistant S. aureus AR TI CL E IN P RE SS .. MCP-1 Monocyte Chemoattractant Protein-1 AR TI CL E IN P RE SS Abbreviation Definition MD Molecular Dynamics MIC minimal inhibitory concentration ML machine learning MOA mode of action MRSA methicillin-resistant Staphylococcus aureus NMR Nuclear Magnetic Resonance NOESY Nuclear Overhauser Effect Spectroscopy NTML Nebraska Transposon Mutant Library OD600 optical density at 600 nm Orn ornithine PBS phosphate-buffered saline PCR polymerase chain reaction PG phosphatidylglycerol PI propidium iodide PMF proton motive force QSAR quantitative-structure activity relationship RF random forest RNA-seq RNA sequencing ROS reactive oxygen species S. aureus Staphylococcus aureus SDS sodium dodecyl sulfate SEM Scanning electron microscopy TNF-α Tumor Necrosis Factor alpha TOCSY Total Correlation Spectroscopy TPSA topological polar surface area TSA tryptic soy agar TSB tryptic soy broth VRSA vancomycin-resistant S. aureus AR TI CL E IN P RE SS

    Activity Assay:

    Article Title: CAMPER: mechanistic artificial intelligence for designing peptides that target MRSA persisters.
    Article Snippet: Abbreviation Definition AI artificial intelligence AMPs antimicrobial peptides AMR antimicrobial resistance ANOVA analysis of variance APD Antimicrobial Peptide Database ATP adenosine triphosphate AUC area under the curve BCECF 2′,7′-Bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein BUN blood urea nitrogen CD circular dichroism CDC Centers for Disease Control and Prevention cDNA complementary DNA CFU Colony Forming Units CG coarse-grained cryo-EM cryo-electron microscopy Dab diaminobutyric acid Dap diaminopimelic acid DBAASP Database of Antimicrobial Activity and Structure of Peptides DCFH-DA 2′,7′-dichlorofluorescein diacetate DMEM Dulbecco's modified eagle medium DOPC 1,2-Dioleoyl-sn-glycero-3-phosphocholine DOPG dioleoylphosphatidylglycerol GRAVY Grand Average of Hydropathy HaCaT human keratinocytes HKC-8 human kidney cortical cells HPC High-Performance Computing HSQC Heteronuclear Single Quantum Coherence IFN-γ Interferon gamma IL-1β Interleukin-1 beta IL-6 Interleukin 6 LD50 lethal dose, 50% LogP octanol-water partition coefficient LPG lysylphosphatidylglycerol MBEC50 Minimal Biofilm Eradication Concentration 50%. .. MCP-1 Monocyte Chemoattractant Protein-1 AR TI CL E IN P RE SS Abbreviation Definition MD Molecular Dynamics MIC minimal inhibitory concentration ML machine learning MOA mode of action MRSA methicillin-resistant Staphylococcus aureus NMR Nuclear Magnetic Resonance NOESY Nuclear Overhauser Effect Spectroscopy NTML Nebraska Transposon Mutant Library OD600 optical density at 600 nm Orn ornithine PBS phosphate-buffered saline PCR polymerase chain reaction PG phosphatidylglycerol PI propidium iodide PMF proton motive force QSAR quantitative-structure activity relationship RF random forest RNA-seq RNA sequencing ROS reactive oxygen species S. aureus Staphylococcus aureus SDS sodium dodecyl sulfate SEM Scanning electron microscopy TNF-α Tumor Necrosis Factor alpha TOCSY Total Correlation Spectroscopy TPSA topological polar surface area TSA tryptic soy agar TSB tryptic soy broth VRSA vancomycin-resistant S. aureus AR TI CL E IN P RE SS .. MCP-1 Monocyte Chemoattractant Protein-1 AR TI CL E IN P RE SS Abbreviation Definition MD Molecular Dynamics MIC minimal inhibitory concentration ML machine learning MOA mode of action MRSA methicillin-resistant Staphylococcus aureus NMR Nuclear Magnetic Resonance NOESY Nuclear Overhauser Effect Spectroscopy NTML Nebraska Transposon Mutant Library OD600 optical density at 600 nm Orn ornithine PBS phosphate-buffered saline PCR polymerase chain reaction PG phosphatidylglycerol PI propidium iodide PMF proton motive force QSAR quantitative-structure activity relationship RF random forest RNA-seq RNA sequencing ROS reactive oxygen species S. aureus Staphylococcus aureus SDS sodium dodecyl sulfate SEM Scanning electron microscopy TNF-α Tumor Necrosis Factor alpha TOCSY Total Correlation Spectroscopy TPSA topological polar surface area TSA tryptic soy agar TSB tryptic soy broth VRSA vancomycin-resistant S. aureus AR TI CL E IN P RE SS

    RNA Sequencing:

    Article Title: CAMPER: mechanistic artificial intelligence for designing peptides that target MRSA persisters.
    Article Snippet: Abbreviation Definition AI artificial intelligence AMPs antimicrobial peptides AMR antimicrobial resistance ANOVA analysis of variance APD Antimicrobial Peptide Database ATP adenosine triphosphate AUC area under the curve BCECF 2′,7′-Bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein BUN blood urea nitrogen CD circular dichroism CDC Centers for Disease Control and Prevention cDNA complementary DNA CFU Colony Forming Units CG coarse-grained cryo-EM cryo-electron microscopy Dab diaminobutyric acid Dap diaminopimelic acid DBAASP Database of Antimicrobial Activity and Structure of Peptides DCFH-DA 2′,7′-dichlorofluorescein diacetate DMEM Dulbecco's modified eagle medium DOPC 1,2-Dioleoyl-sn-glycero-3-phosphocholine DOPG dioleoylphosphatidylglycerol GRAVY Grand Average of Hydropathy HaCaT human keratinocytes HKC-8 human kidney cortical cells HPC High-Performance Computing HSQC Heteronuclear Single Quantum Coherence IFN-γ Interferon gamma IL-1β Interleukin-1 beta IL-6 Interleukin 6 LD50 lethal dose, 50% LogP octanol-water partition coefficient LPG lysylphosphatidylglycerol MBEC50 Minimal Biofilm Eradication Concentration 50%. .. MCP-1 Monocyte Chemoattractant Protein-1 AR TI CL E IN P RE SS Abbreviation Definition MD Molecular Dynamics MIC minimal inhibitory concentration ML machine learning MOA mode of action MRSA methicillin-resistant Staphylococcus aureus NMR Nuclear Magnetic Resonance NOESY Nuclear Overhauser Effect Spectroscopy NTML Nebraska Transposon Mutant Library OD600 optical density at 600 nm Orn ornithine PBS phosphate-buffered saline PCR polymerase chain reaction PG phosphatidylglycerol PI propidium iodide PMF proton motive force QSAR quantitative-structure activity relationship RF random forest RNA-seq RNA sequencing ROS reactive oxygen species S. aureus Staphylococcus aureus SDS sodium dodecyl sulfate SEM Scanning electron microscopy TNF-α Tumor Necrosis Factor alpha TOCSY Total Correlation Spectroscopy TPSA topological polar surface area TSA tryptic soy agar TSB tryptic soy broth VRSA vancomycin-resistant S. aureus AR TI CL E IN P RE SS .. MCP-1 Monocyte Chemoattractant Protein-1 AR TI CL E IN P RE SS Abbreviation Definition MD Molecular Dynamics MIC minimal inhibitory concentration ML machine learning MOA mode of action MRSA methicillin-resistant Staphylococcus aureus NMR Nuclear Magnetic Resonance NOESY Nuclear Overhauser Effect Spectroscopy NTML Nebraska Transposon Mutant Library OD600 optical density at 600 nm Orn ornithine PBS phosphate-buffered saline PCR polymerase chain reaction PG phosphatidylglycerol PI propidium iodide PMF proton motive force QSAR quantitative-structure activity relationship RF random forest RNA-seq RNA sequencing ROS reactive oxygen species S. aureus Staphylococcus aureus SDS sodium dodecyl sulfate SEM Scanning electron microscopy TNF-α Tumor Necrosis Factor alpha TOCSY Total Correlation Spectroscopy TPSA topological polar surface area TSA tryptic soy agar TSB tryptic soy broth VRSA vancomycin-resistant S. aureus AR TI CL E IN P RE SS

    Electron Microscopy:

    Article Title: CAMPER: mechanistic artificial intelligence for designing peptides that target MRSA persisters.
    Article Snippet: Abbreviation Definition AI artificial intelligence AMPs antimicrobial peptides AMR antimicrobial resistance ANOVA analysis of variance APD Antimicrobial Peptide Database ATP adenosine triphosphate AUC area under the curve BCECF 2′,7′-Bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein BUN blood urea nitrogen CD circular dichroism CDC Centers for Disease Control and Prevention cDNA complementary DNA CFU Colony Forming Units CG coarse-grained cryo-EM cryo-electron microscopy Dab diaminobutyric acid Dap diaminopimelic acid DBAASP Database of Antimicrobial Activity and Structure of Peptides DCFH-DA 2′,7′-dichlorofluorescein diacetate DMEM Dulbecco's modified eagle medium DOPC 1,2-Dioleoyl-sn-glycero-3-phosphocholine DOPG dioleoylphosphatidylglycerol GRAVY Grand Average of Hydropathy HaCaT human keratinocytes HKC-8 human kidney cortical cells HPC High-Performance Computing HSQC Heteronuclear Single Quantum Coherence IFN-γ Interferon gamma IL-1β Interleukin-1 beta IL-6 Interleukin 6 LD50 lethal dose, 50% LogP octanol-water partition coefficient LPG lysylphosphatidylglycerol MBEC50 Minimal Biofilm Eradication Concentration 50%. .. MCP-1 Monocyte Chemoattractant Protein-1 AR TI CL E IN P RE SS Abbreviation Definition MD Molecular Dynamics MIC minimal inhibitory concentration ML machine learning MOA mode of action MRSA methicillin-resistant Staphylococcus aureus NMR Nuclear Magnetic Resonance NOESY Nuclear Overhauser Effect Spectroscopy NTML Nebraska Transposon Mutant Library OD600 optical density at 600 nm Orn ornithine PBS phosphate-buffered saline PCR polymerase chain reaction PG phosphatidylglycerol PI propidium iodide PMF proton motive force QSAR quantitative-structure activity relationship RF random forest RNA-seq RNA sequencing ROS reactive oxygen species S. aureus Staphylococcus aureus SDS sodium dodecyl sulfate SEM Scanning electron microscopy TNF-α Tumor Necrosis Factor alpha TOCSY Total Correlation Spectroscopy TPSA topological polar surface area TSA tryptic soy agar TSB tryptic soy broth VRSA vancomycin-resistant S. aureus AR TI CL E IN P RE SS .. MCP-1 Monocyte Chemoattractant Protein-1 AR TI CL E IN P RE SS Abbreviation Definition MD Molecular Dynamics MIC minimal inhibitory concentration ML machine learning MOA mode of action MRSA methicillin-resistant Staphylococcus aureus NMR Nuclear Magnetic Resonance NOESY Nuclear Overhauser Effect Spectroscopy NTML Nebraska Transposon Mutant Library OD600 optical density at 600 nm Orn ornithine PBS phosphate-buffered saline PCR polymerase chain reaction PG phosphatidylglycerol PI propidium iodide PMF proton motive force QSAR quantitative-structure activity relationship RF random forest RNA-seq RNA sequencing ROS reactive oxygen species S. aureus Staphylococcus aureus SDS sodium dodecyl sulfate SEM Scanning electron microscopy TNF-α Tumor Necrosis Factor alpha TOCSY Total Correlation Spectroscopy TPSA topological polar surface area TSA tryptic soy agar TSB tryptic soy broth VRSA vancomycin-resistant S. aureus AR TI CL E IN P RE SS

    Membrane:

    Article Title: Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction.
    Article Snippet: .. Overall, MTMs are membrane-bound and dephosphorylate phosphatidyl-inositol-3-monophosphate (PI(3)P) and − 3, Abbreviations aa amino acid Ab antibody AKT protein kinase B APC adenomatous polyposis coli CC coiled coil CD circular dichroism CEA carcinoembryonic antigen CRC colorectal cancer EGF(R) epidermal growth factor (receptor) ERK1/2 extracellular signal-regulated kinase-1/2 EV empty vector FCS fetal calf serum FFPE formalin-fixed-paraffin-embedded FI fluorescence intensity FL full-length FOS FBJ murine osteosarcoma viral oncogene homologue GAP GTPase activating protein GD globular domain GDS guanine nucleotide dissociation factor GEF guanine nucleotide exchange factor GFP green fluorescence protein GI gastrointestinal H&E haematoxylin&eosin HSP90 heat shock protein 90 HCS catalytical site (MTMs) HVR hypervariable region IB immunoblotting IF immunofluorescence IHC immunohistochemistry Ins(1,3)P2 inositol-1,3-bisphosphate KCA3.1 calcium-activated potassium channel SK4 K-RAS Kirsten rat sarcoma viral oncogene homologue M7-CC514-554 recombinant MTMR7-CC mimicry protein MD molecular dynamics MEK1/2 mitogen-activated kinase kinase-1/2 MT synthetic MTMR7-CC mimicry peptide MTM myotubularin MTMR7 myotubularin-related-protein-7 MRI magnetic resonance imaging mTOR mechanistic target of rapamycin kinase NMR nuclear magnetic resonance OD optical density PET/CT positron emission tomography/computed tomography PH plextrin homology (domain) PI phosphatidyl-inositol PI3K phosphoinositide-3-kinase PI(3)P phosphatidyl-inositol-3-monophosphate PI(3,5)P2 phosphatidyl-inositol-3,5-bisphosphate PIP phosphoinositide PLC phospholipase C PS phosphatidylserine PTP protein tyrosine phosphatase RAF proto-oncogene serine/threonine-protein kinase RAB Ras-related protein RAL Ras-like proto-oncogene S6RP S6 ribosomal protein SC scrambled control peptide SCF subcellular fractionation SID SET-interaction domain SOS Son of Sevenless Homologue SRE serum-response element SV40 simian virus-40 t time TAg large T-antigen UT untreated (control) VC vehicle control WT wild-type P. Weidner et al. Cancer Letters 588 (2024) 216783 5-bisphosphate (PI(3,5)P2) at the 3′-position [18]. ..

    Circular Dichroism:

    Article Title: Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction.
    Article Snippet: .. Overall, MTMs are membrane-bound and dephosphorylate phosphatidyl-inositol-3-monophosphate (PI(3)P) and − 3, Abbreviations aa amino acid Ab antibody AKT protein kinase B APC adenomatous polyposis coli CC coiled coil CD circular dichroism CEA carcinoembryonic antigen CRC colorectal cancer EGF(R) epidermal growth factor (receptor) ERK1/2 extracellular signal-regulated kinase-1/2 EV empty vector FCS fetal calf serum FFPE formalin-fixed-paraffin-embedded FI fluorescence intensity FL full-length FOS FBJ murine osteosarcoma viral oncogene homologue GAP GTPase activating protein GD globular domain GDS guanine nucleotide dissociation factor GEF guanine nucleotide exchange factor GFP green fluorescence protein GI gastrointestinal H&E haematoxylin&eosin HSP90 heat shock protein 90 HCS catalytical site (MTMs) HVR hypervariable region IB immunoblotting IF immunofluorescence IHC immunohistochemistry Ins(1,3)P2 inositol-1,3-bisphosphate KCA3.1 calcium-activated potassium channel SK4 K-RAS Kirsten rat sarcoma viral oncogene homologue M7-CC514-554 recombinant MTMR7-CC mimicry protein MD molecular dynamics MEK1/2 mitogen-activated kinase kinase-1/2 MT synthetic MTMR7-CC mimicry peptide MTM myotubularin MTMR7 myotubularin-related-protein-7 MRI magnetic resonance imaging mTOR mechanistic target of rapamycin kinase NMR nuclear magnetic resonance OD optical density PET/CT positron emission tomography/computed tomography PH plextrin homology (domain) PI phosphatidyl-inositol PI3K phosphoinositide-3-kinase PI(3)P phosphatidyl-inositol-3-monophosphate PI(3,5)P2 phosphatidyl-inositol-3,5-bisphosphate PIP phosphoinositide PLC phospholipase C PS phosphatidylserine PTP protein tyrosine phosphatase RAF proto-oncogene serine/threonine-protein kinase RAB Ras-related protein RAL Ras-like proto-oncogene S6RP S6 ribosomal protein SC scrambled control peptide SCF subcellular fractionation SID SET-interaction domain SOS Son of Sevenless Homologue SRE serum-response element SV40 simian virus-40 t time TAg large T-antigen UT untreated (control) VC vehicle control WT wild-type P. Weidner et al. Cancer Letters 588 (2024) 216783 5-bisphosphate (PI(3,5)P2) at the 3′-position [18]. ..

    Plasmid Preparation:

    Article Title: Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction.
    Article Snippet: .. Overall, MTMs are membrane-bound and dephosphorylate phosphatidyl-inositol-3-monophosphate (PI(3)P) and − 3, Abbreviations aa amino acid Ab antibody AKT protein kinase B APC adenomatous polyposis coli CC coiled coil CD circular dichroism CEA carcinoembryonic antigen CRC colorectal cancer EGF(R) epidermal growth factor (receptor) ERK1/2 extracellular signal-regulated kinase-1/2 EV empty vector FCS fetal calf serum FFPE formalin-fixed-paraffin-embedded FI fluorescence intensity FL full-length FOS FBJ murine osteosarcoma viral oncogene homologue GAP GTPase activating protein GD globular domain GDS guanine nucleotide dissociation factor GEF guanine nucleotide exchange factor GFP green fluorescence protein GI gastrointestinal H&E haematoxylin&eosin HSP90 heat shock protein 90 HCS catalytical site (MTMs) HVR hypervariable region IB immunoblotting IF immunofluorescence IHC immunohistochemistry Ins(1,3)P2 inositol-1,3-bisphosphate KCA3.1 calcium-activated potassium channel SK4 K-RAS Kirsten rat sarcoma viral oncogene homologue M7-CC514-554 recombinant MTMR7-CC mimicry protein MD molecular dynamics MEK1/2 mitogen-activated kinase kinase-1/2 MT synthetic MTMR7-CC mimicry peptide MTM myotubularin MTMR7 myotubularin-related-protein-7 MRI magnetic resonance imaging mTOR mechanistic target of rapamycin kinase NMR nuclear magnetic resonance OD optical density PET/CT positron emission tomography/computed tomography PH plextrin homology (domain) PI phosphatidyl-inositol PI3K phosphoinositide-3-kinase PI(3)P phosphatidyl-inositol-3-monophosphate PI(3,5)P2 phosphatidyl-inositol-3,5-bisphosphate PIP phosphoinositide PLC phospholipase C PS phosphatidylserine PTP protein tyrosine phosphatase RAF proto-oncogene serine/threonine-protein kinase RAB Ras-related protein RAL Ras-like proto-oncogene S6RP S6 ribosomal protein SC scrambled control peptide SCF subcellular fractionation SID SET-interaction domain SOS Son of Sevenless Homologue SRE serum-response element SV40 simian virus-40 t time TAg large T-antigen UT untreated (control) VC vehicle control WT wild-type P. Weidner et al. Cancer Letters 588 (2024) 216783 5-bisphosphate (PI(3,5)P2) at the 3′-position [18]. ..

    Formalin-fixed Paraffin-Embedded:

    Article Title: Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction.
    Article Snippet: .. Overall, MTMs are membrane-bound and dephosphorylate phosphatidyl-inositol-3-monophosphate (PI(3)P) and − 3, Abbreviations aa amino acid Ab antibody AKT protein kinase B APC adenomatous polyposis coli CC coiled coil CD circular dichroism CEA carcinoembryonic antigen CRC colorectal cancer EGF(R) epidermal growth factor (receptor) ERK1/2 extracellular signal-regulated kinase-1/2 EV empty vector FCS fetal calf serum FFPE formalin-fixed-paraffin-embedded FI fluorescence intensity FL full-length FOS FBJ murine osteosarcoma viral oncogene homologue GAP GTPase activating protein GD globular domain GDS guanine nucleotide dissociation factor GEF guanine nucleotide exchange factor GFP green fluorescence protein GI gastrointestinal H&E haematoxylin&eosin HSP90 heat shock protein 90 HCS catalytical site (MTMs) HVR hypervariable region IB immunoblotting IF immunofluorescence IHC immunohistochemistry Ins(1,3)P2 inositol-1,3-bisphosphate KCA3.1 calcium-activated potassium channel SK4 K-RAS Kirsten rat sarcoma viral oncogene homologue M7-CC514-554 recombinant MTMR7-CC mimicry protein MD molecular dynamics MEK1/2 mitogen-activated kinase kinase-1/2 MT synthetic MTMR7-CC mimicry peptide MTM myotubularin MTMR7 myotubularin-related-protein-7 MRI magnetic resonance imaging mTOR mechanistic target of rapamycin kinase NMR nuclear magnetic resonance OD optical density PET/CT positron emission tomography/computed tomography PH plextrin homology (domain) PI phosphatidyl-inositol PI3K phosphoinositide-3-kinase PI(3)P phosphatidyl-inositol-3-monophosphate PI(3,5)P2 phosphatidyl-inositol-3,5-bisphosphate PIP phosphoinositide PLC phospholipase C PS phosphatidylserine PTP protein tyrosine phosphatase RAF proto-oncogene serine/threonine-protein kinase RAB Ras-related protein RAL Ras-like proto-oncogene S6RP S6 ribosomal protein SC scrambled control peptide SCF subcellular fractionation SID SET-interaction domain SOS Son of Sevenless Homologue SRE serum-response element SV40 simian virus-40 t time TAg large T-antigen UT untreated (control) VC vehicle control WT wild-type P. Weidner et al. Cancer Letters 588 (2024) 216783 5-bisphosphate (PI(3,5)P2) at the 3′-position [18]. ..

    Fluorescence:

    Article Title: Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction.
    Article Snippet: .. Overall, MTMs are membrane-bound and dephosphorylate phosphatidyl-inositol-3-monophosphate (PI(3)P) and − 3, Abbreviations aa amino acid Ab antibody AKT protein kinase B APC adenomatous polyposis coli CC coiled coil CD circular dichroism CEA carcinoembryonic antigen CRC colorectal cancer EGF(R) epidermal growth factor (receptor) ERK1/2 extracellular signal-regulated kinase-1/2 EV empty vector FCS fetal calf serum FFPE formalin-fixed-paraffin-embedded FI fluorescence intensity FL full-length FOS FBJ murine osteosarcoma viral oncogene homologue GAP GTPase activating protein GD globular domain GDS guanine nucleotide dissociation factor GEF guanine nucleotide exchange factor GFP green fluorescence protein GI gastrointestinal H&E haematoxylin&eosin HSP90 heat shock protein 90 HCS catalytical site (MTMs) HVR hypervariable region IB immunoblotting IF immunofluorescence IHC immunohistochemistry Ins(1,3)P2 inositol-1,3-bisphosphate KCA3.1 calcium-activated potassium channel SK4 K-RAS Kirsten rat sarcoma viral oncogene homologue M7-CC514-554 recombinant MTMR7-CC mimicry protein MD molecular dynamics MEK1/2 mitogen-activated kinase kinase-1/2 MT synthetic MTMR7-CC mimicry peptide MTM myotubularin MTMR7 myotubularin-related-protein-7 MRI magnetic resonance imaging mTOR mechanistic target of rapamycin kinase NMR nuclear magnetic resonance OD optical density PET/CT positron emission tomography/computed tomography PH plextrin homology (domain) PI phosphatidyl-inositol PI3K phosphoinositide-3-kinase PI(3)P phosphatidyl-inositol-3-monophosphate PI(3,5)P2 phosphatidyl-inositol-3,5-bisphosphate PIP phosphoinositide PLC phospholipase C PS phosphatidylserine PTP protein tyrosine phosphatase RAF proto-oncogene serine/threonine-protein kinase RAB Ras-related protein RAL Ras-like proto-oncogene S6RP S6 ribosomal protein SC scrambled control peptide SCF subcellular fractionation SID SET-interaction domain SOS Son of Sevenless Homologue SRE serum-response element SV40 simian virus-40 t time TAg large T-antigen UT untreated (control) VC vehicle control WT wild-type P. Weidner et al. Cancer Letters 588 (2024) 216783 5-bisphosphate (PI(3,5)P2) at the 3′-position [18]. ..

    Western Blot:

    Article Title: Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction.
    Article Snippet: .. Overall, MTMs are membrane-bound and dephosphorylate phosphatidyl-inositol-3-monophosphate (PI(3)P) and − 3, Abbreviations aa amino acid Ab antibody AKT protein kinase B APC adenomatous polyposis coli CC coiled coil CD circular dichroism CEA carcinoembryonic antigen CRC colorectal cancer EGF(R) epidermal growth factor (receptor) ERK1/2 extracellular signal-regulated kinase-1/2 EV empty vector FCS fetal calf serum FFPE formalin-fixed-paraffin-embedded FI fluorescence intensity FL full-length FOS FBJ murine osteosarcoma viral oncogene homologue GAP GTPase activating protein GD globular domain GDS guanine nucleotide dissociation factor GEF guanine nucleotide exchange factor GFP green fluorescence protein GI gastrointestinal H&E haematoxylin&eosin HSP90 heat shock protein 90 HCS catalytical site (MTMs) HVR hypervariable region IB immunoblotting IF immunofluorescence IHC immunohistochemistry Ins(1,3)P2 inositol-1,3-bisphosphate KCA3.1 calcium-activated potassium channel SK4 K-RAS Kirsten rat sarcoma viral oncogene homologue M7-CC514-554 recombinant MTMR7-CC mimicry protein MD molecular dynamics MEK1/2 mitogen-activated kinase kinase-1/2 MT synthetic MTMR7-CC mimicry peptide MTM myotubularin MTMR7 myotubularin-related-protein-7 MRI magnetic resonance imaging mTOR mechanistic target of rapamycin kinase NMR nuclear magnetic resonance OD optical density PET/CT positron emission tomography/computed tomography PH plextrin homology (domain) PI phosphatidyl-inositol PI3K phosphoinositide-3-kinase PI(3)P phosphatidyl-inositol-3-monophosphate PI(3,5)P2 phosphatidyl-inositol-3,5-bisphosphate PIP phosphoinositide PLC phospholipase C PS phosphatidylserine PTP protein tyrosine phosphatase RAF proto-oncogene serine/threonine-protein kinase RAB Ras-related protein RAL Ras-like proto-oncogene S6RP S6 ribosomal protein SC scrambled control peptide SCF subcellular fractionation SID SET-interaction domain SOS Son of Sevenless Homologue SRE serum-response element SV40 simian virus-40 t time TAg large T-antigen UT untreated (control) VC vehicle control WT wild-type P. Weidner et al. Cancer Letters 588 (2024) 216783 5-bisphosphate (PI(3,5)P2) at the 3′-position [18]. ..

    Article Title: The Protective Effects and Material Basis of Astragalus membranaceus in the Prevention and Treatment of Radiation-Induced Lung Injury via Modulation of the Keap1-Nrf2 Signaling Pathway.
    Article Snippet: This is a PDF of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability.. This version will undergo additional copyediting, typesetting and review before it is published in its final form.. As such, this version is no longer the Accepted Manuscript, but it is not yet the definitive Version of Record; we are providing this early version to give early visibility of the article.

    Immunofluorescence:

    Article Title: Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction.
    Article Snippet: .. Overall, MTMs are membrane-bound and dephosphorylate phosphatidyl-inositol-3-monophosphate (PI(3)P) and − 3, Abbreviations aa amino acid Ab antibody AKT protein kinase B APC adenomatous polyposis coli CC coiled coil CD circular dichroism CEA carcinoembryonic antigen CRC colorectal cancer EGF(R) epidermal growth factor (receptor) ERK1/2 extracellular signal-regulated kinase-1/2 EV empty vector FCS fetal calf serum FFPE formalin-fixed-paraffin-embedded FI fluorescence intensity FL full-length FOS FBJ murine osteosarcoma viral oncogene homologue GAP GTPase activating protein GD globular domain GDS guanine nucleotide dissociation factor GEF guanine nucleotide exchange factor GFP green fluorescence protein GI gastrointestinal H&E haematoxylin&eosin HSP90 heat shock protein 90 HCS catalytical site (MTMs) HVR hypervariable region IB immunoblotting IF immunofluorescence IHC immunohistochemistry Ins(1,3)P2 inositol-1,3-bisphosphate KCA3.1 calcium-activated potassium channel SK4 K-RAS Kirsten rat sarcoma viral oncogene homologue M7-CC514-554 recombinant MTMR7-CC mimicry protein MD molecular dynamics MEK1/2 mitogen-activated kinase kinase-1/2 MT synthetic MTMR7-CC mimicry peptide MTM myotubularin MTMR7 myotubularin-related-protein-7 MRI magnetic resonance imaging mTOR mechanistic target of rapamycin kinase NMR nuclear magnetic resonance OD optical density PET/CT positron emission tomography/computed tomography PH plextrin homology (domain) PI phosphatidyl-inositol PI3K phosphoinositide-3-kinase PI(3)P phosphatidyl-inositol-3-monophosphate PI(3,5)P2 phosphatidyl-inositol-3,5-bisphosphate PIP phosphoinositide PLC phospholipase C PS phosphatidylserine PTP protein tyrosine phosphatase RAF proto-oncogene serine/threonine-protein kinase RAB Ras-related protein RAL Ras-like proto-oncogene S6RP S6 ribosomal protein SC scrambled control peptide SCF subcellular fractionation SID SET-interaction domain SOS Son of Sevenless Homologue SRE serum-response element SV40 simian virus-40 t time TAg large T-antigen UT untreated (control) VC vehicle control WT wild-type P. Weidner et al. Cancer Letters 588 (2024) 216783 5-bisphosphate (PI(3,5)P2) at the 3′-position [18]. ..

    Article Title: Specnuezhenide Attenuates Rheumatoid Arthritis Bone Destruction via Dual Regulation of Osteoclast-Osteoblast Balance through KEAP1/NRF2 Signaling
    Article Snippet: This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record.. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article.. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

    Immunohistochemistry:

    Article Title: Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction.
    Article Snippet: .. Overall, MTMs are membrane-bound and dephosphorylate phosphatidyl-inositol-3-monophosphate (PI(3)P) and − 3, Abbreviations aa amino acid Ab antibody AKT protein kinase B APC adenomatous polyposis coli CC coiled coil CD circular dichroism CEA carcinoembryonic antigen CRC colorectal cancer EGF(R) epidermal growth factor (receptor) ERK1/2 extracellular signal-regulated kinase-1/2 EV empty vector FCS fetal calf serum FFPE formalin-fixed-paraffin-embedded FI fluorescence intensity FL full-length FOS FBJ murine osteosarcoma viral oncogene homologue GAP GTPase activating protein GD globular domain GDS guanine nucleotide dissociation factor GEF guanine nucleotide exchange factor GFP green fluorescence protein GI gastrointestinal H&E haematoxylin&eosin HSP90 heat shock protein 90 HCS catalytical site (MTMs) HVR hypervariable region IB immunoblotting IF immunofluorescence IHC immunohistochemistry Ins(1,3)P2 inositol-1,3-bisphosphate KCA3.1 calcium-activated potassium channel SK4 K-RAS Kirsten rat sarcoma viral oncogene homologue M7-CC514-554 recombinant MTMR7-CC mimicry protein MD molecular dynamics MEK1/2 mitogen-activated kinase kinase-1/2 MT synthetic MTMR7-CC mimicry peptide MTM myotubularin MTMR7 myotubularin-related-protein-7 MRI magnetic resonance imaging mTOR mechanistic target of rapamycin kinase NMR nuclear magnetic resonance OD optical density PET/CT positron emission tomography/computed tomography PH plextrin homology (domain) PI phosphatidyl-inositol PI3K phosphoinositide-3-kinase PI(3)P phosphatidyl-inositol-3-monophosphate PI(3,5)P2 phosphatidyl-inositol-3,5-bisphosphate PIP phosphoinositide PLC phospholipase C PS phosphatidylserine PTP protein tyrosine phosphatase RAF proto-oncogene serine/threonine-protein kinase RAB Ras-related protein RAL Ras-like proto-oncogene S6RP S6 ribosomal protein SC scrambled control peptide SCF subcellular fractionation SID SET-interaction domain SOS Son of Sevenless Homologue SRE serum-response element SV40 simian virus-40 t time TAg large T-antigen UT untreated (control) VC vehicle control WT wild-type P. Weidner et al. Cancer Letters 588 (2024) 216783 5-bisphosphate (PI(3,5)P2) at the 3′-position [18]. ..

    Article Title: The Protective Effects and Material Basis of Astragalus membranaceus in the Prevention and Treatment of Radiation-Induced Lung Injury via Modulation of the Keap1-Nrf2 Signaling Pathway.
    Article Snippet: This is a PDF of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability.. This version will undergo additional copyediting, typesetting and review before it is published in its final form.. As such, this version is no longer the Accepted Manuscript, but it is not yet the definitive Version of Record; we are providing this early version to give early visibility of the article.

    Recombinant:

    Article Title: Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction.
    Article Snippet: .. Overall, MTMs are membrane-bound and dephosphorylate phosphatidyl-inositol-3-monophosphate (PI(3)P) and − 3, Abbreviations aa amino acid Ab antibody AKT protein kinase B APC adenomatous polyposis coli CC coiled coil CD circular dichroism CEA carcinoembryonic antigen CRC colorectal cancer EGF(R) epidermal growth factor (receptor) ERK1/2 extracellular signal-regulated kinase-1/2 EV empty vector FCS fetal calf serum FFPE formalin-fixed-paraffin-embedded FI fluorescence intensity FL full-length FOS FBJ murine osteosarcoma viral oncogene homologue GAP GTPase activating protein GD globular domain GDS guanine nucleotide dissociation factor GEF guanine nucleotide exchange factor GFP green fluorescence protein GI gastrointestinal H&E haematoxylin&eosin HSP90 heat shock protein 90 HCS catalytical site (MTMs) HVR hypervariable region IB immunoblotting IF immunofluorescence IHC immunohistochemistry Ins(1,3)P2 inositol-1,3-bisphosphate KCA3.1 calcium-activated potassium channel SK4 K-RAS Kirsten rat sarcoma viral oncogene homologue M7-CC514-554 recombinant MTMR7-CC mimicry protein MD molecular dynamics MEK1/2 mitogen-activated kinase kinase-1/2 MT synthetic MTMR7-CC mimicry peptide MTM myotubularin MTMR7 myotubularin-related-protein-7 MRI magnetic resonance imaging mTOR mechanistic target of rapamycin kinase NMR nuclear magnetic resonance OD optical density PET/CT positron emission tomography/computed tomography PH plextrin homology (domain) PI phosphatidyl-inositol PI3K phosphoinositide-3-kinase PI(3)P phosphatidyl-inositol-3-monophosphate PI(3,5)P2 phosphatidyl-inositol-3,5-bisphosphate PIP phosphoinositide PLC phospholipase C PS phosphatidylserine PTP protein tyrosine phosphatase RAF proto-oncogene serine/threonine-protein kinase RAB Ras-related protein RAL Ras-like proto-oncogene S6RP S6 ribosomal protein SC scrambled control peptide SCF subcellular fractionation SID SET-interaction domain SOS Son of Sevenless Homologue SRE serum-response element SV40 simian virus-40 t time TAg large T-antigen UT untreated (control) VC vehicle control WT wild-type P. Weidner et al. Cancer Letters 588 (2024) 216783 5-bisphosphate (PI(3,5)P2) at the 3′-position [18]. ..

    Magnetic Resonance Imaging:

    Article Title: Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction.
    Article Snippet: .. Overall, MTMs are membrane-bound and dephosphorylate phosphatidyl-inositol-3-monophosphate (PI(3)P) and − 3, Abbreviations aa amino acid Ab antibody AKT protein kinase B APC adenomatous polyposis coli CC coiled coil CD circular dichroism CEA carcinoembryonic antigen CRC colorectal cancer EGF(R) epidermal growth factor (receptor) ERK1/2 extracellular signal-regulated kinase-1/2 EV empty vector FCS fetal calf serum FFPE formalin-fixed-paraffin-embedded FI fluorescence intensity FL full-length FOS FBJ murine osteosarcoma viral oncogene homologue GAP GTPase activating protein GD globular domain GDS guanine nucleotide dissociation factor GEF guanine nucleotide exchange factor GFP green fluorescence protein GI gastrointestinal H&E haematoxylin&eosin HSP90 heat shock protein 90 HCS catalytical site (MTMs) HVR hypervariable region IB immunoblotting IF immunofluorescence IHC immunohistochemistry Ins(1,3)P2 inositol-1,3-bisphosphate KCA3.1 calcium-activated potassium channel SK4 K-RAS Kirsten rat sarcoma viral oncogene homologue M7-CC514-554 recombinant MTMR7-CC mimicry protein MD molecular dynamics MEK1/2 mitogen-activated kinase kinase-1/2 MT synthetic MTMR7-CC mimicry peptide MTM myotubularin MTMR7 myotubularin-related-protein-7 MRI magnetic resonance imaging mTOR mechanistic target of rapamycin kinase NMR nuclear magnetic resonance OD optical density PET/CT positron emission tomography/computed tomography PH plextrin homology (domain) PI phosphatidyl-inositol PI3K phosphoinositide-3-kinase PI(3)P phosphatidyl-inositol-3-monophosphate PI(3,5)P2 phosphatidyl-inositol-3,5-bisphosphate PIP phosphoinositide PLC phospholipase C PS phosphatidylserine PTP protein tyrosine phosphatase RAF proto-oncogene serine/threonine-protein kinase RAB Ras-related protein RAL Ras-like proto-oncogene S6RP S6 ribosomal protein SC scrambled control peptide SCF subcellular fractionation SID SET-interaction domain SOS Son of Sevenless Homologue SRE serum-response element SV40 simian virus-40 t time TAg large T-antigen UT untreated (control) VC vehicle control WT wild-type P. Weidner et al. Cancer Letters 588 (2024) 216783 5-bisphosphate (PI(3,5)P2) at the 3′-position [18]. ..

    Positron Emission Tomography-Computed Tomography:

    Article Title: Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction.
    Article Snippet: .. Overall, MTMs are membrane-bound and dephosphorylate phosphatidyl-inositol-3-monophosphate (PI(3)P) and − 3, Abbreviations aa amino acid Ab antibody AKT protein kinase B APC adenomatous polyposis coli CC coiled coil CD circular dichroism CEA carcinoembryonic antigen CRC colorectal cancer EGF(R) epidermal growth factor (receptor) ERK1/2 extracellular signal-regulated kinase-1/2 EV empty vector FCS fetal calf serum FFPE formalin-fixed-paraffin-embedded FI fluorescence intensity FL full-length FOS FBJ murine osteosarcoma viral oncogene homologue GAP GTPase activating protein GD globular domain GDS guanine nucleotide dissociation factor GEF guanine nucleotide exchange factor GFP green fluorescence protein GI gastrointestinal H&E haematoxylin&eosin HSP90 heat shock protein 90 HCS catalytical site (MTMs) HVR hypervariable region IB immunoblotting IF immunofluorescence IHC immunohistochemistry Ins(1,3)P2 inositol-1,3-bisphosphate KCA3.1 calcium-activated potassium channel SK4 K-RAS Kirsten rat sarcoma viral oncogene homologue M7-CC514-554 recombinant MTMR7-CC mimicry protein MD molecular dynamics MEK1/2 mitogen-activated kinase kinase-1/2 MT synthetic MTMR7-CC mimicry peptide MTM myotubularin MTMR7 myotubularin-related-protein-7 MRI magnetic resonance imaging mTOR mechanistic target of rapamycin kinase NMR nuclear magnetic resonance OD optical density PET/CT positron emission tomography/computed tomography PH plextrin homology (domain) PI phosphatidyl-inositol PI3K phosphoinositide-3-kinase PI(3)P phosphatidyl-inositol-3-monophosphate PI(3,5)P2 phosphatidyl-inositol-3,5-bisphosphate PIP phosphoinositide PLC phospholipase C PS phosphatidylserine PTP protein tyrosine phosphatase RAF proto-oncogene serine/threonine-protein kinase RAB Ras-related protein RAL Ras-like proto-oncogene S6RP S6 ribosomal protein SC scrambled control peptide SCF subcellular fractionation SID SET-interaction domain SOS Son of Sevenless Homologue SRE serum-response element SV40 simian virus-40 t time TAg large T-antigen UT untreated (control) VC vehicle control WT wild-type P. Weidner et al. Cancer Letters 588 (2024) 216783 5-bisphosphate (PI(3,5)P2) at the 3′-position [18]. ..

    Tomography:

    Article Title: Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction.
    Article Snippet: .. Overall, MTMs are membrane-bound and dephosphorylate phosphatidyl-inositol-3-monophosphate (PI(3)P) and − 3, Abbreviations aa amino acid Ab antibody AKT protein kinase B APC adenomatous polyposis coli CC coiled coil CD circular dichroism CEA carcinoembryonic antigen CRC colorectal cancer EGF(R) epidermal growth factor (receptor) ERK1/2 extracellular signal-regulated kinase-1/2 EV empty vector FCS fetal calf serum FFPE formalin-fixed-paraffin-embedded FI fluorescence intensity FL full-length FOS FBJ murine osteosarcoma viral oncogene homologue GAP GTPase activating protein GD globular domain GDS guanine nucleotide dissociation factor GEF guanine nucleotide exchange factor GFP green fluorescence protein GI gastrointestinal H&E haematoxylin&eosin HSP90 heat shock protein 90 HCS catalytical site (MTMs) HVR hypervariable region IB immunoblotting IF immunofluorescence IHC immunohistochemistry Ins(1,3)P2 inositol-1,3-bisphosphate KCA3.1 calcium-activated potassium channel SK4 K-RAS Kirsten rat sarcoma viral oncogene homologue M7-CC514-554 recombinant MTMR7-CC mimicry protein MD molecular dynamics MEK1/2 mitogen-activated kinase kinase-1/2 MT synthetic MTMR7-CC mimicry peptide MTM myotubularin MTMR7 myotubularin-related-protein-7 MRI magnetic resonance imaging mTOR mechanistic target of rapamycin kinase NMR nuclear magnetic resonance OD optical density PET/CT positron emission tomography/computed tomography PH plextrin homology (domain) PI phosphatidyl-inositol PI3K phosphoinositide-3-kinase PI(3)P phosphatidyl-inositol-3-monophosphate PI(3,5)P2 phosphatidyl-inositol-3,5-bisphosphate PIP phosphoinositide PLC phospholipase C PS phosphatidylserine PTP protein tyrosine phosphatase RAF proto-oncogene serine/threonine-protein kinase RAB Ras-related protein RAL Ras-like proto-oncogene S6RP S6 ribosomal protein SC scrambled control peptide SCF subcellular fractionation SID SET-interaction domain SOS Son of Sevenless Homologue SRE serum-response element SV40 simian virus-40 t time TAg large T-antigen UT untreated (control) VC vehicle control WT wild-type P. Weidner et al. Cancer Letters 588 (2024) 216783 5-bisphosphate (PI(3,5)P2) at the 3′-position [18]. ..

    Article Title: The Protective Effects and Material Basis of Astragalus membranaceus in the Prevention and Treatment of Radiation-Induced Lung Injury via Modulation of the Keap1-Nrf2 Signaling Pathway.
    Article Snippet: This is a PDF of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability.. This version will undergo additional copyediting, typesetting and review before it is published in its final form.. As such, this version is no longer the Accepted Manuscript, but it is not yet the definitive Version of Record; we are providing this early version to give early visibility of the article.

    Planar Chromatography:

    Article Title: Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction.
    Article Snippet: .. Overall, MTMs are membrane-bound and dephosphorylate phosphatidyl-inositol-3-monophosphate (PI(3)P) and − 3, Abbreviations aa amino acid Ab antibody AKT protein kinase B APC adenomatous polyposis coli CC coiled coil CD circular dichroism CEA carcinoembryonic antigen CRC colorectal cancer EGF(R) epidermal growth factor (receptor) ERK1/2 extracellular signal-regulated kinase-1/2 EV empty vector FCS fetal calf serum FFPE formalin-fixed-paraffin-embedded FI fluorescence intensity FL full-length FOS FBJ murine osteosarcoma viral oncogene homologue GAP GTPase activating protein GD globular domain GDS guanine nucleotide dissociation factor GEF guanine nucleotide exchange factor GFP green fluorescence protein GI gastrointestinal H&E haematoxylin&eosin HSP90 heat shock protein 90 HCS catalytical site (MTMs) HVR hypervariable region IB immunoblotting IF immunofluorescence IHC immunohistochemistry Ins(1,3)P2 inositol-1,3-bisphosphate KCA3.1 calcium-activated potassium channel SK4 K-RAS Kirsten rat sarcoma viral oncogene homologue M7-CC514-554 recombinant MTMR7-CC mimicry protein MD molecular dynamics MEK1/2 mitogen-activated kinase kinase-1/2 MT synthetic MTMR7-CC mimicry peptide MTM myotubularin MTMR7 myotubularin-related-protein-7 MRI magnetic resonance imaging mTOR mechanistic target of rapamycin kinase NMR nuclear magnetic resonance OD optical density PET/CT positron emission tomography/computed tomography PH plextrin homology (domain) PI phosphatidyl-inositol PI3K phosphoinositide-3-kinase PI(3)P phosphatidyl-inositol-3-monophosphate PI(3,5)P2 phosphatidyl-inositol-3,5-bisphosphate PIP phosphoinositide PLC phospholipase C PS phosphatidylserine PTP protein tyrosine phosphatase RAF proto-oncogene serine/threonine-protein kinase RAB Ras-related protein RAL Ras-like proto-oncogene S6RP S6 ribosomal protein SC scrambled control peptide SCF subcellular fractionation SID SET-interaction domain SOS Son of Sevenless Homologue SRE serum-response element SV40 simian virus-40 t time TAg large T-antigen UT untreated (control) VC vehicle control WT wild-type P. Weidner et al. Cancer Letters 588 (2024) 216783 5-bisphosphate (PI(3,5)P2) at the 3′-position [18]. ..

    Control:

    Article Title: Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction.
    Article Snippet: .. Overall, MTMs are membrane-bound and dephosphorylate phosphatidyl-inositol-3-monophosphate (PI(3)P) and − 3, Abbreviations aa amino acid Ab antibody AKT protein kinase B APC adenomatous polyposis coli CC coiled coil CD circular dichroism CEA carcinoembryonic antigen CRC colorectal cancer EGF(R) epidermal growth factor (receptor) ERK1/2 extracellular signal-regulated kinase-1/2 EV empty vector FCS fetal calf serum FFPE formalin-fixed-paraffin-embedded FI fluorescence intensity FL full-length FOS FBJ murine osteosarcoma viral oncogene homologue GAP GTPase activating protein GD globular domain GDS guanine nucleotide dissociation factor GEF guanine nucleotide exchange factor GFP green fluorescence protein GI gastrointestinal H&E haematoxylin&eosin HSP90 heat shock protein 90 HCS catalytical site (MTMs) HVR hypervariable region IB immunoblotting IF immunofluorescence IHC immunohistochemistry Ins(1,3)P2 inositol-1,3-bisphosphate KCA3.1 calcium-activated potassium channel SK4 K-RAS Kirsten rat sarcoma viral oncogene homologue M7-CC514-554 recombinant MTMR7-CC mimicry protein MD molecular dynamics MEK1/2 mitogen-activated kinase kinase-1/2 MT synthetic MTMR7-CC mimicry peptide MTM myotubularin MTMR7 myotubularin-related-protein-7 MRI magnetic resonance imaging mTOR mechanistic target of rapamycin kinase NMR nuclear magnetic resonance OD optical density PET/CT positron emission tomography/computed tomography PH plextrin homology (domain) PI phosphatidyl-inositol PI3K phosphoinositide-3-kinase PI(3)P phosphatidyl-inositol-3-monophosphate PI(3,5)P2 phosphatidyl-inositol-3,5-bisphosphate PIP phosphoinositide PLC phospholipase C PS phosphatidylserine PTP protein tyrosine phosphatase RAF proto-oncogene serine/threonine-protein kinase RAB Ras-related protein RAL Ras-like proto-oncogene S6RP S6 ribosomal protein SC scrambled control peptide SCF subcellular fractionation SID SET-interaction domain SOS Son of Sevenless Homologue SRE serum-response element SV40 simian virus-40 t time TAg large T-antigen UT untreated (control) VC vehicle control WT wild-type P. Weidner et al. Cancer Letters 588 (2024) 216783 5-bisphosphate (PI(3,5)P2) at the 3′-position [18]. ..

    Fractionation:

    Article Title: Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction.
    Article Snippet: .. Overall, MTMs are membrane-bound and dephosphorylate phosphatidyl-inositol-3-monophosphate (PI(3)P) and − 3, Abbreviations aa amino acid Ab antibody AKT protein kinase B APC adenomatous polyposis coli CC coiled coil CD circular dichroism CEA carcinoembryonic antigen CRC colorectal cancer EGF(R) epidermal growth factor (receptor) ERK1/2 extracellular signal-regulated kinase-1/2 EV empty vector FCS fetal calf serum FFPE formalin-fixed-paraffin-embedded FI fluorescence intensity FL full-length FOS FBJ murine osteosarcoma viral oncogene homologue GAP GTPase activating protein GD globular domain GDS guanine nucleotide dissociation factor GEF guanine nucleotide exchange factor GFP green fluorescence protein GI gastrointestinal H&E haematoxylin&eosin HSP90 heat shock protein 90 HCS catalytical site (MTMs) HVR hypervariable region IB immunoblotting IF immunofluorescence IHC immunohistochemistry Ins(1,3)P2 inositol-1,3-bisphosphate KCA3.1 calcium-activated potassium channel SK4 K-RAS Kirsten rat sarcoma viral oncogene homologue M7-CC514-554 recombinant MTMR7-CC mimicry protein MD molecular dynamics MEK1/2 mitogen-activated kinase kinase-1/2 MT synthetic MTMR7-CC mimicry peptide MTM myotubularin MTMR7 myotubularin-related-protein-7 MRI magnetic resonance imaging mTOR mechanistic target of rapamycin kinase NMR nuclear magnetic resonance OD optical density PET/CT positron emission tomography/computed tomography PH plextrin homology (domain) PI phosphatidyl-inositol PI3K phosphoinositide-3-kinase PI(3)P phosphatidyl-inositol-3-monophosphate PI(3,5)P2 phosphatidyl-inositol-3,5-bisphosphate PIP phosphoinositide PLC phospholipase C PS phosphatidylserine PTP protein tyrosine phosphatase RAF proto-oncogene serine/threonine-protein kinase RAB Ras-related protein RAL Ras-like proto-oncogene S6RP S6 ribosomal protein SC scrambled control peptide SCF subcellular fractionation SID SET-interaction domain SOS Son of Sevenless Homologue SRE serum-response element SV40 simian virus-40 t time TAg large T-antigen UT untreated (control) VC vehicle control WT wild-type P. Weidner et al. Cancer Letters 588 (2024) 216783 5-bisphosphate (PI(3,5)P2) at the 3′-position [18]. ..

    Virus:

    Article Title: Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction.
    Article Snippet: .. Overall, MTMs are membrane-bound and dephosphorylate phosphatidyl-inositol-3-monophosphate (PI(3)P) and − 3, Abbreviations aa amino acid Ab antibody AKT protein kinase B APC adenomatous polyposis coli CC coiled coil CD circular dichroism CEA carcinoembryonic antigen CRC colorectal cancer EGF(R) epidermal growth factor (receptor) ERK1/2 extracellular signal-regulated kinase-1/2 EV empty vector FCS fetal calf serum FFPE formalin-fixed-paraffin-embedded FI fluorescence intensity FL full-length FOS FBJ murine osteosarcoma viral oncogene homologue GAP GTPase activating protein GD globular domain GDS guanine nucleotide dissociation factor GEF guanine nucleotide exchange factor GFP green fluorescence protein GI gastrointestinal H&E haematoxylin&eosin HSP90 heat shock protein 90 HCS catalytical site (MTMs) HVR hypervariable region IB immunoblotting IF immunofluorescence IHC immunohistochemistry Ins(1,3)P2 inositol-1,3-bisphosphate KCA3.1 calcium-activated potassium channel SK4 K-RAS Kirsten rat sarcoma viral oncogene homologue M7-CC514-554 recombinant MTMR7-CC mimicry protein MD molecular dynamics MEK1/2 mitogen-activated kinase kinase-1/2 MT synthetic MTMR7-CC mimicry peptide MTM myotubularin MTMR7 myotubularin-related-protein-7 MRI magnetic resonance imaging mTOR mechanistic target of rapamycin kinase NMR nuclear magnetic resonance OD optical density PET/CT positron emission tomography/computed tomography PH plextrin homology (domain) PI phosphatidyl-inositol PI3K phosphoinositide-3-kinase PI(3)P phosphatidyl-inositol-3-monophosphate PI(3,5)P2 phosphatidyl-inositol-3,5-bisphosphate PIP phosphoinositide PLC phospholipase C PS phosphatidylserine PTP protein tyrosine phosphatase RAF proto-oncogene serine/threonine-protein kinase RAB Ras-related protein RAL Ras-like proto-oncogene S6RP S6 ribosomal protein SC scrambled control peptide SCF subcellular fractionation SID SET-interaction domain SOS Son of Sevenless Homologue SRE serum-response element SV40 simian virus-40 t time TAg large T-antigen UT untreated (control) VC vehicle control WT wild-type P. Weidner et al. Cancer Letters 588 (2024) 216783 5-bisphosphate (PI(3,5)P2) at the 3′-position [18]. ..

    Article Title: Unravelling the dynamics of the maturation protein in MS2 bacteriophage via molecular simulations.
    Article Snippet: Keywords MS2 bacteriophage, Maturation protein, Molecular dynamics simulations, Viral infectivity, Protein dynamics, Capsid stability, Ion interactions .. MD Molecular dynamics CP Capsid protein MP Maturation protein MS2 bacteriophage is a small, icosahedral, non-enveloped, single-stranded RNA (+ ssRNA) virus that infects Gram-negative bacteria, particularly Escherichia coli. ..

    other:

    Article Title: Rigorous expressions for thermodynamic properties in the <i>NpH</i> ensemble
    Article Snippet: Molecular expressions for thermodynamic properties of fluids and derivatives of the entropy up to third order in the isoenthalpic-isobaric ensemble are derived by using the methodology developed by Lustig for the microcanonical and canonical ensembles [J. Chem.. Phys.. 100, 3048 (1994); Mol.

    Thermal Shift Assay:

    Article Title: Specnuezhenide Attenuates Rheumatoid Arthritis Bone Destruction via Dual Regulation of Osteoclast-Osteoblast Balance through KEAP1/NRF2 Signaling
    Article Snippet: This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record.. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article.. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

    Adjuvant:

    Article Title: Specnuezhenide Attenuates Rheumatoid Arthritis Bone Destruction via Dual Regulation of Osteoclast-Osteoblast Balance through KEAP1/NRF2 Signaling
    Article Snippet: This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record.. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article.. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

    Micro-CT:

    Article Title: Specnuezhenide Attenuates Rheumatoid Arthritis Bone Destruction via Dual Regulation of Osteoclast-Osteoblast Balance through KEAP1/NRF2 Signaling
    Article Snippet: This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record.. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article.. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

    Infection:

    Article Title: Specnuezhenide Attenuates Rheumatoid Arthritis Bone Destruction via Dual Regulation of Osteoclast-Osteoblast Balance through KEAP1/NRF2 Signaling
    Article Snippet: This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record.. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article.. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

    Solvent:

    Article Title: Specnuezhenide Attenuates Rheumatoid Arthritis Bone Destruction via Dual Regulation of Osteoclast-Osteoblast Balance through KEAP1/NRF2 Signaling
    Article Snippet: This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record.. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article.. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

    shRNA:

    Article Title: Specnuezhenide Attenuates Rheumatoid Arthritis Bone Destruction via Dual Regulation of Osteoclast-Osteoblast Balance through KEAP1/NRF2 Signaling
    Article Snippet: This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record.. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article.. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

    SPR Assay:

    Article Title: Specnuezhenide Attenuates Rheumatoid Arthritis Bone Destruction via Dual Regulation of Osteoclast-Osteoblast Balance through KEAP1/NRF2 Signaling
    Article Snippet: This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record.. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article.. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

    Bacteria:

    Article Title: Unravelling the dynamics of the maturation protein in MS2 bacteriophage via molecular simulations.
    Article Snippet: Keywords MS2 bacteriophage, Maturation protein, Molecular dynamics simulations, Viral infectivity, Protein dynamics, Capsid stability, Ion interactions .. MD Molecular dynamics CP Capsid protein MP Maturation protein MS2 bacteriophage is a small, icosahedral, non-enveloped, single-stranded RNA (+ ssRNA) virus that infects Gram-negative bacteria, particularly Escherichia coli. ..

    CCK-8 Assay:

    Article Title: AI and pharmacophore-based screening, molecular docking, and dynamic simulation for identification of CDK6 inhibitors to combat NSCLC.
    Article Snippet: The overactivated CDK6/Cyclin D3 complex is considered to be associated with poor prognosis in patients with NSCLC, thus developing CDK6/Cyclin D3 inhibitors is expected to provide new options for NSCLC patients.. This study successfully utilized a mixed virtual screening workflow based on artificial intelligence, pharmacophores, and docking to rapidly identify multiple CDK6/Cyclin D3 inhibitors from a compound library consisting of 12,563 compounds, achieving a hit rate of over 40% (2 out of 5 selected candidate compounds).. Among these, compound 2 exhibited the most potent CDK6/Cyclin D3 inhibitory activity, with an IC50 value of 38.6 nM, comparable to CDK6 inhibitors in clinical trial phases.

    Pyrolysis Gas Chromatography:

    Article Title: AI and pharmacophore-based screening, molecular docking, and dynamic simulation for identification of CDK6 inhibitors to combat NSCLC.
    Article Snippet: The overactivated CDK6/Cyclin D3 complex is considered to be associated with poor prognosis in patients with NSCLC, thus developing CDK6/Cyclin D3 inhibitors is expected to provide new options for NSCLC patients.. This study successfully utilized a mixed virtual screening workflow based on artificial intelligence, pharmacophores, and docking to rapidly identify multiple CDK6/Cyclin D3 inhibitors from a compound library consisting of 12,563 compounds, achieving a hit rate of over 40% (2 out of 5 selected candidate compounds).. Among these, compound 2 exhibited the most potent CDK6/Cyclin D3 inhibitory activity, with an IC50 value of 38.6 nM, comparable to CDK6 inhibitors in clinical trial phases.

    Molecular Weight:

    Article Title: AI and pharmacophore-based screening, molecular docking, and dynamic simulation for identification of CDK6 inhibitors to combat NSCLC.
    Article Snippet: The overactivated CDK6/Cyclin D3 complex is considered to be associated with poor prognosis in patients with NSCLC, thus developing CDK6/Cyclin D3 inhibitors is expected to provide new options for NSCLC patients.. This study successfully utilized a mixed virtual screening workflow based on artificial intelligence, pharmacophores, and docking to rapidly identify multiple CDK6/Cyclin D3 inhibitors from a compound library consisting of 12,563 compounds, achieving a hit rate of over 40% (2 out of 5 selected candidate compounds).. Among these, compound 2 exhibited the most potent CDK6/Cyclin D3 inhibitory activity, with an IC50 value of 38.6 nM, comparable to CDK6 inhibitors in clinical trial phases.

    Pan Assay:

    Article Title: AI and pharmacophore-based screening, molecular docking, and dynamic simulation for identification of CDK6 inhibitors to combat NSCLC.
    Article Snippet: The overactivated CDK6/Cyclin D3 complex is considered to be associated with poor prognosis in patients with NSCLC, thus developing CDK6/Cyclin D3 inhibitors is expected to provide new options for NSCLC patients.. This study successfully utilized a mixed virtual screening workflow based on artificial intelligence, pharmacophores, and docking to rapidly identify multiple CDK6/Cyclin D3 inhibitors from a compound library consisting of 12,563 compounds, achieving a hit rate of over 40% (2 out of 5 selected candidate compounds).. Among these, compound 2 exhibited the most potent CDK6/Cyclin D3 inhibitory activity, with an IC50 value of 38.6 nM, comparable to CDK6 inhibitors in clinical trial phases.

    Enzyme-linked Immunosorbent Assay:

    Article Title: The Protective Effects and Material Basis of Astragalus membranaceus in the Prevention and Treatment of Radiation-Induced Lung Injury via Modulation of the Keap1-Nrf2 Signaling Pathway.
    Article Snippet: This is a PDF of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability.. This version will undergo additional copyediting, typesetting and review before it is published in its final form.. As such, this version is no longer the Accepted Manuscript, but it is not yet the definitive Version of Record; we are providing this early version to give early visibility of the article.

    Quantitative RT-PCR:

    Article Title: The Protective Effects and Material Basis of Astragalus membranaceus in the Prevention and Treatment of Radiation-Induced Lung Injury via Modulation of the Keap1-Nrf2 Signaling Pathway.
    Article Snippet: This is a PDF of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability.. This version will undergo additional copyediting, typesetting and review before it is published in its final form.. As such, this version is no longer the Accepted Manuscript, but it is not yet the definitive Version of Record; we are providing this early version to give early visibility of the article.



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