Review



linear maleimide-functionalized poly(ethylene glycol) peg-mi  (JenKem Inc)

 
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 90
      Buy from Supplier

    Structured Review

    JenKem Inc linear maleimide-functionalized poly(ethylene glycol) peg-mi
    A) Reducing-microenvironment- or light-sensitive hydrogels were formed by reacting B) an aryl-thiol end <t>functionalized</t> poly(ethylene glycol) macromolecular precursor (PEG-4-MPA) or a photodegradable aryl-thiol end functionalized PEG (PEG-4-PD-MPA) with a <t>maleimide-end</t> functionalized PEG (PEG-2-MI) and a maleimide functionalized low molecular heparin (Heparin-MI) via a Michael-type reaction in an aqueous microenvironment. Low molecular weight proteins, such as growth factors (FGF-2 in the present study), cytokines, and immunomodulatory agents, can be incorporated within the hydrogel during network formation utilizing heparin-associated receptor-ligand interactions for protein retention. C) Aryl-thiol based succinimide thioether linkages exchange with free thiols in solution leading to the formation of a relatively stable alkyl-thiol (i.e., cysteine) based succinimide thioether linkage, resulting in hydrogel degradation. D) The photolabile o-nitrobenzyl moieties undergo irreversible photoisomerization in response to cytocompatible doses of long wavelength UV or visible light, yielding ketone and amide products.
    Linear Maleimide Functionalized Poly(ethylene Glycol) Peg Mi, supplied by JenKem Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/mi+function/linear+maleimide+functionalized+poly+ethylene+glycol++peg+mi/pmc05806702-373-13-26
    Average 90 stars, based on 1 article reviews
    linear maleimide-functionalized poly(ethylene glycol) peg-mi - by Bioz Stars, 2026-09
    90/100 stars

    Images

    1) Product Images from "Controlling the release of small, bioactive proteins via dual mechanisms with therapeutic potential"

    Article Title: Controlling the release of small, bioactive proteins via dual mechanisms with therapeutic potential

    Journal: Advanced healthcare materials

    doi: 10.1002/adhm.201700713

    A) Reducing-microenvironment- or light-sensitive hydrogels were formed by reacting B) an aryl-thiol end functionalized poly(ethylene glycol) macromolecular precursor (PEG-4-MPA) or a photodegradable aryl-thiol end functionalized PEG (PEG-4-PD-MPA) with a maleimide-end functionalized PEG (PEG-2-MI) and a maleimide functionalized low molecular heparin (Heparin-MI) via a Michael-type reaction in an aqueous microenvironment. Low molecular weight proteins, such as growth factors (FGF-2 in the present study), cytokines, and immunomodulatory agents, can be incorporated within the hydrogel during network formation utilizing heparin-associated receptor-ligand interactions for protein retention. C) Aryl-thiol based succinimide thioether linkages exchange with free thiols in solution leading to the formation of a relatively stable alkyl-thiol (i.e., cysteine) based succinimide thioether linkage, resulting in hydrogel degradation. D) The photolabile o-nitrobenzyl moieties undergo irreversible photoisomerization in response to cytocompatible doses of long wavelength UV or visible light, yielding ketone and amide products.
    Figure Legend Snippet: A) Reducing-microenvironment- or light-sensitive hydrogels were formed by reacting B) an aryl-thiol end functionalized poly(ethylene glycol) macromolecular precursor (PEG-4-MPA) or a photodegradable aryl-thiol end functionalized PEG (PEG-4-PD-MPA) with a maleimide-end functionalized PEG (PEG-2-MI) and a maleimide functionalized low molecular heparin (Heparin-MI) via a Michael-type reaction in an aqueous microenvironment. Low molecular weight proteins, such as growth factors (FGF-2 in the present study), cytokines, and immunomodulatory agents, can be incorporated within the hydrogel during network formation utilizing heparin-associated receptor-ligand interactions for protein retention. C) Aryl-thiol based succinimide thioether linkages exchange with free thiols in solution leading to the formation of a relatively stable alkyl-thiol (i.e., cysteine) based succinimide thioether linkage, resulting in hydrogel degradation. D) The photolabile o-nitrobenzyl moieties undergo irreversible photoisomerization in response to cytocompatible doses of long wavelength UV or visible light, yielding ketone and amide products.

    Techniques Used: Molecular Weight

    Related Articles

    Molecular Weight:

    Article Title: Controlling the release of small, bioactive proteins via dual mechanisms with therapeutic potential
    Article Snippet: 4-arm amine-functionalized poly(ethylene glycol) (PEG-4-NH 2 , M n ~ 10,000 g/mol) and linear maleimide-functionalized poly(ethylene glycol) (PEG-MI, M n ~ 5,000 g/mol) were purchased from JenKem Technology USA Inc. (Allen, TX).



    Similar Products

    version 18 0 mi function  (STATA Corporation)
    99
    STATA Corporation version 18 0 mi function
    Version 18 0 Mi Function, supplied by STATA Corporation, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/mi+function/STATA+1%2E0/pmc12922625-73-16-15
    Average 99 stars, based on 1 article reviews
    version 18 0 mi function - by Bioz Stars, 2026-09
    99/100 stars
    		  Buy from Supplier
    function mi imput mvn  (STATA Corporation)
    90
    STATA Corporation function mi imput mvn
    Function Mi Imput Mvn, supplied by STATA Corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/mi+function/function+mi+imput+mvn/pm40088116-133-23-22
    Average 90 stars, based on 1 article reviews
    function mi imput mvn - by Bioz Stars, 2026-09
    90/100 stars
    		  Buy from Supplier
    furan-protected maleimide-functionalized poly(ethylene glycol) (fu-mi-peg45-oh)  (Sinopeg Biotech Co Ltd)
    90
    Sinopeg Biotech Co Ltd furan-protected maleimide-functionalized poly(ethylene glycol) (fu-mi-peg45-oh)
    Furan Protected Maleimide Functionalized Poly(ethylene Glycol) (Fu Mi Peg45 Oh), supplied by Sinopeg Biotech Co Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/mi+function/furan+protected+maleimide+functionalized+poly+ethylene+glycol+++fu+mi+peg45+oh+/pm39780364__ja4c17178_si_001-2-27-35
    Average 90 stars, based on 1 article reviews
    furan-protected maleimide-functionalized poly(ethylene glycol) (fu-mi-peg45-oh) - by Bioz Stars, 2026-09
    90/100 stars
    		  Buy from Supplier
    proc mi function  (SAS institute)
    90
    SAS institute proc mi function
    Proc Mi Function, supplied by SAS institute, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/mi+function/proc+mi+function/pm39899474-136-12-16
    Average 90 stars, based on 1 article reviews
    proc mi function - by Bioz Stars, 2026-09
    90/100 stars
    		  Buy from Supplier
    function 'mi estimate  (STATA Corporation)
    90
    STATA Corporation function 'mi estimate
    Function 'Mi Estimate, supplied by STATA Corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/mi+function/command++mi+estimate/pmc11590615-184-9-7
    Average 90 stars, based on 1 article reviews
    function 'mi estimate - by Bioz Stars, 2026-09
    90/100 stars
    		  Buy from Supplier
    mi impute chained function in stata version 18.40  (STATA Corporation)
    90
    STATA Corporation mi impute chained function in stata version 18.40
    Mi Impute Chained Function In Stata Version 18.40, supplied by STATA Corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/mi+function/mi+impute+chained+function+in+stata+version+18+40/10__1097_slash_gme__0000000000002443-404-13-18
    Average 90 stars, based on 1 article reviews
    mi impute chained function in stata version 18.40 - by Bioz Stars, 2026-09
    90/100 stars
    		  Buy from Supplier
    function mi impute in stata 13  (STATA Corporation)
    90
    STATA Corporation function mi impute in stata 13
    Function Mi Impute In Stata 13, supplied by STATA Corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/mi+function/stata+version+14/pmc11112846__12885_2024_12344_MOESM1_ESM-49-11-17
    Average 90 stars, based on 1 article reviews
    function mi impute in stata 13 - by Bioz Stars, 2026-09
    90/100 stars
    		  Buy from Supplier
    function proc mi  (SAS institute)
    90
    SAS institute function proc mi
    Function Proc Mi, supplied by SAS institute, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/mi+function/proc+mi+function/pm38526603-72-10-9
    Average 90 stars, based on 1 article reviews
    function proc mi - by Bioz Stars, 2026-09
    90/100 stars
    		  Buy from Supplier

    Image Search Results