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Article Title: Centenarian clocks: epigenetic clocks for validating claims of exceptional longevity
Journal: GeroScience
doi: 10.1007/s11357-023-00731-7
Figure Legend Snippet: Cross-validation analysis of three epigenetic clocks for centenarians. Age estimation 20-fold cross-validation (LOFO20) of the ENCen40 + , ENCen100 + , and NNCen40 + clocks in blood, saliva, and buccals cells, for different age ranges (columns). The panels relate chronological age ( x -axis) to DNAm age estimates ( y -axis) from the ENCen40 + ( A , B , C ) and NNCen40 + ( D , E , F ), and ENCen100 + ( G , H , I ), respectively. Each column corresponds to a different age range. DNA methylation data from age 40 to 115 ( A , D , G ), 100 to 115 ( B , E , H ), and 80 to 115 ( C , F , I ). Each panel reports the sample size (N), the median absolute error (MAE), Pearson correlation coefficient ( r ), the p value ( p ), and each point is color coded by sex (blue = male)
Techniques Used: Biomarker Discovery, DNA Methylation Assay
Figure Legend Snippet: Individual CpGs and mean CpG in chromatin states. Chronological age ( x -axis) versus A ELOVL2 methylation ( y -axis) or mean methylation in B chromatin state BivProm2, C target sites of polycomb repressive complex 2, D chromatin state EnhA1, E chromatin state TxEx4, and F chromatin state PromF2. Each panel reports the sample size ( N ), Pearson correlation coefficient ( r ), and the p value ( p ), and red line is the LOWESS regression smooth curve
Techniques Used: Methylation
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Methylation:Article Title: Centenarian clocks: epigenetic clocks for validating claims of exceptional longevity. Article Snippet: .. Please contact Steve Horvath (shorvath@mednet.ucla. edu) regarding access to the Article Title: Centenarian clocks: epigenetic clocks for validating claims of exceptional longevity Article Snippet: .. Please contact Steve Horvath (shorvath@mednet.ucla.edu) regarding access to the |
