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INFINIUM Inc massarray system
CpG sites analyzed by the <t> MassARRAY system. </t>
Massarray System, supplied by INFINIUM Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/massarray+methylation+spectra+analysis+samples/massarray+system/pmc04530927-216-6-9
Average 90 stars, based on 1 article reviews
massarray system - by Bioz Stars, 2026-09
90/100 stars

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1) Product Images from "Prognostic implication of PTPRH hypomethylation in non-small cell lung cancer"

Article Title: Prognostic implication of PTPRH hypomethylation in non-small cell lung cancer

Journal: Oncology Reports

doi: 10.3892/or.2015.4082

CpG sites analyzed by the  MassARRAY system.
Figure Legend Snippet: CpG sites analyzed by the MassARRAY system.

Techniques Used:

(A) Median DNA methylation levels of PTPRH in N and T with no recurrence and those with recurrence in LC-C2. DNA methylation levels of each CpG unit were evaluated quantitatively using the MassARRAY system. The error bars are defined by 25/75% quartiles. DNA methylation levels at most CpG sites showed a significant decrease in tumorous tissue with recurrence compared with those with no recurrence. Significantly different methylated CpG sites are marked as * P<0.05 and ** P<0.01). (B) Kaplan-Meier survival curves of patients with PTPRH hypermethylation (>0.782 at CpG_9.10) and hypomethylation (≤0.782). The cutoff was determined by ROC curve analysis. The recurrence-free (P=1.64×10 −4 ) and overall (P=5.54×10 −5 ) survival rates of patients with hypomethylation were significantly lower compared to those of patients with hypermethylation (log-rank test). N, non-cancerous lung tissue; T, corresponding tumorous tissue; ROC, receiver operating characteristic.
Figure Legend Snippet: (A) Median DNA methylation levels of PTPRH in N and T with no recurrence and those with recurrence in LC-C2. DNA methylation levels of each CpG unit were evaluated quantitatively using the MassARRAY system. The error bars are defined by 25/75% quartiles. DNA methylation levels at most CpG sites showed a significant decrease in tumorous tissue with recurrence compared with those with no recurrence. Significantly different methylated CpG sites are marked as * P<0.05 and ** P<0.01). (B) Kaplan-Meier survival curves of patients with PTPRH hypermethylation (>0.782 at CpG_9.10) and hypomethylation (≤0.782). The cutoff was determined by ROC curve analysis. The recurrence-free (P=1.64×10 −4 ) and overall (P=5.54×10 −5 ) survival rates of patients with hypomethylation were significantly lower compared to those of patients with hypermethylation (log-rank test). N, non-cancerous lung tissue; T, corresponding tumorous tissue; ROC, receiver operating characteristic.

Techniques Used: DNA Methylation Assay, Methylation

Related Articles

DNA Methylation Assay:

Article Title: Prognostication of patients with clear cell renal cell carcinomas based on quantification of DNA methylation levels of CpG island methylator phenotype marker genes
Article Snippet: .. All 14 ccRCCs showing DNA methylation levels higher than the cutoff values listed in Table at 16 or more CpG units based on the present MassARRAY analysis (red bars in Figure B) were CIMP-positive ccRCCs identified by our previous hierarchical clustering based on the Infinium assay. .. All 88 ccRCCs showing DNA methylation levels higher than the cutoff values listed in Table at less than 16 CpG units based on the present MassARRAY analysis (blue bars in Figure B) were CIMP-negative ccRCCs identified by our previous hierarchical clustering based on the Infinium assay.

Article Title: Novel method for DNA methylation analysis using high‐performance liquid chromatography and its clinical application
Article Snippet: .. In our previous study, 14 ccRCC included in the present study were found to be CIMP‐positive using genome‐wide DNA methylation analysis by Infinium assay and DNA methylation quantification of the 7 ccRCC‐specific CIMP marker genes using the MassARRAY system. ..

Article Title: DNA methylation profile distinguishes clear cell sarcoma of the kidney from other pediatric renal tumors.
Article Snippet: .. We analyzed 6 each of RTK, CCSK, ESFT, and NK, the results of MassARRAY were well correlated with those of the Infinium assay, and each type of tumor revealed a specific DNA methylation pattern (Figure S2). ..

Article Title: Prognostic implication of PTPRH hypomethylation in non-small cell lung cancer
Article Snippet: Because investigation of DNA methylation by the MassARRAY system allowed a comprehensive coverage of CpG sites, we assessed DNA methylation levels at the relatively CpG-rich region containing the CpG site cg11261264 in the same LC-C2 samples using the MassARRAY system (Genomic positions of the CpG sites are shown in ). .. DNA methylation levels obtained by the MassARRAY system and Infinium assay correlated well (r=0.952, P=1.44×10 −73 ), confirming the reliability of the latter assay. ..

Article Title: DNA Methylation Profile Distinguishes Clear Cell Sarcoma of the Kidney from Other Pediatric Renal Tumors
Article Snippet: .. We analyzed 6 each of RTK, CCSK, ESFT, and NK, the results of MassARRAY were well correlated with those of the Infinium assay, and each type of tumor revealed a specific DNA methylation pattern ( ). ..

Article Title: Prognostication of patients with clear cell renal cell carcinomas based on quantification of DNA methylation levels of CpG island methylator phenotype marker genes
Article Snippet: All 14 ccRCCs showing DNA methylation levels higher than the cutoff values listed in Table at 16 or more CpG units based on the present MassARRAY analysis (red bars in Figure B) were CIMP-positive ccRCCs identified by our previous hierarchical clustering based on the Infinium assay. .. All 88 ccRCCs showing DNA methylation levels higher than the cutoff values listed in Table at less than 16 CpG units based on the present MassARRAY analysis (blue bars in Figure B) were CIMP-negative ccRCCs identified by our previous hierarchical clustering based on the Infinium assay. ..

Article Title: Prognostication of patients with clear cell renal cell carcinomas based on quantification of DNA methylation levels of CpG island methylator phenotype marker genes
Article Snippet: Significant correlations between DNA methylation levels determined by our previous Infinium assay [ ] and those determined by the present MassArray analysis were statistically confirmed ( P = 1.25 × 10 −35 , P = 1.98 × 10 −32 , P = 1.31 × 10 −41 , P = 5.30 × 10 −34 , P = 7.91 × 10 −22 and P = 7.61 × 10 −44 , respectively). .. In the present study, our primary intention was to evaluate quantitatively the DNA methylation status of not only the Infinium probe sites but also the entire promoter CpG islands in the ccRCC-specific CIMP marker genes using the MassARRAY system [ ]. ..

Genome Wide:

Article Title: Novel method for DNA methylation analysis using high‐performance liquid chromatography and its clinical application
Article Snippet: .. In our previous study, 14 ccRCC included in the present study were found to be CIMP‐positive using genome‐wide DNA methylation analysis by Infinium assay and DNA methylation quantification of the 7 ccRCC‐specific CIMP marker genes using the MassARRAY system. ..

Marker:

Article Title: Novel method for DNA methylation analysis using high‐performance liquid chromatography and its clinical application
Article Snippet: .. In our previous study, 14 ccRCC included in the present study were found to be CIMP‐positive using genome‐wide DNA methylation analysis by Infinium assay and DNA methylation quantification of the 7 ccRCC‐specific CIMP marker genes using the MassARRAY system. ..

Article Title: Prognostication of patients with clear cell renal cell carcinomas based on quantification of DNA methylation levels of CpG island methylator phenotype marker genes
Article Snippet: Significant correlations between DNA methylation levels determined by our previous Infinium assay [ ] and those determined by the present MassArray analysis were statistically confirmed ( P = 1.25 × 10 −35 , P = 1.98 × 10 −32 , P = 1.31 × 10 −41 , P = 5.30 × 10 −34 , P = 7.91 × 10 −22 and P = 7.61 × 10 −44 , respectively). .. In the present study, our primary intention was to evaluate quantitatively the DNA methylation status of not only the Infinium probe sites but also the entire promoter CpG islands in the ccRCC-specific CIMP marker genes using the MassARRAY system [ ]. ..

Amplification:

Article Title: How to Translate DNA Methylation Biomarkers Into Clinical Practice
Article Snippet: .. Targeted epigenetic clocks for pyrosequencing, MassArray, ddPCR, or barcoded amplicon sequencing can reach almost similar precision as described for Infinium BeadChip clocks ( ). ..

Sequencing:

Article Title: How to Translate DNA Methylation Biomarkers Into Clinical Practice
Article Snippet: .. Targeted epigenetic clocks for pyrosequencing, MassArray, ddPCR, or barcoded amplicon sequencing can reach almost similar precision as described for Infinium BeadChip clocks ( ). ..



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