Review



iplex® gold massarray maldi-tof ms detection  (Sequenom)

 
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
  • 90

    Structured Review

    Sequenom iplex® gold massarray maldi-tof ms detection
    Iplex® Gold Massarray Maldi Tof Ms Detection, supplied by Sequenom, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/massarray+detection+system/maldi+tof+mass+spectrometry+iplex+platform/pmc04299921-50-6-5
    Average 90 stars, based on 1 article reviews
    iplex® gold massarray maldi-tof ms detection - by Bioz Stars, 2026-09
    90/100 stars

    Images

    Related Articles

    Extraction:

    Article Title: Screening for Cardiac Disease with Genetic risk scoring, Advanced ECG, Echocardiography, Protein Biomarkers and Metabolomics
    Article Snippet: DNA was extracted from Buffy coat using DNA mini extraction kits (Qiagen, Netherlands) and genotyped for the SNPs used in a 27 SNP genetic risk score (GRS27) for coronary artery disease by Mega et al ( ) and atrial fibrillation (AF GRS) by Lubitz et al , using Sequenom MALDI-TOF mass spectrometry iPLEX technology.

    Article Title: Multilocus analysis reveals three candidate genes for Chinese migraine susceptibility.
    Article Snippet: Several genome-wide association studies (GWASs) in Caucasian populations have identified 12 loci that are significantly associated with migraine.. More evidence suggests that serotonin receptors are also involved in migraine pathophysiology.. In the present study, a case-control study was conducted in a cohort of 581 migraine cases and 533 ethnically matched controls among a Chinese population.

    Article Title: A novel predictive approach for GVHD after allogeneic SCT based on clinical variables and cytokine gene polymorphisms
    Article Snippet: 7 , 15 , 20 SNPs were genotyped using the MALDI-TOF MassARRAY iPLEX Gold platform (Sequenom, San Diego, CA) at CeGen (National Genotyping Centre, Santiago de Compostela, Spain).

    Article Title: An insight into the burial practices of the late pre-Hispanic Los Amarillos community (northwestern Argentina) through the study of ancient DNA
    Article Snippet: A palaeogenetic analysis has been undertaken on the pre-Hispanic settlement of Los Amarillos (Regional Development Period, Jujuy Province, Argentina) to reconstruct kin relationship between individuals buried in two domestic areas.. The aim of this study was first to genetically characterize the relationships between the individuals buried within the same funerary structure and, secondly, to correlate these genetic data with archaeo-anthropological data to discuss the burial practices and social organization of the Los Amarillos community.. An analysis of both uniparental (mtDNA and Y-chromosome) and biparental (autosomal STRs) genetic markers was conducted on eighteen individuals recovered from three different burial structures.

    Article Title: Common Genetic Variation and Antidepressant Efficacy in Major Depressive Disorder: A Meta-Analysis of Three Genome-Wide Pharmacogenetic Studies
    Article Snippet: TaqMan was used in the GENDEP study, while the MARS and STAR*D studies used a Sequenom MALDI-TOF (matrix-assisted laser desorption/ionization time-of-flight) mass-spectrometer platform with iPlex technology (Sequenom, San Diego).

    Article Title: MEASURES OF EXPOSURE IMPACT GENETIC ASSOCIATION STUDIES: AN EXAMPLE IN VITAMIN K LEVELS AND VKORC1
    Article Snippet: SNP rs2884737 was genotyped using Sequenom's iPLEX® Gold coupled with MassARRAY MALDI-TOF MS detection (San Diego, CA).

    Article Title: Association of the rs1760944 polymorphism in the APEX1 base excision repair gene with risk of nasopharyngeal carcinoma in a population from an endemic area in South China
    Article Snippet: Amplified fragments were genotyped using allele‐specific mass spectrometry on a MassARRAY iPLEX MALDI‐TOF platform (Sequenom) equipped with MassARRAY TYPER4.0 software.

    Mass Spectrometry:

    Article Title: Screening for Cardiac Disease with Genetic risk scoring, Advanced ECG, Echocardiography, Protein Biomarkers and Metabolomics
    Article Snippet: DNA was extracted from Buffy coat using DNA mini extraction kits (Qiagen, Netherlands) and genotyped for the SNPs used in a 27 SNP genetic risk score (GRS27) for coronary artery disease by Mega et al ( ) and atrial fibrillation (AF GRS) by Lubitz et al , using Sequenom MALDI-TOF mass spectrometry iPLEX technology.

    Article Title: Multilocus analysis reveals three candidate genes for Chinese migraine susceptibility.
    Article Snippet: Several genome-wide association studies (GWASs) in Caucasian populations have identified 12 loci that are significantly associated with migraine.. More evidence suggests that serotonin receptors are also involved in migraine pathophysiology.. In the present study, a case-control study was conducted in a cohort of 581 migraine cases and 533 ethnically matched controls among a Chinese population.

    Article Title: A novel predictive approach for GVHD after allogeneic SCT based on clinical variables and cytokine gene polymorphisms
    Article Snippet: 7 , 15 , 20 SNPs were genotyped using the MALDI-TOF MassARRAY iPLEX Gold platform (Sequenom, San Diego, CA) at CeGen (National Genotyping Centre, Santiago de Compostela, Spain).

    Article Title: An insight into the burial practices of the late pre-Hispanic Los Amarillos community (northwestern Argentina) through the study of ancient DNA
    Article Snippet: A palaeogenetic analysis has been undertaken on the pre-Hispanic settlement of Los Amarillos (Regional Development Period, Jujuy Province, Argentina) to reconstruct kin relationship between individuals buried in two domestic areas.. The aim of this study was first to genetically characterize the relationships between the individuals buried within the same funerary structure and, secondly, to correlate these genetic data with archaeo-anthropological data to discuss the burial practices and social organization of the Los Amarillos community.. An analysis of both uniparental (mtDNA and Y-chromosome) and biparental (autosomal STRs) genetic markers was conducted on eighteen individuals recovered from three different burial structures.

    Article Title: Common Genetic Variation and Antidepressant Efficacy in Major Depressive Disorder: A Meta-Analysis of Three Genome-Wide Pharmacogenetic Studies
    Article Snippet: TaqMan was used in the GENDEP study, while the MARS and STAR*D studies used a Sequenom MALDI-TOF (matrix-assisted laser desorption/ionization time-of-flight) mass-spectrometer platform with iPlex technology (Sequenom, San Diego).

    Article Title: MEASURES OF EXPOSURE IMPACT GENETIC ASSOCIATION STUDIES: AN EXAMPLE IN VITAMIN K LEVELS AND VKORC1
    Article Snippet: SNP rs2884737 was genotyped using Sequenom's iPLEX® Gold coupled with MassARRAY MALDI-TOF MS detection (San Diego, CA).

    Article Title: Association of the rs1760944 polymorphism in the APEX1 base excision repair gene with risk of nasopharyngeal carcinoma in a population from an endemic area in South China
    Article Snippet: Amplified fragments were genotyped using allele‐specific mass spectrometry on a MassARRAY iPLEX MALDI‐TOF platform (Sequenom) equipped with MassARRAY TYPER4.0 software.

    Amplification:

    Article Title: Screening for Cardiac Disease with Genetic risk scoring, Advanced ECG, Echocardiography, Protein Biomarkers and Metabolomics
    Article Snippet: DNA was extracted from Buffy coat using DNA mini extraction kits (Qiagen, Netherlands) and genotyped for the SNPs used in a 27 SNP genetic risk score (GRS27) for coronary artery disease by Mega et al ( ) and atrial fibrillation (AF GRS) by Lubitz et al , using Sequenom MALDI-TOF mass spectrometry iPLEX technology.

    Article Title: Multilocus analysis reveals three candidate genes for Chinese migraine susceptibility.
    Article Snippet: Several genome-wide association studies (GWASs) in Caucasian populations have identified 12 loci that are significantly associated with migraine.. More evidence suggests that serotonin receptors are also involved in migraine pathophysiology.. In the present study, a case-control study was conducted in a cohort of 581 migraine cases and 533 ethnically matched controls among a Chinese population.

    Article Title: A novel predictive approach for GVHD after allogeneic SCT based on clinical variables and cytokine gene polymorphisms
    Article Snippet: 7 , 15 , 20 SNPs were genotyped using the MALDI-TOF MassARRAY iPLEX Gold platform (Sequenom, San Diego, CA) at CeGen (National Genotyping Centre, Santiago de Compostela, Spain).

    Article Title: An insight into the burial practices of the late pre-Hispanic Los Amarillos community (northwestern Argentina) through the study of ancient DNA
    Article Snippet: A palaeogenetic analysis has been undertaken on the pre-Hispanic settlement of Los Amarillos (Regional Development Period, Jujuy Province, Argentina) to reconstruct kin relationship between individuals buried in two domestic areas.. The aim of this study was first to genetically characterize the relationships between the individuals buried within the same funerary structure and, secondly, to correlate these genetic data with archaeo-anthropological data to discuss the burial practices and social organization of the Los Amarillos community.. An analysis of both uniparental (mtDNA and Y-chromosome) and biparental (autosomal STRs) genetic markers was conducted on eighteen individuals recovered from three different burial structures.

    Article Title: Common Genetic Variation and Antidepressant Efficacy in Major Depressive Disorder: A Meta-Analysis of Three Genome-Wide Pharmacogenetic Studies
    Article Snippet: TaqMan was used in the GENDEP study, while the MARS and STAR*D studies used a Sequenom MALDI-TOF (matrix-assisted laser desorption/ionization time-of-flight) mass-spectrometer platform with iPlex technology (Sequenom, San Diego).

    Article Title: MEASURES OF EXPOSURE IMPACT GENETIC ASSOCIATION STUDIES: AN EXAMPLE IN VITAMIN K LEVELS AND VKORC1
    Article Snippet: SNP rs2884737 was genotyped using Sequenom's iPLEX® Gold coupled with MassARRAY MALDI-TOF MS detection (San Diego, CA).

    Article Title: Association of the rs1760944 polymorphism in the APEX1 base excision repair gene with risk of nasopharyngeal carcinoma in a population from an endemic area in South China
    Article Snippet: Amplified fragments were genotyped using allele‐specific mass spectrometry on a MassARRAY iPLEX MALDI‐TOF platform (Sequenom) equipped with MassARRAY TYPER4.0 software.

    Software:

    Article Title: Screening for Cardiac Disease with Genetic risk scoring, Advanced ECG, Echocardiography, Protein Biomarkers and Metabolomics
    Article Snippet: DNA was extracted from Buffy coat using DNA mini extraction kits (Qiagen, Netherlands) and genotyped for the SNPs used in a 27 SNP genetic risk score (GRS27) for coronary artery disease by Mega et al ( ) and atrial fibrillation (AF GRS) by Lubitz et al , using Sequenom MALDI-TOF mass spectrometry iPLEX technology.

    Article Title: Multilocus analysis reveals three candidate genes for Chinese migraine susceptibility.
    Article Snippet: Several genome-wide association studies (GWASs) in Caucasian populations have identified 12 loci that are significantly associated with migraine.. More evidence suggests that serotonin receptors are also involved in migraine pathophysiology.. In the present study, a case-control study was conducted in a cohort of 581 migraine cases and 533 ethnically matched controls among a Chinese population.

    Article Title: A novel predictive approach for GVHD after allogeneic SCT based on clinical variables and cytokine gene polymorphisms
    Article Snippet: 7 , 15 , 20 SNPs were genotyped using the MALDI-TOF MassARRAY iPLEX Gold platform (Sequenom, San Diego, CA) at CeGen (National Genotyping Centre, Santiago de Compostela, Spain).

    Article Title: An insight into the burial practices of the late pre-Hispanic Los Amarillos community (northwestern Argentina) through the study of ancient DNA
    Article Snippet: A palaeogenetic analysis has been undertaken on the pre-Hispanic settlement of Los Amarillos (Regional Development Period, Jujuy Province, Argentina) to reconstruct kin relationship between individuals buried in two domestic areas.. The aim of this study was first to genetically characterize the relationships between the individuals buried within the same funerary structure and, secondly, to correlate these genetic data with archaeo-anthropological data to discuss the burial practices and social organization of the Los Amarillos community.. An analysis of both uniparental (mtDNA and Y-chromosome) and biparental (autosomal STRs) genetic markers was conducted on eighteen individuals recovered from three different burial structures.

    Article Title: Common Genetic Variation and Antidepressant Efficacy in Major Depressive Disorder: A Meta-Analysis of Three Genome-Wide Pharmacogenetic Studies
    Article Snippet: TaqMan was used in the GENDEP study, while the MARS and STAR*D studies used a Sequenom MALDI-TOF (matrix-assisted laser desorption/ionization time-of-flight) mass-spectrometer platform with iPlex technology (Sequenom, San Diego).

    Article Title: MEASURES OF EXPOSURE IMPACT GENETIC ASSOCIATION STUDIES: AN EXAMPLE IN VITAMIN K LEVELS AND VKORC1
    Article Snippet: SNP rs2884737 was genotyped using Sequenom's iPLEX® Gold coupled with MassARRAY MALDI-TOF MS detection (San Diego, CA).

    Article Title: Association of the rs1760944 polymorphism in the APEX1 base excision repair gene with risk of nasopharyngeal carcinoma in a population from an endemic area in South China
    Article Snippet: Amplified fragments were genotyped using allele‐specific mass spectrometry on a MassARRAY iPLEX MALDI‐TOF platform (Sequenom) equipped with MassARRAY TYPER4.0 software.



    Similar Products

    90
    agena bioscience kit for the qualitative detection of sars-cov-2 using rt-pcr reaction together with the massarray system
    Kit For The Qualitative Detection Of Sars Cov 2 Using Rt Pcr Reaction Together With The Massarray System, supplied by agena bioscience, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/massarray+detection+system/massarray+sars+cov+2+panel/pm36747014-37-9-18
    Average 90 stars, based on 1 article reviews
    kit for the qualitative detection of sars-cov-2 using rt-pcr reaction together with the massarray system - by Bioz Stars, 2026-09
    90/100 stars
      Buy from Supplier

    90
    agena bioscience massarray detection platform
    Massarray Detection Platform, supplied by agena bioscience, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/massarray+detection+system/massarray+platform/pmc09910734-173-0-3
    Average 90 stars, based on 1 article reviews
    massarray detection platform - by Bioz Stars, 2026-09
    90/100 stars
      Buy from Supplier

    90
    agena bioscience commercial kit for the qualitative detection of sars-cov-2 using rt-pcr reaction together with the massarray system
    Comparison of SARS-CoV-2 variant identification using Next Generation Sequencing (NGS) and MassARRY PMA-ABDO and PMA-Omicron (n = 358).
    Commercial Kit For The Qualitative Detection Of Sars Cov 2 Using Rt Pcr Reaction Together With The Massarray System, supplied by agena bioscience, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/massarray+detection+system/massarray+sars+cov+2+panel/pmc09900542-103-9-18
    Average 90 stars, based on 1 article reviews
    commercial kit for the qualitative detection of sars-cov-2 using rt-pcr reaction together with the massarray system - by Bioz Stars, 2026-09
    90/100 stars
      Buy from Supplier

    90
    Sequenom iplex® gold massarray maldi-tof ms detection
    Comparison of SARS-CoV-2 variant identification using Next Generation Sequencing (NGS) and MassARRY PMA-ABDO and PMA-Omicron (n = 358).
    Iplex® Gold Massarray Maldi Tof Ms Detection, supplied by Sequenom, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/massarray+detection+system/maldi+tof+mass+spectrometry+iplex+platform/pmc04299921-50-6-5
    Average 90 stars, based on 1 article reviews
    iplex® gold massarray maldi-tof ms detection - by Bioz Stars, 2026-09
    90/100 stars
      Buy from Supplier

    96
    agena bioscience agena massarray methylation detection
    Comparison of SARS-CoV-2 variant identification using Next Generation Sequencing (NGS) and MassARRY PMA-ABDO and PMA-Omicron (n = 358).
    Agena Massarray Methylation Detection, supplied by agena bioscience, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/massarray+detection+system/Methylation/ppr0552502-125-0-0
    Average 96 stars, based on 1 article reviews
    agena massarray methylation detection - by Bioz Stars, 2026-09
    96/100 stars
      Buy from Supplier

    90
    Sequenom massarray methylation detection
    A A negative correlation between ZNF334 <t>methylation</t> level and its mRNA expression (Pearson r = −0.53, R 2 = 0.28) B mRNA expression of ZNF334 in cancer and adjacent tissues of 213 liver cancer patients. C Western-blot diagram of ZNF334 expression in cancer and adjacent tissues of 12 liver cancer patients. D Methylation mass spectrum primers of ZNF334 promoter region and mass spectrometry detection product sequence (green indicates the EPIC chip probe cg07139762 site, which is in the ZNF334 promoter region; yellow indicates the <t>MassARRAY</t> methylation mass spectrometry detection sites, a total of 29). E Heat map of methylation level of ZNF334 promoter region in cancer and adjacent tissues of 25 patients with liver cancer. F The ratio of methylation degree of ZNF334 promoter in cancer and adjacent tissues (T/P) of 25 patients with liver cancer. G The average methylation degree of ZNF334 promoter in cancer and adjacent tissues of 25 patients with liver cancer. **** p < 0.0001.
    Massarray Methylation Detection, supplied by Sequenom, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/massarray+detection+system/massarray+quantitative+methylation+analysis/pmc09085879-231-0-4
    Average 90 stars, based on 1 article reviews
    massarray methylation detection - by Bioz Stars, 2026-09
    90/100 stars
      Buy from Supplier

    90
    Sequenom massarray sequenom detection
    A A negative correlation between ZNF334 methylation level and its mRNA expression (Pearson r = −0.53, R 2 = 0.28) B mRNA expression of ZNF334 in cancer and adjacent tissues of 213 liver cancer patients. C Western-blot diagram of ZNF334 expression in cancer and adjacent tissues of 12 liver cancer patients. D Methylation mass spectrum primers of ZNF334 promoter region and mass spectrometry detection product sequence (green indicates the EPIC chip probe cg07139762 site, which is in the ZNF334 promoter region; yellow indicates the <t>MassARRAY</t> methylation mass spectrometry detection sites, a total of 29). E Heat map of methylation level of ZNF334 promoter region in cancer and adjacent tissues of 25 patients with liver cancer. F The ratio of methylation degree of ZNF334 promoter in cancer and adjacent tissues (T/P) of 25 patients with liver cancer. G The average methylation degree of ZNF334 promoter in cancer and adjacent tissues of 25 patients with liver cancer. **** p < 0.0001.
    Massarray Sequenom Detection, supplied by Sequenom, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/massarray+detection+system/sequenom+massarray/pmc09085879-184-7-8
    Average 90 stars, based on 1 article reviews
    massarray sequenom detection - by Bioz Stars, 2026-09
    90/100 stars
      Buy from Supplier

    90
    agena bioscience massarray dna mass spectrometry detection
    A A negative correlation between ZNF334 methylation level and its mRNA expression (Pearson r = −0.53, R 2 = 0.28) B mRNA expression of ZNF334 in cancer and adjacent tissues of 213 liver cancer patients. C Western-blot diagram of ZNF334 expression in cancer and adjacent tissues of 12 liver cancer patients. D Methylation mass spectrum primers of ZNF334 promoter region and mass spectrometry detection product sequence (green indicates the EPIC chip probe cg07139762 site, which is in the ZNF334 promoter region; yellow indicates the <t>MassARRAY</t> methylation mass spectrometry detection sites, a total of 29). E Heat map of methylation level of ZNF334 promoter region in cancer and adjacent tissues of 25 patients with liver cancer. F The ratio of methylation degree of ZNF334 promoter in cancer and adjacent tissues (T/P) of 25 patients with liver cancer. G The average methylation degree of ZNF334 promoter in cancer and adjacent tissues of 25 patients with liver cancer. **** p < 0.0001.
    Massarray Dna Mass Spectrometry Detection, supplied by agena bioscience, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/massarray+detection+system/massarray+mass+spectrometer/pm34260825-63-8-13
    Average 90 stars, based on 1 article reviews
    massarray dna mass spectrometry detection - by Bioz Stars, 2026-09
    90/100 stars
      Buy from Supplier

    90
    Sequenom massarray snp detection
    A A negative correlation between ZNF334 methylation level and its mRNA expression (Pearson r = −0.53, R 2 = 0.28) B mRNA expression of ZNF334 in cancer and adjacent tissues of 213 liver cancer patients. C Western-blot diagram of ZNF334 expression in cancer and adjacent tissues of 12 liver cancer patients. D Methylation mass spectrum primers of ZNF334 promoter region and mass spectrometry detection product sequence (green indicates the EPIC chip probe cg07139762 site, which is in the ZNF334 promoter region; yellow indicates the <t>MassARRAY</t> methylation mass spectrometry detection sites, a total of 29). E Heat map of methylation level of ZNF334 promoter region in cancer and adjacent tissues of 25 patients with liver cancer. F The ratio of methylation degree of ZNF334 promoter in cancer and adjacent tissues (T/P) of 25 patients with liver cancer. G The average methylation degree of ZNF334 promoter in cancer and adjacent tissues of 25 patients with liver cancer. **** p < 0.0001.
    Massarray Snp Detection, supplied by Sequenom, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/massarray+detection+system/sequenom+massarray/pmc08787141-153-1-0
    Average 90 stars, based on 1 article reviews
    massarray snp detection - by Bioz Stars, 2026-09
    90/100 stars
      Buy from Supplier

    Image Search Results


    Comparison of SARS-CoV-2 variant identification using Next Generation Sequencing (NGS) and MassARRY PMA-ABDO and PMA-Omicron (n = 358).

    Journal: Scientific Reports

    Article Title: Simultaneous detection of omicron and other SARS-CoV-2 variants by multiplex PCR MassARRAY technology

    doi: 10.1038/s41598-023-28715-9

    Figure Lengend Snippet: Comparison of SARS-CoV-2 variant identification using Next Generation Sequencing (NGS) and MassARRY PMA-ABDO and PMA-Omicron (n = 358).

    Article Snippet: Recently, the commercial kit for the qualitative detection of SARS-CoV-2 using RT-PCR reaction together with the MassARRAY system (Agena Bioscience ® , San Diego, CA, USA) has been developed, and it showed superiority over Real-time PCR assay .

    Techniques: Comparison, Variant Assay, Next-Generation Sequencing

    A A negative correlation between ZNF334 methylation level and its mRNA expression (Pearson r = −0.53, R 2 = 0.28) B mRNA expression of ZNF334 in cancer and adjacent tissues of 213 liver cancer patients. C Western-blot diagram of ZNF334 expression in cancer and adjacent tissues of 12 liver cancer patients. D Methylation mass spectrum primers of ZNF334 promoter region and mass spectrometry detection product sequence (green indicates the EPIC chip probe cg07139762 site, which is in the ZNF334 promoter region; yellow indicates the MassARRAY methylation mass spectrometry detection sites, a total of 29). E Heat map of methylation level of ZNF334 promoter region in cancer and adjacent tissues of 25 patients with liver cancer. F The ratio of methylation degree of ZNF334 promoter in cancer and adjacent tissues (T/P) of 25 patients with liver cancer. G The average methylation degree of ZNF334 promoter in cancer and adjacent tissues of 25 patients with liver cancer. **** p < 0.0001.

    Journal: Cell Death & Disease

    Article Title: DNA hypermethylation modification promotes the development of hepatocellular carcinoma by depressing the tumor suppressor gene ZNF334

    doi: 10.1038/s41419-022-04895-6

    Figure Lengend Snippet: A A negative correlation between ZNF334 methylation level and its mRNA expression (Pearson r = −0.53, R 2 = 0.28) B mRNA expression of ZNF334 in cancer and adjacent tissues of 213 liver cancer patients. C Western-blot diagram of ZNF334 expression in cancer and adjacent tissues of 12 liver cancer patients. D Methylation mass spectrum primers of ZNF334 promoter region and mass spectrometry detection product sequence (green indicates the EPIC chip probe cg07139762 site, which is in the ZNF334 promoter region; yellow indicates the MassARRAY methylation mass spectrometry detection sites, a total of 29). E Heat map of methylation level of ZNF334 promoter region in cancer and adjacent tissues of 25 patients with liver cancer. F The ratio of methylation degree of ZNF334 promoter in cancer and adjacent tissues (T/P) of 25 patients with liver cancer. G The average methylation degree of ZNF334 promoter in cancer and adjacent tissues of 25 patients with liver cancer. **** p < 0.0001.

    Article Snippet: MassARRAY methylation detection technology (Sequenom, USA) performed by CapitalBio Technology (Shanghai, China) was used to detect the methylation level of ZNF334 promoter (human) in carcinoma and paracancerous tissues of 25 HCC patients and Zfp334 promoter (mice) in treatment and control group.

    Techniques: Methylation, Expressing, Western Blot, Mass Spectrometry, Sequencing

    A A negative correlation between ZNF334 methylation level and its mRNA expression (Pearson r = −0.53, R 2 = 0.28) B mRNA expression of ZNF334 in cancer and adjacent tissues of 213 liver cancer patients. C Western-blot diagram of ZNF334 expression in cancer and adjacent tissues of 12 liver cancer patients. D Methylation mass spectrum primers of ZNF334 promoter region and mass spectrometry detection product sequence (green indicates the EPIC chip probe cg07139762 site, which is in the ZNF334 promoter region; yellow indicates the MassARRAY methylation mass spectrometry detection sites, a total of 29). E Heat map of methylation level of ZNF334 promoter region in cancer and adjacent tissues of 25 patients with liver cancer. F The ratio of methylation degree of ZNF334 promoter in cancer and adjacent tissues (T/P) of 25 patients with liver cancer. G The average methylation degree of ZNF334 promoter in cancer and adjacent tissues of 25 patients with liver cancer. **** p < 0.0001.

    Journal: Cell Death & Disease

    Article Title: DNA hypermethylation modification promotes the development of hepatocellular carcinoma by depressing the tumor suppressor gene ZNF334

    doi: 10.1038/s41419-022-04895-6

    Figure Lengend Snippet: A A negative correlation between ZNF334 methylation level and its mRNA expression (Pearson r = −0.53, R 2 = 0.28) B mRNA expression of ZNF334 in cancer and adjacent tissues of 213 liver cancer patients. C Western-blot diagram of ZNF334 expression in cancer and adjacent tissues of 12 liver cancer patients. D Methylation mass spectrum primers of ZNF334 promoter region and mass spectrometry detection product sequence (green indicates the EPIC chip probe cg07139762 site, which is in the ZNF334 promoter region; yellow indicates the MassARRAY methylation mass spectrometry detection sites, a total of 29). E Heat map of methylation level of ZNF334 promoter region in cancer and adjacent tissues of 25 patients with liver cancer. F The ratio of methylation degree of ZNF334 promoter in cancer and adjacent tissues (T/P) of 25 patients with liver cancer. G The average methylation degree of ZNF334 promoter in cancer and adjacent tissues of 25 patients with liver cancer. **** p < 0.0001.

    Article Snippet: And meanwhile, in clinical samples, we used MassArray Sequenom detection to further verify the DNA methylation changes of ZNF334 promoter in cancerous tissues and adjacent tissues.

    Techniques: Methylation, Expressing, Western Blot, Mass Spectrometry, Sequencing