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Provencher Inc linear combination model lcmodel
Linear Combination Model Lcmodel, supplied by Provencher Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/linear+combination+modeling+lcmodel/linear+combination++lc++model/pmc10722015-106-9-14
Average 90 stars, based on 1 article reviews
linear combination model lcmodel - by Bioz Stars, 2026-09
90/100 stars

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Spectroscopy:

Article Title: Proton MR Spectroscopy–Detectable Major Neurotransmitters of the Brain: Biology and Possible Clinical Applications
Article Snippet: .. So far, the Linear Combination LC Model (Steven Provencher, Oakville, Ontario, Canada) has been considered a standard fitting program for 1-dimensional 1H-MR spectroscopy data.58 Therefore, to improve confidence in 1H-MR spectroscopy, to make it a financially reimbursable diagnostic tool, and to meet the criteria of evidence-based medicine, development and standardization of methods are essential. ..

Article Title: Proton MR Spectroscopy—Detectable Major Neurotransmitters of the Brain: Biology and Possible Clinical Applications
Article Snippet: .. So far, the Linear Combination LC Model (Steven Provencher, Oakville, Ontario, Canada) has been considered a standard fitting program for 1-dimensional 1 H-MR spectroscopy data. ..

Diagnostic Assay:

Article Title: Proton MR Spectroscopy–Detectable Major Neurotransmitters of the Brain: Biology and Possible Clinical Applications
Article Snippet: .. So far, the Linear Combination LC Model (Steven Provencher, Oakville, Ontario, Canada) has been considered a standard fitting program for 1-dimensional 1H-MR spectroscopy data.58 Therefore, to improve confidence in 1H-MR spectroscopy, to make it a financially reimbursable diagnostic tool, and to meet the criteria of evidence-based medicine, development and standardization of methods are essential. ..

other:

Article Title: Neurodegenerative Changes in the Brains of the 5xFAD Alzheimer’s Disease Model Mice Investigated by High-Field and High-Resolution Magnetic Resonance Imaging and Multi-Nuclei Magnetic Resonance Spectroscopy
Article Snippet: Quantifying 1 H MRS was conducted using the linear combination of model (LCModel; Version 6.3-0I; http://s-provencher.com/lcmodel.shtml (accessed on 28 May 2022)).

Article Title: Brain metabolite differences in one-year-old infants born small at term and association with neurodevelopmental outcome.
Article Snippet: STUDY DESIGN: A total of 40 infants born small (birthweight <10th centile for gestational age) and 30 AGA infants underwent brain MRS at age 1 year on a 3-T scanner.. Small-born infants were subclassified as late intrauterine growth restriction or as small for gestational age, based on the presence or absence of prenatal Doppler and birthweight predictors of an adverse perinatal outcome, respectively.. Single-voxel proton magnetic resonance spectroscopy (H-MRS) data were acquired from the frontal lobe at short echo time.

Article Title: Neurochemical Correlates of Executive Function in Children with Attention-Deficit/Hyperactivity Disorder
Article Snippet: The MRS data were analyzed using the Linear Combination (LC) Model method ( Provencher, 1993 ; 2001 ; 2016 ). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Right-Prefrontal Cortex (R-PFC) and Left-Striatum (L-Striatum) spectroscopy voxel placement example shown on an anatomical brain scan.

Article Title: Association of brain metabolism with sulcation and corpus callosum development assessed by MRI in late-onset small fetuses.
Article Snippet: STUDY DESIGN: A total of 119 fetuses, 64 that were small for gestational age (estimated fetal weight <10th centile and normal umbilical artery Doppler) and 55 controls underwent a 3T MR imaging/H-MRS exam at 37 weeks.. Anatomical T2-weighted images were obtained in the 3 orthogonal planes and long echo time (TE) H-MRS acquired from the frontal lobe.. Head biometrics, cortical fissure depths (insula, Sylvian, parietooccipital, cingulate, and calcarine), and CC area and biometries were blindly performed by manual and semiautomated delineation using Analyze software and corrected creating ratios for biparietal diameter and frontooccipital diameter, respectively, for group comparison.

Article Title: Metabolic heterogeneity in different subtypes of malformations of cortical development causing epilepsy: a proton magnetic resonance spectroscopy study
Article Snippet: All raw MRS data were processed using the linear combination model (LCModel; version 6.3-1H; http://s-provencher.com/lcmodel.shtml ), which has automated baseline and phase correction and yields the absolute metabolite concentrations using the tissue water signal as an internal reference ( ).

Concentration Assay:

Article Title: In vivo 1H MRS study in microlitre voxels in the hippocampus of a mouse model of Down syndrome at 11.7 T.
Article Snippet: In this article, we report in vivo H MRS performed in 1.8-μL voxels in a mouse model of Down syndrome (DS).. To characterise the excitation–inhibition imbalance observed in DS, metabolite concentrations in the hippocampi of adult Ts65Dn mice, which recapitulate features of DS, were compared with those of their euploid littermates at a voxel 42-fold smaller than in a previously published study.. Quantification of the metabolites was performed using a linear combination model. We detected 16 metabolites in the right and left hippocampi.



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