helplessness procedure (Med Associates Inc)
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helplessness procedure
Helplessness Procedure, supplied by Med Associates Inc, used in various techniques. Bioz Stars score: 97/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/learning/Shuttle+Box+Learned+Helplessness+Protocol/pm22885997-413-2-11
Average 97 stars, based on 4 article reviews
Helplessness Procedure, supplied by Med Associates Inc, used in various techniques. Bioz Stars score: 97/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/learning/Shuttle+Box+Learned+Helplessness+Protocol/pm22885997-413-2-11
Average 97 stars, based on 4 article reviews
helplessness procedure - by Bioz Stars,
2026-10
97/100 stars
Images
1) Product Images from "Decreased expression of synapse-related genes and loss of synapses in major depressive disorder."
Article Title: Decreased expression of synapse-related genes and loss of synapses in major depressive disorder.
Journal: Nature medicine
doi: 10.1038/nm.2886
Figure Legend Snippet: Figure 4 Viral expression of GATA1 in rat PFCs causes depressive behavior. (a) Schematic diagram of the experimental schedule. Control rAAV and rAAV-GATA1-eGFP vectors were surgically infused into the medial PFC (rAAV surgery) and rats were allowed to recover for 5 weeks (recovery/rAAV expression). LA, locomotor activity; FST, forced swim test; LH, learned helplessness; IHC, immunochemistry. (b) Representative low-power (left) image of GFP IHC showing the location of the viral infusion site in the medial PFC. On the right is an image of the labeled neurons at a higher magnification. (c,d) Influence of control virus (rAAV-control) and rAAV-GATA1 on the behavior in the forced swim test (c) and the learned helplessness (d) paradigm. Avoidance testing was separated into trials 1–5 and 6–10. Data are the mean ± s.e.m. (n = 9 for rAAV-control and n = 10 for rAAV-GATA1). * P < 0.05 compared to rAAV-control (t test). (e) Schematic diagram of Gata1 shRNA knockdown in the CUS paradigm. SPT, sucrose preference test. (f) Representative image of GFP IHC showing the location of viral infusion in the same region of the PFC as is shown in b. (g) Influence of rAAV-ScrshRNA and rAAV-GATA1shRNA on sucrose preference in control nonstressed and CUS-exposed rats. Data are the mean ± s.e.m. (controls: n = 6 for rAAV-ScrshRNA and n = 8 for rAAV-GATA1shRNA; CUS: n = 7 for rAAV-ScrshRNA and n = 8 for rAAV-GATA1shRNA). *P < 0.05 compared to the respective control group (analysis of variance and Fisher’s protected least significant difference post-hoc analysis).
Techniques Used: Expressing, Control, Activity Assay, Labeling, Virus, shRNA, Knockdown
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Expressing:Article Title: Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole. Article Snippet: The active avoidance procedure was performed in one learned helplessness chamber of custom-built Article Title: Decreased expression of synapse-related genes and loss of synapses in major depressive disorder. Article Snippet: The learned helplessness procedure was performed in custom-built, two-chambered Control:Article Title: Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole. Article Snippet: The active avoidance procedure was performed in one learned helplessness chamber of custom-built Article Title: Decreased expression of synapse-related genes and loss of synapses in major depressive disorder. Article Snippet: The learned helplessness procedure was performed in custom-built, two-chambered Activity Assay:Article Title: Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole. Article Snippet: The active avoidance procedure was performed in one learned helplessness chamber of custom-built Article Title: Decreased expression of synapse-related genes and loss of synapses in major depressive disorder. Article Snippet: The learned helplessness procedure was performed in custom-built, two-chambered Labeling:Article Title: Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole. Article Snippet: The active avoidance procedure was performed in one learned helplessness chamber of custom-built Article Title: Decreased expression of synapse-related genes and loss of synapses in major depressive disorder. Article Snippet: The learned helplessness procedure was performed in custom-built, two-chambered Virus:Article Title: Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole. Article Snippet: The active avoidance procedure was performed in one learned helplessness chamber of custom-built Article Title: Decreased expression of synapse-related genes and loss of synapses in major depressive disorder. Article Snippet: The learned helplessness procedure was performed in custom-built, two-chambered shRNA:Article Title: Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole. Article Snippet: The active avoidance procedure was performed in one learned helplessness chamber of custom-built Article Title: Decreased expression of synapse-related genes and loss of synapses in major depressive disorder. Article Snippet: The learned helplessness procedure was performed in custom-built, two-chambered Knockdown:Article Title: Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole. Article Snippet: The active avoidance procedure was performed in one learned helplessness chamber of custom-built Article Title: Decreased expression of synapse-related genes and loss of synapses in major depressive disorder. Article Snippet: The learned helplessness procedure was performed in custom-built, two-chambered |