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ActivX Inc activex component
Activex Component, supplied by ActivX Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Article Title: Advance Control & Process Measurement
Article Snippet: Data exchange via the OPC interface system area, screen build using ActiveX components, and configuration data file formatted on XML are provided to connect with other vendors' DCS or other solutions procedures system processment system area level.

Article Title: Use of Neural Networks for Lifetime Analysis of Teeming Ladles.
Article Snippet: The result of the training is a prediction model that can be used using the ActiveX component in any common programming environment under MS Windows or is directly usable in the G2 environment with the NeurOn-Line superstructure.

Article Title: Adaptive transformable design generation
Article Snippet: Accordingly, clients 902 may utilize ACTIVEX components/component object model (COM) or distributed COM (DCOM) components to provide a user interface on a display of client 902.

Article Title: Systems, methods, and apparatuses for implementing a broadcast integration platform with real-time interactive content synchronization
Article Snippet: For example, supported standard media forms include but are not limited to: Bit-mapped graphic files; Text documents; Video files; Animation data files; Sound data files; Web documents; Script files; ActiveX components; Real-time formats; Broadcast formats; Streaming formats; etc.

Article Title: Ultrasound probe with integrated electronics
Article Snippet: The USAutoView program is a Windows® dialog application with three ActiveX components.

Article Title: Information rights management through editors implemented in a browser
Article Snippet: Instead it may be an ActiveX component or a FLASH component or a JAVA Applet that can be embedded and run inside the browser or inside a standalone application or app other than the browser itself.

Control:

Article Title: Modeling approach and analysis time comparison of single-link flexible steel- and epoxy-glass/carbon-fiber composite manipulators
Article Snippet: This paper presents different modeling technique approaches of the single-link uniform cross-sectional shape manipulators.. Three different materials of manipulators which are epoxy-glass and carbon-fiber for composite manipulators and steel manipulator are considered for both simulation and experimental analyses.. Three different modelling techniques which are solid, beam and shell models are used for both manipulators.

Software:

Article Title: System and method for providing location-based positioning and navigation in GPS-denied environments
Article Snippet: .. The terms “page” or “display page” may include embedded functions comprising software programs stored on a memory, such as, for example, Cocoa, VBScript routines, Jscript routines, javascript routines, Java applets, ActiveX components, ASP.NET, AJAX, Flash applets, Silverlight applets, Adobe AIR routines, or any other scripting language. ..



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Comparison of vaccine efficacy between H5 Texas Mut vaccine and H5 Ast20 Mut vaccine in mice (A) Schematic of cleavage-defective mutant (Mut) HA mRNA vaccines. (B) Western blotting analysis of HA protein expression in transfected BHK-21 cells. Cells were transfected with varying doses (50, 100, 200, and 500 ng/μL) of Texas Mut or Ast20 Mut mRNA. (C) Mice were vaccinated (i.m.) with 1 or 5 μg Texas/Ast20 mRNA-LNP (SM102) encoding Mut HA or placebo using in a prime-boost schedule with an interval of 4 weeks. Blood samples ( n = 8) were collected from mice 2 weeks after prime and boost. Binding IgG of serum, reactive to the Texas HA protein, was measured by ELISA. Titers of placebo group were below detection limit. (D) 50% neutralization titers of pseudotyped virus (A/Texas/37/2024) in serum collected 2 weeks post-boost (week 6). Titers of placebo group were below detection limit. (E and F) Binding IgG of 1 μg Texas vaccine group (E) and Ast20 vaccine group (F) was measured by ELISA, reactive to the HA of clade 1 virus (A/Viet Nam/1203/2004), clade 2.1.3.2 virus <t>(A/Indonesia/5/2005),</t> clade 2.2 virus (A/bar-headed goose/Qinghai/5/2005), clade 2.3.2.1a virus (A/Hubei/1/2010), clade 2.3.4 virus (A/Anhui/1/2005), clade 2.3.4.4b virus (A/Astrakhan/3212/2020), and clade 2.3.4.4b virus (A/Texas/37/2024). (G) Radar chart of broad-binding IgG levels elicited by 1 μg Texas vaccine and Ast20 vaccine. (H) Vaccination schedule. Mice were vaccinated (i.m.) with 1 or 5 μg mRNA-LNP (SM102) encoding Texas HA-Mut, Ast20 HA-Mut, or placebo. Four weeks post-vaccination (week 4), mice were challenged with 50 × LD 50 of A/ostrich/China/HB/2024. Virus load of organs in vaccinated mice 1, 3, 5 days post-infection determined using plaque assays on MDCK cells. (I–L) Virus load of lung (I), heart (J), kidney (K), and brain (L). The dashed horizontal line indicates the assay limit of detection. Data are presented as the mean ± SD; p values are analyzed with t test (∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001) (C–L). ∗/∗∗∗ (E and F) indicates significant differences between other HA proteins and Texas (E) or Ast20 (F) protein. ∗ (E and F) indicates significant differences between other HA proteins and Texas (E) or Ast20 (F) protein. ∗ (I–L) indicates significant differences between placebo and vaccination groups in the same day.
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Comparison of vaccine efficacy between H5 Texas Mut vaccine and H5 Ast20 Mut vaccine in mice (A) Schematic of cleavage-defective mutant (Mut) HA mRNA vaccines. (B) Western blotting analysis of HA protein expression in transfected BHK-21 cells. Cells were transfected with varying doses (50, 100, 200, and 500 ng/μL) of Texas Mut or Ast20 Mut mRNA. (C) Mice were vaccinated (i.m.) with 1 or 5 μg Texas/Ast20 mRNA-LNP (SM102) encoding Mut HA or placebo using in a prime-boost schedule with an interval of 4 weeks. Blood samples ( n = 8) were collected from mice 2 weeks after prime and boost. Binding IgG of serum, reactive to the Texas HA protein, was measured by ELISA. Titers of placebo group were below detection limit. (D) 50% neutralization titers of pseudotyped virus (A/Texas/37/2024) in serum collected 2 weeks post-boost (week 6). Titers of placebo group were below detection limit. (E and F) Binding IgG of 1 μg Texas vaccine group (E) and Ast20 vaccine group (F) was measured by ELISA, reactive to the HA of clade 1 virus (A/Viet Nam/1203/2004), clade 2.1.3.2 virus <t>(A/Indonesia/5/2005),</t> clade 2.2 virus (A/bar-headed goose/Qinghai/5/2005), clade 2.3.2.1a virus (A/Hubei/1/2010), clade 2.3.4 virus (A/Anhui/1/2005), clade 2.3.4.4b virus (A/Astrakhan/3212/2020), and clade 2.3.4.4b virus (A/Texas/37/2024). (G) Radar chart of broad-binding IgG levels elicited by 1 μg Texas vaccine and Ast20 vaccine. (H) Vaccination schedule. Mice were vaccinated (i.m.) with 1 or 5 μg mRNA-LNP (SM102) encoding Texas HA-Mut, Ast20 HA-Mut, or placebo. Four weeks post-vaccination (week 4), mice were challenged with 50 × LD 50 of A/ostrich/China/HB/2024. Virus load of organs in vaccinated mice 1, 3, 5 days post-infection determined using plaque assays on MDCK cells. (I–L) Virus load of lung (I), heart (J), kidney (K), and brain (L). The dashed horizontal line indicates the assay limit of detection. Data are presented as the mean ± SD; p values are analyzed with t test (∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001) (C–L). ∗/∗∗∗ (E and F) indicates significant differences between other HA proteins and Texas (E) or Ast20 (F) protein. ∗ (E and F) indicates significant differences between other HA proteins and Texas (E) or Ast20 (F) protein. ∗ (I–L) indicates significant differences between placebo and vaccination groups in the same day.
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Comparison of vaccine efficacy between H5 Texas Mut vaccine and H5 Ast20 Mut vaccine in mice (A) Schematic of cleavage-defective mutant (Mut) HA mRNA vaccines. (B) Western blotting analysis of HA protein expression in transfected BHK-21 cells. Cells were transfected with varying doses (50, 100, 200, and 500 ng/μL) of Texas Mut or Ast20 Mut mRNA. (C) Mice were vaccinated (i.m.) with 1 or 5 μg Texas/Ast20 mRNA-LNP (SM102) encoding Mut HA or placebo using in a prime-boost schedule with an interval of 4 weeks. Blood samples ( n = 8) were collected from mice 2 weeks after prime and boost. Binding IgG of serum, reactive to the Texas HA protein, was measured by ELISA. Titers of placebo group were below detection limit. (D) 50% neutralization titers of pseudotyped virus (A/Texas/37/2024) in serum collected 2 weeks post-boost (week 6). Titers of placebo group were below detection limit. (E and F) Binding IgG of 1 μg Texas vaccine group (E) and Ast20 vaccine group (F) was measured by ELISA, reactive to the HA of clade 1 virus (A/Viet Nam/1203/2004), clade 2.1.3.2 virus <t>(A/Indonesia/5/2005),</t> clade 2.2 virus (A/bar-headed goose/Qinghai/5/2005), clade 2.3.2.1a virus (A/Hubei/1/2010), clade 2.3.4 virus (A/Anhui/1/2005), clade 2.3.4.4b virus (A/Astrakhan/3212/2020), and clade 2.3.4.4b virus (A/Texas/37/2024). (G) Radar chart of broad-binding IgG levels elicited by 1 μg Texas vaccine and Ast20 vaccine. (H) Vaccination schedule. Mice were vaccinated (i.m.) with 1 or 5 μg mRNA-LNP (SM102) encoding Texas HA-Mut, Ast20 HA-Mut, or placebo. Four weeks post-vaccination (week 4), mice were challenged with 50 × LD 50 of A/ostrich/China/HB/2024. Virus load of organs in vaccinated mice 1, 3, 5 days post-infection determined using plaque assays on MDCK cells. (I–L) Virus load of lung (I), heart (J), kidney (K), and brain (L). The dashed horizontal line indicates the assay limit of detection. Data are presented as the mean ± SD; p values are analyzed with t test (∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001) (C–L). ∗/∗∗∗ (E and F) indicates significant differences between other HA proteins and Texas (E) or Ast20 (F) protein. ∗ (E and F) indicates significant differences between other HA proteins and Texas (E) or Ast20 (F) protein. ∗ (I–L) indicates significant differences between placebo and vaccination groups in the same day.
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Comparison of vaccine efficacy between H5 Texas Mut vaccine and H5 Ast20 Mut vaccine in mice (A) Schematic of cleavage-defective mutant (Mut) HA mRNA vaccines. (B) Western blotting analysis of HA protein expression in transfected BHK-21 cells. Cells were transfected with varying doses (50, 100, 200, and 500 ng/μL) of Texas Mut or Ast20 Mut mRNA. (C) Mice were vaccinated (i.m.) with 1 or 5 μg Texas/Ast20 mRNA-LNP (SM102) encoding Mut HA or placebo using in a prime-boost schedule with an interval of 4 weeks. Blood samples ( n = 8) were collected from mice 2 weeks after prime and boost. Binding IgG of serum, reactive to the Texas HA protein, was measured by ELISA. Titers of placebo group were below detection limit. (D) 50% neutralization titers of pseudotyped virus (A/Texas/37/2024) in serum collected 2 weeks post-boost (week 6). Titers of placebo group were below detection limit. (E and F) Binding IgG of 1 μg Texas vaccine group (E) and Ast20 vaccine group (F) was measured by ELISA, reactive to the HA of clade 1 virus (A/Viet Nam/1203/2004), clade 2.1.3.2 virus <t>(A/Indonesia/5/2005),</t> clade 2.2 virus (A/bar-headed goose/Qinghai/5/2005), clade 2.3.2.1a virus (A/Hubei/1/2010), clade 2.3.4 virus (A/Anhui/1/2005), clade 2.3.4.4b virus (A/Astrakhan/3212/2020), and clade 2.3.4.4b virus (A/Texas/37/2024). (G) Radar chart of broad-binding IgG levels elicited by 1 μg Texas vaccine and Ast20 vaccine. (H) Vaccination schedule. Mice were vaccinated (i.m.) with 1 or 5 μg mRNA-LNP (SM102) encoding Texas HA-Mut, Ast20 HA-Mut, or placebo. Four weeks post-vaccination (week 4), mice were challenged with 50 × LD 50 of A/ostrich/China/HB/2024. Virus load of organs in vaccinated mice 1, 3, 5 days post-infection determined using plaque assays on MDCK cells. (I–L) Virus load of lung (I), heart (J), kidney (K), and brain (L). The dashed horizontal line indicates the assay limit of detection. Data are presented as the mean ± SD; p values are analyzed with t test (∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001) (C–L). ∗/∗∗∗ (E and F) indicates significant differences between other HA proteins and Texas (E) or Ast20 (F) protein. ∗ (E and F) indicates significant differences between other HA proteins and Texas (E) or Ast20 (F) protein. ∗ (I–L) indicates significant differences between placebo and vaccination groups in the same day.
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Comparison of vaccine efficacy between H5 Texas Mut vaccine and H5 Ast20 Mut vaccine in mice (A) Schematic of cleavage-defective mutant (Mut) HA mRNA vaccines. (B) Western blotting analysis of HA protein expression in transfected BHK-21 cells. Cells were transfected with varying doses (50, 100, 200, and 500 ng/μL) of Texas Mut or Ast20 Mut mRNA. (C) Mice were vaccinated (i.m.) with 1 or 5 μg Texas/Ast20 mRNA-LNP (SM102) encoding Mut HA or placebo using in a prime-boost schedule with an interval of 4 weeks. Blood samples ( n = 8) were collected from mice 2 weeks after prime and boost. Binding IgG of serum, reactive to the Texas HA protein, was measured by ELISA. Titers of placebo group were below detection limit. (D) 50% neutralization titers of pseudotyped virus (A/Texas/37/2024) in serum collected 2 weeks post-boost (week 6). Titers of placebo group were below detection limit. (E and F) Binding IgG of 1 μg Texas vaccine group (E) and Ast20 vaccine group (F) was measured by ELISA, reactive to the HA of clade 1 virus (A/Viet Nam/1203/2004), clade 2.1.3.2 virus <t>(A/Indonesia/5/2005),</t> clade 2.2 virus (A/bar-headed goose/Qinghai/5/2005), clade 2.3.2.1a virus (A/Hubei/1/2010), clade 2.3.4 virus (A/Anhui/1/2005), clade 2.3.4.4b virus (A/Astrakhan/3212/2020), and clade 2.3.4.4b virus (A/Texas/37/2024). (G) Radar chart of broad-binding IgG levels elicited by 1 μg Texas vaccine and Ast20 vaccine. (H) Vaccination schedule. Mice were vaccinated (i.m.) with 1 or 5 μg mRNA-LNP (SM102) encoding Texas HA-Mut, Ast20 HA-Mut, or placebo. Four weeks post-vaccination (week 4), mice were challenged with 50 × LD 50 of A/ostrich/China/HB/2024. Virus load of organs in vaccinated mice 1, 3, 5 days post-infection determined using plaque assays on MDCK cells. (I–L) Virus load of lung (I), heart (J), kidney (K), and brain (L). The dashed horizontal line indicates the assay limit of detection. Data are presented as the mean ± SD; p values are analyzed with t test (∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001) (C–L). ∗/∗∗∗ (E and F) indicates significant differences between other HA proteins and Texas (E) or Ast20 (F) protein. ∗ (E and F) indicates significant differences between other HA proteins and Texas (E) or Ast20 (F) protein. ∗ (I–L) indicates significant differences between placebo and vaccination groups in the same day.
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Comparison of vaccine efficacy between H5 Texas Mut vaccine and H5 Ast20 Mut vaccine in mice (A) Schematic of cleavage-defective mutant (Mut) HA mRNA vaccines. (B) Western blotting analysis of HA protein expression in transfected BHK-21 cells. Cells were transfected with varying doses (50, 100, 200, and 500 ng/μL) of Texas Mut or Ast20 Mut mRNA. (C) Mice were vaccinated (i.m.) with 1 or 5 μg Texas/Ast20 mRNA-LNP (SM102) encoding Mut HA or placebo using in a prime-boost schedule with an interval of 4 weeks. Blood samples ( n = 8) were collected from mice 2 weeks after prime and boost. Binding IgG of serum, reactive to the Texas HA protein, was measured by ELISA. Titers of placebo group were below detection limit. (D) 50% neutralization titers of pseudotyped virus (A/Texas/37/2024) in serum collected 2 weeks post-boost (week 6). Titers of placebo group were below detection limit. (E and F) Binding IgG of 1 μg Texas vaccine group (E) and Ast20 vaccine group (F) was measured by ELISA, reactive to the HA of clade 1 virus (A/Viet Nam/1203/2004), clade 2.1.3.2 virus <t>(A/Indonesia/5/2005),</t> clade 2.2 virus (A/bar-headed goose/Qinghai/5/2005), clade 2.3.2.1a virus (A/Hubei/1/2010), clade 2.3.4 virus (A/Anhui/1/2005), clade 2.3.4.4b virus (A/Astrakhan/3212/2020), and clade 2.3.4.4b virus (A/Texas/37/2024). (G) Radar chart of broad-binding IgG levels elicited by 1 μg Texas vaccine and Ast20 vaccine. (H) Vaccination schedule. Mice were vaccinated (i.m.) with 1 or 5 μg mRNA-LNP (SM102) encoding Texas HA-Mut, Ast20 HA-Mut, or placebo. Four weeks post-vaccination (week 4), mice were challenged with 50 × LD 50 of A/ostrich/China/HB/2024. Virus load of organs in vaccinated mice 1, 3, 5 days post-infection determined using plaque assays on MDCK cells. (I–L) Virus load of lung (I), heart (J), kidney (K), and brain (L). The dashed horizontal line indicates the assay limit of detection. Data are presented as the mean ± SD; p values are analyzed with t test (∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001) (C–L). ∗/∗∗∗ (E and F) indicates significant differences between other HA proteins and Texas (E) or Ast20 (F) protein. ∗ (E and F) indicates significant differences between other HA proteins and Texas (E) or Ast20 (F) protein. ∗ (I–L) indicates significant differences between placebo and vaccination groups in the same day.
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Comparison of vaccine efficacy between H5 Texas Mut vaccine and H5 Ast20 Mut vaccine in mice (A) Schematic of cleavage-defective mutant (Mut) HA mRNA vaccines. (B) Western blotting analysis of HA protein expression in transfected BHK-21 cells. Cells were transfected with varying doses (50, 100, 200, and 500 ng/μL) of Texas Mut or Ast20 Mut mRNA. (C) Mice were vaccinated (i.m.) with 1 or 5 μg Texas/Ast20 mRNA-LNP (SM102) encoding Mut HA or placebo using in a prime-boost schedule with an interval of 4 weeks. Blood samples ( n = 8) were collected from mice 2 weeks after prime and boost. Binding IgG of serum, reactive to the Texas HA protein, was measured by ELISA. Titers of placebo group were below detection limit. (D) 50% neutralization titers of pseudotyped virus (A/Texas/37/2024) in serum collected 2 weeks post-boost (week 6). Titers of placebo group were below detection limit. (E and F) Binding IgG of 1 μg Texas vaccine group (E) and Ast20 vaccine group (F) was measured by ELISA, reactive to the HA of clade 1 virus (A/Viet Nam/1203/2004), clade 2.1.3.2 virus (A/Indonesia/5/2005), clade 2.2 virus (A/bar-headed goose/Qinghai/5/2005), clade 2.3.2.1a virus (A/Hubei/1/2010), clade 2.3.4 virus (A/Anhui/1/2005), clade 2.3.4.4b virus (A/Astrakhan/3212/2020), and clade 2.3.4.4b virus (A/Texas/37/2024). (G) Radar chart of broad-binding IgG levels elicited by 1 μg Texas vaccine and Ast20 vaccine. (H) Vaccination schedule. Mice were vaccinated (i.m.) with 1 or 5 μg mRNA-LNP (SM102) encoding Texas HA-Mut, Ast20 HA-Mut, or placebo. Four weeks post-vaccination (week 4), mice were challenged with 50 × LD 50 of A/ostrich/China/HB/2024. Virus load of organs in vaccinated mice 1, 3, 5 days post-infection determined using plaque assays on MDCK cells. (I–L) Virus load of lung (I), heart (J), kidney (K), and brain (L). The dashed horizontal line indicates the assay limit of detection. Data are presented as the mean ± SD; p values are analyzed with t test (∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001) (C–L). ∗/∗∗∗ (E and F) indicates significant differences between other HA proteins and Texas (E) or Ast20 (F) protein. ∗ (E and F) indicates significant differences between other HA proteins and Texas (E) or Ast20 (F) protein. ∗ (I–L) indicates significant differences between placebo and vaccination groups in the same day.

Journal: Cell Reports Medicine

Article Title: Preclinical evaluation of an mRNA vaccine developed from the first human isolate of bovine H5N1

doi: 10.1016/j.xcrm.2026.102702

Figure Lengend Snippet: Comparison of vaccine efficacy between H5 Texas Mut vaccine and H5 Ast20 Mut vaccine in mice (A) Schematic of cleavage-defective mutant (Mut) HA mRNA vaccines. (B) Western blotting analysis of HA protein expression in transfected BHK-21 cells. Cells were transfected with varying doses (50, 100, 200, and 500 ng/μL) of Texas Mut or Ast20 Mut mRNA. (C) Mice were vaccinated (i.m.) with 1 or 5 μg Texas/Ast20 mRNA-LNP (SM102) encoding Mut HA or placebo using in a prime-boost schedule with an interval of 4 weeks. Blood samples ( n = 8) were collected from mice 2 weeks after prime and boost. Binding IgG of serum, reactive to the Texas HA protein, was measured by ELISA. Titers of placebo group were below detection limit. (D) 50% neutralization titers of pseudotyped virus (A/Texas/37/2024) in serum collected 2 weeks post-boost (week 6). Titers of placebo group were below detection limit. (E and F) Binding IgG of 1 μg Texas vaccine group (E) and Ast20 vaccine group (F) was measured by ELISA, reactive to the HA of clade 1 virus (A/Viet Nam/1203/2004), clade 2.1.3.2 virus (A/Indonesia/5/2005), clade 2.2 virus (A/bar-headed goose/Qinghai/5/2005), clade 2.3.2.1a virus (A/Hubei/1/2010), clade 2.3.4 virus (A/Anhui/1/2005), clade 2.3.4.4b virus (A/Astrakhan/3212/2020), and clade 2.3.4.4b virus (A/Texas/37/2024). (G) Radar chart of broad-binding IgG levels elicited by 1 μg Texas vaccine and Ast20 vaccine. (H) Vaccination schedule. Mice were vaccinated (i.m.) with 1 or 5 μg mRNA-LNP (SM102) encoding Texas HA-Mut, Ast20 HA-Mut, or placebo. Four weeks post-vaccination (week 4), mice were challenged with 50 × LD 50 of A/ostrich/China/HB/2024. Virus load of organs in vaccinated mice 1, 3, 5 days post-infection determined using plaque assays on MDCK cells. (I–L) Virus load of lung (I), heart (J), kidney (K), and brain (L). The dashed horizontal line indicates the assay limit of detection. Data are presented as the mean ± SD; p values are analyzed with t test (∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001) (C–L). ∗/∗∗∗ (E and F) indicates significant differences between other HA proteins and Texas (E) or Ast20 (F) protein. ∗ (E and F) indicates significant differences between other HA proteins and Texas (E) or Ast20 (F) protein. ∗ (I–L) indicates significant differences between placebo and vaccination groups in the same day.

Article Snippet: HA recombinant protein of A/Indonesia/5/2005 , Synthesized from Novoprotein , N/A.

Techniques: Comparison, Mutagenesis, Vaccines, Western Blot, Expressing, Transfection, Binding Assay, Enzyme-linked Immunosorbent Assay, Neutralization, Virus, Infection