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ipsc lines wt ips cell line ips imr90  (WiCell Research Institute Inc)


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    WiCell Research Institute Inc ipsc lines wt ips cell line ips imr90
    Ipsc Lines Wt Ips Cell Line Ips Imr90, supplied by WiCell Research Institute Inc, used in various techniques. Bioz Stars score: 97/100, based on 254 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/ipsc+lines/iPS(IMR90)-4/pm41981306-261-26-36
    Average 97 stars, based on 254 article reviews
    ipsc lines wt ips cell line ips imr90 - by Bioz Stars, 2026-11
    97/100 stars

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    Related Articles

    Cell Culture:

    Article Title: Induction of fibrosis in human kidney organoids delineates mechanisms and therapeutic targets of fibrotic kidney disease
    Article Snippet: .. iPS(IMR90)-4 hiPSCs (WiCell) were maintained in mTeSR medium (STEMCELL Technologies) on 6-well cell culture plates (Greiner), coated with hESC-qualified Matrigel (Corning). .. Medium was changed daily, and cells were passaged with Gentle Cell Dissociation Reagent (STEMCELL Technologies) every 4–5 days at a 1:20 split ratio.

    Stem Cell:

    Article Title: Encephalitic alphavirus infection reduces neurite outgrowth and downregulates Rho GTPase pathways in human iPSC-derived neurospheres
    Article Snippet: Mycoplasma testing was performed twice a year applying the Mycoplasma Detection Kit (Southern Biotech). .. The human induced pluripotent stem cell (iPSC) line IMR90-04, originally obtained from WiCell , was used for the generation of neural progenitor cells and neurospheres. .. Monthly Mycoplasma testing was performed, applying the Mycoplasma PCR Detection kit (Applied Biological Materials).

    Article Title: Zolpidem-induced synaptic disruption and multi-omics alterations in human cerebral organoids under simulated microgravity
    Article Snippet: Long-duration spaceflight severely disrupts astronauts' circadian rhythms, leading to a high reliance on hypnotics such as zolpidem, a GABAA receptor positive allosteric modulator.. However, how altered gravitational vectors modulate human central nervous system psychopharmacology remains uncharacterized.. Here, we established a platform with human induced pluripotent stem cell-derived cerebral organoids to evaluate the molecular, neurochemical, and biophysical impacts of chronic zolpidem exposure under simulated microgravity and subsequent normal gravity re-adaptation.

    Generated:

    Article Title: Zolpidem-induced synaptic disruption and multi-omics alterations in human cerebral organoids under simulated microgravity
    Article Snippet: Long-duration spaceflight severely disrupts astronauts' circadian rhythms, leading to a high reliance on hypnotics such as zolpidem, a GABAA receptor positive allosteric modulator.. However, how altered gravitational vectors modulate human central nervous system psychopharmacology remains uncharacterized.. Here, we established a platform with human induced pluripotent stem cell-derived cerebral organoids to evaluate the molecular, neurochemical, and biophysical impacts of chronic zolpidem exposure under simulated microgravity and subsequent normal gravity re-adaptation.

    Transfection:

    Article Title: Priming of human iPSCs with doxorubicin causes genome-wide transcriptional reprogramming and functional impairments in iPSC-derived cardiomyocytes.
    Article Snippet: .. Human fetal-derived iPSC line iPS (IMR90)-4 (lentiviral transfection with Oct4, Sox2, Nanog and Lin28, WiCell) were used for experimental procedures72. .. iPSCs were cultured in feeder-free conditions on Geltrexcoated plates (Thermo Fisher Scientific Inc.) using mTeSR Plus media (STEMCELL Technologies Inc.) supplemented with 1% Penicillin/Streptomycin.

    other:

    Article Title: Gliomas phenocopy an inborn error of metabolism to drive neuronal activity and tumor growth
    Article Snippet: iPS(IMR-90)-4 , WiCell , RRID:CVCL_C437.



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    Overview of experimental workflow Affinity purification MS were completed on the undifferentiated KOLF2.1J WT cell line. Bulk RNA-seq and ONT long-read WGS + 5 mC methylation analysis was completed on undifferentiated KOLF2.1J clones containing the following rs11610045 genotypes: A|A (WT), G|G (edited), and A|A (reversed). WT and edited (but not reverse edited) clones were differentiated to iPSC-derived cortical neurons and bulk RNA-seq completed. iPSC, induced pluripotent stem cell; sgRNA, single-guide ribonucleic acid; ssODN, single-strand oligodeoxynucleotide; RNP, ribonucleoprotein; HDR enhancer, homology-directed repair enhancer; ONT, Oxford Nanopore Technologies; WGS, whole-genome sequencing.

    Journal: iScience

    Article Title: Dissecting genotype-specific effects of disease-associated genetic variants

    doi: 10.1016/j.isci.2026.116143

    Figure Lengend Snippet: Overview of experimental workflow Affinity purification MS were completed on the undifferentiated KOLF2.1J WT cell line. Bulk RNA-seq and ONT long-read WGS + 5 mC methylation analysis was completed on undifferentiated KOLF2.1J clones containing the following rs11610045 genotypes: A|A (WT), G|G (edited), and A|A (reversed). WT and edited (but not reverse edited) clones were differentiated to iPSC-derived cortical neurons and bulk RNA-seq completed. iPSC, induced pluripotent stem cell; sgRNA, single-guide ribonucleic acid; ssODN, single-strand oligodeoxynucleotide; RNP, ribonucleoprotein; HDR enhancer, homology-directed repair enhancer; ONT, Oxford Nanopore Technologies; WGS, whole-genome sequencing.

    Article Snippet: The KOLF2.1J iPSC line , was obtained from Jackson laboratory ( https://www.jax.org/jax-mice-and-services/ipsc ).

    Techniques: Affinity Purification, RNA Sequencing, Methylation, Clone Assay, Derivative Assay, Sequencing

    Restoring the rs11610045 G|G genotype to A|A also restores gene expression for a subset of genes (A) CRISPR-Cas9 editing of the rs11610045 G|G genotype to A|A restored the expression of 75 genes to WT levels. Green bars represent the log2FC when comparing the edited rs11610045 G|G genotype with that of the A|A genotype (WT) KOLF2.1J cells. Blue bars represent the log2FC when comparing gene expression in the rs11610045 A|A (reversed) with that of the rs11610045 G|G genotype (edit) clones. In all instances, log2FC > 1 and Bonferroni adj. p value <0.05. (B) Expression of CEL , PDGFB , and THBS2 are rs11610045 genotype dependent and have been linked to PD. Boxplots show the median (center line), interquartile range (box), and whiskers extending to 1.5× the interquartile range. Individual data points are overlaid. (C) PDGFB interacts with THBS1 in a protein-protein interaction network (StringDB, high confidence interaction score ≥0.700).

    Journal: iScience

    Article Title: Dissecting genotype-specific effects of disease-associated genetic variants

    doi: 10.1016/j.isci.2026.116143

    Figure Lengend Snippet: Restoring the rs11610045 G|G genotype to A|A also restores gene expression for a subset of genes (A) CRISPR-Cas9 editing of the rs11610045 G|G genotype to A|A restored the expression of 75 genes to WT levels. Green bars represent the log2FC when comparing the edited rs11610045 G|G genotype with that of the A|A genotype (WT) KOLF2.1J cells. Blue bars represent the log2FC when comparing gene expression in the rs11610045 A|A (reversed) with that of the rs11610045 G|G genotype (edit) clones. In all instances, log2FC > 1 and Bonferroni adj. p value <0.05. (B) Expression of CEL , PDGFB , and THBS2 are rs11610045 genotype dependent and have been linked to PD. Boxplots show the median (center line), interquartile range (box), and whiskers extending to 1.5× the interquartile range. Individual data points are overlaid. (C) PDGFB interacts with THBS1 in a protein-protein interaction network (StringDB, high confidence interaction score ≥0.700).

    Article Snippet: The KOLF2.1J iPSC line , was obtained from Jackson laboratory ( https://www.jax.org/jax-mice-and-services/ipsc ).

    Techniques: Gene Expression, CRISPR, Expressing, Clone Assay