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hivacat t-cell immunogen (hti)  (ImmunoGen Inc)

 
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    ImmunoGen Inc hivacat t-cell immunogen (hti)
    Hivacat T Cell Immunogen (Hti), supplied by ImmunoGen Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/immunogen+sequence/hivacat+t+cell+immunogen++hti++sequence/pmc12197663-10-3-5
    Average 90 stars, based on 1 article reviews
    hivacat t-cell immunogen (hti) - by Bioz Stars, 2026-11
    90/100 stars

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    other:

    Article Title: Safety, immunogenicity and effect on viral rebound of HTI vaccines in early treated HIV-1 infection: a randomized, placebo-controlled phase 1 trial.
    Article Snippet: To overcome this, HTI (HIVACAT T-cell immunogen)-based vaccines were designed to induce functional HIV-1-specific T-cell responses that were Received: 3 November 2021 Accepted: 28 September 2022

    Article Title: Recombinant Mycobacterium bovis BCG-Based HIV Vaccine: Failures and Promising Approaches for a Successful Vaccine Strategy
    Article Snippet: Mice (BALB/c) , HIVACAT T-cell immunogen (HTI) , ɑ-antigen promoter, 19-kDa signal peptide, pJH222 , ID , 10 6 CFU rBCG + 10 6 PFU MVA.HTI , BCG.HTI2auxo.int boosted with MVA.HTI was safe and elicited specific T-cell response with a wider recognition profile. , [ ] .

    Article Title: Impact of ChAdOx1 or DNA Prime Vaccination on Magnitude, Breadth, and Focus of MVA-Boosted Immunogen-Specific T Cell Responses
    Article Snippet: Based on these regions, we designed the HIV T-cell Immunogen (HTI) to target T-cell responses to HIV proteome fragments vulnerable to T-cell immunity, avoiding responses to decoy epitopes [ ].

    Article Title: New vector and vaccine platforms: mRNA, DNA, viral vectors
    Article Snippet: Naked HIVACAT T-cell immunogen (HTI) Volume 17 Number 6 November 2022 D ow nloaded from http://journals.lw w .com /co-hivandaids by B hD M f5eP H K av1zE oum 1tQ fN 4a+ kJLhE Z gbsIH o4X M i0 hC yw C X 1A W nY Q p/IlQ rH D 3i3D 0O dR yi7T vS F l4C f3V C 1y0abggQ Z X dtw nfK Z B Y tw s= on 02/02/2024 [35] mRNA adjuvanted with TriMix mRNAs encoding two dendritic cell activating proteins cluster of differentiation (CD)40L and caTLR4, a constitutively active form of TLR4, as well as T cell-activating CD70 [36] was delivered intranodally and was well tolerated (NCT02413645) [37].

    Article Title: Utilizing Computational Machine Learning Tools to Understand Immunogenic Breadth in the Context of a CD8 T-Cell Mediated HIV Response
    Article Snippet: A third approach, HIVACAT T-cell Immunogen, involves the construction a chimeric protein encoding 16 continuous segments of HIV derived from Gag, Pol, Vif, and Nef ( ).

    Article Title: Arenavirus-Based Vectors Generate Robust SIV Immunity in Non-Human Primates
    Article Snippet: Consistent with this, a recent trial with a vaccine using the HIVACAT T-cell immunogen (HTI) was associated with prolonged time off ART in post hoc analyses [ ].

    Immunopeptidomics:

    Article Title: Off the beaten path: Novel mRNA-nanoformulations for therapeutic vaccination against HIV.
    Article Snippet: .. Various methods were used for identifying antigen inserts: (i) screening T-cell epitopes in HIV infected individuals with low viral load, (HIVACAT T cell immunogen) [98,99], (ii) combining the most conserved subprotein domains of HIV-1 (HIVconsv) [100], (iii) taking only the conserved elements of p24gag (p24CE) [101] or (iv) assembling ̳mosaic‘ proteins by in silico recombination of natural sequences [102]. ..

    Infection:

    Article Title: Off the beaten path: Novel mRNA-nanoformulations for therapeutic vaccination against HIV.
    Article Snippet: .. Various methods were used for identifying antigen inserts: (i) screening T-cell epitopes in HIV infected individuals with low viral load, (HIVACAT T cell immunogen) [98,99], (ii) combining the most conserved subprotein domains of HIV-1 (HIVconsv) [100], (iii) taking only the conserved elements of p24gag (p24CE) [101] or (iv) assembling ̳mosaic‘ proteins by in silico recombination of natural sequences [102]. ..

    In Silico:

    Article Title: Off the beaten path: Novel mRNA-nanoformulations for therapeutic vaccination against HIV.
    Article Snippet: .. Various methods were used for identifying antigen inserts: (i) screening T-cell epitopes in HIV infected individuals with low viral load, (HIVACAT T cell immunogen) [98,99], (ii) combining the most conserved subprotein domains of HIV-1 (HIVconsv) [100], (iii) taking only the conserved elements of p24gag (p24CE) [101] or (iv) assembling ̳mosaic‘ proteins by in silico recombination of natural sequences [102]. ..



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    (A) An alignment of human PAX6 sequences reveals that all fifteen isoforms share the <t>immunogenic</t> sequence (highlighted in dark grey). NCBI sequence numbers are to the left of the sequences which are arranged alphabetically by isoform. (B) The four isoforms of axolotl PAX6 (sequences 1–4) contain the immunogenic sequence as does PAX6 from the Japanese fire-bellied newt (sequence 5) and the hypothetical protein from the Iberian ribbed newt (sequence 6). Sequence 7 is human PAX6. (C) Partial sequence obtained from E . nana containing 16/19 amino acids from the PAX6 immunogenic sequence.
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    Image Search Results


    (A) An alignment of human PAX6 sequences reveals that all fifteen isoforms share the immunogenic sequence (highlighted in dark grey). NCBI sequence numbers are to the left of the sequences which are arranged alphabetically by isoform. (B) The four isoforms of axolotl PAX6 (sequences 1–4) contain the immunogenic sequence as does PAX6 from the Japanese fire-bellied newt (sequence 5) and the hypothetical protein from the Iberian ribbed newt (sequence 6). Sequence 7 is human PAX6. (C) Partial sequence obtained from E . nana containing 16/19 amino acids from the PAX6 immunogenic sequence.

    Journal: PLOS ONE

    Article Title: PAX6 protein in neuromasts of the lateral line system of salamanders ( Eurycea )

    doi: 10.1371/journal.pone.0293163

    Figure Lengend Snippet: (A) An alignment of human PAX6 sequences reveals that all fifteen isoforms share the immunogenic sequence (highlighted in dark grey). NCBI sequence numbers are to the left of the sequences which are arranged alphabetically by isoform. (B) The four isoforms of axolotl PAX6 (sequences 1–4) contain the immunogenic sequence as does PAX6 from the Japanese fire-bellied newt (sequence 5) and the hypothetical protein from the Iberian ribbed newt (sequence 6). Sequence 7 is human PAX6. (C) Partial sequence obtained from E . nana containing 16/19 amino acids from the PAX6 immunogenic sequence.

    Article Snippet: Primary antibody was diluted 1:10,000 in 5% non-fat dry milk in Tris-buffered saline with Tween20 (TBST), and half was incubated with custom peptide (Thermo Fisher) matching the antibody’s immunogenic sequence, resuspended in PBS at a concentration at least 5 times the molarity of the antibody.

    Techniques: Sequencing