human umbilical vein (Cell Applications Inc)

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Cell Applications Inc human umbilical vein
Human Umbilical Vein, supplied by Cell Applications Inc, used in various techniques. Bioz Stars score: 95/100, based on 88 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/huvec/Human+Umbilical+Vein+Endothelial+Cells%3A+S-HUVEC%3A+Pre-Screened/pm18988897-24-0-16
Average 95 stars, based on 88 article reviews

human umbilical vein - by Bioz Stars, 2026-10

95/100 stars

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In Vitro:

Article Title: A synthetic microRNA-92a inhibitor (MRG-110) accelerates angiogenesis and wound healing in diabetic and nondiabetic wounds.
Article Snippet: There is a strong unmet need for new therapeutics to accelerate wound healing across both chronic and acute indications.. It is well established that local tissue hypoxia, vascular insufficiency and/or insufficient angiogenesis contribute to inadequate wound repair in the context of diabetic foot ulcers as well as to other chronic wounds such as venous stasis and pressure ulcers. microRNA-92a-3p (miR-92a) is a potent antiangiogenic miRNA whose inhibition has led to increases in angiogenesis in multiple organ systems, resulting in an improvement in function following myocardial infarction, limb ischemia, vascular injury and bone fracture.. Due to their pro-angiogenic effects, miR-92a inhibitors offer potential therapeutics to accelerate the healing process in cutaneous wounds as well. .. There is a strong unmet need for new therapeutics to accelerate wound healing across both chronic and acute indications.. It is well established that local tissue hypoxia, vascular insufficiency and/or insufficient angiogenesis contribute to inadequate wound repair in the context of diabetic foot ulcers as well as to other chronic wounds such as venous stasis and pressure ulcers. microRNA-92a-3p (miR-92a) is a potent antiangiogenic miRNA whose inhibition has led to increases in angiogenesis in multiple organ systems, resulting in an improvement in function following myocardial infarction, limb ischemia, vascular injury and bone fracture.. Due to their pro-angiogenic effects, miR-92a inhibitors offer potential therapeutics to accelerate the healing process in cutaneous wounds as well. .. There is a strong unmet need for new therapeutics to accelerate wound healing across both chronic and acute indications.. It is well established that local tissue hypoxia, vascular insufficiency and/or insufficient angiogenesis contribute to inadequate wound repair in the context of diabetic foot ulcers as well as to other chronic wounds such as venous stasis and pressure ulcers. microRNA-92a-3p (miR-92a) is a potent antiangiogenic miRNA whose inhibition has led to increases in angiogenesis in multiple organ systems, resulting in an improvement in function following myocardial infarction, limb ischemia, vascular injury and bone fracture.. Due to their pro-angiogenic effects, miR-92a inhibitors offer potential therapeutics to accelerate the healing process in cutaneous wounds as well.

Expressing:

Cell Culture:

Article Title: Regulation of Vascular Smooth Muscle Cell Turnover by Endothelial Cell–Secreted MicroRNA-126
Article Snippet: .. Human umbilical vein ECs (HUVECs) were cultured in medium 199 (Gibco) supplemented with 10% fetal bovine serum (FBS) (Omega Scientific) and 10% Endothelial Growth Medium (Cell Applications). .. Human umbilical artery SMCs (HUASMCs) were cultured in Nutrient Mixture F12 Ham Kaighn’s Modification (Sigma-Aldrich) supplemented with 10% FBS and 50% SMC Growth Medium (Cell Applications).

Article Title: Glycolytic PFKFB3 and Glycogenic UGP2 Axis Regulates Perfusion Recovery in Experimental Hind Limb Ischemia
Article Snippet: BACKGROUND: Despite being in an oxygen-rich environment, endothelial cells (ECs) use anaerobic glycolysis (Warburg effect) as the primary metabolic pathway for cellular energy needs.. PFKFB (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase)-3 regulates a critical enzymatic checkpoint in glycolysis and has been shown to induce angiogenesis.. This study builds on our efforts to determine the metabolic regulation of ischemic angiogenesis and perfusion recovery in the ischemic muscle.

Article Title: Akt downregulation by flavin oxidase-induced ROS generation mediates dose-dependent endothelial cell damage elicited by natural antioxidants.
Article Snippet: .. Human umbilical vein ECs (Cell Applications, San Diego, CA) were cultured in EC basal medium (Cell Applications) supplemented with Endothelial Cell Growth Supplement (Cell Applications). ..

Isolation:

Article Title: Interleukin-22 receptor 1 upregulation and activation in hypoxic endothelial cells improves perfusion recovery in experimental peripheral arterial disease.
Article Snippet: Objective: Inflammation induced by muscle ischemia is involved in tissue repair and perfusion recovery in peripheral arterial disease (PAD) patients.. Interleukin (IL)-22 is an inflammatory cytokine discovered in recent years and shows versatile functions; however, its role in PAD remains unknown.. Here, we test whether IL-22 and its receptors are involved in angiogenesis in experimental PAD.

Derivative Assay:

Article Title: Plasminogen activator inhibitor-1 regulates myoendothelial junction formation
Article Snippet: Mice used for high fat comparison were C57Bl/6 mice fed a caloric-rich diet (5.45 kcal/g, 0.2% cholesterol, 35.5% fat; Bio-Serv). . Vascular cell-co-culture Vascular cell co-cultures were assembled as described 22 . .. Cells were derived from human umbilical vein (Cell Applications, Inc, San Diego) and grown in M199 (Gibco) supplemented with 10% FBS (Gibco), 1% glutamine (Gibco), 1% penicillin/streptomycin (Gibco), EC media also contained endothelial cell growth supplement (5ug/mL, BD Biosciences); Additional cell lines were derived from human coronary artery (Lonza, Walkersville). .. Endothelial cells were grown in EBM-2 MV (Lonza) supplemented with Lonza bullet kits (Lonza), VSMC were grown in SmBM (Lonza) supplemented with Lonza bullet kits (Lonza).

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