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human islets  (Prodo Labs)

 
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    Prodo Labs human islets
    Human Islets, supplied by Prodo Labs, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/human+islets/human+islets+primary/pmc13147482-1-0-3
    Average 86 stars, based on 1 article reviews
    human islets - by Bioz Stars, 2026-11
    86/100 stars

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    Related Articles

    other:

    Article Title: Divergent cell-type specific hypoxia responses in human stem cell-derived and primary islets.
    Article Snippet: Primary human islets were obtained from Prodo Laboratories with consent from the donor’s relatives for research use.

    Software:

    Article Title: Acute and Repeated Treatment with 5-PAHSA or 9-PAHSA Isomers Does Not Improve Glucose Control in Mice.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Critical Commercial Assays HTRF insulin (in vitro work) Cisbio Bioassays Cat# 62INSPEC Glucose assay (Glucose HK in hemolysate Gen.2) Roche Diagnostics GmbH, Germany Order Id: 20767131322 Mouse insulin assay Meso Scale Discovery, USA Cat: K152BZC Total GLP-1 assay Meso Scale Discovery, USA Cat: K150JVC Active GLP-1 assay Meso Scale Discovery, USA Cat: K150JWC Experimental Models: Cell Lines Human pre-adipocytes (subcutaneous depot) CellSystems Biotechnologie Vertrieb GmbH product code: PT-5001 L6-GLUT4-myc-AS160-like Sanofi N/A EndoC-bH1 cells Univercell Biosolutions; Ravassard et al. J Clin Invest 121(9): 3589–3597, 2011. .. N/A GLUTag mouse cell line Lee et al. 267(15): 10705-8, 1992; License: Dr. D. Drucker; Mount Sinai Hospital Toronto N/A GPR120 cell line (HEK 293-PSC-Galpha16-GPR120); HEK293 cells co-expressing the human GPR120 (NM_181745) and human G-alpha protein 16 (Ga,16) Sanofi N/A Experimental Models: Organisms/Strains Mouse: C57BL/6J Charles River N/A Mouse: C57BL/6J The Jackson Laboratory N/A Rat islets: obtained from Sprague Dawley rats The Jackson Laboratory N/A Mouse islets: obtained from C57Bl/6J mice The Jackson Laboratory N/A Human pancreatic islets Prodo Laboratories, distributor: tebu-bio 196HIR-IEQ-5000 Software and Algorithms GraphPad Prism Version 7.02 GraphPad Software La Jolla, USA V 7.02 Deposited Data NMR spectra related to synthesis of PAHSAs Mendeley dataset https://doi.org/10.17632/74zyd6xtk5.1 Other Diet: BT-LFD Ssniff Control for TD97366 Diet: BT-HFD Ssniff TD97366 Diet: VS-LFD Harlan Purina 5008 Diet: VS-HFD Harlan HFD TD93075 Diet: CN-LFD Ssniff Control for TD90262 Diet: CN-HFD Ssniff TD90262 Diet: LARD-LFD Research Diets D12450B Diet: LARD-HFD Research Diets D12492 .. Further information and requests for resources and reagents should be directed to and will be fulfilled by the Lead Contact, Maximilian Bielohuby (maximilian.bielohuby@sanofi.com).

    Nuclear Magnetic Resonance:

    Article Title: Acute and Repeated Treatment with 5-PAHSA or 9-PAHSA Isomers Does Not Improve Glucose Control in Mice.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Critical Commercial Assays HTRF insulin (in vitro work) Cisbio Bioassays Cat# 62INSPEC Glucose assay (Glucose HK in hemolysate Gen.2) Roche Diagnostics GmbH, Germany Order Id: 20767131322 Mouse insulin assay Meso Scale Discovery, USA Cat: K152BZC Total GLP-1 assay Meso Scale Discovery, USA Cat: K150JVC Active GLP-1 assay Meso Scale Discovery, USA Cat: K150JWC Experimental Models: Cell Lines Human pre-adipocytes (subcutaneous depot) CellSystems Biotechnologie Vertrieb GmbH product code: PT-5001 L6-GLUT4-myc-AS160-like Sanofi N/A EndoC-bH1 cells Univercell Biosolutions; Ravassard et al. J Clin Invest 121(9): 3589–3597, 2011. .. N/A GLUTag mouse cell line Lee et al. 267(15): 10705-8, 1992; License: Dr. D. Drucker; Mount Sinai Hospital Toronto N/A GPR120 cell line (HEK 293-PSC-Galpha16-GPR120); HEK293 cells co-expressing the human GPR120 (NM_181745) and human G-alpha protein 16 (Ga,16) Sanofi N/A Experimental Models: Organisms/Strains Mouse: C57BL/6J Charles River N/A Mouse: C57BL/6J The Jackson Laboratory N/A Rat islets: obtained from Sprague Dawley rats The Jackson Laboratory N/A Mouse islets: obtained from C57Bl/6J mice The Jackson Laboratory N/A Human pancreatic islets Prodo Laboratories, distributor: tebu-bio 196HIR-IEQ-5000 Software and Algorithms GraphPad Prism Version 7.02 GraphPad Software La Jolla, USA V 7.02 Deposited Data NMR spectra related to synthesis of PAHSAs Mendeley dataset https://doi.org/10.17632/74zyd6xtk5.1 Other Diet: BT-LFD Ssniff Control for TD97366 Diet: BT-HFD Ssniff TD97366 Diet: VS-LFD Harlan Purina 5008 Diet: VS-HFD Harlan HFD TD93075 Diet: CN-LFD Ssniff Control for TD90262 Diet: CN-HFD Ssniff TD90262 Diet: LARD-LFD Research Diets D12450B Diet: LARD-HFD Research Diets D12492 .. Further information and requests for resources and reagents should be directed to and will be fulfilled by the Lead Contact, Maximilian Bielohuby (maximilian.bielohuby@sanofi.com).

    Control:

    Article Title: Acute and Repeated Treatment with 5-PAHSA or 9-PAHSA Isomers Does Not Improve Glucose Control in Mice.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Critical Commercial Assays HTRF insulin (in vitro work) Cisbio Bioassays Cat# 62INSPEC Glucose assay (Glucose HK in hemolysate Gen.2) Roche Diagnostics GmbH, Germany Order Id: 20767131322 Mouse insulin assay Meso Scale Discovery, USA Cat: K152BZC Total GLP-1 assay Meso Scale Discovery, USA Cat: K150JVC Active GLP-1 assay Meso Scale Discovery, USA Cat: K150JWC Experimental Models: Cell Lines Human pre-adipocytes (subcutaneous depot) CellSystems Biotechnologie Vertrieb GmbH product code: PT-5001 L6-GLUT4-myc-AS160-like Sanofi N/A EndoC-bH1 cells Univercell Biosolutions; Ravassard et al. J Clin Invest 121(9): 3589–3597, 2011. .. N/A GLUTag mouse cell line Lee et al. 267(15): 10705-8, 1992; License: Dr. D. Drucker; Mount Sinai Hospital Toronto N/A GPR120 cell line (HEK 293-PSC-Galpha16-GPR120); HEK293 cells co-expressing the human GPR120 (NM_181745) and human G-alpha protein 16 (Ga,16) Sanofi N/A Experimental Models: Organisms/Strains Mouse: C57BL/6J Charles River N/A Mouse: C57BL/6J The Jackson Laboratory N/A Rat islets: obtained from Sprague Dawley rats The Jackson Laboratory N/A Mouse islets: obtained from C57Bl/6J mice The Jackson Laboratory N/A Human pancreatic islets Prodo Laboratories, distributor: tebu-bio 196HIR-IEQ-5000 Software and Algorithms GraphPad Prism Version 7.02 GraphPad Software La Jolla, USA V 7.02 Deposited Data NMR spectra related to synthesis of PAHSAs Mendeley dataset https://doi.org/10.17632/74zyd6xtk5.1 Other Diet: BT-LFD Ssniff Control for TD97366 Diet: BT-HFD Ssniff TD97366 Diet: VS-LFD Harlan Purina 5008 Diet: VS-HFD Harlan HFD TD93075 Diet: CN-LFD Ssniff Control for TD90262 Diet: CN-HFD Ssniff TD90262 Diet: LARD-LFD Research Diets D12450B Diet: LARD-HFD Research Diets D12492 .. Further information and requests for resources and reagents should be directed to and will be fulfilled by the Lead Contact, Maximilian Bielohuby (maximilian.bielohuby@sanofi.com).



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    (A, B) EBs were generated at day 0 after either d4 (A) or d10 (B) NMP formation and then treated with RA for 10 days (control). In the experimental samples, BMPs were added at day 1 (BMP4+1), day 2 (BMP4+2) or day 4 (BMP4+4) after EB formation, until day 10. Samples were further differentiated for 6 days and then processed for immunohistochemistry (IHC). (C) EBs were labeled with antibodies against LHX2 (dI1, green), FOXD3 (dI2, white), ISL1 (dI3, red) and DAPI (all nuclei, blue). (D, E) Quantification of EBs formed from either d4 (D) or d10 (E) NMPs, suggests that dI1s form robustly from the BMP4+1 condition for both d4 and d10 NMPs. In contrast, dI3s form most robustly from BMP4+4 condition for d4 NMPs and the BMP4+1 condition for d10 NMPs. Probability of similarity between control and experimental groups: * p<0.05, ** p<0.005, *** p<0.0005; two-way ANOVA.

    Journal: bioRxiv

    Article Title: In vivo human embryonic spinal cord atlas validates stem cell–derived human dorsal interneurons and reveals ASD spinal signatures

    doi: 10.64898/2025.12.22.696129

    Figure Lengend Snippet: (A, B) EBs were generated at day 0 after either d4 (A) or d10 (B) NMP formation and then treated with RA for 10 days (control). In the experimental samples, BMPs were added at day 1 (BMP4+1), day 2 (BMP4+2) or day 4 (BMP4+4) after EB formation, until day 10. Samples were further differentiated for 6 days and then processed for immunohistochemistry (IHC). (C) EBs were labeled with antibodies against LHX2 (dI1, green), FOXD3 (dI2, white), ISL1 (dI3, red) and DAPI (all nuclei, blue). (D, E) Quantification of EBs formed from either d4 (D) or d10 (E) NMPs, suggests that dI1s form robustly from the BMP4+1 condition for both d4 and d10 NMPs. In contrast, dI3s form most robustly from BMP4+4 condition for d4 NMPs and the BMP4+1 condition for d10 NMPs. Probability of similarity between control and experimental groups: * p<0.05, ** p<0.005, *** p<0.0005; two-way ANOVA.

    Article Snippet: The following antibodies were used: LHX2 (mouse; DSHB, PCRP-LHX2-1C11; 1:50), FOXD3 (guinea pig, a gift from Thomas Mueller, Germany, 1:10,000), ISL1 (goat; R&D systems, AF1837; 1:500), PAX2 (rabbit; Invitrogen, 71-6000; 1:500), LMX1B (guinea pig; Thomas Muller Lab), LHX1/5 (mouse; DSHB, 4F2; 1:50) for 12–14 hours (overnight) at 2–8°C in a humidified chamber.

    Techniques: Generated, Control, Immunohistochemistry, Labeling

    (A, B) EBs were generated at day 0 after either d4 (A) or d10 (B) NMP formation and then treated with RA for 10 days (control). In the experimental samples, BMPs were added at day 1 (BMP4+1), day 2 (BMP4+2) or day 4 (BMP4+4) after EB formation, until day 10. Samples were further differentiated for 6 days and then processed for immunohistochemistry (IHC). (C) EBs were labeled with antibodies against LHX2 (dI1, green), FOXD3 (dI2, white), ISL1 (dI3, red) and DAPI (all nuclei, blue). (D, E) Quantification of EBs formed from either d4 (D) or d10 (E) NMPs, suggests that dI1s form robustly from the BMP4+1 condition for both d4 and d10 NMPs. In contrast, dI3s form most robustly from BMP4+4 condition for d4 NMPs and the BMP4+1 condition for d10 NMPs. Probability of similarity between control and experimental groups: * p<0.05, ** p<0.005, *** p<0.0005; two-way ANOVA.

    Journal: bioRxiv

    Article Title: In vivo human embryonic spinal cord atlas validates stem cell–derived human dorsal interneurons and reveals ASD spinal signatures

    doi: 10.64898/2025.12.22.696129

    Figure Lengend Snippet: (A, B) EBs were generated at day 0 after either d4 (A) or d10 (B) NMP formation and then treated with RA for 10 days (control). In the experimental samples, BMPs were added at day 1 (BMP4+1), day 2 (BMP4+2) or day 4 (BMP4+4) after EB formation, until day 10. Samples were further differentiated for 6 days and then processed for immunohistochemistry (IHC). (C) EBs were labeled with antibodies against LHX2 (dI1, green), FOXD3 (dI2, white), ISL1 (dI3, red) and DAPI (all nuclei, blue). (D, E) Quantification of EBs formed from either d4 (D) or d10 (E) NMPs, suggests that dI1s form robustly from the BMP4+1 condition for both d4 and d10 NMPs. In contrast, dI3s form most robustly from BMP4+4 condition for d4 NMPs and the BMP4+1 condition for d10 NMPs. Probability of similarity between control and experimental groups: * p<0.05, ** p<0.005, *** p<0.0005; two-way ANOVA.

    Article Snippet: The following antibodies were used: LHX2 (mouse; DSHB, PCRP-LHX2-1C11; 1:50), FOXD3 (guinea pig, a gift from Thomas Mueller, Germany, 1:10,000), ISL1 (goat; R&D systems, AF1837; 1:500), PAX2 (rabbit; Invitrogen, 71-6000; 1:500), LMX1B (guinea pig; Thomas Muller Lab), LHX1/5 (mouse; DSHB, 4F2; 1:50) for 12–14 hours (overnight) at 2–8°C in a humidified chamber.

    Techniques: Generated, Control, Immunohistochemistry, Labeling