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microarray  (INFINIUM Inc)

 
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    INFINIUM Inc microarray
    Microarray, supplied by INFINIUM Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/human+dna+methylation+450k+microarray/microarray/pmc08894425-113-11-8
    Average 90 stars, based on 1 article reviews
    microarray - by Bioz Stars, 2026-09
    90/100 stars

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    other:

    Article Title: Developmental programming of the HPA axis and related behaviours: epigenetic mechanisms
    Article Snippet: An additional challenge is that these techniques are based on microarray technologies, such that the number of sites amenable to distinguish cell types is limited to a fraction of CpG sites that can be potentially methylated (e.g. <2% in the case of Infinium microarrays).

    Article Title: Comprehensive Bioinformatics Analyses and Experimental Validation of the Cell Cycle Related Protein SAPCD2 as a New Biomarker and Potential Therapeutic Target in Pancreatic Cancer
    Article Snippet: Each probe (Infinium Human Methylation 450 microarray data) was indicated on the left side, and the numbers on the right side indicated the correlation coefficient or P value.

    Microarray:

    Article Title: Genome wide DNA methylation profiling identifies specific epigenetic features in high-risk cutaneous squamous cell carcinoma
    Article Snippet: .. In the past decade, the advent of genome-scale analysis techniques, such as Infinium microarray systems, has revolutionized the field and has opened up the new era of epigenomics. ..

    Article Title: SAMHD1 single nucleotide polymorphisms impact outcome in children with newly diagnosed acute myeloid leukemia.
    Article Snippet: .. We sought to investigate this SNP in our pediatric AML cohorts for association with clinical outcome, however the rs6102991 SNP is not included on the Infinium Omni2.5Exome-8 Kit microarray. ..

    Article Title: A Targeted Epigenetic Clock for the Prediction of Biological Age
    Article Snippet: .. Overlap with Infinium microarray data [ ] , 120 , 60 , 60. ..

    Article Title: Hypermethylation of PDX1, EN2, and MSX1 predicts the prognosis of colorectal cancer
    Article Snippet: .. We preliminarily selected tumor-specific methylated regions from the Infinium 450 K microarray data downloaded from TCGA. ..

    Article Title: The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space
    Article Snippet: .. Finally, the single-allele resolution of RRBS provided initial insights into epigenetic tumor heterogeneity in glioblastoma, and it distinguishes our approach from recent studies that used the Infinium microarray platform for diagnostic classification of brain tumors 17 , 52 . ..

    Genome Wide:

    Article Title: DNA methylation QTL analysis identifies new regulators of human longevity
    Article Snippet: .. Compared to Infinium microarrays, RRBS provides higher genome-wide coverage, single-site and single-allele resolution, and insights into DNA methylation heterogeneity ( ). ..

    DNA Methylation Assay:

    Article Title: DNA methylation QTL analysis identifies new regulators of human longevity
    Article Snippet: .. Compared to Infinium microarrays, RRBS provides higher genome-wide coverage, single-site and single-allele resolution, and insights into DNA methylation heterogeneity ( ). ..

    Methylation:

    Article Title: Hypermethylation of PDX1, EN2, and MSX1 predicts the prognosis of colorectal cancer
    Article Snippet: .. We preliminarily selected tumor-specific methylated regions from the Infinium 450 K microarray data downloaded from TCGA. ..

    Diagnostic Assay:

    Article Title: The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space
    Article Snippet: .. Finally, the single-allele resolution of RRBS provided initial insights into epigenetic tumor heterogeneity in glioblastoma, and it distinguishes our approach from recent studies that used the Infinium microarray platform for diagnostic classification of brain tumors 17 , 52 . ..



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    Genes with significantly different <t>DNA</t> methylation in one or more CpG sites in non-polymorphic regions. ( a ) List of 18 genes that have one of more CpG sites in non-polymorphic regions with difference in methylation ≥20%. DCAF6 and ZNF714 , highlighted orange, have variable copy number in genome. ( b ) Proportion of the locations of CpG sites in the 18 genes. TSS, transcription start site; TSS1500, the sequence region from −200 to −1,500 nucleotides upstream of the transcription start site; TSS200, the region from −200 nucleotides upstream to the TSS itself; UTR, untranslated region. ( c ) TaqMan Copy Number Assays for DCAF6 showed that among 14 donors, four have one copy of the gene (N2, N6, N7 and O4), five have two copies (N1, N3, N4, N5, and O1) and also five have three copies (O2, O3, O5, O6, and O7). All four WJ MSC samples that showed significantly different DCAF6 DNA methylation (*) originated from the donors that have three copies of the gene (O2, O3, O6, and O7). Each sample bar represents the mean calculated copy number and error bars show the standard deviation for three replicates. ( d and e ) Expression gene array did not detect significant difference DCAF6 mRNA expression in any of the samples indicating that duplicated DCAF6 genes might not be functional. ( f ) TaqMan Copy Number Assays for ZNF714 showed that all non-obese and obese donors have two copies of the ZNF714 gene. *Five donors that had significantly different DNA methylation of all CpG sites in ZNF714 (O1, O2, O4, O5, and O7). Each sample bar represents the mean calculated copy number and error bars show the standard deviation for three replicates. ( g and h ) Expression gene array did not detect significant difference ZNF714 mRNA expression in any of the samples indicating that the extra copy of ZNF714 gene might be either functional or not in all donors uniformly. ( i ) The mRNA expression levels of 16 genes showed no differences in the obese and non-obese groups. The Y axis represents the log2 of the normalized intensity values. The single exception was the PNPLA7 gene, which showed higher expression in the non-obese group than in the obese group (**p ≤ 0.01), the adjusted p-values from Linear Models for <t>Microarray</t> and RNA-Seq Data (limma) statistical test , .
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    Image Search Results


    Genes with significantly different DNA methylation in one or more CpG sites in non-polymorphic regions. ( a ) List of 18 genes that have one of more CpG sites in non-polymorphic regions with difference in methylation ≥20%. DCAF6 and ZNF714 , highlighted orange, have variable copy number in genome. ( b ) Proportion of the locations of CpG sites in the 18 genes. TSS, transcription start site; TSS1500, the sequence region from −200 to −1,500 nucleotides upstream of the transcription start site; TSS200, the region from −200 nucleotides upstream to the TSS itself; UTR, untranslated region. ( c ) TaqMan Copy Number Assays for DCAF6 showed that among 14 donors, four have one copy of the gene (N2, N6, N7 and O4), five have two copies (N1, N3, N4, N5, and O1) and also five have three copies (O2, O3, O5, O6, and O7). All four WJ MSC samples that showed significantly different DCAF6 DNA methylation (*) originated from the donors that have three copies of the gene (O2, O3, O6, and O7). Each sample bar represents the mean calculated copy number and error bars show the standard deviation for three replicates. ( d and e ) Expression gene array did not detect significant difference DCAF6 mRNA expression in any of the samples indicating that duplicated DCAF6 genes might not be functional. ( f ) TaqMan Copy Number Assays for ZNF714 showed that all non-obese and obese donors have two copies of the ZNF714 gene. *Five donors that had significantly different DNA methylation of all CpG sites in ZNF714 (O1, O2, O4, O5, and O7). Each sample bar represents the mean calculated copy number and error bars show the standard deviation for three replicates. ( g and h ) Expression gene array did not detect significant difference ZNF714 mRNA expression in any of the samples indicating that the extra copy of ZNF714 gene might be either functional or not in all donors uniformly. ( i ) The mRNA expression levels of 16 genes showed no differences in the obese and non-obese groups. The Y axis represents the log2 of the normalized intensity values. The single exception was the PNPLA7 gene, which showed higher expression in the non-obese group than in the obese group (**p ≤ 0.01), the adjusted p-values from Linear Models for Microarray and RNA-Seq Data (limma) statistical test , .

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    Figure Lengend Snippet: Genes with significantly different DNA methylation in one or more CpG sites in non-polymorphic regions. ( a ) List of 18 genes that have one of more CpG sites in non-polymorphic regions with difference in methylation ≥20%. DCAF6 and ZNF714 , highlighted orange, have variable copy number in genome. ( b ) Proportion of the locations of CpG sites in the 18 genes. TSS, transcription start site; TSS1500, the sequence region from −200 to −1,500 nucleotides upstream of the transcription start site; TSS200, the region from −200 nucleotides upstream to the TSS itself; UTR, untranslated region. ( c ) TaqMan Copy Number Assays for DCAF6 showed that among 14 donors, four have one copy of the gene (N2, N6, N7 and O4), five have two copies (N1, N3, N4, N5, and O1) and also five have three copies (O2, O3, O5, O6, and O7). All four WJ MSC samples that showed significantly different DCAF6 DNA methylation (*) originated from the donors that have three copies of the gene (O2, O3, O6, and O7). Each sample bar represents the mean calculated copy number and error bars show the standard deviation for three replicates. ( d and e ) Expression gene array did not detect significant difference DCAF6 mRNA expression in any of the samples indicating that duplicated DCAF6 genes might not be functional. ( f ) TaqMan Copy Number Assays for ZNF714 showed that all non-obese and obese donors have two copies of the ZNF714 gene. *Five donors that had significantly different DNA methylation of all CpG sites in ZNF714 (O1, O2, O4, O5, and O7). Each sample bar represents the mean calculated copy number and error bars show the standard deviation for three replicates. ( g and h ) Expression gene array did not detect significant difference ZNF714 mRNA expression in any of the samples indicating that the extra copy of ZNF714 gene might be either functional or not in all donors uniformly. ( i ) The mRNA expression levels of 16 genes showed no differences in the obese and non-obese groups. The Y axis represents the log2 of the normalized intensity values. The single exception was the PNPLA7 gene, which showed higher expression in the non-obese group than in the obese group (**p ≤ 0.01), the adjusted p-values from Linear Models for Microarray and RNA-Seq Data (limma) statistical test , .

    Article Snippet: Methylation levels at >480,000 CpG sites throughout the genome were measured using the Infinium Human DNA Methylation 450k BeadChip microarray(Illumina) in triplicate, each array representing an independent bisulfite conversion of a donor sample; performed at the Genomics Facility of the Biomedical Research Centre at the Guy’s and St Thomas’ National Health Service Foundation Trust and King’s College London.

    Techniques: DNA Methylation Assay, Methylation, Sequencing, Standard Deviation, Expressing, Functional Assay, Microarray, RNA Sequencing Assay

    Technical DNA methylation validation. (A) Scatter plot of DNA methylation levels obtained by Infinium Human Methylation 450k BeadChip (Illumina Inc., San Diego, CA) (Y-axis) and bisulfite pyrosequencing (X-axis) (n = 11). A highly significant correlation (P < 0.001, R 2 = 0.978 and R 2 = 0.968, respectably) between microarray and pyrosequencing data was observed. Example of pyrograms with methylated (B) and unmethylated (C) cytosines.

    Journal: Genomics Data

    Article Title: DNA methylation fingerprint of neuroblastoma reveals new biological and clinical insights

    doi: 10.1016/j.gdata.2015.07.016

    Figure Lengend Snippet: Technical DNA methylation validation. (A) Scatter plot of DNA methylation levels obtained by Infinium Human Methylation 450k BeadChip (Illumina Inc., San Diego, CA) (Y-axis) and bisulfite pyrosequencing (X-axis) (n = 11). A highly significant correlation (P < 0.001, R 2 = 0.978 and R 2 = 0.968, respectably) between microarray and pyrosequencing data was observed. Example of pyrograms with methylated (B) and unmethylated (C) cytosines.

    Article Snippet: Microarray DNA methylation data (Infinium Human Methylation 450k BeadChip) were analyzed and associated with functional/regulatory genome annotation data, transcriptional profiles and clinico-biological parameters.

    Techniques: DNA Methylation Assay, Biomarker Discovery, Methylation, Microarray

    Journal: Genomics Data

    Article Title: DNA methylation fingerprint of neuroblastoma reveals new biological and clinical insights

    doi: 10.1016/j.gdata.2015.07.016

    Figure Lengend Snippet:

    Article Snippet: Microarray DNA methylation data (Infinium Human Methylation 450k BeadChip) were analyzed and associated with functional/regulatory genome annotation data, transcriptional profiles and clinico-biological parameters.

    Techniques: Methylation