adult normal human brain tissue lysates (Novus Biologicals)
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Novus Biologicals
adult normal human brain tissue lysates
Adult Normal Human Brain Tissue Lysates, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 93/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+brain+tissue/Human+Brain+Tissue+MicroArray+(Normal)/pmc07000683-223-0-9
Average 93 stars, based on 2 article reviews
Adult Normal Human Brain Tissue Lysates, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 93/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+brain+tissue/Human+Brain+Tissue+MicroArray+(Normal)/pmc07000683-223-0-9
Average 93 stars, based on 2 article reviews
adult normal human brain tissue lysates - by Bioz Stars,
2026-09
93/100 stars
Images
1) Product Images from "Chondroitin sulfate synthase 1 enhances proliferation of glioblastoma by modulating PDGFRA stability"
Article Title: Chondroitin sulfate synthase 1 enhances proliferation of glioblastoma by modulating PDGFRA stability
Journal: Oncogenesis
doi: 10.1038/s41389-020-0197-0
Figure Legend Snippet: a Comparison of CHSY1 gene expression in glioma subtypes and normal brain tissue in the REMBRANDT glioma microarray database. ** P < 0.01, **** P < 0.0001. b High expression of CHSY1 was associated with worse overall survival in glioma patients. The high and low expression groups were divided by median expression level of CHSY1 in 329 cases. These data were from the REMBRANDT database ( http://www.betastasis.com/glioma/rembrandt/ ). c Immunohistochemistry of CHSY1 (upper panel) and CS56 (lower panel) on tissue array contains 85 primary glioma cases. The staining was visualized in brown color with a 3,3-diaminobenzidine liquid substrate system. All sections were counterstained with hematoxylin. Representative images of four glioma cases with different staining intensities are shown. Amplified images are shown at the bottom right of each image. Scale bars, 50 μm. Arrows indicate positive stained glioma cells. d Representative images of CHSY1 staining on normal brain tissue ( n = 5). e Statistical analysis of immunohistochemistry in glioma tissue array. Mann–Whitney U -test was used. P -values are shown at top. f Expression of CHSY1 in glioma cell lines and normal human brain tissue. The protein expression was analyzed by western blotting. Total loading protein is shown at bottom. Relative expression levels to total brain tissue form three independent blots are shown at the right.
Techniques Used: Comparison, Gene Expression, Microarray, Expressing, Immunohistochemistry, Staining, Amplification, MANN-WHITNEY, Western Blot
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![PVSRIPO directs infection of, non-cytopathogenic vRNA replication in, and IFN-I signaling in the microglial compartment in vivo . (A-C) Flow cytometry analyses of microglia before/after CD11b + -bead isolation from hCD155 -tg mouse (A, C) or <t>human</t> <t>brain</t> <t>tissue</t> (B) . The same kit and identical procedures were used to process human/mouse brain tissue samples (see Materials and methods ). Consistently, ∼90-95% of CD45 hi , CD11b + , MERTK + , Cx3cx1 + (A, B) and Tmem119 + (C) cells were recovered from brain tissue of either species. (D) RT-qPCR analyses of total RNA from hCD155 -tg murine or human microglia as shown. Microglia were either infected ex vivo [multiplicity of infection (MOI) 10; left and middle panels], or CD11b + -bead isolated after infection in vivo [single intracerebral inoculation of PVSRIPO (5 x 10 7 pfu); right panel]. Ipsilateral (to the site of virus inoculation) and contralateral hemispheres were processed separately. vRNA levels in mouse microglia were analyzed by two-tailed Mann-Whitney test on ΔΔCt values at 8 weeks pi (n=5; left panel); the same test was used to analyze vRNA levels in human microglia at 72hpi (n=3; right middle panel). (E) HCR-FISH analyses of vRNA species in human CD11b + -bead isolated microglia infected ex vivo with PVSRIPO (MOI 10). Two individual microglia cells at 24 and 72hpi, each, are shown. (F-G) IF and HCR-FISH analyses in non-tumor-bearing hCD155 -tg mouse brains 48h post single intracerebral PVSRIPO infusion (5 x 10 7 pfu). Tmem119 + microglia stain positive for (-)strand vRNA (F) with widespread ISG15 induction in the microglial compartment (G) .](https://bio-rxiv-images-cdn.bioz.com/dois_ending_with_90/10__64898_slash_2026__04__06__716590/10__64898_slash_2026__04__06__716590___F2.large.jpg)