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human circrna arrays arraystar rockville, md  (Arraystar inc)

 
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    Arraystar inc human circrna arrays arraystar rockville, md
    <t>CircRNA</t> expression profiles of CD patients (n = 5) in comparison with HCs (n = 5) screened by microarray analysis. A, Boxplot view showed the distribution of normalized intensity values for CD patients (T12, T40, T49, and T51) and HCs (C1, C2, C3, C4, and C5). B, Scatter plot indicated the variation of circRNA expression between groups. Dots outside the green lines represented circRNAs with logarithmized expression changes greater than 2-fold between groups. C, Volcano plots showed the values of FC and P of the microarray data. Red dots indicated significantly dysregulated circRNAs. D, Hierarchical clustering revealed circRNA expression profiles of CD and HCs. Red color strip represented relatively high expression, while green color one indicated relatively low expression. circRNA = circular RNA, CD = Crohn disease, FC = fold-change, HCs = health controls.
    Human Circrna Arrays Arraystar Rockville, Md, supplied by Arraystar inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/human+arraystar+circrna+array/pmc06617429-56-19-22?v=Arraystar+inc
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    human circrna arrays arraystar rockville, md - by Bioz Stars, 2026-08
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    1) Product Images from "Circular RNA expression profile in peripheral blood mononuclear cells from Crohn disease patients"

    Article Title: Circular RNA expression profile in peripheral blood mononuclear cells from Crohn disease patients

    Journal: Medicine

    doi: 10.1097/MD.0000000000016072

    CircRNA expression profiles of CD patients (n = 5) in comparison with HCs (n = 5) screened by microarray analysis. A, Boxplot view showed the distribution of normalized intensity values for CD patients (T12, T40, T49, and T51) and HCs (C1, C2, C3, C4, and C5). B, Scatter plot indicated the variation of circRNA expression between groups. Dots outside the green lines represented circRNAs with logarithmized expression changes greater than 2-fold between groups. C, Volcano plots showed the values of FC and P of the microarray data. Red dots indicated significantly dysregulated circRNAs. D, Hierarchical clustering revealed circRNA expression profiles of CD and HCs. Red color strip represented relatively high expression, while green color one indicated relatively low expression. circRNA = circular RNA, CD = Crohn disease, FC = fold-change, HCs = health controls.
    Figure Legend Snippet: CircRNA expression profiles of CD patients (n = 5) in comparison with HCs (n = 5) screened by microarray analysis. A, Boxplot view showed the distribution of normalized intensity values for CD patients (T12, T40, T49, and T51) and HCs (C1, C2, C3, C4, and C5). B, Scatter plot indicated the variation of circRNA expression between groups. Dots outside the green lines represented circRNAs with logarithmized expression changes greater than 2-fold between groups. C, Volcano plots showed the values of FC and P of the microarray data. Red dots indicated significantly dysregulated circRNAs. D, Hierarchical clustering revealed circRNA expression profiles of CD and HCs. Red color strip represented relatively high expression, while green color one indicated relatively low expression. circRNA = circular RNA, CD = Crohn disease, FC = fold-change, HCs = health controls.

    Techniques Used: Expressing, Comparison, Microarray, Stripping Membranes

    Verification of the relatively expression level of 5 up-regulated circRNAs (092520, 102610, 004662, 103124, and 103546) by RT-PCR and qPCR. PBMCs from 52 CD patients and 38 HCs were used for initial verification. CircRNA_004662 was further validated in 87 CD patients and 55 HCs and 50 UC patients. The statistical significance between CD, UC, and HCs was calculated by Student t test or one-way ANOVA. A, The relative expression of circRNA_09250. B, The relative expression of circRNA_102610. C, The relative expression of circRNA_004662. D, The relative expression of circRNA_103124. E, The relative expression of circRNA_103546. P < .05 was considered as statistically significant. ∗ P = .01; ∗∗ P < .001. ANOVA = analysis of variance, CD = Crohn disease,circRNA = circular RNA, HCs = health controls, qPCR = quantitative polymerase chain reaction, RT-PCR = reverse transcription polymerase chain reaction, PBMCs = peripheral blood mononuclear cells, UC = ulcerative colitis.
    Figure Legend Snippet: Verification of the relatively expression level of 5 up-regulated circRNAs (092520, 102610, 004662, 103124, and 103546) by RT-PCR and qPCR. PBMCs from 52 CD patients and 38 HCs were used for initial verification. CircRNA_004662 was further validated in 87 CD patients and 55 HCs and 50 UC patients. The statistical significance between CD, UC, and HCs was calculated by Student t test or one-way ANOVA. A, The relative expression of circRNA_09250. B, The relative expression of circRNA_102610. C, The relative expression of circRNA_004662. D, The relative expression of circRNA_103124. E, The relative expression of circRNA_103546. P < .05 was considered as statistically significant. ∗ P = .01; ∗∗ P < .001. ANOVA = analysis of variance, CD = Crohn disease,circRNA = circular RNA, HCs = health controls, qPCR = quantitative polymerase chain reaction, RT-PCR = reverse transcription polymerase chain reaction, PBMCs = peripheral blood mononuclear cells, UC = ulcerative colitis.

    Techniques Used: Expressing, Reverse Transcription Polymerase Chain Reaction, Real-time Polymerase Chain Reaction, Reverse Transcription, Polymerase Chain Reaction

    ROC curve analysis to evaluate diagnostic value of validated circRNAs. Four up-regulated circRNAs (103124, 004662, 102610, and 092520) verified were analyzed. AUC = area under curve, circRNA = circular RNA, CI = confidence interval, ROC = receiver operating characteristic, SEM = standard error of mean.
    Figure Legend Snippet: ROC curve analysis to evaluate diagnostic value of validated circRNAs. Four up-regulated circRNAs (103124, 004662, 102610, and 092520) verified were analyzed. AUC = area under curve, circRNA = circular RNA, CI = confidence interval, ROC = receiver operating characteristic, SEM = standard error of mean.

    Techniques Used: Diagnostic Assay

    CircRNA_004662 and the 5 most potential target miRNAs predicted. miRNAs that may bind to circRNA were predicted by TargetScan and miRanda. circRNA = circular RNA, miRNA = microRNA.
    Figure Legend Snippet: CircRNA_004662 and the 5 most potential target miRNAs predicted. miRNAs that may bind to circRNA were predicted by TargetScan and miRanda. circRNA = circular RNA, miRNA = microRNA.

    Techniques Used:

    Network of circRNA_004662-miRNA-mRNA. circRNA = circular RNA, miRNA = microRNA.
    Figure Legend Snippet: Network of circRNA_004662-miRNA-mRNA. circRNA = circular RNA, miRNA = microRNA.

    Techniques Used:



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    Image Search Results


    Circular RNAs are deregulated in human abdominal aortic aneurysm (A) Volcano plot depicting downregulated (51, blue) and upregulated (40, red). Circular RNAs (circRNAs) in human elective human abdominal aortic aneurysm (eAAA, n = 11) vs . control (CTRL, n = 6) aorta specimens, as resulted by array experiments. Log2 fold change and -log10 p value are plotted on the x and y axes, respectively. IDs of circRNAs meant for a first round of validation are highlighted. Statistics: unpaired t test; p values <0.05 are considered significant. (B) Pie chart illustrating the proportion of exonic (89.8%), intronic (5.7%), sense overlapping (3.4%), and antisense (1.1%) array-identified differentially expressed circRNAs. Absolute numbers are further indicated for each group. (C) Real-time quantitative PCR (qPCR) validation of hsa_circ_0005660 (c NFIX ), hsa_circ_0003641 (c ATM ), hsa_circ0042103 (c MYOCD ), hsa_circ003218 (c BMPR2 ), hsa_circ0004771 (c NRIP1 ), and hsa_circ0005615 (c NFATC3 ) differential expression in human eAAA (N = 8) and CTRL (N = 4) aortas. 2 –ddCT was calculated by normalizing on RPLPO . Data are represented as mean ± SEM. Statistics: unpaired t test; p values <0.05 are considered significant. NS, not significant; eAAA, elective AAA.

    Journal: Molecular Therapy. Nucleic Acids

    Article Title: The circular RNA Ataxia Telangiectasia Mutated regulates oxidative stress in smooth muscle cells in expanding abdominal aortic aneurysms

    doi: 10.1016/j.omtn.2023.08.017

    Figure Lengend Snippet: Circular RNAs are deregulated in human abdominal aortic aneurysm (A) Volcano plot depicting downregulated (51, blue) and upregulated (40, red). Circular RNAs (circRNAs) in human elective human abdominal aortic aneurysm (eAAA, n = 11) vs . control (CTRL, n = 6) aorta specimens, as resulted by array experiments. Log2 fold change and -log10 p value are plotted on the x and y axes, respectively. IDs of circRNAs meant for a first round of validation are highlighted. Statistics: unpaired t test; p values <0.05 are considered significant. (B) Pie chart illustrating the proportion of exonic (89.8%), intronic (5.7%), sense overlapping (3.4%), and antisense (1.1%) array-identified differentially expressed circRNAs. Absolute numbers are further indicated for each group. (C) Real-time quantitative PCR (qPCR) validation of hsa_circ_0005660 (c NFIX ), hsa_circ_0003641 (c ATM ), hsa_circ0042103 (c MYOCD ), hsa_circ003218 (c BMPR2 ), hsa_circ0004771 (c NRIP1 ), and hsa_circ0005615 (c NFATC3 ) differential expression in human eAAA (N = 8) and CTRL (N = 4) aortas. 2 –ddCT was calculated by normalizing on RPLPO . Data are represented as mean ± SEM. Statistics: unpaired t test; p values <0.05 are considered significant. NS, not significant; eAAA, elective AAA.

    Article Snippet: The resulting labeled cDNA was then purified and 1 μg was fragmented, heated, and subsequently hybridized with an 8 × 15k commercially available array chip displaying 13,617 human circRNAs (Arraystar, no. AS-S-CR-H-V2.0) for 17 h at 65°C in an Agilent Hybridization Oven.

    Techniques: Control, Biomarker Discovery, Real-time Polymerase Chain Reaction, Quantitative Proteomics