Journal: Materials Today Bio
Article Title: Localized delivery of hyaluronic acid-doxorubicin from a surgical paste for post-operative glioblastoma treatment
doi: 10.1016/j.mtbio.2026.103142
Figure Lengend Snippet: Biocompatible and degradable hemostatic paste scaffold induces sustained cargo release. A ) Schematic representation of paste preparation and representative images of the hemostatic paste. B ) Representative SEM images of paste-HA-DOX. C ) Pore diameter (expressed in μm) of blank paste and paste-HA-DOX after production, analyzed from representative SEM images (5 images per sample) captured for each sample (n = 3) via ImageJ analysis of pore diameter. Statistical analyses performed via an unpaired t -test (∗p < 0.0001). D ) Paste-HA-DOX degradation over time in CSF-like medium at pH 5.5 or 7.4 expressed in terms of pore diameters. Representative SEM images (5 images per sample) captured for each sample (n = 3) at each time point. Statistical analyses performed via an unpaired t -test at each time point at pH 5.5 and 7.4 (∗p < 0.05, ∗∗p < 0.01). E) Cumulative cargo release from paste-DOX and paste HA-DOX over time in vitro following incubation in CSF-like medium at pH 5.5 or 7.4. F ) Representative brain cavity images depicting in vivo biocompatibility in healthy mouse brains following resection and resection and treatment with paste-HA-DOX according to Iba-1 (microglia; orange), GFAP (astrocytes; white), and TUNEL (cytotoxicity; green) signals. G) Graphs representing the % ratio of positive cells to Iba-1, GFAP, and TUNEL, relative to the total number of cells. Statistical analyses performed with an unpaired t -test (ns – not significant).
Article Snippet: Residual blood in the surgery cavity was removed using an absorbable hemostatic patch (Fine Science Tools, Germany).
Techniques: In Vitro, Incubation, In Vivo, TUNEL Assay
