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chemically modified sirnas with the sinp-1496 sequence and gl3 firefly luciferase sequence (si1955/luc)  (Alnylam Inc)

 
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    Alnylam Inc chemically modified sirnas with the sinp-1496 sequence and gl3 firefly luciferase sequence (si1955/luc)
    In vitro RNA interference of influenza virus using native and <t>chemically</t> <t>modified</t> <t>siRNAs.</t> Cultured Vero cells were infected with PR/8 influenza virus and transfected with siRNAs. Viral titer is expressed as a percentage relative to nontreated control viral titers. The dose–response RNA interference effects of siRNA were not significantly altered by chemical modifications. The different siRNA duplexes are identified by sense and antisense strand (S/AS) as listed in . The parent unmodified siRNA is represented by 4746/4747; 4746/4747 MM represents a mismatched version of 4746/4747, while all other duplexes represent introduction of additional modifications into the original 4746/4747 parent siRNA duplex. siRNA, short-interfering RNA.
    Chemically Modified Sirnas With The Sinp 1496 Sequence And Gl3 Firefly Luciferase Sequence (Si1955/Luc), supplied by Alnylam Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/gl3+sequence/chemically+modified+sirnas+with+the+sinp+1496+sequence+and+gl3+firefly+luciferase+sequence++si1955+luc+/pmc02835254-141-2-16
    Average 90 stars, based on 1 article reviews
    chemically modified sirnas with the sinp-1496 sequence and gl3 firefly luciferase sequence (si1955/luc) - by Bioz Stars, 2026-08
    90/100 stars

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    1) Product Images from "Drug Delivery–mediated Control of RNA Immunostimulation"

    Article Title: Drug Delivery–mediated Control of RNA Immunostimulation

    Journal: Molecular Therapy: the Journal of the American Society of Gene Therapy

    doi: 10.1038/mt.2009.147

    In vitro RNA interference of influenza virus using native and chemically modified siRNAs. Cultured Vero cells were infected with PR/8 influenza virus and transfected with siRNAs. Viral titer is expressed as a percentage relative to nontreated control viral titers. The dose–response RNA interference effects of siRNA were not significantly altered by chemical modifications. The different siRNA duplexes are identified by sense and antisense strand (S/AS) as listed in . The parent unmodified siRNA is represented by 4746/4747; 4746/4747 MM represents a mismatched version of 4746/4747, while all other duplexes represent introduction of additional modifications into the original 4746/4747 parent siRNA duplex. siRNA, short-interfering RNA.
    Figure Legend Snippet: In vitro RNA interference of influenza virus using native and chemically modified siRNAs. Cultured Vero cells were infected with PR/8 influenza virus and transfected with siRNAs. Viral titer is expressed as a percentage relative to nontreated control viral titers. The dose–response RNA interference effects of siRNA were not significantly altered by chemical modifications. The different siRNA duplexes are identified by sense and antisense strand (S/AS) as listed in . The parent unmodified siRNA is represented by 4746/4747; 4746/4747 MM represents a mismatched version of 4746/4747, while all other duplexes represent introduction of additional modifications into the original 4746/4747 parent siRNA duplex. siRNA, short-interfering RNA.

    Techniques Used: In Vitro, Virus, Modification, Cell Culture, Infection, Transfection, Control, Small Interfering RNA



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    In vitro RNA interference of influenza virus using native and <t>chemically</t> <t>modified</t> <t>siRNAs.</t> Cultured Vero cells were infected with PR/8 influenza virus and transfected with siRNAs. Viral titer is expressed as a percentage relative to nontreated control viral titers. The dose–response RNA interference effects of siRNA were not significantly altered by chemical modifications. The different siRNA duplexes are identified by sense and antisense strand (S/AS) as listed in . The parent unmodified siRNA is represented by 4746/4747; 4746/4747 MM represents a mismatched version of 4746/4747, while all other duplexes represent introduction of additional modifications into the original 4746/4747 parent siRNA duplex. siRNA, short-interfering RNA.
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    In vitro RNA interference of influenza virus using native and chemically modified siRNAs. Cultured Vero cells were infected with PR/8 influenza virus and transfected with siRNAs. Viral titer is expressed as a percentage relative to nontreated control viral titers. The dose–response RNA interference effects of siRNA were not significantly altered by chemical modifications. The different siRNA duplexes are identified by sense and antisense strand (S/AS) as listed in . The parent unmodified siRNA is represented by 4746/4747; 4746/4747 MM represents a mismatched version of 4746/4747, while all other duplexes represent introduction of additional modifications into the original 4746/4747 parent siRNA duplex. siRNA, short-interfering RNA.

    Journal: Molecular Therapy: the Journal of the American Society of Gene Therapy

    Article Title: Drug Delivery–mediated Control of RNA Immunostimulation

    doi: 10.1038/mt.2009.147

    Figure Lengend Snippet: In vitro RNA interference of influenza virus using native and chemically modified siRNAs. Cultured Vero cells were infected with PR/8 influenza virus and transfected with siRNAs. Viral titer is expressed as a percentage relative to nontreated control viral titers. The dose–response RNA interference effects of siRNA were not significantly altered by chemical modifications. The different siRNA duplexes are identified by sense and antisense strand (S/AS) as listed in . The parent unmodified siRNA is represented by 4746/4747; 4746/4747 MM represents a mismatched version of 4746/4747, while all other duplexes represent introduction of additional modifications into the original 4746/4747 parent siRNA duplex. siRNA, short-interfering RNA.

    Article Snippet: Chemically modified siRNAs with the siNP-1496 sequence and GL3 firefly luciferase sequence (si1955/Luc) were synthesized by Alnylam Pharmaceuticals (Cambridge, MA).

    Techniques: In Vitro, Virus, Modification, Cell Culture, Infection, Transfection, Control, Small Interfering RNA