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medi1873 hexameric gitrl fusion protein (gitrl fp)  (AstraZeneca ltd)

 
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    Structured Review

    AstraZeneca ltd medi1873 hexameric gitrl fusion protein (gitrl fp)
    Structure of GITR agonists being evaluated in ongoing or completed clinical trials
    Medi1873 Hexameric Gitrl Fusion Protein (Gitrl Fp), supplied by AstraZeneca ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/gitrl-fp/medi1873/pmc10278658-11-16-2
    Average 90 stars, based on 1 article reviews
    medi1873 hexameric gitrl fusion protein (gitrl fp) - by Bioz Stars, 2026-09
    90/100 stars

    Images

    1) Product Images from "Targeting GITR in cancer immunotherapy – there is no perfect knowledge"

    Article Title: Targeting GITR in cancer immunotherapy – there is no perfect knowledge

    Journal: Oncotarget

    doi: 10.18632/oncotarget.28461

    Structure of GITR agonists being evaluated in ongoing or completed clinical trials
    Figure Legend Snippet: Structure of GITR agonists being evaluated in ongoing or completed clinical trials

    Techniques Used: Binding Assay

    Related Articles

    other:

    Article Title: IRAK degraders and uses thereof
    Article Snippet: KIR inhibitors that are being studied in clinical trials include lirilumab (IPH2102/BMS-986015, Innate Pharma/Bristol-Myers Squibb), an anti-KIR antibody, in leukemias (NCT01687387, NCT02399917, NCT02481297, NCT02599649), multiple myeloma (NCT02252263), and lymphoma (NCT01592370); IPH2101 (1-7F9, Innate Pharma) in myeloma (NCT01222286 and NCT01217203); and IPH4102 (Innate Pharma), an anti-KIR antibody that binds to three domains of the long cytoplasmic tail (KIR3DL2), in lymphoma (NCT02593045).

    Article Title: Targeting GITR in cancer immunotherapy – there is no perfect knowledge
    Article Snippet: MEDI1873 (AstraZeneca) , All solid tumors , Not studied , I , Completed , NCT02583165 , No objective responses (prolonged stable disease) , N/A , Balmanoukian et al. [ ] .

    Clinical Proteomics:

    Article Title: Protein degraders and uses thereof
    Article Snippet: .. GITR agonists that are being studied in clinical trials include TRX518 (Leap Therapeutics), an agonistic anti-GITR antibody, in malignant melanoma and other malignant solid tumors (NCT01239134 and NCT02628574); GWN323 (Novartis), an agonistic anti-GITR antibody, in solid tumors and lymphoma (NCT 02740270); INCAGN01876 (Incyte/Agenus), an agonistic anti-GITR antibody, in advanced cancers (NCT02697591 and NCT03126110); MK-4166 (Merck), an agonistic anti-GITR antibody, in solid tumors (NCT02132754) and MEDI1873 (Medimmune/AstraZeneca), an agonistic hexameric GITR-ligand molecule with a human IgG1 Fc domain, in advanced solid tumors (NCT02583165). ..

    Article Title: Bicyclic peptide ligands specific for Nectin-4
    Article Snippet: .. GITR agonists that are being studied in clinical trials include: TRX518 (Leap Therapeutics), an agonistic anti-GITR antibody, in malignant melanoma and other malignant solid tumors (NCT01239134 and NCT02628574); GWN323 (Novartis), an agonistic anti-GITR antibody, in solid tumors and lymphoma (NCT02740270); INCAGN01876 (Incyte/Agenus), an agonistic anti-GITR antibody, in advanced cancers (NCT02697591 and NCT03126110); MK-4166 (Merck), an agonistic anti-GITR antibody, in solid tumors (NCT02132754) and MEDI1873 (Medimmune/AstraZeneca), an agonistic hexameric GITR-ligand molecule with a human IgG1 Fc domain, in advanced solid tumors (NCT02583165). ..

    Article Title: EIF4E inhibitors and uses thereof
    Article Snippet: GITR agonists that are being studied in clinical trials include TRX518 (Leap Therapeutics), an agonistic anti-GITR antibody, in malignant melanoma and other malignant solid tumors (NCT01239134 and NCT02628574); GWN323 (Novartis), an agonistic anti-GITR antibody, in solid tumors and lymphoma (NCT02740270); INCAGN01876 (Incyte/Agenus), an agonistic anti-GITR antibody, in advanced cancers (NCT02697591 and NCT03126110); MK-4166 (Merck), an agonistic anti-GITR antibody, in solid tumors (NCT02132754) and MEDI1873 (Medimmune/AstraZeneca), an agonistic hexameric GITR-ligand molecule with a human IgG1 Fc domain, in advanced solid tumors (NCT02583165). .. GITR agonists that are being studied in clinical trials include TRX518 (Leap Therapeutics), an agonistic anti-GITR antibody, in malignant melanoma and other malignant solid tumors (NCT01239134 and NCT02628574); GWN323 (Novartis), an agonistic anti-GITR antibody, in solid tumors and lymphoma (NCT02740270); INCAGN01876 (Incyte/Agenus), an agonistic anti-GITR antibody, in advanced cancers (NCT02697591 and NCT03126110); MK-4166 (Merck), an agonistic anti-GITR antibody, in solid tumors (NCT02132754) and MEDI1873 (Medimmune/AstraZeneca), an agonistic hexameric GITR-ligand molecule with a human IgG1 Fc domain, in advanced solid tumors (NCT02583165). .. ICOS agonists that are being studied in clinical trials include MEDI-570 (Medimmune), an agonistic anti-ICOS antibody, in lymphomas (NCT02520791); GSK3359609 (Merck), an agonistic anti-ICOS antibody, in Phase 1 (NCT02723955); JTX-2011 (Jounce Therapeutics), an agonistic anti-ICOS antibody, in Phase 1 (NCT02904226).

    Article Title: Antiproliferation compounds and uses thereof
    Article Snippet: .. GITR agonists that are being studied in clinical trials include TRX518 (Leap Therapeutics), an agonistic anti-GITR antibody, in malignant melanoma and other malignant solid tumors (NCT01239134 and NCT02628574); GWN323 (Novartis), an agonistic anti-GITR antibody, in solid tumors and lymphoma (NCT 02740270); INCAGN01876 (Incyte/Agenus), an agonistic anti-GITR antibody, in advanced cancers (NCT02697591 and NCT03126110); MK-4166 (Merck & Co.), an agonistic anti-GITR antibody, in solid tumors (NCT02132754) and MEDI1873 (Medimmune/AstraZeneca), an agonistic hexameric GITR-ligand molecule with a human IgG1 Fc domain, in advanced solid tumors (NCT02583165). ..



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    Image Search Results


    Structure of GITR agonists being evaluated in ongoing or completed clinical trials

    Journal: Oncotarget

    Article Title: Targeting GITR in cancer immunotherapy – there is no perfect knowledge

    doi: 10.18632/oncotarget.28461

    Figure Lengend Snippet: Structure of GITR agonists being evaluated in ongoing or completed clinical trials

    Article Snippet: MEDI1873 , AstraZeneca , Hexameric GITRL fusion protein (GITRL FP) comprising 2 GITRL ECD trimers and IgG1 Fc linked by isoleucine zipper trimerization domain , Fully human IgG1 , Yes , Hexavalent.

    Techniques: Binding Assay