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mouse glucocorticoid-induced tnfr-related protein ligand-fusion protein (gitrl-fp) migg2a  (AstraZeneca ltd)

 
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    Structured Review

    AstraZeneca ltd mouse glucocorticoid-induced tnfr-related protein ligand-fusion protein (gitrl-fp) migg2a
    Mouse Glucocorticoid Induced Tnfr Related Protein Ligand Fusion Protein (Gitrl Fp) Migg2a, supplied by AstraZeneca ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/gitrl-fp/mouse+glucocorticoid+induced+tnfr+related+protein+ligand+fusion+protein++gitrl+fp++migg2a/pmc08215240-41-12-17
    Average 90 stars, based on 1 article reviews
    mouse glucocorticoid-induced tnfr-related protein ligand-fusion protein (gitrl-fp) migg2a - by Bioz Stars, 2026-11
    90/100 stars

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    Related Articles

    Produced:

    Article Title: Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional <i>STK11</i> Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown
    Article Snippet: Drug treatments included: anti-mouse PD-L1 mIgG1 D265A clone 80 (anti-mouse PD-L1 lacking effector function, produced by AstraZeneca, 10 mg/kg twice weekly); anti-mouse CTLA4 mIgG1 clone 9D9 (anti-mouse CTLA4 lacking effector function, produced by AstraZeneca, 10 mg/kg twice weekly); anti-mouse OX40 clone OX86 mIgG2a (anti-mouse OX40 mAb with effector function, produced by AstraZeneca, 0.1 mg/kg, one dose at randomization); anti-mouse CD137 mIgG1 (produced by AstraZeneca, 0.1 mg/kg, one dose at randomization); anti-mouse ICOS mIgG2a (anti-mouse ICOS with effector function, produced by AstraZeneca, 0.1 mg/kg, one dose at randomization); anti-mouse IL6 rat IgG1 mAb clone MP5–20F3 (Bio-X-Cell; 1 mg/kg twice weekly); AZD2014 mTORC1/2 inhibitor (AstraZeneca, daily oral gavage, 15 mg/kg, 2 days on 5 days off treatment); AZD5069 CXCR2 inhibitor (AstraZeneca, twice-daily oral gavage, 100 mg/kg); AZD7507 CSF1R inhibitor (AstraZeneca, twice-daily oral gavage, 50 mg/kg); anti-mouse STAT3 ASO (Ionis Pharmaceuticals, Inc. and AstraZeneca, once-daily subcutaneous injection, 50 mg/kg, 5 days on 2 days off treatment).

    Article Title: Novel non-terminal tumor sampling procedure using fine needle aspiration supports immuno-oncology biomarker discovery in preclinical mouse models
    Article Snippet: Mice were randomized by body weight and dosed with mouse glucocorticoid-induced TNFR-related protein ligand-fusion protein (GITRL-FP) mIgG2a (AstraZeneca) intraperitoneally at 0.2 mg/kg or 1 mg/kg 6 days after tumor cell implantation.

    Allele-specific Oligonucleotide:

    Article Title: Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional <i>STK11</i> Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown
    Article Snippet: Drug treatments included: anti-mouse PD-L1 mIgG1 D265A clone 80 (anti-mouse PD-L1 lacking effector function, produced by AstraZeneca, 10 mg/kg twice weekly); anti-mouse CTLA4 mIgG1 clone 9D9 (anti-mouse CTLA4 lacking effector function, produced by AstraZeneca, 10 mg/kg twice weekly); anti-mouse OX40 clone OX86 mIgG2a (anti-mouse OX40 mAb with effector function, produced by AstraZeneca, 0.1 mg/kg, one dose at randomization); anti-mouse CD137 mIgG1 (produced by AstraZeneca, 0.1 mg/kg, one dose at randomization); anti-mouse ICOS mIgG2a (anti-mouse ICOS with effector function, produced by AstraZeneca, 0.1 mg/kg, one dose at randomization); anti-mouse IL6 rat IgG1 mAb clone MP5–20F3 (Bio-X-Cell; 1 mg/kg twice weekly); AZD2014 mTORC1/2 inhibitor (AstraZeneca, daily oral gavage, 15 mg/kg, 2 days on 5 days off treatment); AZD5069 CXCR2 inhibitor (AstraZeneca, twice-daily oral gavage, 100 mg/kg); AZD7507 CSF1R inhibitor (AstraZeneca, twice-daily oral gavage, 50 mg/kg); anti-mouse STAT3 ASO (Ionis Pharmaceuticals, Inc. and AstraZeneca, once-daily subcutaneous injection, 50 mg/kg, 5 days on 2 days off treatment).

    Article Title: Novel non-terminal tumor sampling procedure using fine needle aspiration supports immuno-oncology biomarker discovery in preclinical mouse models
    Article Snippet: Mice were randomized by body weight and dosed with mouse glucocorticoid-induced TNFR-related protein ligand-fusion protein (GITRL-FP) mIgG2a (AstraZeneca) intraperitoneally at 0.2 mg/kg or 1 mg/kg 6 days after tumor cell implantation.

    Injection:

    Article Title: Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional <i>STK11</i> Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown
    Article Snippet: Drug treatments included: anti-mouse PD-L1 mIgG1 D265A clone 80 (anti-mouse PD-L1 lacking effector function, produced by AstraZeneca, 10 mg/kg twice weekly); anti-mouse CTLA4 mIgG1 clone 9D9 (anti-mouse CTLA4 lacking effector function, produced by AstraZeneca, 10 mg/kg twice weekly); anti-mouse OX40 clone OX86 mIgG2a (anti-mouse OX40 mAb with effector function, produced by AstraZeneca, 0.1 mg/kg, one dose at randomization); anti-mouse CD137 mIgG1 (produced by AstraZeneca, 0.1 mg/kg, one dose at randomization); anti-mouse ICOS mIgG2a (anti-mouse ICOS with effector function, produced by AstraZeneca, 0.1 mg/kg, one dose at randomization); anti-mouse IL6 rat IgG1 mAb clone MP5–20F3 (Bio-X-Cell; 1 mg/kg twice weekly); AZD2014 mTORC1/2 inhibitor (AstraZeneca, daily oral gavage, 15 mg/kg, 2 days on 5 days off treatment); AZD5069 CXCR2 inhibitor (AstraZeneca, twice-daily oral gavage, 100 mg/kg); AZD7507 CSF1R inhibitor (AstraZeneca, twice-daily oral gavage, 50 mg/kg); anti-mouse STAT3 ASO (Ionis Pharmaceuticals, Inc. and AstraZeneca, once-daily subcutaneous injection, 50 mg/kg, 5 days on 2 days off treatment).

    Article Title: Novel non-terminal tumor sampling procedure using fine needle aspiration supports immuno-oncology biomarker discovery in preclinical mouse models
    Article Snippet: Mice were randomized by body weight and dosed with mouse glucocorticoid-induced TNFR-related protein ligand-fusion protein (GITRL-FP) mIgG2a (AstraZeneca) intraperitoneally at 0.2 mg/kg or 1 mg/kg 6 days after tumor cell implantation.



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    Structure of GITR agonists being evaluated in ongoing or completed clinical trials

    Journal: Oncotarget

    Article Title: Targeting GITR in cancer immunotherapy – there is no perfect knowledge

    doi: 10.18632/oncotarget.28461

    Figure Lengend Snippet: Structure of GITR agonists being evaluated in ongoing or completed clinical trials

    Article Snippet: MEDI1873 , AstraZeneca , Hexameric GITRL fusion protein (GITRL FP) comprising 2 GITRL ECD trimers and IgG1 Fc linked by isoleucine zipper trimerization domain , Fully human IgG1 , Yes , Hexavalent.

    Techniques: Binding Assay