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spatial gene expression pattern  (Allen Institute for Brain Science)

 
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    Allen Institute for Brain Science spatial gene expression pattern
    Spatial Gene Expression Pattern, supplied by Allen Institute for Brain Science, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/gene+expression+patterns/spatial+gene+expression+pattern/pmc09383440-92-15-21
    Average 90 stars, based on 1 article reviews
    spatial gene expression pattern - by Bioz Stars, 2026-11
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    Gene Expression:

    Article Title: Increased brain volume from higher cereal and lower coffee intake: shared genetic determinants and impacts on cognition and metabolism
    Article Snippet: .. Particularly, we evaluated the similarity between the GMV-association pattern of the coffee intake and the spatial gene expression pattern from the Allen Institute for Brain Science ( ) and identified 1,737 validated significant genes ( P FDR,perm < 0.05 in the discovery sample and P perm < 0.05 in the replication sample; see Section 2 for details). ..



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    Image Search Results


    NGS analysis identified the variant c.1088_1089del within the CAPN6 gene ( NM_014289.4 ) in the family examined. ( A ) Both the chromosomal and exon localization of the CAPN6 gene and variant are depicted. ( B ) The Integrative Genomics Viewer (IGV) image displays this variant, with arrows indicating the father, mother, and their three sons. ( C ) Confirmation of the variant through conventional Sanger sequencing is presented for the father, mother, and their three sons, as indicated by the black arrows. Specifically, the variant has been found in hemizygous condition in the affected male offspring while in heterozygous condition for both the mother and daughter.

    Journal: International Journal of Molecular Sciences

    Article Title: Potential Link Between a Disruptive CAPN6 Variant and Neurodevelopmental Disorders

    doi: 10.3390/ijms27031140

    Figure Lengend Snippet: NGS analysis identified the variant c.1088_1089del within the CAPN6 gene ( NM_014289.4 ) in the family examined. ( A ) Both the chromosomal and exon localization of the CAPN6 gene and variant are depicted. ( B ) The Integrative Genomics Viewer (IGV) image displays this variant, with arrows indicating the father, mother, and their three sons. ( C ) Confirmation of the variant through conventional Sanger sequencing is presented for the father, mother, and their three sons, as indicated by the black arrows. Specifically, the variant has been found in hemizygous condition in the affected male offspring while in heterozygous condition for both the mother and daughter.

    Article Snippet: CAPN6 gene expression patterns of placenta tissues were obtained from the Human Protein Atlas (HPA) database ( https://www.proteinatlas.org/ ) (accessed on 26 May 2025).

    Techniques: Variant Assay, Sequencing

    Pedigree analysis of the examined family with an X-linked genetic disorder associated with the mutation c.1088_1089del (p.Asp363GlyfsTer2) in the CAPN6 ( NM_014289.4 ) gene. Both the mother and the daughter exhibited mild intellectual disability. Furthermore, both the male sons exhibited severe neurodevelopmental and mild motor coordination disorders. Red arrows indicate the specific position of the variant. Blue and red asterisks indicate wild type and mutated sequence, respectively.

    Journal: International Journal of Molecular Sciences

    Article Title: Potential Link Between a Disruptive CAPN6 Variant and Neurodevelopmental Disorders

    doi: 10.3390/ijms27031140

    Figure Lengend Snippet: Pedigree analysis of the examined family with an X-linked genetic disorder associated with the mutation c.1088_1089del (p.Asp363GlyfsTer2) in the CAPN6 ( NM_014289.4 ) gene. Both the mother and the daughter exhibited mild intellectual disability. Furthermore, both the male sons exhibited severe neurodevelopmental and mild motor coordination disorders. Red arrows indicate the specific position of the variant. Blue and red asterisks indicate wild type and mutated sequence, respectively.

    Article Snippet: CAPN6 gene expression patterns of placenta tissues were obtained from the Human Protein Atlas (HPA) database ( https://www.proteinatlas.org/ ) (accessed on 26 May 2025).

    Techniques: Mutagenesis, Variant Assay, Sequencing

    Domain organization and structural prediction of wild-type CAPN6. ( A ) Schematic representation of the functional domains of CAPN6, annotated according to the ProRule and InterPRO databases. A black arrow marks the mutation site at position 363 in the amino acid sequence. ( B ) Structural model generated using AlphaFold3, with domains colored according to panel. ( A ) The mutation site (Asp363) is highlighted in turquoise and indicated by a black square. ( C ) Close-up view of the wild-type residue (turquoise) and its hydrogen-bonding interactions with Asp365 and Asn369. Structural visualization and modeling were performed using UCSF ChimeraX.

    Journal: International Journal of Molecular Sciences

    Article Title: Potential Link Between a Disruptive CAPN6 Variant and Neurodevelopmental Disorders

    doi: 10.3390/ijms27031140

    Figure Lengend Snippet: Domain organization and structural prediction of wild-type CAPN6. ( A ) Schematic representation of the functional domains of CAPN6, annotated according to the ProRule and InterPRO databases. A black arrow marks the mutation site at position 363 in the amino acid sequence. ( B ) Structural model generated using AlphaFold3, with domains colored according to panel. ( A ) The mutation site (Asp363) is highlighted in turquoise and indicated by a black square. ( C ) Close-up view of the wild-type residue (turquoise) and its hydrogen-bonding interactions with Asp365 and Asn369. Structural visualization and modeling were performed using UCSF ChimeraX.

    Article Snippet: CAPN6 gene expression patterns of placenta tissues were obtained from the Human Protein Atlas (HPA) database ( https://www.proteinatlas.org/ ) (accessed on 26 May 2025).

    Techniques: Structural Proteomics, Functional Assay, Mutagenesis, Sequencing, Generated, Residue