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inavolisib  (Selleck Chemicals)


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    Structured Review

    Selleck Chemicals inavolisib
    Inavolisib, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 7 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/gdc+0077/GDC-0077/pmc12820070-243-0-1
    Average 93 stars, based on 7 article reviews
    inavolisib - by Bioz Stars, 2026-10
    93/100 stars

    Images

    Related Articles

    Transduction:

    Article Title: AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution.
    Article Snippet: TBK1 inhibitor GSK8612 was used at 16 μM (S8872, Selleckchem).

    Article Title: AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution
    Article Snippet: For all assays except synergy assays, tazemetosat was used at 5 μM (S7128, Selleckchem), ipatasertib was used at 5 μM (S2808, Selleckchem), BYL719 was used at 5 μM (S2814, Selleckchem), GDC0077 was used at 5 μM (S8668, Selleckchem), GDC0941 was used at 3 μM (S1065, Selleckchem), MAK683 was used at 5 μM (S8983, Selleckchem) and itacitinib (JAK1i) was used at 500 nM (S7812, Selleckchem).

    Article Title: AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution.
    Article Snippet: For all assays except synergy assays, tazemetosat was used at 5 μM (S7128, Selleckchem), ipatasertib was used at 5 μM (S2808, Selleckchem), BYL719 was used at 5 μM (S2814, Selleckchem), GDC0077 was used at 5 μM (S8668, Selleckchem), GDC0941 was used at 3 μM (S1065, Selleckchem), MAK683 was used at 5 μM (S8983, Selleckchem) and itacitinib ( JAK1i) was used at 500 nM (S7812, Selleckchem).


    Recombinant:

    Article Title: AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution.
    Article Snippet: TBK1 inhibitor GSK8612 was used at 16 μM (S8872, Selleckchem).

    Article Title: AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution
    Article Snippet: For all assays except synergy assays, tazemetosat was used at 5 μM (S7128, Selleckchem), ipatasertib was used at 5 μM (S2808, Selleckchem), BYL719 was used at 5 μM (S2814, Selleckchem), GDC0077 was used at 5 μM (S8668, Selleckchem), GDC0941 was used at 3 μM (S1065, Selleckchem), MAK683 was used at 5 μM (S8983, Selleckchem) and itacitinib (JAK1i) was used at 500 nM (S7812, Selleckchem).

    Article Title: AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution.
    Article Snippet: For all assays except synergy assays, tazemetosat was used at 5 μM (S7128, Selleckchem), ipatasertib was used at 5 μM (S2808, Selleckchem), BYL719 was used at 5 μM (S2814, Selleckchem), GDC0077 was used at 5 μM (S8668, Selleckchem), GDC0941 was used at 3 μM (S1065, Selleckchem), MAK683 was used at 5 μM (S8983, Selleckchem) and itacitinib ( JAK1i) was used at 500 nM (S7812, Selleckchem).


    Saline:

    Article Title: AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution.
    Article Snippet: TBK1 inhibitor GSK8612 was used at 16 μM (S8872, Selleckchem).

    Article Title: AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution
    Article Snippet: For all assays except synergy assays, tazemetosat was used at 5 μM (S7128, Selleckchem), ipatasertib was used at 5 μM (S2808, Selleckchem), BYL719 was used at 5 μM (S2814, Selleckchem), GDC0077 was used at 5 μM (S8668, Selleckchem), GDC0941 was used at 3 μM (S1065, Selleckchem), MAK683 was used at 5 μM (S8983, Selleckchem) and itacitinib (JAK1i) was used at 500 nM (S7812, Selleckchem).

    Article Title: AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution.
    Article Snippet: For all assays except synergy assays, tazemetosat was used at 5 μM (S7128, Selleckchem), ipatasertib was used at 5 μM (S2808, Selleckchem), BYL719 was used at 5 μM (S2814, Selleckchem), GDC0077 was used at 5 μM (S8668, Selleckchem), GDC0941 was used at 3 μM (S1065, Selleckchem), MAK683 was used at 5 μM (S8983, Selleckchem) and itacitinib ( JAK1i) was used at 500 nM (S7812, Selleckchem).


    Software:

    Article Title: AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution.
    Article Snippet: TBK1 inhibitor GSK8612 was used at 16 μM (S8872, Selleckchem).

    Article Title: AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution
    Article Snippet: For all assays except synergy assays, tazemetosat was used at 5 μM (S7128, Selleckchem), ipatasertib was used at 5 μM (S2808, Selleckchem), BYL719 was used at 5 μM (S2814, Selleckchem), GDC0077 was used at 5 μM (S8668, Selleckchem), GDC0941 was used at 3 μM (S1065, Selleckchem), MAK683 was used at 5 μM (S8983, Selleckchem) and itacitinib (JAK1i) was used at 500 nM (S7812, Selleckchem).

    Article Title: AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution.
    Article Snippet: For all assays except synergy assays, tazemetosat was used at 5 μM (S7128, Selleckchem), ipatasertib was used at 5 μM (S2808, Selleckchem), BYL719 was used at 5 μM (S2814, Selleckchem), GDC0077 was used at 5 μM (S8668, Selleckchem), GDC0941 was used at 3 μM (S1065, Selleckchem), MAK683 was used at 5 μM (S8983, Selleckchem) and itacitinib ( JAK1i) was used at 500 nM (S7812, Selleckchem).


    Sterility:

    Article Title: AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution.
    Article Snippet: TBK1 inhibitor GSK8612 was used at 16 μM (S8872, Selleckchem).

    Article Title: AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution
    Article Snippet: For all assays except synergy assays, tazemetosat was used at 5 μM (S7128, Selleckchem), ipatasertib was used at 5 μM (S2808, Selleckchem), BYL719 was used at 5 μM (S2814, Selleckchem), GDC0077 was used at 5 μM (S8668, Selleckchem), GDC0941 was used at 3 μM (S1065, Selleckchem), MAK683 was used at 5 μM (S8983, Selleckchem) and itacitinib (JAK1i) was used at 500 nM (S7812, Selleckchem).

    Article Title: AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution.
    Article Snippet: For all assays except synergy assays, tazemetosat was used at 5 μM (S7128, Selleckchem), ipatasertib was used at 5 μM (S2808, Selleckchem), BYL719 was used at 5 μM (S2814, Selleckchem), GDC0077 was used at 5 μM (S8668, Selleckchem), GDC0941 was used at 3 μM (S1065, Selleckchem), MAK683 was used at 5 μM (S8983, Selleckchem) and itacitinib ( JAK1i) was used at 500 nM (S7812, Selleckchem).


    Transferring:

    Article Title: AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution.
    Article Snippet: TBK1 inhibitor GSK8612 was used at 16 μM (S8872, Selleckchem).

    Article Title: AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution
    Article Snippet: For all assays except synergy assays, tazemetosat was used at 5 μM (S7128, Selleckchem), ipatasertib was used at 5 μM (S2808, Selleckchem), BYL719 was used at 5 μM (S2814, Selleckchem), GDC0077 was used at 5 μM (S8668, Selleckchem), GDC0941 was used at 3 μM (S1065, Selleckchem), MAK683 was used at 5 μM (S8983, Selleckchem) and itacitinib (JAK1i) was used at 500 nM (S7812, Selleckchem).

    Article Title: AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution.
    Article Snippet: For all assays except synergy assays, tazemetosat was used at 5 μM (S7128, Selleckchem), ipatasertib was used at 5 μM (S2808, Selleckchem), BYL719 was used at 5 μM (S2814, Selleckchem), GDC0077 was used at 5 μM (S8668, Selleckchem), GDC0941 was used at 3 μM (S1065, Selleckchem), MAK683 was used at 5 μM (S8983, Selleckchem) and itacitinib ( JAK1i) was used at 500 nM (S7812, Selleckchem).


    Ointment:

    Article Title: AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution.
    Article Snippet: TBK1 inhibitor GSK8612 was used at 16 μM (S8872, Selleckchem).

    Article Title: AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution
    Article Snippet: For all assays except synergy assays, tazemetosat was used at 5 μM (S7128, Selleckchem), ipatasertib was used at 5 μM (S2808, Selleckchem), BYL719 was used at 5 μM (S2814, Selleckchem), GDC0077 was used at 5 μM (S8668, Selleckchem), GDC0941 was used at 3 μM (S1065, Selleckchem), MAK683 was used at 5 μM (S8983, Selleckchem) and itacitinib (JAK1i) was used at 500 nM (S7812, Selleckchem).

    Article Title: AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution.
    Article Snippet: For all assays except synergy assays, tazemetosat was used at 5 μM (S7128, Selleckchem), ipatasertib was used at 5 μM (S2808, Selleckchem), BYL719 was used at 5 μM (S2814, Selleckchem), GDC0077 was used at 5 μM (S8668, Selleckchem), GDC0941 was used at 3 μM (S1065, Selleckchem), MAK683 was used at 5 μM (S8983, Selleckchem) and itacitinib ( JAK1i) was used at 500 nM (S7812, Selleckchem).




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    Image Search Results


    Inhibition of cervical cancer cell lines by PI3K α inhibitors. The maximum dose for each cell line was selected, and the percentage inhibition was compared with the corresponding control. (A) Alpelisib (BYL-719). (B) Inavolisib (GDC-0077). All cell lines have PIK3CA mutations except SiHa. **** = p < 0.0001 by one-way ANOVA and Dunnett’s multiple comparison test. <20% inhibition interpreted as no or negative response.

    Journal: Neoplasia (New York, N.Y.)

    Article Title: PIK3CA mutant cervical cancer is selectively suppressed by PI3Kα inhibition (Alpelisib/BYL-719 and Inavolisib/GDC-0077) and cooperates with HPV directed T cell therapy

    doi: 10.1016/j.neo.2026.101305

    Figure Lengend Snippet: Inhibition of cervical cancer cell lines by PI3K α inhibitors. The maximum dose for each cell line was selected, and the percentage inhibition was compared with the corresponding control. (A) Alpelisib (BYL-719). (B) Inavolisib (GDC-0077). All cell lines have PIK3CA mutations except SiHa. **** = p < 0.0001 by one-way ANOVA and Dunnett’s multiple comparison test. <20% inhibition interpreted as no or negative response.

    Article Snippet: GDC-0077 was also purchased from MedChem Express (Cat# HY-101562.

    Techniques: Inhibition, Control, Comparison

    Journal: Cell Reports Medicine

    Article Title: A patient-derived T cell lymphoma biorepository uncovers pathogenetic mechanisms and host-related therapeutic vulnerabilities

    doi: 10.1016/j.xcrm.2025.102029

    Figure Lengend Snippet:

    Article Snippet: GDC-0077 , Selleckchem , S8668.

    Techniques: Transduction, Recombinant, Saline, Software, Sterility, Transferring, Ointment