fluorogenic hdac 1 (BPS Bioscience)
Structured Review
Fluorogenic Hdac 1, supplied by BPS Bioscience, used in various techniques. Bioz Stars score: 93/100, based on 52 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/fluorogenic+hdac+1/HDAC1+Fluorogenic+Assay+Kit/pm39357770-233-0-8
Average 93 stars, based on 52 article reviews
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other:Article Title: Design, synthesis and molecular modeling of new coumarin–thiazole derivatives as dual EGFR/HDAC1 inhibitors: in vitro and in vivo anticancer assays Article Snippet: MCF-7 (human breast adenocarcinoma), HCT116 (human colorectal carcinoma) and the normal human skin fibroblast (BJ-1) cell lines were purchased from the American Type Culture Collection (Rockville, MD, USA) and maintained in the RPMI-1640 medium, which was supplemented with 10% heat-inactivated FBS, 100 U per mL penicillin, and 100 U per mL streptomycin. Activity Assay:Article Title: 1,3,4-oxadiazole-tethered alkylidene acetohydrazides as potential anticancer agents: synthesis and in vitro biological evaluation Article Snippet: In this work, the synthesis and anticancer studies of 15 heterocyclic compounds (6a-6c, 7a-7c, 8a-8c, 9a-9c, and 10a-10c) bearing 1,3,4-oxadiazole-based alkylidene acetohydrazide moieties are reported.. The structural confirmation of these compounds was carried out using HRMS (Q-TOF), NMR, and single-crystal XRD (SC-XRD).. The cytotoxicity of the compounds was evaluated using cancer cell lines (4T1, MCF-7, PC3, and A549) and normal cell lines (HEK-293 & MCF-10A), with BG45, a selective HDAC3 inhibitor, as the reference compound. Article Title: Mitochondrial ATP production promotes T cell differentiation and function by regulating chromatin accessibility Article Snippet: After incubation for 1 h at 37 °C, the HDAC-Glo I/II reagent was added for 30 min at room temperature followed by luminescence acquisition using a Cytation 3 plate reader (Agilent). .. Cell-free Article Title: A Hybrid compound H93 treats prostate cancer by directly binding UHRF1 and promoting protein dimerization Article Snippet: .. The inhibition effect of H93 on the deacetylase activity of class I HDACs was measured by the Histone Deacetylase Assay:Article Title: 1,3,4-oxadiazole-tethered alkylidene acetohydrazides as potential anticancer agents: synthesis and in vitro biological evaluation Article Snippet: In this work, the synthesis and anticancer studies of 15 heterocyclic compounds (6a-6c, 7a-7c, 8a-8c, 9a-9c, and 10a-10c) bearing 1,3,4-oxadiazole-based alkylidene acetohydrazide moieties are reported.. The structural confirmation of these compounds was carried out using HRMS (Q-TOF), NMR, and single-crystal XRD (SC-XRD).. The cytotoxicity of the compounds was evaluated using cancer cell lines (4T1, MCF-7, PC3, and A549) and normal cell lines (HEK-293 & MCF-10A), with BG45, a selective HDAC3 inhibitor, as the reference compound. Article Title: A Hybrid compound H93 treats prostate cancer by directly binding UHRF1 and promoting protein dimerization Article Snippet: .. The inhibition effect of H93 on the deacetylase activity of class I HDACs was measured by the Recombinant:Article Title: Mitochondrial ATP production promotes T cell differentiation and function by regulating chromatin accessibility Article Snippet: After incubation for 1 h at 37 °C, the HDAC-Glo I/II reagent was added for 30 min at room temperature followed by luminescence acquisition using a Cytation 3 plate reader (Agilent). .. Cell-free Inhibition:Article Title: A Hybrid compound H93 treats prostate cancer by directly binding UHRF1 and promoting protein dimerization Article Snippet: .. The inhibition effect of H93 on the deacetylase activity of class I HDACs was measured by the Enzymatic Assay:Article Title: Design, synthesis, and biological evaluation of indazole-based histone deacetylase 6 inhibitors. Article Snippet: Histone deacetylases (HDACs) have been explored as anticancer targets for over two decades, with six HDAC inhibitors approved for clinical use.. However, these pan-HDAC inhibitors exhibit off-target effects, necessitating the development of isoform-selective inhibitors.. Among HDACs, HDAC6 has garnered attention due to its dual catalytic domains, cytoplasmic localization, and zinc-finger ubiquitin-binding domain (Zf-UBD). |
