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fluorogenic hdac3  (BPS Bioscience)


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    BPS Bioscience fluorogenic hdac3
    Fluorogenic Hdac3, supplied by BPS Bioscience, used in various techniques. Bioz Stars score: 90/100, based on 7 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/fluorogenic+hdac+1/Fluorogenic+HDAC+substrate+1/pm28809557-59-0-13
    Average 90 stars, based on 7 article reviews
    fluorogenic hdac3 - by Bioz Stars, 2026-11
    90/100 stars

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    Related Articles

    Recombinant:

    Article Title: Identification of HDAC inhibitors using a cell-based HDAC I/II assay
    Article Snippet: .. Fluorogenic Isoform-specific HDAC Assays The fluorogenic assays were performed at BPS Bioscience (San Diego, CA) for individual HDAC I/II enzymes (BPS Bioscience) using human recombinant enzymes and fluorogenic HDAC substrates 12 - 14 ( Suppl. ..

    Article Title: Identification of HDAC inhibitors using a cell-based HDAC I/II assay
    Article Snippet: .. The fluorogenic assays were performed at BPS Bioscience (San Diego, CA) for individual HDAC I/II enzymes (BPS Bioscience) using human recombinant enzymes and fluorogenic HDAC substrates 12 - 14 ( Suppl. ..

    other:

    Article Title: In Silico and in Vitro Interactions between Short Chain Fatty Acids and Human Histone Deacetylases.
    Article Snippet: Short chain fatty acids (SCFAs) are postulated to modulate the immune development of neonates via epigenetic regulations such as histone deacetylase (HDAC) inhibition.. In the context of atopic diseases, the inhibition of HDAC maintains T-cell homeostasis and induces naïve T-cell differentiation into adaptive Treg, which regulates the production of anti-inflammatory cytokines and suppression of Th2 immune responses.. We investigated the structure-inhibition relationships of SCFAs with class I HDAC3 and class IIa HDAC7 using in silico docking simulation and in vitro human recombinant HDAC inhibition assay.

    Concentration Assay:

    Article Title: Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors
    Article Snippet: .. The complex was then diluted to a final concentration of 2 nM in HDAC assay buffer (BPS Bioscience, 50031) containing 200 μM HDAC substrate 1 (BPS Bioscience, 50032) and 0.1 mg ml −1 BSA. .. 50 μl aliquots were quenched at 0, 5, 10, 20, 40, 120 min with an equal volume of Developer (BPS Bioscience, 50030) and fluorescence was measured as described in the HDAC1 inhibition assay.

    Histone Deacetylase Assay:

    Article Title: Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors
    Article Snippet: .. The complex was then diluted to a final concentration of 2 nM in HDAC assay buffer (BPS Bioscience, 50031) containing 200 μM HDAC substrate 1 (BPS Bioscience, 50032) and 0.1 mg ml −1 BSA. .. 50 μl aliquots were quenched at 0, 5, 10, 20, 40, 120 min with an equal volume of Developer (BPS Bioscience, 50030) and fluorescence was measured as described in the HDAC1 inhibition assay.

    Fluorescence:

    Article Title: Sir2-Related Protein 1 fromLeishmania amazonensisis a glycosylated NAD+-dependent deacetylase
    Article Snippet: .. The fluorescence of the HDAC substrate 1 (a fluorogenic acetylated peptide derived from a regulatory acetylation site of p53, BPS Bioscience, USA) was measured using excitation at 360 nm, and emission was collected from 455 to 465 nm. ..

    Derivative Assay:

    Article Title: Sir2-Related Protein 1 fromLeishmania amazonensisis a glycosylated NAD+-dependent deacetylase
    Article Snippet: .. The fluorescence of the HDAC substrate 1 (a fluorogenic acetylated peptide derived from a regulatory acetylation site of p53, BPS Bioscience, USA) was measured using excitation at 360 nm, and emission was collected from 455 to 465 nm. ..



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    In vitro inhibitory activity of compound 5 against histone deacetylase isotypes.

    Journal: Medicine

    Article Title: Design, synthesis, and biological evaluation of histone deacetylase inhibitor with novel salicylamide zinc binding group

    doi: 10.1097/MD.0000000000029049

    Figure Lengend Snippet: In vitro inhibitory activity of compound 5 against histone deacetylase isotypes.

    Article Snippet: HDAC fluorogenic assay kits (HDAC1, #50061; HDAC2, #50062; HDAC3, #50073; HDAC4, #50064; HDAC6, #50076; HDAC11, #50687) were bought from BPS Bioscience (San Diego, CA).

    Techniques: In Vitro, Activity Assay, Histone Deacetylase Assay

    Effect of compound 5 on the acetylation status of Histone H3 and α-tubulin. MDA-MB-231 cells were incubated with the indicated concentrations of compound 5 for 24 hours and the expression level of Histone H3, Ac-Histone H3, α-tubulin, Ac-α-tubulin, HDAC1, HDAC6, and GAPDH were analyzed using Western blotting. DMSO (D) was used as a negative control. GAPDH = glyceraldehyde 3-phosphate dehydrogenase, HDAC = Histone deacetylase.

    Journal: Medicine

    Article Title: Design, synthesis, and biological evaluation of histone deacetylase inhibitor with novel salicylamide zinc binding group

    doi: 10.1097/MD.0000000000029049

    Figure Lengend Snippet: Effect of compound 5 on the acetylation status of Histone H3 and α-tubulin. MDA-MB-231 cells were incubated with the indicated concentrations of compound 5 for 24 hours and the expression level of Histone H3, Ac-Histone H3, α-tubulin, Ac-α-tubulin, HDAC1, HDAC6, and GAPDH were analyzed using Western blotting. DMSO (D) was used as a negative control. GAPDH = glyceraldehyde 3-phosphate dehydrogenase, HDAC = Histone deacetylase.

    Article Snippet: HDAC fluorogenic assay kits (HDAC1, #50061; HDAC2, #50062; HDAC3, #50073; HDAC4, #50064; HDAC6, #50076; HDAC11, #50687) were bought from BPS Bioscience (San Diego, CA).

    Techniques: Incubation, Expressing, Western Blot, Negative Control, Histone Deacetylase Assay

    Molecular docking pose of compound 5 bound in the substrate-binding pocket of HDAC2 (PDB code: 4LXZ). The docking pose of compound 5 (lime) and the crystal structure of SAHA (pink) complex were overlapped in the substrate-binding pocket of HDAC2. The oxygen, nitrogen, and hydrogen atoms of compound 5 and SAHA are shown in red, blue, and white, respectively. The side chains of the binding site are colored according to the atom types (carbon, light blue; oxygen, red; nitrogen, blue) and labeled with their residue name. The hydrogen bonds are shown as dashed red lines. The docking poses are visualized using PyMOL1.3.

    Journal: Medicine

    Article Title: Design, synthesis, and biological evaluation of histone deacetylase inhibitor with novel salicylamide zinc binding group

    doi: 10.1097/MD.0000000000029049

    Figure Lengend Snippet: Molecular docking pose of compound 5 bound in the substrate-binding pocket of HDAC2 (PDB code: 4LXZ). The docking pose of compound 5 (lime) and the crystal structure of SAHA (pink) complex were overlapped in the substrate-binding pocket of HDAC2. The oxygen, nitrogen, and hydrogen atoms of compound 5 and SAHA are shown in red, blue, and white, respectively. The side chains of the binding site are colored according to the atom types (carbon, light blue; oxygen, red; nitrogen, blue) and labeled with their residue name. The hydrogen bonds are shown as dashed red lines. The docking poses are visualized using PyMOL1.3.

    Article Snippet: HDAC fluorogenic assay kits (HDAC1, #50061; HDAC2, #50062; HDAC3, #50073; HDAC4, #50064; HDAC6, #50076; HDAC11, #50687) were bought from BPS Bioscience (San Diego, CA).

    Techniques: Binding Assay, Labeling